LOCUS       NM_001165955           10967 bp    mRNA    linear   ROD 03-SEP-2024
DEFINITION  Mus musculus polyhomeotic 3 (Phc3), transcript variant 3, mRNA.
ACCESSION   NM_001165955
VERSION     NM_001165955.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 10967)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 10967)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 10967)
  AUTHORS   Elsen,G.E., Bedogni,F., Hodge,R.D., Bammler,T.K., MacDonald,J.W.,
            Lindtner,S., Rubenstein,J.L.R. and Hevner,R.F.
  TITLE     The Epigenetic Factor Landscape of Developing Neocortex Is
            Regulated by Transcription Factors Pax6--> Tbr2--> Tbr1
  JOURNAL   Front Neurosci 12, 571 (2018)
   PUBMED   30186101
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 10967)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 10967)
  AUTHORS   Puschendorf,M., Terranova,R., Boutsma,E., Mao,X., Isono,K.,
            Brykczynska,U., Kolb,C., Otte,A.P., Koseki,H., Orkin,S.H., van
            Lohuizen,M. and Peters,A.H.
  TITLE     PRC1 and Suv39h specify parental asymmetry at constitutive
            heterochromatin in early mouse embryos
  JOURNAL   Nat Genet 40 (4), 411-420 (2008)
   PUBMED   18311137
REFERENCE   6  (bases 1 to 10967)
  AUTHORS   Deshpande,A.M., Akunowicz,J.D., Reveles,X.T., Patel,B.B.,
            Saria,E.A., Gorlick,R.G., Naylor,S.L., Leach,R.J. and Hansen,M.F.
  TITLE     PHC3, a component of the hPRC-H complex, associates with E2F6
            during G0 and is lost in osteosarcoma tumors
  JOURNAL   Oncogene 26 (12), 1714-1722 (2007)
   PUBMED   17001316
REFERENCE   7  (bases 1 to 10967)
  AUTHORS   Vogel,T., Stoykova,A. and Gruss,P.
  TITLE     Differential expression of polycomb repression complex 1 (PRC1)
            members in the developing mouse brain reveals multiple complexes
  JOURNAL   Dev Dyn 235 (9), 2574-2585 (2006)
   PUBMED   16786585
REFERENCE   8  (bases 1 to 10967)
  AUTHORS   Tonkin,E., Hagan,D.M., Li,W. and Strachan,T.
  TITLE     Identification and characterisation of novel mammalian homologues
            of Drosophila polyhomeoticpermits new insights into relationships
            between members of the polyhomeotic family
  JOURNAL   Hum Genet 111 (4-5), 435-442 (2002)
   PUBMED   12384788
REFERENCE   9  (bases 1 to 10967)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC111093.10 and AK087339.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR, uses a
            downstream translational start codon, and lacks an alternate
            in-frame exon in the central coding region, compared to variant 1.
            The encoded isoform (3) is shorter than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK087339.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AC111093.10        126311-126320       c
            11-510              AK087339.1         2-501
            511-581             AC111093.10        107810-107880       c
            582-1023            AK087339.1         576-1017
            1024-1156           AC111093.10        93760-93892         c
            1157-2360           AK087339.1         1151-2354
            2361-2361           AC111093.10        73553-73553         c
            2362-2626           AK087339.1         2356-2620
            2627-3478           AK087339.1         2622-3473
