LOCUS       NM_001195130            3949 bp    mRNA    linear   ROD 03-SEP-2024
DEFINITION  Mus musculus polyhomeotic 2 (Phc2), transcript variant 2, mRNA.
ACCESSION   NM_001195130
VERSION     NM_001195130.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3949)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3949)
  AUTHORS   Kubo,S., Yamamoto,H., Kajimura,N., Omori,Y., Maeda,Y., Chaya,T. and
            Furukawa,T.
  TITLE     Functional analysis of Samd11, a retinal photoreceptor PRC1
            component, in establishing rod photoreceptor identity
  JOURNAL   Sci Rep 11 (1), 4180 (2021)
   PUBMED   33603070
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3949)
  AUTHORS   Bae,J., Choi,S.P., Isono,K., Lee,J.Y., Park,S.W., Choi,C.Y.,
            Han,J., Kim,S.H., Lee,H.H., Park,K., Jin,H.Y., Lee,S.J., Park,C.G.,
            Koseki,H., Lee,Y.S. and Chun,T.
  TITLE     Phc2 controls hematopoietic stem and progenitor cell mobilization
            from bone marrow by repressing Vcam1 expression
  JOURNAL   Nat Commun 10 (1), 3496 (2019)
   PUBMED   31375680
  REMARK    GeneRIF: Study demonstrates that Phc2 regulates hematopoietic stem
            and progenitor cells mobilization through the repression of Vcam1
            expression by enhancing both H3K27me3 and H2AK119ub in bone marrow
            stromal cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3949)
  AUTHORS   Elsen,G.E., Bedogni,F., Hodge,R.D., Bammler,T.K., MacDonald,J.W.,
            Lindtner,S., Rubenstein,J.L.R. and Hevner,R.F.
  TITLE     The Epigenetic Factor Landscape of Developing Neocortex Is
            Regulated by Transcription Factors Pax6--> Tbr2--> Tbr1
  JOURNAL   Front Neurosci 12, 571 (2018)
   PUBMED   30186101
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3949)
  AUTHORS   Omori,Y., Kubo,S., Kon,T., Furuhashi,M., Narita,H., Kominami,T.,
            Ueno,A., Tsutsumi,R., Chaya,T., Yamamoto,H., Suetake,I., Ueno,S.,
            Koseki,H., Nakagawa,A. and Furukawa,T.
  TITLE     Samd7 is a cell type-specific PRC1 component essential for
            establishing retinal rod photoreceptor identity
  JOURNAL   Proc Natl Acad Sci U S A 114 (39), E8264-E8273 (2017)
   PUBMED   28900001
REFERENCE   6  (bases 1 to 3949)
  AUTHORS   Tonkin,E., Hagan,D.M., Li,W. and Strachan,T.
  TITLE     Identification and characterisation of novel mammalian homologues
            of Drosophila polyhomeoticpermits new insights into relationships
            between members of the polyhomeotic family
  JOURNAL   Hum Genet 111 (4-5), 435-442 (2002)
   PUBMED   12384788
REFERENCE   7  (bases 1 to 3949)
  AUTHORS   Suzuki,M., Mizutani-Koseki,Y., Fujimura,Y., Miyagishima,H.,
            Kaneko,T., Takada,Y., Akasaka,T., Tanzawa,H., Takihara,Y.,
            Nakano,M., Masumoto,H., Vidal,M., Isono,K. and Koseki,H.
  TITLE     Involvement of the Polycomb-group gene Ring1B in the specification
            of the anterior-posterior axis in mice
  JOURNAL   Development 129 (18), 4171-4183 (2002)
   PUBMED   12183370
REFERENCE   8  (bases 1 to 3949)
  AUTHORS   Yamaki,M., Isono,K., Takada,Y., Abe,K., Akasaka,T., Tanzawa,H. and
            Koseki,H.
  TITLE     The mouse Edr2 (Mph2) gene has two forms of mRNA encoding 90- and
            36-kDa polypeptides
  JOURNAL   Gene 288 (1-2), 103-110 (2002)
   PUBMED   12034499
REFERENCE   9  (bases 1 to 3949)
  AUTHORS   Koga,H., Kaji,Y., Nishii,K., Shirai,M., Tomotsune,D., Osugi,T.,
            Sawada,A., Kim,J.Y., Hara,J., Miwa,T., Yamauchi-Takihara,K.,
            Shibata,Y. and Takihara,Y.
