LOCUS       NM_011077               6265 bp    mRNA    linear   ROD 11-DEC-2024
DEFINITION  Mus musculus phosphate regulating endopeptidase homolog, X-linked
            (Phex), mRNA.
ACCESSION   NM_011077 XM_890857
VERSION     NM_011077.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6265)
  AUTHORS   Sorsby,M., Almardini,S., Alayyat,A., Hughes,A., Venkat,S.,
            Rahman,M., Baker,J., Rana,R., Rosen,V. and Liu,E.S.
  TITLE     The role of GDF5 in regulating enthesopathy development in the Hyp
            mouse model of XLH
  JOURNAL   J Bone Miner Res 39 (8), 1162-1173 (2024)
   PUBMED   38836497
REFERENCE   2  (bases 1 to 6265)
  AUTHORS   Almubarak,A., Zhang,Q., Zhang,C.H., Abdelwahab,N., Kume,T.,
            Lassar,A.B. and Berry,F.B.
  TITLE     FOXC1 and FOXC2 regulate growth plate chondrocyte maturation
            towards hypertrophy in the embryonic mouse limb skeleton
  JOURNAL   Development 151 (16) (2024)
   PUBMED   39012257
REFERENCE   3  (bases 1 to 6265)
  AUTHORS   Wu,H., Ying,H., Zhao,W., Sun,Y., Wang,Y., Chen,X., Li,G., Yao,Y.,
            Xu,S., Li,T., Fang,L., Sun,X., Wang,N., Xu,J., Guan,Q., Xia,W.,
            Wang,L., Gao,L., Zhao,J. and Xu,C.
  TITLE     Characterization of Novel PHEX Variants in X-linked
            Hypophosphatemic Rickets and Genotype-PHEX Activity Correlation
  JOURNAL   J Clin Endocrinol Metab 109 (9), 2242-2255 (2024)
   PUBMED   38442738
  REMARK    GeneRIF: Characterization of Novel PHEX Variants in X-linked
            Hypophosphatemic Rickets and Genotype-PHEX Activity Correlation.
REFERENCE   4  (bases 1 to 6265)
  AUTHORS   Nakanishi,T., Yamazaki,M., Tachikawa,K., Ueta,A., Kawai,M.,
            Ozono,K. and Michigami,T.
  TITLE     Complex intrinsic abnormalities in osteoblast lineage cells of
            X-linked hypophosphatemia: Analysis of human iPS cell models
            generated by CRISPR/Cas9-mediated gene ablation
  JOURNAL   Bone 181, 117044 (2024)
   PUBMED   38331306
REFERENCE   5  (bases 1 to 6265)
  AUTHORS   Yadav,P.S., Kobelski,M.M., Martins,J.S., Tao,T., Liu,E.S. and
            Demay,M.B.
  TITLE     Impaired Growth Plate Maturation in XLH Is due to Both Excess FGF23
            and Decreased 1,25-Dihydroxyvitamin D Signaling
  JOURNAL   Endocrinology 165 (1) (2023)
   PUBMED   38066669
REFERENCE   6  (bases 1 to 6265)
  AUTHORS   Gonzalez,C.D., Meyer,R.A. Jr. and Iorio,R.J.
  TITLE     Craniometric measurements of craniofacial malformations in the
            X-linked hypophosphatemic (Hyp) mouse on two different genetic
            backgrounds: C57BL/6J and B6C3H
  JOURNAL   Teratology 46 (6), 605-613 (1992)
   PUBMED   1290161
REFERENCE   7  (bases 1 to 6265)
  AUTHORS   Cowgill,L.D., Goldfarb,S., Lau,K., Slatopolsky,E. and Agus,Z.S.
  TITLE     Evidence for an intrinsic renal tubular defect in mice with genetic
            hypophosphatemic rickets
  JOURNAL   J Clin Invest 63 (6), 1203-1210 (1979)
   PUBMED   221535
REFERENCE   8  (bases 1 to 6265)
  AUTHORS   Tenenhouse,H.S. and Scriver,C.R.
  TITLE     The defect in transcellular transport of phosphate in the nephron
            is located in brush-border membranes in X-linked hypophosphatemia
            (Hyp mouse model)
  JOURNAL   Can J Biochem 56 (6), 640-646 (1978)
   PUBMED   566613
REFERENCE   9  (bases 1 to 6265)
  AUTHORS   O'Doherty,P.J., DeLuca,H.F. and Eicher,E.M.