            3479-10967          AC111093.10        56200-63688         c
FEATURES             Location/Qualifiers
     source          1..10967
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 14.36 cM"
     gene            1..10967
                     /gene="Phc3"
                     /gene_synonym="E030046K01Rik; Edr3; Hph3"
                     /note="polyhomeotic 3"
                     /db_xref="GeneID:241915"
                     /db_xref="MGI:MGI:2181434"
     exon            1..57
                     /gene="Phc3"
                     /gene_synonym="E030046K01Rik; Edr3; Hph3"
                     /inference="alignment:Splign:2.1.0"
     exon            58..220
                     /gene="Phc3"
                     /gene_synonym="E030046K01Rik; Edr3; Hph3"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..2926
                     /gene="Phc3"
                     /gene_synonym="E030046K01Rik; Edr3; Hph3"
                     /note="isoform 3 is encoded by transcript variant 3;
                     polyhomeotic-like protein 3; polyhomeotic-like 3"
                     /codon_start=1
                     /product="polyhomeotic-like protein 3 isoform 3"
                     /protein_id="NP_001159427.1"
                     /db_xref="CCDS:CCDS50884.1"
                     /db_xref="GeneID:241915"
                     /db_xref="MGI:MGI:2181434"
                     /translation="MDSEPSSGTSVSTTASSTTTTTITTSSSRMQQPQISVYSGSDRH
                     AVQVIQQALHRPPSSAAQYLQQMYAAQQQHLMLHTAALQQQHLSSSQLQSLAAVQASL
                     SSGRPSTSPTGSVTQQSSMSQTSILSASPAPAQLMNRSQTSSSTSGSITQQTMLLGST
                     SPTLTASQAQMYLRAQMVQNLTLRSQKLGVLSSSQNGSPKSAGQTQSLTICHNKTTVT
                     SSKISQRDPSPESKKGGSPGLESRSTAVTRTSSIHQLIAPASYSPIQPHSLIKHQQIP
                     LHSPPPKVSHHQLLLQQQQQQIQPITLQSPSQDPPPSQHCIPLPNHGLSPAPSNAQPQ
                     HCSPVQSHPPPLTVSPNQAQSAQQSVVVSPPPPHSPSQSPTIIIHPQALIQPHPLVSS
                     ALQTGPNLQQAAADQVQSTAQLNLPSHLPLPASPVVHIGPVQQSALVSPGQQMVSPTS
                     HQQYSALQSSPIPIATPPQMSASPPAQLPPLPLQSMQSLQVQPEILSQGQVLVQNALV
                     SEEELPAAEALVQLPFQTLPPPQTVAVNLQVQPPAPVDPPVVYQVEDVCEEEMPEESD
                     ECARMDRTPPPPTLSPAAVTVGRGEDLTSEHPLLEQVELPAVASVSASVIKSPSDPTH
                     ASAPAPPLLIPAASTRSSSTSLASSTPSLENKPPQAIVKPQILTHVIEGFVIQEGLEP
                     FPVSRSSLLIEQPVKKRPLLDNQVVNSVCVQPELQNNTKHADNSSDTEIEDMMAEETL
                     EEMDSELLKCEFCGKMGYPNEFLRSKRFCTMSCAKRYNVSCSKKFALSRWNRKPDNQS
                     LGHRGRRPSGPEGAAREHILRQLPITYPSAEEDVASHEDPVPSAMTTRLRRQSERERE
                     RELRDVRIRKMPENSDLLPVAQTEPSIWTVDDVWAFIHSLPGCQDVADEFRAQEIDGQ
                     ALLLLKEDHLMSAMNMKLGPALKICARINSLKDS"
     exon            221..376
                     /gene="Phc3"
                     /gene_synonym="E030046K01Rik; Edr3; Hph3"
                     /inference="alignment:Splign:2.1.0"
     exon            377..454
                     /gene="Phc3"
                     /gene_synonym="E030046K01Rik; Edr3; Hph3"
                     /inference="alignment:Splign:2.1.0"
     exon            455..610
                     /gene="Phc3"
                     /gene_synonym="E030046K01Rik; Edr3; Hph3"
                     /inference="alignment:Splign:2.1.0"
     exon            611..854