  TITLE     Overexpression of Polycomb-group gene rae28 in cardiomyocytes does
            not complement abnormal cardiac morphogenesis in mice lacking rae28
            but causes dilated cardiomyopathy
  JOURNAL   Lab Invest 82 (4), 375-385 (2002)
   PUBMED   11950896
REFERENCE   10 (bases 1 to 3949)
  AUTHORS   Hemenway,C.S., Halligan,B.W. and Levy,L.S.
  TITLE     The Bmi-1 oncoprotein interacts with dinG and MPh2: the role of
            RING finger domains
  JOURNAL   Oncogene 16 (19), 2541-2547 (1998)
   PUBMED   9627119
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL611969.15 and AL611983.23.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein
            (isoform A).
            
            Sequence Note: This RefSeq record was created from genomic sequence
            data to make the sequence consistent with the reference genome
            assembly. The genomic coordinates used for the transcript record
            were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.1763964.1,
                                           SRR11927932.3575389.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-115               AL611969.15        117206-117320
            116-352             AL611969.15        167502-167738
            353-511             AL611969.15        170441-170599
            512-589             AL611969.15        171481-171558
            590-754             AL611969.15        172003-172167
            755-841             AL611969.15        173562-173648
            842-1142            AL611983.23        2258-2558
            1143-1534           AL611983.23        13108-13499
            1535-1700           AL611983.23        13747-13912
            1701-1903           AL611983.23        33553-33755
            1904-2033           AL611983.23        35201-35330
            2034-2148           AL611983.23        35989-36103
            2149-2290           AL611983.23        37300-37441
            2291-2567           AL611983.23        38207-38483
            2568-3949           AL611983.23        41699-43080
FEATURES             Location/Qualifiers
     source          1..3949
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 62.12 cM"
     gene            1..3949
                     /gene="Phc2"
                     /gene_synonym="A3galt2; D130050K19Rik; D4Ertd810e; Edr2;
                     Mph2; p36"
                     /note="polyhomeotic 2"
                     /db_xref="GeneID:54383"
                     /db_xref="MGI:MGI:1860454"
     exon            1..115
                     /gene="Phc2"
                     /gene_synonym="A3galt2; D130050K19Rik; D4Ertd810e; Edr2;
                     Mph2; p36"
                     /inference="alignment:Splign:2.1.0"
     exon            116..352
                     /gene="Phc2"
                     /gene_synonym="A3galt2; D130050K19Rik; D4Ertd810e; Edr2;
                     Mph2; p36"
                     /inference="alignment:Splign:2.1.0"
     CDS             170..2722
                     /gene="Phc2"
                     /gene_synonym="A3galt2; D130050K19Rik; D4Ertd810e; Edr2;
                     Mph2; p36"
                     /note="isoform A is encoded by transcript variant 2;
                     polyhomeotic 2 protein; early development regulator 2;