  TITLE     Lack of effect of vitamin D and its metabolites on intestinal
            phosphate transport in familial hypophosphatemia of mice
  JOURNAL   Endocrinology 101 (4), 1325-1330 (1977)
   PUBMED   908280
REFERENCE   10 (bases 1 to 6265)
  AUTHORS   Eicher,E.M., Southard,J.L., Scriver,C.R. and Glorieux,F.H.
  TITLE     Hypophosphatemia: mouse model for human familial hypophosphatemic
            (vitamin D-resistant) rickets
  JOURNAL   Proc Natl Acad Sci U S A 73 (12), 4667-4671 (1976)
   PUBMED   188049
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK158481.1, U49908.1 and CT572987.3.
            
            On Oct 26, 2006 this sequence version replaced NM_011077.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U49908.1, U73910.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1249              AK158481.1         28-1276
            1250-2764           U49908.1           1242-2756
            2765-3047           AK158481.1         2792-3074
            3048-6265           CT572987.3         32742-35959         c
FEATURES             Location/Qualifiers
     source          1..6265
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 72.38 cM"
     gene            1..6265
                     /gene="Phex"
                     /gene_synonym="Gy; HPDR; HPDR1; Hyp; PEX"
                     /note="phosphate regulating endopeptidase homolog,
                     X-linked"
                     /db_xref="GeneID:18675"
                     /db_xref="MGI:MGI:107489"
     exon            1..648
                     /gene="Phex"
                     /gene_synonym="Gy; HPDR; HPDR1; Hyp; PEX"
                     /inference="alignment:Splign:2.1.0"
     exon            649..717
                     /gene="Phex"
                     /gene_synonym="Gy; HPDR; HPDR1; Hyp; PEX"
                     /inference="alignment:Splign:2.1.0"
     exon            718..879
                     /gene="Phex"
                     /gene_synonym="Gy; HPDR; HPDR1; Hyp; PEX"
                     /inference="alignment:Splign:2.1.0"
     exon            880..966
                     /gene="Phex"
                     /gene_synonym="Gy; HPDR; HPDR1; Hyp; PEX"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1193
                     /gene="Phex"
                     /gene_synonym="Gy; HPDR; HPDR1; Hyp; PEX"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1262
                     /gene="Phex"
                     /gene_synonym="Gy; HPDR; HPDR1; Hyp; PEX"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1379
                     /gene="Phex"
                     /gene_synonym="Gy; HPDR; HPDR1; Hyp; PEX"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1463
                     /gene="Phex"
                     /gene_synonym="Gy; HPDR; HPDR1; Hyp; PEX"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1609
                     /gene="Phex"
                     /gene_synonym="Gy; HPDR; HPDR1; Hyp; PEX"
                     /inference="alignment:Splign:2.1.0"
     exon            1610..1703
                     /gene="Phex"
                     /gene_synonym="Gy; HPDR; HPDR1; Hyp; PEX"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..1832
                     /gene="Phex"
                     /gene_synonym="Gy; HPDR; HPDR1; Hyp; PEX"
                     /inference="alignment:Splign:2.1.0"
     exon            1833..1934
                     /gene="Phex"