                     /gene="Phc3"
                     /gene_synonym="E030046K01Rik; Edr3; Hph3"
                     /inference="alignment:Splign:2.1.0"
     exon            855..1726
                     /gene="Phc3"
                     /gene_synonym="E030046K01Rik; Edr3; Hph3"
                     /inference="alignment:Splign:2.1.0"
     exon            1727..1880
                     /gene="Phc3"
                     /gene_synonym="E030046K01Rik; Edr3; Hph3"
                     /inference="alignment:Splign:2.1.0"
     exon            1881..2131
                     /gene="Phc3"
                     /gene_synonym="E030046K01Rik; Edr3; Hph3"
                     /inference="alignment:Splign:2.1.0"
     exon            2132..2291
                     /gene="Phc3"
                     /gene_synonym="E030046K01Rik; Edr3; Hph3"
                     /inference="alignment:Splign:2.1.0"
     exon            2292..2406
                     /gene="Phc3"
                     /gene_synonym="E030046K01Rik; Edr3; Hph3"
                     /inference="alignment:Splign:2.1.0"
     exon            2407..2539
                     /gene="Phc3"
                     /gene_synonym="E030046K01Rik; Edr3; Hph3"
                     /inference="alignment:Splign:2.1.0"
     exon            2540..2771
                     /gene="Phc3"
                     /gene_synonym="E030046K01Rik; Edr3; Hph3"
                     /inference="alignment:Splign:2.1.0"
     exon            2772..10967
                     /gene="Phc3"
                     /gene_synonym="E030046K01Rik; Edr3; Hph3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9779..9784
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Phc3"
                     /gene_synonym="E030046K01Rik; Edr3; Hph3"
                     /note="hexamer: AATATA"
     polyA_site      9800
                     /gene="Phc3"
                     /gene_synonym="E030046K01Rik; Edr3; Hph3"
     regulatory      10872..10877
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Phc3"
                     /gene_synonym="E030046K01Rik; Edr3; Hph3"
                     /note="hexamer: AATAAA"
     polyA_site      10896
                     /gene="Phc3"
                     /gene_synonym="E030046K01Rik; Edr3; Hph3"
                     /note="major polyA site"
     regulatory      10935..10940
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Phc3"
                     /gene_synonym="E030046K01Rik; Edr3; Hph3"
                     /note="hexamer: AATAAA"
     polyA_site      10953
                     /gene="Phc3"
                     /gene_synonym="E030046K01Rik; Edr3; Hph3"
ORIGIN      
        1 acttcgtgtt agtgatggag gagagaagat ggcggaagcg gagtgagtga cttgctggtt
       61 taaggaccac agcacagcta tggatagtga gccgagctct ggaacatccg tgtcaacaac
      121 agccagcagt accaccacca ccaccatcac cacatcctcc tcccgaatgc agcagccaca
      181 gatctctgtc tacagcgggt cagaccgaca tgctgttcag gtaattcagc aggccttgca
      241 tcggcccccc agctcggcag ctcagtacct gcagcagatg tacgcggctc agcagcagca
      301 cctgatgctg cacacggctg ctctgcagca gcagcaccta agcagctcgc agctccagag
      361 ccttgcggct gtccaggcaa gtttgtccag tggaagacca tctacatccc ccacaggcag
      421 tgttacacaa cagtcaagta tgtcccagac atctatcctg tccgcttctc ctgcacctgc
      481 tcagctgatg aaccgctccc agacgtccag ttctaccagc ggcagtatta cccagcagac
