LOCUS       NM_001408250            4150 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Mus musculus polyhomeotic 1 (Phc1), transcript variant 9, mRNA.
ACCESSION   NM_001408250 XM_006505499
VERSION     NM_001408250.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4150)
  AUTHORS   Ong,A.L.C., Kokaji,T., Kishi,A., Takihara,Y., Shinozuka,T.,
            Shimamoto,R., Isotani,A., Shirai,M. and Sasai,N.
  TITLE     Acquisition of neural fate by combination of BMP blockade and
            chromatin modification
  JOURNAL   iScience 26 (10), 107887 (2023)
   PUBMED   37771660
  REMARK    Erratum:[iScience. 2023 Oct 22;26(11):108257. doi:
            10.1016/j.isci.2023.108257.. PMID: 37920664]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4150)
  AUTHORS   Cho,K.W., Andrade,M., Bae,S., Kim,S., Eyun Kim,J., Jang,E.Y.,
            Lee,S., Husain,A., Sutliff,R.L., Calvert,J.W., Park,C. and
            Yoon,Y.S.
  TITLE     Polycomb Group Protein CBX7 Represses Cardiomyocyte Proliferation
            Through Modulation of the TARDBP/RBM38 Axis
  JOURNAL   Circulation 147 (24), 1823-1842 (2023)
   PUBMED   37158107
REFERENCE   3  (bases 1 to 4150)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4150)
  AUTHORS   Chen,L., Tong,Q., Chen,X., Jiang,P., Yu,H., Zhao,Q., Sun,L.,
            Liu,C., Gu,B., Zheng,Y., Fei,L., Jiang,X., Li,W., Volpe,G.,
            Abdul,M.M., Guo,G., Zhang,J., Qian,P., Sun,Q., Neculai,D.,
            Esteban,M.A., Li,C., Wen,F. and Ji,J.
  TITLE     PHC1 maintains pluripotency by organizing genome-wide chromatin
            interactions of the Nanog locus
  JOURNAL   Nat Commun 12 (1), 2829 (2021)
   PUBMED   33990559
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4150)
  AUTHORS   Elsen,G.E., Bedogni,F., Hodge,R.D., Bammler,T.K., MacDonald,J.W.,
            Lindtner,S., Rubenstein,J.L.R. and Hevner,R.F.
  TITLE     The Epigenetic Factor Landscape of Developing Neocortex Is
            Regulated by Transcription Factors Pax6--> Tbr2--> Tbr1
  JOURNAL   Front Neurosci 12, 571 (2018)
   PUBMED   30186101
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4150)
  AUTHORS   Hashimoto,N., Brock,H.W., Nomura,M., Kyba,M., Hodgson,J.,
            Fujita,Y., Takihara,Y., Shimada,K. and Higashinakagawa,T.
  TITLE     RAE28, BMI1, and M33 are members of heterogeneous multimeric
            mammalian Polycomb group complexes
  JOURNAL   Biochem Biophys Res Commun 245 (2), 356-365 (1998)
   PUBMED   9571155
REFERENCE   7  (bases 1 to 4150)
  AUTHORS   Takihara,Y., Tomotsune,D., Shirai,M., Katoh-Fukui,Y., Nishii,K.,
            Motaleb,M.A., Nomura,M., Tsuchiya,R., Fujita,Y., Shibata,Y.,
            Higashinakagawa,T. and Shimada,K.
  TITLE     Targeted disruption of the mouse homologue of the Drosophila
            polyhomeotic gene leads to altered anteroposterior patterning and
            neural crest defects
  JOURNAL   Development 124 (19), 3673-3682 (1997)
   PUBMED   9367423
REFERENCE   8  (bases 1 to 4150)
  AUTHORS   Alkema,M.J., Bronk,M., Verhoeven,E., Otte,A., van 't Veer,L.J.,
            Berns,A. and van Lohuizen,M.
