LOCUS       NP_033369                559 aa            linear   ROD 28-APR-2025
DEFINITION  PHD finger protein 1 isoform 1 [Mus musculus].
ACCESSION   NP_033369 XP_919985 XP_928545
VERSION     NP_033369.2
DBSOURCE    REFSEQ: accession NM_009343.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 559)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 559)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 559)
  AUTHORS   Dong,C., Nakagawa,R., Oyama,K., Yamamoto,Y., Zhang,W., Dong,A.,
            Li,Y., Yoshimura,Y., Kamiya,H., Nakayama,J.I., Ueda,J. and Min,J.
  TITLE     Structural basis for histone variant H3tK27me3 recognition by PHF1
            and PHF19
  JOURNAL   Elife 9, e58675 (2020)
   PUBMED   32869745
  REMARK    GeneRIF: Structural basis for histone variant H3tK27me3 recognition
            by PHF1 and PHF19.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 559)
  AUTHORS   Ragazzini,R., Perez-Palacios,R., Baymaz,I.H., Diop,S., Ancelin,K.,
            Zielinski,D., Michaud,A., Givelet,M., Borsos,M., Aflaki,S.,
            Legoix,P., Jansen,P.W.T.C., Servant,N., Torres-Padilla,M.E.,
            Bourc'his,D., Fouchet,P., Vermeulen,M. and Margueron,R.
  TITLE     EZHIP constrains Polycomb Repressive Complex 2 activity in germ
            cells
  JOURNAL   Nat Commun 10 (1), 3858 (2019)
   PUBMED   31451685
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 559)
  AUTHORS   Qu,Y., Wang,Y. and Qiao,J.
  TITLE     PHF1 is required for chromosome alignment and asymmetric division
            during mouse meiotic oocyte maturation
  JOURNAL   Cell Cycle 17 (21-22), 2447-2459 (2018)
   PUBMED   30382790
  REMARK    GeneRIF: PHF1 is necessary for the accurate alignment of
            chromosomes and oocyte euploidy, as well for the regulation of the
            asymmetric division of oocytes in mouse.
REFERENCE   6  (residues 1 to 559)
  AUTHORS   Cao,R., Wang,H., He,J., Erdjument-Bromage,H., Tempst,P. and
            Zhang,Y.
  TITLE     Role of hPHF1 in H3K27 methylation and Hox gene silencing
  JOURNAL   Mol Cell Biol 28 (5), 1862-1872 (2008)
   PUBMED   18086877
REFERENCE   7  (residues 1 to 559)
  AUTHORS   Jacquemin,P., Chen,Z., Martial,J.A. and Davidson,I.
  TITLE     Genomic structure and chromosomal mapping of the mouse
            transcription factor TEF-5 (Tead3) gene
  JOURNAL   Mamm Genome 10 (6), 632-634 (1999)
   PUBMED   10341100
REFERENCE   8  (residues 1 to 559)
  AUTHORS   Kawakami,S., Mitsunaga,K., Kikuti,Y.Y., Ando,A., Inoko,H.,
            Yamamura,K. and Abe,K.
  TITLE     Tctex3, related to Drosophila polycomblike, is expressed in male
            germ cells and mapped to the mouse t-complex
  JOURNAL   Mamm Genome 9 (11), 874-880 (1998)
   PUBMED   9799836
REFERENCE   9  (residues 1 to 559)
  AUTHORS   Yeom,Y.I., Abe,K., Bennett,D. and Artzt,K.
  TITLE     Testis-/embryo-expressed genes are clustered in the mouse H-2K
            region
  JOURNAL   Proc Natl Acad Sci U S A 89 (2), 773-777 (1992)
   PUBMED   1731353
REFERENCE   10 (residues 1 to 559)
  AUTHORS   Ha,H., Howard,C.A., Yeom,Y.I., Abe,K., Uehara,H., Artzt,K. and
            Bennett,D.