      541 tatgctactc gggagtacct ctcccaccct aactgccagc caagcccaga tgtatctccg
      601 agctcagatg gttcagaatt taaccttacg cagccagaag ctgggtgtct tatctagctc
      661 acagaatggc tcaccaaaaa gcgctggtca aacccagtcc ttgacaattt gccataataa
      721 aacaacagtg accagttcta aaatcagcca acgagaccct tctccagaga gcaagaaggg
      781 aggaagccca ggtctggaat ctcggagcac ggccgtcact cggacatcaa gcatccacca
      841 gttaatagca ccagcttcat attctccaat tcagcctcat tctctaatca aacatcagca
      901 gattcctctt cattcaccac ctcctaaagt ttcccatcat cagctgctat tacaacagca
      961 acaacagcaa attcagccaa tcacccttca gagtccaagt caagatccac ccccatccca
     1021 gcactgtatc ccactcccaa accatggcct ttctccggct cccagtaatg cccagccgca
     1081 gcattgctcc ccagttcaga gccatcctcc gcctttaact gtgtctccca accaggcaca
     1141 gtccgcacag cagtctgtag tggtgtctcc tcccccccct cattccccaa gtcagtctcc
     1201 tactataatt atccatccac aagcacttat ccagccacac cctcttgtgt cttcagctct
     1261 tcaaacaggg ccaaatttgc agcaggctgc tgctgatcag gtacagtcca ccgcacagct
     1321 gaatcttcca tcccatcttc cacttccagc atcccctgtt gtacacattg gccctgtcca
     1381 gcagtctgcc ttggtgtccc ctggtcagca gatggtgtcc ccaacatcac accagcagta
     1441 ttcagcccta cagtcctctc caattcccat cgcgacccct ccacagatgt cggcatctcc
     1501 tccagctcag ctcccaccac tgcccttgca gtctatgcag tctttacaag tgcagcctga
     1561 aattctatcc cagggccagg ttttggtgca gaatgctttg gtgtcagaag aggagctacc
     1621 tgctgcagaa gctttggtcc agttgccatt tcagactctt cctcctccac agactgttgc
     1681 ggtaaatcta caagtacagc cgccagcacc tgttgatcca ccagtggttt atcaagtaga
     1741 agatgtgtgt gaggaagaaa tgccagagga gtccgatgag tgtgcaagga tggacagaac
     1801 ccccccaccc cccaccttgt ctccagcagc tgtcactgtg gggaggggag aggacttgac
     1861 atccgaacat cctttgttag agcaagtgga gttgcctgct gtggcctcag tcagtgcttc
     1921 cgtgatcaag tctccatcag accccaccca tgcctctgct cctgcacctc ccctcttaat
     1981 ccctgctgcc tccaccagga gcagcagcac ttctctggcc agcagcactc ccagcctgga
     2041 aaacaagcct ccacaggcta ttgtgaaacc acagattttg acccacgtta tagaaggctt
     2101 tgtgattcag gaggggctgg agccgtttcc tgtgagtcga tcatcactgc tgatagaaca
     2161 acctgtgaag aagaggcctc tcttggataa tcaggtggta aactctgtgt gtgtccagcc
     2221 agagttacag aataacacaa agcatgcaga taactcatcc gacacagaga tagaagacat
     2281 gatggctgaa gagacattgg aagaaatgga tagcgagtta ctcaagtgtg aattctgtgg
     2341 aaaaatggga tatcctaatg aatttttacg gtccaaacga ttctgtacta tgtcatgtgc
     2401 caaaaggtac aacgttagct gttctaaaaa atttgcactt agtcgttgga atcgtaagcc
     2461 tgataatcag agtcttgggc atcggggccg tcgtccaagt ggccctgaag gggcagcaag
     2521 agaacatatc cttaggcagc ttccaattac ttatccatct gcagaagaag acgtggcctc
     2581 tcatgaagat cctgtgcctt ctgctatgac gacccgtctg cgaaggcaga gcgagcggga
     2641 aagagagcga gagcttcggg atgtgaggat taggaagatg cctgagaata gtgacttgct
     2701 cccagtcgca cagactgagc cctccatatg gacagtcgac gacgtctggg ccttcatcca
     2761 ttctttgccc ggctgccagg acgttgcaga tgagttcagg gcacaagaga ttgatgggca
     2821 ggccctgctc ttgctaaaag aagaccatct catgagtgca atgaacatga agctgggccc
     2881 agccctgaag atttgtgcac gcatcaactc tctgaaggac tcttaacagg agcgaggctt
     2941 tgtgcttctc agcccattcc tctcacaagg tgaaggtaaa gcctcgctgg gattctctcc
     3001 tgagaatatc agactgatgg aggaaggccg agtgcactgg gaccgccacg gccagtgccg
     3061 acgtttctct tcagatgtcc taactcatca tacattttca taattagtga acatcggtga