                     polyhomeotic-like protein 2; early development regulatory
                     protein 2; polyhomeotic-like 2"
                     /codon_start=1
                     /product="polyhomeotic-like protein 2 isoform A"
                     /protein_id="NP_001182059.1"
                     /db_xref="CCDS:CCDS18674.1"
                     /db_xref="GeneID:54383"
                     /db_xref="MGI:MGI:1860454"
                     /translation="MENELPVPHTSNRASVTTNTSGTNSSSGCISSSGGGGGSGGRPT
                     APQISVYSGIPDRQTVQVIQQALHRQPSTAAQYLQQMYAAQQQHLMLQTAALQQQHLS
                     SAQLQSLAAVQQASLVANRQGSTPGSSVSSQAPAQSSSLNLAASPAAAQLINRAQSVN
                     SAAASGLAQQAVLLGNTSSPALTASQAQMYLRAQMLIFTPTATVATVQPELCTGSPAR
                     PPTPAQVQNLTLRTQQTPAAAASGPPPTQPVLPSLALKPTPSSSQPLPAPPQGRTMAQ
                     GSPAGAKPSGTDNAPETLKAGDGNCNMEGRPGPGRAVPAVATHPLIAPAYAHLQSHQL
                     LPQPPAKHPQPQFVAQQQPQPPRPAPQVQSQPQLASVSPSLALQSSPEDHALPLGSVT
                     QALPLQCSTTHVHKPGNSQQCHLPTLDTGSQNGHPEGGSHPPQRRFQHTSAVILQVQP
                     ASPVTPQQCAPDDWKEVVPAEKSVPVARPGPSPHQQAIIPAIPGGLPGPKSPNIQQCP
                     AHETGQGIVHALTDLSSPGMTSGNGNSASSIAGTAPQNGENKPPQAIVKPQILTHVIE
                     GFVIQEGAEPFPVGRSSLLVGNLKKKYAQGFLPEKPPQQDHTTTTDSEMEEPYLQESK
                     EEGTPLKLKCELCGRVDFAYKFKRSKRFCSMACAKRYNVGCTKRVGLFHSDRSKLQKA
                     GTTTHNRRRASKASLPTLTKDTKKQPSGTVPLSVTAALQLAHSQEDSSRCSDNSSYEE
                     PLSPISASSSTSRRRQGQRDLDLPDMHMRDLVGVGHHFLPSEPTKWNVEDVYEFIRSL
                     PGCQEIAEEFRAQEIDGQALLLLKEDHLMSAMNIKLGPALKIYARISMLKDS"
     exon            353..511
                     /gene="Phc2"
                     /gene_synonym="A3galt2; D130050K19Rik; D4Ertd810e; Edr2;
                     Mph2; p36"
                     /inference="alignment:Splign:2.1.0"
     exon            512..589
                     /gene="Phc2"
                     /gene_synonym="A3galt2; D130050K19Rik; D4Ertd810e; Edr2;
                     Mph2; p36"
                     /inference="alignment:Splign:2.1.0"
     exon            590..754
                     /gene="Phc2"
                     /gene_synonym="A3galt2; D130050K19Rik; D4Ertd810e; Edr2;
                     Mph2; p36"
                     /inference="alignment:Splign:2.1.0"
     exon            755..841
                     /gene="Phc2"
                     /gene_synonym="A3galt2; D130050K19Rik; D4Ertd810e; Edr2;
                     Mph2; p36"
                     /inference="alignment:Splign:2.1.0"
     exon            842..1142
                     /gene="Phc2"
                     /gene_synonym="A3galt2; D130050K19Rik; D4Ertd810e; Edr2;
                     Mph2; p36"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1534
                     /gene="Phc2"
                     /gene_synonym="A3galt2; D130050K19Rik; D4Ertd810e; Edr2;
                     Mph2; p36"
                     /inference="alignment:Splign:2.1.0"
     exon            1535..1700
                     /gene="Phc2"
                     /gene_synonym="A3galt2; D130050K19Rik; D4Ertd810e; Edr2;
                     Mph2; p36"
                     /inference="alignment:Splign:2.1.0"
     exon            1701..1903
                     /gene="Phc2"
                     /gene_synonym="A3galt2; D130050K19Rik; D4Ertd810e; Edr2;
                     Mph2; p36"