  TITLE     Identification of Bmi1-interacting proteins as constituents of a
            multimeric mammalian polycomb complex
  JOURNAL   Genes Dev 11 (2), 226-240 (1997)
   PUBMED   9009205
REFERENCE   9  (bases 1 to 4150)
  AUTHORS   Abdul Motaleb,M., Takihara,Y., Nomura,M., Matsuda,Y.,
            Higashinakagawa,T. and Shimada,K.
  TITLE     Structural organization of the rae28 gene, a putative murine
            homologue of the Drosophila polyhomeotic gene
  JOURNAL   J Biochem 120 (4), 797-802 (1996)
   PUBMED   8947844
REFERENCE   10 (bases 1 to 4150)
  AUTHORS   Nomura,M., Takihara,Y. and Shimada,K.
  TITLE     Isolation and characterization of retinoic acid-inducible cDNA
            clones in F9 cells: one of the early inducible clones encodes a
            novel protein sharing several highly homologous regions with a
            Drosophila polyhomeotic protein
  JOURNAL   Differentiation 57 (1), 39-50 (1994)
   PUBMED   8070621
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153579.10.
            
            On Jun 14, 2022 this sequence version replaced XM_006505499.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219382.91671.1,
                                           SRR17253014.4572789.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-330               AC153579.10        127104-127433       c
            331-488             AC153579.10        124460-124617       c
            489-599             AC153579.10        122575-122685       c
            600-680             AC153579.10        121672-121752       c
            681-830             AC153579.10        120893-121042       c
            831-986             AC153579.10        120124-120279       c
            987-1479            AC153579.10        113060-113552       c
            1480-2285           AC153579.10        110610-111415       c
            2286-2433           AC153579.10        109927-110074       c
            2434-2645           AC153579.10        109474-109685       c
            2646-2760           AC153579.10        108540-108654       c
            2761-2869           AC153579.10        107817-107925       c
            2870-3020           AC153579.10        107503-107653       c
            3021-3252           AC153579.10        106919-107150       c
            3253-4150           AC153579.10        105352-106249       c
FEATURES             Location/Qualifiers
     source          1..4150
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 57.52 cM"
     gene            1..4150
                     /gene="Phc1"
                     /gene_synonym="Edr; Edr1; Mph1; Rae-28; rae28"
                     /note="polyhomeotic 1"
                     /db_xref="GeneID:13619"
                     /db_xref="MGI:MGI:103248"
     exon            1..330
                     /gene="Phc1"
                     /gene_synonym="Edr; Edr1; Mph1; Rae-28; rae28"
                     /inference="alignment:Splign:2.1.0"
     CDS             294..3407
                     /gene="Phc1"
                     /gene_synonym="Edr; Edr1; Mph1; Rae-28; rae28"
                     /note="isoform d is encoded by transcript variant 9; early
                     development regulator1 (homolog of polyhomeotic 1);
                     polyhomeotic-like protein 1; early development regulatory