     3121 cattaatttt accacttaca tgctacactg aaagacttgt tacagaggcc catatttttc
     3181 aaagaaacat gttatactag ataatttttt aaaggtaatg tttatcatta atataaaaaa
     3241 accttttaaa aataattatt gatttacact ccccctcctt taattctctt ttcttatacg
     3301 ttttcctacc cagttagttt tctaaatgtt gtcatagaga tataggataa tttaggagcc
     3361 cattgacaga actgaatgca atgaaatgcc agtctgtttt aaaaagcgta tcttccagac
     3421 aaatgctttg gctgtgaaaa gggattgtgt tttagcataa acagtatttt tgaagttctc
     3481 aagagtctct agtctagcct ttacccaggt tggcatgact gacaattttc ctcctggttt
     3541 gtacattaag agcaatagtt ctcagtggag aacttgtcct ccaggggaca attggcaata
     3601 tctagacaca ttctggttgc catggcttgg gcttgagttt tgtgagggtg gttataggaa
     3661 ctgaggtgtg acagccagtg gagatgttgc tgactaccct acagtacata ggatgcccct
     3721 ctgtcaccag gaacgatgta ttatggatgc cagtggtgcc agtgagcaca gtgggcagcc
     3781 tggctgagca gagaggcata cttaagtgat ggctgtgagg agggcgatgt gcagtgaagg
     3841 gttagccagt ggcaccagag ttctgcagaa gcaggttttg gttttaccgt atactagaaa
     3901 ggaaaggaaa tccataaacc tgggctataa aaccaggcta actcacagac catgtgactc
     3961 tggtgtggcc ctggcccatt gtcacctctt cctgactctg ttctgtgcac cgatgatggt
     4021 gcttgatgca gccatgcctc ggagcctctt tcagcagccc agtggcagtg gaggtggaat
     4081 cccttccttg aagcaaccct gctgagtctg gctagaatgc agttctttct cccttactaa
     4141 ggctgtggat tcttcccacg aagtatttaa agtgatttct cttaatcaga agtttttatt
     4201 caacagtttt ctgttaggac actaagccaa atttttctgt ggatgctctg aaatctttgt
     4261 agtgctgggc atcaaaagat ttgctgacat tgtttgcttt ctctatcttt ttgctacatg
     4321 tttgagaact ctgaacaaat gaagggacat gtgcatagcc ttggcacaga tggaaaagac
     4381 agcagagtct gagctcagtc atctttatgg cgcttttcag agattgggtt gagttagtag
     4441 aagactaaaa gatgtcacaa agacatcaca gataaattta tcttttggct ttgtgtacat
     4501 tagaaaatgt tggttatttt tatacagaaa tatagtggat aattttttta atctttagat
     4561 gcctcttgtt tgaatgtatg ctttgtgaga ttattgctgt agtagtttta agagctgttc
     4621 actagtagtc ctgtgtagac tcagaatgtg taagtagctg aggctcctgt ttcagactac
     4681 agtagtatag gctacgttcc ctatttcttt gtgtcacatt tggttattca catttcaagg
     4741 aaggcaggta ttctacagtc acctgcatat attagtactg agtcatcatg gcagagttgt
     4801 cacggacgtt cctgtctcca acagaggctg gctatgcagc actaaggact gcctgccata
     4861 atgaaggagg cacaaggcac atttcctctg gaatgaaaac tatggtgtag ttagtaatcc
     4921 acagtgaata tgggattgtc cagaatagac ctccagcaat aatgcttccc tcctacaaat
     4981 acttacatct agcctttaag gcattaactc tgcacttgta ctaaaaccag cccatcgtgt
     5041 gcttatgaga aacccctgtg cctagcactg tccataagca cccctacaca gtttacacga
     5101 agggtttctc ttggaggatg ccttcttgtc cttcgtctta gaagtagccc agatcttctg
     5161 ttgtctgcac ttaaatttaa ctagcaaata cacttttttt tttacaagtg ggttatttta
     5221 tttagaagtg gctcatttgg tgtttggtag ttctcccatt gctgtaggta cttctttcta
     5281 ggtaattttt aattgtgcta atttgaaagc ttcaattaca ttaaatgggg acacactctg
     5341 tgtttctctc tatctcctga gtattaggct gttcaatgtg acatggacag gaagaacgct
     5401 agtttcattt cctttcttat tactaagcac ttaagaactt tcttagagga aaaaaagaaa
     5461 aagacaggaa gggaacatgg tttcttccta ttgttgcttt ctgagtttgc cttgcctgac
     5521 ttgaaaccct tcaaccactg tgggacacac ttttcacatg ttatttgttt taagttctgt
     5581 gttcttagga aaataaacag ctggcttgta aaagttactt taaacttaga cgctttgcat
     5641 acacacatgt aaggcacagt gacacagctt tatcagcaaa gcagggaatg ctgccttcgc
     5701 acctgacacc ttccgtgaca gtgactaatg gatgggcaga gtcactacct gggagtagag
