LOCUS       NM_175474               2386 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus PH domain containing endocytic trafficking adaptor 1
            (Pheta1), transcript variant 1, mRNA.
ACCESSION   NM_175474
VERSION     NM_175474.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2386)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2386)
  AUTHORS   Swan,L.E., Tomasini,L., Pirruccello,M., Lunardi,J. and De
            Camilli,P.
  TITLE     Two closely related endocytic proteins that share a common
            OCRL-binding motif with APPL1
  JOURNAL   Proc Natl Acad Sci U S A 107 (8), 3511-3516 (2010)
   PUBMED   20133602
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY347960.1, AK039192.1 and BE993987.1.
            
            On Jan 20, 2018 this sequence version replaced NM_175474.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. All three variants encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK033618.1, CK128893.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-363               BY347960.1         2-364
            364-2071            AK039192.1         281-1988
            2072-2386           BE993987.1         1-315               c
FEATURES             Location/Qualifiers
     source          1..2386
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 62.01 cM"
     gene            1..2386
                     /gene="Pheta1"
                     /gene_synonym="A230106M15Rik; Fam109a; IPIP27A; Ses1"
                     /note="PH domain containing endocytic trafficking adaptor
                     1"
                     /db_xref="GeneID:231717"
                     /db_xref="MGI:MGI:2442708"
     exon            1..128
                     /gene="Pheta1"
                     /gene_synonym="A230106M15Rik; Fam109a; IPIP27A; Ses1"
                     /inference="alignment:Splign:2.1.0"
     exon            129..205
                     /gene="Pheta1"
                     /gene_synonym="A230106M15Rik; Fam109a; IPIP27A; Ses1"
                     /inference="alignment:Splign:2.1.0"
     exon            206..317
                     /gene="Pheta1"
                     /gene_synonym="A230106M15Rik; Fam109a; IPIP27A; Ses1"
                     /inference="alignment:Splign:2.1.0"
     exon            318..2371
                     /gene="Pheta1"
                     /gene_synonym="A230106M15Rik; Fam109a; IPIP27A; Ses1"
                     /inference="alignment:Splign:2.1.0"
     CDS             344..1144
                     /gene="Pheta1"
                     /gene_synonym="A230106M15Rik; Fam109a; IPIP27A; Ses1"
                     /note="27 kDa inositol polyphosphate phosphatase
                     interacting protein A; family with sequence similarity
                     109, member A"
                     /codon_start=1
                     /product="sesquipedalian-1"
                     /protein_id="NP_780683.1"
                     /db_xref="CCDS:CCDS19642.1"
                     /db_xref="GeneID:231717"
                     /db_xref="MGI:MGI:2442708"
                     /translation="MKLNERSLAFYATCDAPVDNAGFLYKRGGRGTGSHRRWFVLRGN
                     ILFYFEAEGSREPLGVILLEGCTVELVDAREEFAFAVRFAGGRSRPYVLAADSQAALE
                     GWVKALSRASFHYLRLVVRELEQQLAAMREGSPANALPANPSPVLTQRPKENGWVVWS
                     TLPEQPSVAPQRPPPLPPRRRASAANGPLASFAQLHARYGLEVQALRDQWRGGQAGLA
                     SLEVPWHPGSAETQTQDQPALRGHSGCKVLHVFRSVEWPVCNPGSQGT"