                     protein 1; polyhomeotic-like 1"
                     /codon_start=1
                     /product="polyhomeotic-like protein 1 isoform d"
                     /protein_id="NP_001395179.1"
                     /db_xref="GeneID:13619"
                     /db_xref="MGI:MGI:103248"
                     /translation="MFPQPPRRVQRPGLESERHSWGPWNAIMETESEQNSSSTNGSSS
                     SGASSRPQIAQMSLYERQAVQALQALQRQPNAAQYFHQFMLQQQLSNAQLHSLAAVQQ
                     ATIAASRQASSPNSSTAQQQTATTQASMNLATTSAAQLISRSQSVSSPSATTLTQSVL
                     LGNTTSPPLNQSQAQMYLRPQLGNLLQVNRTLGRNVPLASQLILMPNGAVAAVQQEVP
                     PAQSPGVHADADQVQNLAVRNQQASAQGPQMPGSTQKAIPPGASPVSGLSQTSSQALA
                     VAQASSGASGQSLNLSQAGGGSGNSLPGSMGPGGGGQAPGGLGQLPSSGLTGGSCPRK
                     GTGVVQPLPAAQTVTVSQGSQTEAESAAAKKAEADGSGQQSVGMNLTRTATPAPSQTL
                     ISSATYTQIQPHSLIQQQQQIHLQQKQVVIQQQIAIHHQQQFQHRQSQLLHTATHLQL
                     AQQQQQQQQQQQQQQQQQQQQQQGTTLTAPQPPQVPPTQQVPPSQSQQQAQTLVVQPM
                     LQSSPLTLPPEPTSKPPIPIQSKPPVAPIKPPQLGAAKMSATQQPPPHIPVQVVGTRQ
                     PGSAQAQALGLAQLAAAVPTPRGITGAVQPGQAHLASSPPSSQAAPGALQECPPALAA
                     GMTLAPVQGTAHVVKGGPTASSPVVAQVPAAFYMQSVHLPGKAQTLAVKRKAESEEER
                     DDLSALASVLPTKASPAAESPKVIEEKNSLGEKAEPVASLNANPPNSDLVALAPTPSA
                     PPPTLALVSRQMGDSKPPQAIVKPQILTHIIEGFVIQEGAEPFPVGCSQFLKETKKPL
                     QAGLPTGLNESQPSGPLGGDSPSVELEKKANLLKCEYCGKYAPAEQFRGSKRFCSMTC
                     AKRYNVSCSHQFRLKRKKMKEFQEASYARVRRRGPRRSSSDIARAKIQGKRHRGQEDS
                     SRGSDNSSYDEALSPTSPGPLSVRAGHGERDLGNTITTPSTPELQGINPVFLSSNPSQ
                     WSVEEVYEFIASLQGCQEIAEEFRSQEIDGQALLLLKEEHLMSAMNIKLGPALKICAK
                     INVLKET"
     exon            331..488
                     /gene="Phc1"
                     /gene_synonym="Edr; Edr1; Mph1; Rae-28; rae28"
                     /inference="alignment:Splign:2.1.0"
     exon            489..599
                     /gene="Phc1"
                     /gene_synonym="Edr; Edr1; Mph1; Rae-28; rae28"
                     /inference="alignment:Splign:2.1.0"
     exon            600..680
                     /gene="Phc1"
                     /gene_synonym="Edr; Edr1; Mph1; Rae-28; rae28"
                     /inference="alignment:Splign:2.1.0"
     exon            681..830
                     /gene="Phc1"
                     /gene_synonym="Edr; Edr1; Mph1; Rae-28; rae28"
                     /inference="alignment:Splign:2.1.0"
     exon            831..986
                     /gene="Phc1"
                     /gene_synonym="Edr; Edr1; Mph1; Rae-28; rae28"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1479
                     /gene="Phc1"
                     /gene_synonym="Edr; Edr1; Mph1; Rae-28; rae28"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..2285
                     /gene="Phc1"
                     /gene_synonym="Edr; Edr1; Mph1; Rae-28; rae28"
                     /inference="alignment:Splign:2.1.0"
     exon            2286..2433
                     /gene="Phc1"
                     /gene_synonym="Edr; Edr1; Mph1; Rae-28; rae28"
                     /inference="alignment:Splign:2.1.0"
     exon            2434..2645
                     /gene="Phc1"
                     /gene_synonym="Edr; Edr1; Mph1; Rae-28; rae28"