                     /inference="alignment:Splign:2.1.0"
     exon            1904..2033
                     /gene="Phc2"
                     /gene_synonym="A3galt2; D130050K19Rik; D4Ertd810e; Edr2;
                     Mph2; p36"
                     /inference="alignment:Splign:2.1.0"
     exon            2034..2148
                     /gene="Phc2"
                     /gene_synonym="A3galt2; D130050K19Rik; D4Ertd810e; Edr2;
                     Mph2; p36"
                     /inference="alignment:Splign:2.1.0"
     exon            2149..2290
                     /gene="Phc2"
                     /gene_synonym="A3galt2; D130050K19Rik; D4Ertd810e; Edr2;
                     Mph2; p36"
                     /inference="alignment:Splign:2.1.0"
     exon            2291..2567
                     /gene="Phc2"
                     /gene_synonym="A3galt2; D130050K19Rik; D4Ertd810e; Edr2;
                     Mph2; p36"
                     /inference="alignment:Splign:2.1.0"
     exon            2568..3949
                     /gene="Phc2"
                     /gene_synonym="A3galt2; D130050K19Rik; D4Ertd810e; Edr2;
                     Mph2; p36"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3924..3929
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Phc2"
                     /gene_synonym="A3galt2; D130050K19Rik; D4Ertd810e; Edr2;
                     Mph2; p36"
                     /note="hexamer: AATAAA"
     polyA_site      3942
                     /gene="Phc2"
                     /gene_synonym="A3galt2; D130050K19Rik; D4Ertd810e; Edr2;
                     Mph2; p36"
                     /note="major polyA site"
ORIGIN      
        1 gcgggccaca gctgggcagc cagcagggtg cgcggcggag agccgagggg gcgggctgag
       61 gggcggcccc gggagagcgc ggccaggtgg aggaggagcg cggaggccac cgcagcatcc
      121 acctgctctt ctgccacctg agcaccctga ctgtaccacc ccataggcca tggagaatga
      181 gctgccagtc ccccacacat ccaaccgggc cagtgtcacc accaacacca gtgggaccaa
      241 tagtagcagt ggctgcatca gcagcagcgg cggtggtggt ggcagcggtg gccgccccac
      301 tgcaccccag atttctgtgt acagtgggat tcctgaccgg cagactgtgc aggtgatcca
      361 gcaggccctg cacaggcagc ccagcacggc ggcgcagtac ctgcagcaga tgtatgctgc
      421 ccagcaacaa cacctcatgc tgcagacagc ggccttacag cagcagcacc tcagcagcgc
      481 gcagctccag agcctggcag cagtgcagca ggcaagcctg gtggccaaca gacaaggaag
      541 tactcccggt agcagtgtgt cctcacaggc tcctgcccag tcttcttcac tcaatctggc
      601 agcctccccg gcagcagccc agcttatcaa ccgggcacag agtgtcaatt cagccgcagc
      661 ctcgggcctt gcccagcagg ccgtgctctt gggcaacacg tcctcccctg ccctgactgc
      721 cagccaagca cagatgtacc tcagggcgca gatgctcatc ttcacgccca cggccaccgt
      781 cgctactgtt cagcctgagc tctgcactgg ttcccctgct cggcccccta cccctgccca
      841 ggtacagaac ctgacgcttc gcacccagca gacaccagca gcagcagcct cgggccctcc
      901 ccccacccag cctgtcctgc ccagcttggc cctgaaaccc acacccagca gtagccagcc
      961 tctgcctgcc ccaccacagg gcaggaccat ggctcagggt tcccctgcgg gtgccaagcc
     1021 tagtgggact gacaatgcgc cagagacact caaggcagga gatggtaact gcaacatgga
     1081 gggccggcca gggcctggcc gggcagttcc tgctgtggct actcacccgc tcattgcacc
     1141 agcttatgct cacctgcagt cacaccagct cctcccacag ccgccagcga agcacccaca
     1201 gccccagttt gtggcccaac agcaaccaca gccaccacga cctgcacccc aagtccagtc
     1261 ccaaccccag cttgcctcag tctccccaag cctggcccta cagtccagtc cagaagacca