     5761 atgccagaac aagaggagag cgtgttggta aagcagctag agtgtggcag agcagacggg
     5821 gcctcttcct ctgctcagtt cattaatcag ggcaacctga ctttctgtgt ttctgtgctg
     5881 ctttcctctt tgtttcttgt gttggaagac tggtgtgtga gactgtattg ttaccatgcc
     5941 tttgagtaac tattcacagt cagtcttcat atattaagtg catctattta taaacacaaa
     6001 tcttggattg aaatctttca gaggactcat tttctcacaa gcttgttagg ttgtgtgtct
     6061 cagcacctgt gtccagtata tgaaatctct gactgggaat actctaaaag cacttcagac
     6121 atgttctcag ctagagaggc tgactaagtg ttgtagtttg aagacttggg gaatgccagc
     6181 aacacttgct gctgactggt actttcagca tgtgatggcc tcacctcctt tcctgcactg
     6241 agtcccatct acctccaacc ccacctccaa ccccacctcc aataaagtac acagactttc
     6301 ttagtttttt acatggggtt gggttgcatc ctggcttgga gagcttcagg ctgttgtact
     6361 agggcgggcc tttataactt caccagttgt atttcaatca aagtcttatc catctatgca
     6421 atcatttcct agtttcttgt gtaccatatg tctgtgtgac ttattccttg aaggttattt
     6481 gagaagggga gtggaaaggg gagtaagcga cagataggaa gatgatattg cgacctgaat
     6541 gaagacgttt agcatgatga tggtccttag tagctagata tccttggtga tggatagcgg
     6601 gacaaggtgt gttgttagtt gttttgtttg ttggtgctag ggactgagtc agggcctcac
     6661 acgccacctg agattgcata ctgtattttt tttcttgttt gcctagacta acctggaatt
     6721 gtggtcctct gaccttctct caagtgctag aacttaatat ctgtgccacc atgccaaacc
     6781 tagcccctat ggttttaact tgtcaagatt tggttaaaat caaattaggt atttctcttt
     6841 atcacctgtc cctgctctga ggagtgttga tattaatagt accactggta cccaagttga
     6901 gtaatcctgg atttttgaag atgataatca gagggagaga atctgtcaaa atgtaggagt
     6961 ttgttatgat cgagtggcca gactacagag gcatatccag tcagatatga cagttggctc
     7021 agttttgcag ccagtcataa agggaaggaa ggcactgcag gacagttgct gactggtgga
     7081 ctccagtaag cccaagccca cttattttct tggcgtaaag cagaatgacc cgtgacatga
     7141 actgttccaa ctccaggctt cagtactgat atgtcactcc attcagagcg ttttgtttca
     7201 tatcaaagct gggttttgag tttagctgag tacaaataag tattaggaag agtaaatgtg
     7261 ttttgttatt caaatttaac aaattgaact cattgaacca agcccttaag gaattctctg
     7321 ggaagatatt tctggtgtta gattttaaaa tgcattacca tatagtttat agttgaaata
     7381 aaagctgttt tccaattaaa aatgttgaaa atgatattga cattttaaaa agtggcctga
     7441 aatggttagc agttgtatat gcagttttag agttaagtct atttatttag agttaagtct
     7501 tatcagttgt atatgcagtt ttagagttaa gtctacttga cattatacta agagaaaact
     7561 tttctttttg aaagttacaa gatatgagtt tatctacaat tattaccatc atgttctaga
     7621 gaaaaacctt aggaggcccc gccctctgtt gacacgcaca gcttctctac agcagagtct
     7681 catttgcaca cactctggcg agtgccatac ctaagggaaa ttatttccac aagggcttta
     7741 ttttctttct cctttgataa cttgtggacc ttttatttta tttaaaaata caatttgaat
     7801 atggtgttag gcacaaaacg agcttctata taactatatt ttaggcagag gtctttctga
     7861 agcttttcaa gtgtaaacct actgctgtct atgatattcc tgatattggg cataaatcta
     7921 taggacgaga aaatttaaag tagtatgtaa tgaatgaatt ttaatttaaa aaatcagtat
     7981 aaatctaaaa catcattatg ctagcatggc atggttttaa tgaaatgtaa gagggatgta
     8041 gttaagtcct ttataatgtc taacttagtt tcagtcatca tcttagatat tcatagtatc
     8101 tattgctttt tggcttaatg gaatacatca gtgttttgtg gacctttctc tgacagtggt
     8161 gaacgagtag tggagattag aacatcattg aggaaaacat gaacccactg aggggacttt
     8221 ttaaatcttg cctcaactaa actaaatatg tacagtgttt aaatccttat acataatgct
     8281 tgtgttaaat gttttggtag tattaaaagt gagcaaatta caacttttct tcaggagtga