                     /inference="alignment:Splign:2.1.0"
     exon            2646..2760
                     /gene="Phc1"
                     /gene_synonym="Edr; Edr1; Mph1; Rae-28; rae28"
                     /inference="alignment:Splign:2.1.0"
     exon            2761..2869
                     /gene="Phc1"
                     /gene_synonym="Edr; Edr1; Mph1; Rae-28; rae28"
                     /inference="alignment:Splign:2.1.0"
     exon            2870..3020
                     /gene="Phc1"
                     /gene_synonym="Edr; Edr1; Mph1; Rae-28; rae28"
                     /inference="alignment:Splign:2.1.0"
     exon            3021..3252
                     /gene="Phc1"
                     /gene_synonym="Edr; Edr1; Mph1; Rae-28; rae28"
                     /inference="alignment:Splign:2.1.0"
     exon            3253..4150
                     /gene="Phc1"
                     /gene_synonym="Edr; Edr1; Mph1; Rae-28; rae28"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3579..3584
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Phc1"
                     /gene_synonym="Edr; Edr1; Mph1; Rae-28; rae28"
                     /note="hexamer: AATAAA"
     polyA_site      3601
                     /gene="Phc1"
                     /gene_synonym="Edr; Edr1; Mph1; Rae-28; rae28"
                     /note="major polyA site"
     regulatory      4124..4129
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Phc1"
                     /gene_synonym="Edr; Edr1; Mph1; Rae-28; rae28"
                     /note="hexamer: ATTAAA"
     polyA_site      4150
                     /gene="Phc1"
                     /gene_synonym="Edr; Edr1; Mph1; Rae-28; rae28"
                     /note="major polyA site"
ORIGIN      
        1 aggcccgcgc gagcccccgg cctggcggag ccgcggcgcg gccagcaccc ggacggcggg
       61 aggggcgggg agcggcggcc gcgccgggca cctcccaccg cgcctgggcc cccgcccctc
      121 caggaagggg aggaggcggc gcgccgccgc cgaggccgag cgaccccccc cccctccccc
      181 gcccctgagg tggacgcccc ccgcgaggac tcgggtgcgg agccgggcgc gaaggtaacc
      241 gggcggccgc gggccgggga ggggccgcat cccggggtct cggcggcgcg gggatgtttc
      301 ctcagccacc tcggcgtgtg caacgcccag ggcttgagtc agagcgccat tcttggggac
      361 cctggaacgc tatcatggaa acggagagtg agcagaactc tagttcgacc aatgggagtt
      421 ccagttcagg ggccagctct cggccccaga tagcacagat gtccctgtat gaacggcaag
      481 cagtgcaggc tctgcaagca ctgcagcggc aacctaatgc ggctcaatat ttccaccagt
      541 tcatgctcca gcaacagctc agcaatgccc aactgcacag cctggcagct gtccagcagg
      601 ccacgattgc tgccagtcga caggctagct ccccaaacag cagcactgca cagcagcaga
      661 ccgctaccac ccaggcctcg atgaatctcg cgaccacgtc agctgctcag ctcatcagcc
      721 gatcgcagag tgtgagctcc cccagtgcta ccaccctgac gcagtcggtg ctgctgggga
      781 acaccacttc cccacctctc aaccagtccc aggcccagat gtatctgcgg ccacagctgg
      841 gcaacctatt gcaggttaac cggaccttgg gccggaatgt gcctcttgcc tcccagctca
      901 tcctgatgcc taatggggca gtggctgcag tccagcagga ggtgccaccc gctcagtctc
      961 ctggagttca tgcagatgca gatcaggtgc agaacttggc agtgaggaac caacaggctt
     1021 cagctcaagg accccaaatg ccaggctcca ctcagaaggc catccctcct ggagcttctc
     1081 ctgtttctgg cctctcccag acttctagcc aggccctagc cgtggcacag gcttcttctg
     1141 gggcctcagg ccagtcactc aaccttagtc aagccggtgg aggcagtggg aatagcctcc