  TITLE     Several testis-expressed genes in the mouse t-complex have
            expression differences between wild-type and t-mutant mice
  JOURNAL   Dev Genet 12 (4), 318-332 (1991)
   PUBMED   1718647
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK139088.1, AK133474.1 and
            AC144621.3.
            
            On Aug 5, 2006 this sequence version replaced NP_033369.1.
            
            Summary: The protein encoded by this gene belongs to the
            polycomb-like protein family, which is a component of polycomb
            repressive complex-2. This complex represses gene expression by
            catalyzing the trimethylation of histone H3 lysine 27 and is
            required for the regulation of developmental genes including
            homeotic genes. The gene is expressed primarily in testis tissue.
            Small interfering RNA-mediated knockdown in cultured cell lines
            results in changes in homeotic gene expression coincident with
            alterations in promoter methylation. Alternative splicing results
            in multiple transcript variants. [provided by RefSeq, Oct 2014].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK139088.1, U81490.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..559
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 13.6 cM"
     Protein         1..559
                     /product="PHD finger protein 1 isoform 1"
                     /note="polycomb-like protein 1; t-complex testis-expressed
                     3"
                     /calculated_mol_wt=61009
     Region          30..82
                     /region_name="Tudor_PHF1"
                     /note="Tudor domain found in PHD finger protein1 (PHF1)
                     and similar proteins; cd20449"
                     /db_xref="CDD:410520"
     Site            order(38,41,45..47,65..69,71)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:410520"
     Region          89..139
                     /region_name="PHD1_PHF1"
                     /note="PHD finger 1 found in PHD finger protein1 (PHF1);
                     cd15500"
                     /db_xref="CDD:276975"
     Site            order(89,103..107,111,134)
                     /site_type="other"
                     /note="putative histone H3 binding site [polypeptide
                     binding]"
                     /db_xref="CDD:276975"
     Region          188..239
                     /region_name="PHD2_PHF1"
                     /note="PHD finger 2 found in PHD finger protein1 (PHF1);
                     cd15582"
                     /db_xref="CDD:277057"
     Site            order(188,200..204,208,232)
                     /site_type="other"
                     /note="putative histone H3 binding site [polypeptide
                     binding]"
                     /db_xref="CDD:277057"
     Region          338..434
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z1B8.2)"
     Region          448..526
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z1B8.2)"
     Region          <528..557
                     /region_name="Mtf2_C"
                     /note="Polycomb-like MTF2 factor 2; pfam14061"
                     /db_xref="CDD:464077"
     CDS             1..559
                     /gene="Phf1"
                     /gene_synonym="D17Ertd455e; Pcl1; Phf2; Tctex3"
                     /coded_by="NM_009343.3:425..2104"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS37518.1"
                     /db_xref="GeneID:21652"
                     /db_xref="MGI:MGI:98647"
ORIGIN      
        1 maqlprlsrl gapslwdpas paptsgprpr lwegqdvlar wtdgllylgt ikkvdsarev
       61 clvqfeddsq flvlwkdisp aalpgeellc cvcrsetvvp gnrlvscekc rhayhqdchv
      121 prapapgege gaswvcrqcv faiatkrgga lkkgpyaram lgmklslpyg lkgldwdagh
      181 lsnrqqsycy cggpgewnlk mlqcrsclqw fheactqcls kpllygdrfy efeccvcrgg
      241 pekvrrlqlr wvdvahlvly hlsvcckkky fdfdreilpf tsenwdslll gelsdtpkge
      301 rssqllsaln shkdrfisgr eikkrkclfg lhartpppve lltgdgapts fpsgqgpggg
      361 vsrplgkrwr sepeplrrrq kgkveelgpp taahsrhgsr eqralqasvs ppppspnqsy
      421 egssgynfrp tdarclpssp irmfasfhps astagtsgds eppdrsplgl higfptdtpk
      481 ssphsvtass ssvpaltpgf srhsppsplc rslspgtggg vrggvsylsr gdpvrvlarr
      541 vrpdgsvqyl vewggggif
//