                     /gene_synonym="Gy; HPDR; HPDR1; Hyp; PEX"
                     /inference="alignment:Splign:2.1.0"
     exon            1935..2012
                     /gene="Phex"
                     /gene_synonym="Gy; HPDR; HPDR1; Hyp; PEX"
                     /inference="alignment:Splign:2.1.0"
     exon            2013..2116
                     /gene="Phex"
                     /gene_synonym="Gy; HPDR; HPDR1; Hyp; PEX"
                     /inference="alignment:Splign:2.1.0"
     exon            2117..2175
                     /gene="Phex"
                     /gene_synonym="Gy; HPDR; HPDR1; Hyp; PEX"
                     /inference="alignment:Splign:2.1.0"
     exon            2176..2230
                     /gene="Phex"
                     /gene_synonym="Gy; HPDR; HPDR1; Hyp; PEX"
                     /inference="alignment:Splign:2.1.0"
     exon            2231..2298
                     /gene="Phex"
                     /gene_synonym="Gy; HPDR; HPDR1; Hyp; PEX"
                     /inference="alignment:Splign:2.1.0"
     exon            2299..2429
                     /gene="Phex"
                     /gene_synonym="Gy; HPDR; HPDR1; Hyp; PEX"
                     /inference="alignment:Splign:2.1.0"
     exon            2430..2495
                     /gene="Phex"
                     /gene_synonym="Gy; HPDR; HPDR1; Hyp; PEX"
                     /inference="alignment:Splign:2.1.0"
     exon            2496..2600
                     /gene="Phex"
                     /gene_synonym="Gy; HPDR; HPDR1; Hyp; PEX"
                     /inference="alignment:Splign:2.1.0"
     exon            2601..2677
                     /gene="Phex"
                     /gene_synonym="Gy; HPDR; HPDR1; Hyp; PEX"
                     /inference="alignment:Splign:2.1.0"
     exon            2678..6265
                     /gene="Phex"
                     /gene_synonym="Gy; HPDR; HPDR1; Hyp; PEX"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6244..6249
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Phex"
                     /gene_synonym="Gy; HPDR; HPDR1; Hyp; PEX"
                     /note="hexamer: AATAAA"
     polyA_site      6265
                     /gene="Phex"
                     /gene_synonym="Gy; HPDR; HPDR1; Hyp; PEX"
                     /note="major polyA site"
ORIGIN      
        1 aggagaatgg ctgtcatagc agaaatctgt aactaattga gatcttgaat tggatgcaga
       61 ctgtccttgc cacctaactt atcatggtta gggggagggt gggaatccac ttttgataaa
      121 agacaaattt tttttcctcc ccaagtgact atacgtttaa atagctaaaa catctgtgca
      181 gcaacctagt aaaacatgta tactcggaat gcttgagcaa aaagcctgcc aaacaattgc
      241 ttgagaggga ctttgctgag ggagagcacc aagataaagc aactgctgtt tgttttgtct
      301 agtcaaaggc gagccaaggc aaccaatatt ttgagtttct tttatttcat ttgtgaagga
      361 ttatttgaga aagggtgtcg aggggaagtt tcctgacagg aatttttaaa gctgtctatt
      421 agcagacgag caagagagtc ttgaatatca aacgcctgac aaacttttga gaccagccac
      481 caaaccacga aaagtgactt tccttctaag tcttctctcc agcccttctg atggaagcag
      541 aaacagggag caccatggag actggaaagg ggaccaaccg aggcattcgg attgcactgg
      601 ccctgtttat tggtggcacc ctggtgttgg gcacactgct ctttctagtg agtcaaggtc
      661 tcctaagttt ccaagctaaa caggagtact gtctgaagcc agaatgcata gaagccgctg
      721 ctgccatcat gagcaaagta aatctttctg tggatccttg tgagaatttt ttccggtttg
      781 cttgtgatgg ctggataagc aataacccaa ttcctgaaga tatgccaagc tatggggttt