     regulatory      2352..2357
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pheta1"
                     /gene_synonym="A230106M15Rik; Fam109a; IPIP27A; Ses1"
                     /note="hexamer: AATAAA"
     polyA_site      2371
                     /gene="Pheta1"
                     /gene_synonym="A230106M15Rik; Fam109a; IPIP27A; Ses1"
                     /note="major polyA site"
ORIGIN      
        1 agggttaaag gggcgcccgc gggtcgccgc cactcggcct ccgggagaca aagggccctg
       61 tcgtcgccgg cccccgagct gttccgggcc atgggcagga cagaccgtcg cgccggtccc
      121 agagccaggc tccccagcac aggctacaca ctggacactc aaagccagac agaagccccc
      181 acaccccctc tctggactga cgcagatgaa gagctagagg tccagagaga ctgactgtgt
      241 gcccctgaag tgacccagcc tggagactgt gagctgacct tcaaagtgat tgagcagaac
      301 tgggtgggca gcctgtgggg acaggttgca gctcctcgtg accatgaagc tcaacgagcg
      361 cagcttggcc ttctacgcaa cctgcgatgc cccggtggac aacgccggct tcctgtacaa
      421 gcgtggtggc cgtgggaccg gctcgcaccg gcgctggttc gtgctccggg gcaatatcct
      481 cttttacttc gaggcagaag gcagccgcga gccgctgggc gtcatcctgc tggagggctg
      541 cacggtggag ctggtggatg cccgggagga gttcgccttc gcagtgcgct ttgccggggg
      601 ccgatcccgg ccgtacgtgc tggccgctga cagccaggca gccctggagg gctgggtgaa
      661 ggcactgtcc cgggccagct tccactatct gcgcttggtg gtgcgggagc tggaacagca
      721 actggctgcc atgcgcgagg gaagccccgc caacgcctta cccgccaacc cgagcccggt
      781 tttgacccag agacccaagg agaacggctg ggtagtgtgg agcacgctgc ccgagcagcc
      841 ctcggtagcc cctcagcggc cgccgccact gccaccccgc cgcagggcct cagcggccaa
      901 cgggcccttg gcatccttcg cccagctgca tgcgcgatat ggactagagg tgcaggccct
      961 tagggaccag tggcgcggag gccaggctgg cctagccagc ttagaggtcc cctggcatcc
     1021 tggttctgct gagactcaga cccaggacca gccagcccta aggggacata gtgggtgtaa
     1081 ggtattacat gtattccgtt ccgtagaatg gcctgtttgc aatccaggct cccaggggac
     1141 ataggacata tgactcagga gacctgtgcc cctggggtca gaggcactta cttctgagaa
     1201 gaatctggaa cgtgaacctg agggtgcttc tagagcccaa ggagctggtt tctagagaac
     1261 tccgcgccag ggtggcctgt gtgaccttga cagccccgaa gctggccaca ggcccatggg
     1321 gcccagggtt tacctggtgc ctctcaagga tctaaagctt gaacctggaa gctgctgtct
     1381 gggctgctgt gggcctacac cagtaggtgg aatgtgggac ttgaactgga taggtccccc
     1441 aggctcctgg cctggaacca gctaagtcag gactgtgtcc agctttgtag gtgagcccgg
     1501 gcagaagcag ggcctcccct gacctcggtc ctggcctggg acccagcttc ctcccagttt
     1561 cacctggagg agacaggcct ccgactgatt ccatgcctgc agcagggaga gcccaggcac
     1621 tgtccctagc cactgcaggt gaccagtggg cctcaggact gggcctactt ctctctcacc
     1681 acagtgctgg ctgtcttcca gagggttggg caggacagcc ggccccacct gggttcttgt
     1741 ttacagtcct cctcagtgcc ctgccctgag gggacactcc aatcgctgca tcctatgaac
     1801 agatttcacc ctggcccctc cctctcctct ggggggtggg gtggctgggt cccatgggtg
     1861 cttctgtctg tcgccagggc ctcttggctc tctgctggct caggggccag ggcacttggc
     1921 tgtgggtttt tctttgaagt acagaggcta ctgtcttcca ccagtgaagt taagtagtcc
     1981 agtctcaccc ctgccacttt tgttactgtt ggctgcaagg ggtggcattg tctccaggga
     2041 gccaggccct cgcaggagac acacgggcgc ctagctgact tggccctgac ttggccctct
     2101 gtctcctgag ctcagctgtc tgcacaggtg gtgcctctgg ggacttggtc tgtctcctca
     2161 actctcccac tggagtcata cggctgaggt gtagactcta gtctgggacg ggcttacaaa
     2221 ctctaaaggt acggggcagg aggtggggga gacaagggca gagttgttcc ctctccccaa
     2281 agcacaaggt gaacaccagc tgattctggg gctaggagag ttatcaatca tggacagggt
     2341 atgagggcca aaataaaagc cggtcgagaa aaaaaaaaaa aaaaaa
//