     1321 tgccctgcct ctaggctcag tgacacaggc cctgcctctc cagtgctcta ccacgcatgt
     1381 ccacaagcca gggaacagcc agcagtgtca ccttcccaca ctagacaccg ggtctcagaa
     1441 tggacatcct gagggtgggt cccatccccc ccagcgaagg ttccagcaca cctcagctgt
     1501 gatcttacag gtgcagcccg cttctccagt tacgccccag cagtgtgctc ccgatgactg
     1561 gaaggaagtg gtgccagcgg agaagagtgt gcctgtggct cggccaggcc cgtccccaca
     1621 ccagcaagcc atcatccctg ccatacccgg tggcttgcct ggacccaaga gtcccaacat
     1681 ccagcagtgc ccagctcacg agacagggca gggcattgtt catgcactga ccgacctcag
     1741 cagccccggc atgacctcag ggaacggaaa ctctgcctcc agcatcgccg gcactgcccc
     1801 ccagaatggt gagaataaac caccacaggc cattgtgaaa ccccaaatcc tgacgcatgt
     1861 tatcgaaggg tttgtgatcc aggagggggc ggagcctttc ccggtgggac gctcgtccct
     1921 gctggtaggg aatctcaaaa agaagtatgc acaggggttc ttgcctgaga agcctccaca
     1981 gcaggaccac accaccacca ccgactcaga gatggaggag ccctacctgc aagaatccaa
     2041 agaggagggc actcccctca aactcaagtg tgagctctgt ggacgggtgg actttgccta
     2101 caagttcaag cgttccaagc gcttctgttc catggcttgt gcaaagaggt ataatgtggg
     2161 atgcaccaaa cgagtgggac tttttcactc agaccgaagc aagctgcaga aggcagggac
     2221 cacaacccac aaccgccgac gggccagcaa ggccagtctg cccacactca ccaaggacac
     2281 caagaagcag ccctcaggca ctgtacccct ttcagttact gccgccttgc agctggcgca
     2341 cagccaggag gactccagcc ggtgctcaga taactccagc tatgaggagc ccttgtcacc
     2401 catctcagcc agctcgtcca cctcgcgacg gcgccaaggc cagagggacc tggatctccc
     2461 tgacatgcac atgagggacc ttgtgggcgt gggacaccac ttcctgccga gcgagcccac
     2521 aaaatggaat gtagaggatg tctatgagtt catccgctct ctgccaggct gccaggagat
     2581 cgcggaggag ttccgtgcgc aggagattga tgggcaagcc ttgctgctgc tcaaggagga
     2641 ccacctaatg agcgccatga acatcaagct agggcccgcc ctgaagatct acgcacgcat
     2701 cagcatgctc aaggactcct agagtctctg ctgcctgccc actgcaccac caggcagcca
     2761 ggattctaac cccatgcagg caaccgcctc cggatggagc agagcctcac ggacattcct
     2821 gaggagccca ggaaagggcc agcttggcgg gaaggggctc tccctagggg tgcagctggg
     2881 aggaggtccg agtacctctt cagtggctct caggggccat ttctgtggaa ggggtagagg
     2941 taggtggcac agaagatggg gctttgcgct tgtaaatact gatagcactg gcttcctcca
     3001 aagtcccaac gttctagcac ccccctcttc tcctttctct gtcccccatt ttccaggggg
     3061 tttatggtca gggctcccca acctgagttg ggctacttcc aagggcagcc agcaggcctg
     3121 gacagaggtc ttgaaagccc ttgtcttctc ttccccccca ccccactagg cctggttaac
     3181 cttccgtttc cagcttctcc cacttcagcc tgttcccacg gcaccggggt ttctactcct
     3241 gtaccctctg caggtggaga gagagaagct gggcccagtt tggccatgcc tgctggcaca
     3301 gacgccttaa ctgtgtggat gactgtgtga ctgggagcct ggaccggctg acaggccatg
     3361 agctacccac tggcatctcc aggttttttg tagcaaacag ccacttagtg ctttgtcctg
     3421 gactccgctc agcctgaggc tggggaatag aaagggcaga ccccaagagt tggagattag
     3481 aggtcccctc cagatagcaa gaggtttcta gggaagtcac ctcacagcag gcttgcagta
     3541 tgtccagctg gttggcaaac acgaggaagc tgcagggctg gaccatgtgg ccaagcctgc
     3601 gcctcctgtg gcttacctgc ctgcccaccc ttcgcacata cacccgtggc agggagtgtg
     3661 gaactgaaga ctggctggag gcactgcaga agcagccctt ggctttctac tcccacactt
     3721 gcttgtgaaa cgtgtaccag ctacctaagg agggccaagg caggaagggc cagggcctcc
     3781 tctgtcctta ccaactctgg gaagtcagct ctgccggccc gagaggggcg ggcacttttt
     3841 cagcttgcta taaccccttc cccatacctc caggcagggt tggaaatgaa ggactttttt
     3901 aaccttttct tttgttttta aaaaataaat ctgtaaaatt tgcctcttc
//