      841 atccttggct gagacacaat gttgacctca agttgaaggc acttctggag aaatcagtca
      901 gccgaaggcg ggacactgaa gccgtacaga aagccaaaat cctctactca tcctgcatga
      961 atgagaaagc aattgaaaaa gcagatgcca agccactgct ccacatcttg aggcattcac
     1021 ctttccgctg gccagtgctt gaagctaata ttggtcctga aggggtttgg tcagagagaa
     1081 aattcagtct actgcaaaca ctggcaacgt tccgcggtca atacagcaat tctgtgttca
     1141 tccgtttgta tgtgtcccct gatgacaagg catccaatga acatatcttg aagctggacc
     1201 aagcaacact ctctctggct gtaagggaag acttcctgga taacactact gaagccaaat
     1261 cttatcggga tgccctttac aaattcatgg tggacactgc tgtgctttta ggagctaata
     1321 gctctcgagc tgaacatgac atgaagtcgg tgcttagact ggaaattaag atagctgaga
     1381 taatgattcc acatgagaac cgaaccagtg aggctatgta taacaaaatg aacatctcag
     1441 aactcagcgc tatgattccc cagtttgact ggctgggcta tatcaagaag gtcattgata
     1501 ccagactcta cccacacttg aaagacattg gtccctcgga gaatgtggtg gtccgcgtcc
     1561 cacagtactt taaagatttg tttaggatat taggtgccga gaggaagaaa accattgcca
     1621 attatttagt gtggagaatg gtttattcca gaattccaaa cctcagcagg cgctttcaat
     1681 atagatggct agaattctca agggtaatcc aggggaccac aactctgctg cctcagtggg
     1741 acaaatgtgt caactttatt gagagtgcac tcccatatgt tgtggggaaa atgtttgtga
     1801 atgttcactt ccaggaggat aagaaggaaa tgatggaaga attgattgag ggtgttcgct
     1861 gggccttcat tgacatgctg gagaaagaaa atgaatggat ggatgcaggg acaaaaagga
     1921 aagctcaaga aaaggcaaga gctgttttgg caaaagttgg ctatccagag tttataatga
     1981 atgatactta tgttaatgaa gacctcaagg caatcaaatt ttcagaatcg gactactttg
     2041 gcaacgtact gcaaacccgc aagtatttag cacagtctga tttcttctgg ctaagaaaag
     2101 ctgttcccaa aacagagtgg tttacaaacc caacaacagt caatgccttt tacagtgcat
     2161 ctaccaacca gatacgattt cctgctggag agctgcagaa gcctttcttt tggggaacag
     2221 aataccctcg atccctgagt tatggtgcta taggagtaat tgtgggccat gaatttacac
     2281 atggatttga taataatggt agaaaatatg ataaaaatgg aaaccttgat ccgtggtggt
     2341 ctgtggaatc agaagaaaag tttaaggaaa aaacaaaatg catgattaac cagtatagca
     2401 actattattg gaagaaagcc ggcttaaatg tgaaagggaa gaggaccctg ggagaaaata
     2461 ttgctgataa tgggggtctg cgagaagctt ttagggctta caggaaatgg ataaatgata
     2521 gaagacaggg agttgaagag cccctcctac caggcatcac attcaccaac aatcagctct
     2581 tcttcctgag ttatgctcat gtaaggtgca attcctatag accagaagct gccagagaac
     2641 aagtgcaaat tggtgctcac agtcctccac aatttagggt caatggtgcc attagcaact
     2701 ttgaagaatt tcagaaagct tttaactgtc cacgaaattc cactatgaac agaggtgcag
     2761 attcctgccg actctggtag ctggagtgct ggtttctgcc ttcctggcat agctgaggaa
     2821 tgccagtaga ggacgcatta acatacttag cacctactgc tttctgccta tatttccttg
     2881 aagactttta tttttaatgc attttcatta tttgggtaga tgatttgctt cgatctaaac
     2941 agtatctgtt caaagtcatt gggtttataa aaggaattca agaactgagc caaatacttt
     3001 tcttttcttt tcttttcttt tcttttcttt tcttttcttt tcttttcctt tcctttcctt
     3061 tcctttcctt tcctttcctt tcttttcttt ctttctttct tttttttaaa gaaagccaaa
     3121 ccaatgaaaa aaaagtgtca aggctatttg gttaaactgc tcctggcgat gtccctatta
     3181 tccatttctg ttaaccacag ctcggtggta catgacattt caatctacag ctttgcaggg
     3241 ggcctgagta gagtgtatcc atagaaagga tcagtcaatg aaaattgtca ccctcaatga
     3301 taaagacgtg tgccctatgg tgtacagtta ttacacaaca tttcttaatt ctaaggtagt
     3361 taaattagaa atgtgttgga tcttcatttt ataatttctt ttcttttttt caatttttat
     3421 tagatatttt gttcatttac atttaaaatg ttatcctgaa agtctcctat accctcccct
     3481 caccctgctc ccctaaccac ccactcccac ttcttggcct tggcgttcac ctgtactggg