     8341 gagataaaca cacttgctgc tgcattactg tgctgagtgg agagggaaca gagaggctgg
     8401 gagacctggt gttactccag atggccggca gccctgggac tcgatgggca gctatttggc
     8461 tttttatctc atttcaacgt agtgtgatac ctgcactgcc aaataggctg gttttgttgt
     8521 tgttgttgtt gtttgcttaa atcattttta aaggaacacc ctccccgagc tttaaagtta
     8581 caatcctaag ctacacaatt gggattccca cggggctgac cgactggcaa gtgaatatca
     8641 gcacccatgc acttgctcct tcatttgtaa actatctgag cacttggctt ctgtgtgcaa
     8701 tatatgacca agaaaataac aagtaaagtc ttcccaaaca aactcagtgc tgcttcagca
     8761 tctatgtccg cacagccagg aatgaatggc aattaaccag taacgccctg ctctctggga
     8821 gtgggggttt aataacatcc aagtgctaaa ccgcaccacc actcacattg ttcccacctg
     8881 tgggccatct ccttgactgt tgacaacagt aagactgctt gccctgaccg gctgtgaaac
     8941 tcttgtgaca ggcactgtca ggacagtccc tttacgtggt ctgtctgtgg caggatgcaa
     9001 gaagtcaatg tgaaatcatt gtgcattttt agttgcaaaa gtttatatcc agtattgata
     9061 gtggaagagt tttccaaaac agaatcatct gaaacgaggc agagaacagg ttgctacggc
     9121 tgctttctcc acagtgctga ctctattgta gtgtgttaga gacagccact tctcaaagac
     9181 agggtctgca ctgcagcttg aaaatgcaga actggtgaca gaaggcagtt cctagttggg
     9241 tggtggctca cacctttaat cccagccttg ggacacagaa gcaggcagat ctctgtgagt
     9301 ccaaggccag cctggtctac agagcaagtt ccaggacagt caggctacac agagaaaccc
     9361 tgcctcgaaa gccaccacca ccaccaccac caccagaaag cagatcctgc ttgtgctagc
     9421 aagtatttaa ggagtgagtg aagatggggt caaagtcact tttaatggtg tgaattccgg
     9481 tgtcactctg gggctctgtg aatcaggttg taattcttgt tttaaatgct aactaacatc
     9541 agttgctact cacattctct ataaagatat aaaaatatat tttaaaaact ttatgtatca
     9601 tagctatagg tttttaaagc ggggaaatgc ccaaataaag tgttaaatta caatatataa
     9661 tagatgcttt caaattaagg tttttgtaag ttataataat ctaaatagcc cactaatctg
     9721 atctttgtaa tttgtctcat gattctggtt acttttaagg tgttttttaa gtttttgaaa
     9781 tatacctaag ttgtaaaata tcctgtgttg tttagatctc tgttgcataa atgctgttct
     9841 tgtgtctgta ttcttagacc ttaagagttc agctgagaat acagggtgta atttttgtgt
     9901 atgattccca cattgatgga attgactgcc aataacctca ttcagagatg ggtcttggtt
     9961 tgtacagtag gggattaaaa atcaaaattc agaaattgtt ggaaagtgca gggattatgc
    10021 tagaaatgag ggttgtacat tacagacagc catgcacagg gaggcagggg agggaggctg
    10081 ctgacttcaa gcctcttgaa tttggtgaga atgctttgcg aatggcactt aaaatttgtt
    10141 tcacaaaggc aggttgttgg gattatctgt tttttaatat tttaagcaca tttttagaaa
    10201 tcttgctttt ggttctgacc attgttctaa agtcaaagtt ttataattta aaaaaaaaaa
    10261 aaaactcaaa acatgattca tcaaggaaaa aagcatcacc aagggggaaa gaaaacatgt
    10321 tctaatctta gagaaagcaa atgttagggt tataatagct gtgtcttaca ttggatgttg
    10381 tattagagac ctcctcacag gaaatgatat agttctagca cccttagcat agagttccta
    10441 gcctggcgtc catagctaca gttttacagt gtataacctg agaatgaagt taattttgca
    10501 ttgtaagagc acaccattat ctgtgtaaaa agtgttcatt tgctgtattt ttttaagaaa
    10561 agagaaagca ctttcatatt aagtagcatg tgtgtgaact ttagacttcc tctgtgtgtc
    10621 tagtcagtga agttcaagga gcatcgatgt ctgctggcga cgttaactgc taacggaagc
    10681 accttatcct ctgctgctta cccttgcttg gattgcacct ttgttacctg cacactttca
    10741 catagagtat tgtaacacgg cttcgagtgg gtctgggcgg acggctagtg gtgggcctac
    10801 aggatctttt atttatgttg tttatattac aataatatat tgtagaccag ttgtaacttc
    10861 agttctttac aaataaaagc ctgactggtt attgaatttt tatttcttta agcttttgag
    10921 agacagggaa agctaataaa gaccttaatg gagggctgga ctgacta
//