     3541 gcatataaag tttgcaagac caaggggcct ctcttcccaa tgatggccga ctaggaagtt
     3601 tttctcttca ggtttggagt ctattggaca attgtatctc agaacttcca tccgatgtag
     3661 ctaactgccc tgtttaagta agcatgaaca aacatggcat aaaggtgaag gatttgggtc
     3721 tataaaacag ggaaaaaacc aatacgtctt taactgccag cagcattaaa aactattaac
     3781 aacaaccaat cacacaacaa taaagatagt aggaaatgaa ctctgcaaac gttgatccag
     3841 tccctctgta tgatggtgag catctgtctg atggatagca gtcaaggagc agttctgatt
     3901 ttgttttgtt ctgctcagct gtgtttattt cctgactgaa ttgagtagac actgaggaaa
     3961 gaatgttttg tttccatgtc aggaacatat ggctttcatt tccttttagc ataatgatat
     4021 aaacgccacg ctgaggaggg ggcaagatgc tcttctgtct cagcccactt aatgttaact
     4081 ctccttaaaa gaaaatcttt gcaaaagctt ctagaatgaa agcatttggt atatctgaat
     4141 ccaatttaag caatcctacc tagatctaaa ggacatagct ttactcttca catcttatga
     4201 aaggtttatt tttttttcta aaagcagtac tgtattttga tctttagaac attatttttt
     4261 taatcaacac ctatagtgtt aattaactta gtgttagtgt gtatttatgt agggcatttt
     4321 tatcacattt aagagtatat gtaggataaa attgtaatgg cattgaagtg gtgagtactt
     4381 cttgtttttt tttttaaata tttttaatct agtataggca ttttcctacc cccaacacat
     4441 tattcattgt acatggcgtg ctggttaagt gggccaatag aaaattttca aaagcaaaat
     4501 gacaaattca gatgaaccac aggaggtcaa ttttgcatcc ttgtgacttg tcattctttt
     4561 ataaaagaaa tgtaagtgtg aaccatatcc ttttgtaacc atgggaactt ccaaagagag
     4621 aaaaatggaa ggacatcatc ataaggaaaa caattacact gcattagtct gaggagagtg
     4681 attttcccct tgacttcctc ctctccgaat ggatacactt ctgaagggca gcagcctttt
     4741 cttcctctta tccatggttt aaagtgacct tggcttgtat ttctaaacac aaacagcatc
     4801 atgtgaggtg ttagaaatat atgtgccttt tctctggtgt agccattctg atttgtcaat
     4861 actcattttt attcctgaac accgaagttt gccaggctta tataaatagt gcattccttc
     4921 taagtttcct ttttaacaat tccaagcaaa cacattcctg caggtcagag agtgtgtttg
     4981 agaagactat agatttatga ctttggaaat ggtattggtt tattggttaa ggacgactgg
     5041 ttagtgatta gagttctccc agtttctgga tgacaggatt agtaactaag tattttgatc
     5101 aacttggatt ttcaagagat acaaaattac tcttagtagc cacacacatt ttctacaagt
     5161 gctagctttt taagtgtttt ggttaaaccc ttcaaactac aatattgttc tctgtgcagc
     5221 ttgatttcct aaagagacac tgattaaatg gtagagaaag tcagacataa ttgaagaatg
     5281 gaagaaaagc agggggagct agcctaagga aaacaagaca gcatcttttt tgctccttga
     5341 tatacatgtt cactggagga gaaccaaaaa gtctttaaaa ataattatgg taaatcaaag
     5401 ggaaattaaa tattggatct cagactaggg ctacagcaac acactgctct gactcatata
     5461 gcagctgttc tgcaagtgga ttattaactg ggcatttgaa ggagtttttc ttttttaatg
     5521 tgtgtggaat tctcttttgt gagtcaagga ctctgtagat ttaaagctgt gttgtttggc
     5581 cttactaccg ttgtccaaag tttgctgagt ttttcaccaa atactcagta taggcctcct
     5641 attcctgcct cactctcttt tattagatgg attggggcat gactgctgta agatcagatt
     5701 tcataaatta tcctcaagct tatttagtgc cttacgtcaa tggagcttaa agcatagccc
     5761 ataaatttta tcttatttag ccctagagca tcactaagaa gaaactagga actaaggctc
     5821 agcagacaga gagtgctcat gccaagagaa atgggaaagc ttagaattgc ttgtccaaga
     5881 tctcagggca tggaaggaca ggttttgtgc ttcgggatac tgatctttgg attaacttgc
     5941 atctcttaga gtatcttctt ttctaatatg tttattccac cagcatttct aaaattgctt
     6001 atcatttggt agccactgcc tttgatattt ttagcataat gtcacagtac atcttaaatt
     6061 gtggaaaact gcatgattgt tccatggaat aacatcttta tcactagtgg caatgcttta
     6121 ttggttttaa gaaagatgtt cttgtactgt gcagtttaaa aacaatctat gtcattacta
     6181 tcagactggt ttggttgtga tttttttcct ttgtgaagca atgagaatca ttattttaag
     6241 gacaataaaa catttgttga aggtt
//