     1201 caggctccat gggtccaggt ggaggtggcc aggcgcctgg gggtttaggt cagttgcctt
     1261 cttcaggatt gactggtgga agctgtcccc ggaagggcac aggagtggtg cagcccttac
     1321 ctgcagctca aacagtgact gtgagccaag gaagccaaac agaagcagaa agtgcagcag
     1381 ccaagaaggc agaagcagat gggagtggcc agcagagtgt gggcatgaac ctgactcgga
     1441 cagccacacc tgcccccagc cagacgctta ttagctcagc cacatacaca cagatccagc
     1501 cccattcact gattcagcaa cagcagcaga tccacctcca gcagaagcaa gtggtgatcc
     1561 agcagcagat tgccatccac caccagcaac agttccaaca ccgccagtcc cagctgcttc
     1621 acacagccac acacctccag ttggcccagc agcagcagca gcaacagcag caacagcagc
     1681 aacaacagca acagcagcag cagcagcagc aaggaacaac cctcactgcc cctcagccac
     1741 cccaggtccc acctactcag caggtcccac cttcccaatc acaacagcaa gcccagactc
     1801 tggtggtcca acccatgctt cagtcttcac ccctgactct tccacctgaa ccaacctcta
     1861 aaccacccat ccccattcag tccaaacctc ctgtagcgcc tatcaaacct cctcaactag
     1921 gagctgctaa gatgtcagct acacagcagc caccaccaca tatccccgtg caagttgtcg
     1981 gtacccggca gccaggttca gcccaagcac aggctttggg attagcacag ctggctgctg
     2041 ctgtacctac tccccgtgga ataacaggag cagtccagcc tggccaggct catctggcct
     2101 cctcgccacc ttcatcacag gcggctcctg gtgcacttca agaatgtcct cctgcattgg
     2161 ctgctgggat gacccttgct cctgtgcagg ggacagcaca tgtggtaaag ggtgggccta
     2221 cagcctcctc tcctgttgtg gcccaggtcc ctgctgcttt ctacatgcag tcggtgcacc
     2281 tgccgggtaa agcccagacc ttggctgtga aacgcaaagc tgagtctgag gaggagagag
     2341 atgacctctc cgcattggcc tctgtgcttc ctacaaaggc ctccccagca gcagagagcc
     2401 caaaggtaat agaggagaag aatagtcttg gagagaaagc tgaaccagtg gccagtttga
     2461 atgctaatcc tccaaacagt gatctagtag ccttggcccc taccccatca gcaccacctc
     2521 ctactctggc cttggtgtcc agacagatgg gtgactcaaa acccccacag gccattgtga
     2581 agccccagat tctcacgcac atcattgaag gctttgttat ccaggaagga gcagagcctt
     2641 ttccggtggg atgttctcag ttcctgaaag aaaccaagaa gccactgcag gctggccttc
     2701 cgaccgggct gaatgagagt cagccaagtg gccctttggg gggagacagc ccctctgtag
     2761 agttagagaa gaaggcaaat ctcctcaagt gtgagtactg tggcaagtac gccccagcag
     2821 agcagtttcg aggctctaag aggttctgct ccatgacgtg tgcaaagagg tacaatgtga
     2881 gctgcagcca ccagttccgc ttgaagagga aaaaaatgaa agagtttcag gaagccagct
     2941 atgcacgtgt tcggaggcgt ggaccccgcc gcagctcctc tgatattgct cgtgctaaga
     3001 tccagggcaa gcgccatcgg ggtcaagagg actctagccg gggatcagat aattccagct
     3061 atgatgaagc actctctcca acatctcctg ggccactgtc agtaagagcc gggcacggag
     3121 aacgtgatct aggaaacacc attacaaccc catccacgcc agagttacag ggcatcaatc
     3181 ccgtgttctt gtccagtaat cctagccaat ggagcgtcga ggaggtctac gagtttattg
     3241 cttctctgca aggctgccaa gagattgcag aagagtttcg ttcccaggag attgatggac
     3301 aggccctttt attacttaaa gaagaacatc tgatgagtgc catgaacatc aaattaggtc
     3361 ctgctctcaa gatctgtgcc aagatcaatg tcctcaagga gacctaagtg accctctgca
     3421 caattcagac taaggcagaa ggcctggctg ttcaggttat aacctggaag agctgttcct
     3481 tttgtgtgac ctgtggggtt tggaggcaga actctaagga ttggttgctg gtgctacatg
     3541 gtgacagctt tgataccttc tctgggtttc actttaacaa taaaaacctt ctcactattc
     3601 acacctaccc taatccagtt tttaaacagg cagactagag actaggactg cttagccttc
     3661 cttatcctgg agtggaggga ctagccaggg ttcacttctc caaggaggaa tggatggtaa
     3721 ggcaaggaaa tggatgccat gtaggtttgc ctccctatgg gagaggtcag ctttcctagc
     3781 ttatgacagg agcagcaaac ctggtactct gctggagtct cactgtggct gtagctcagt
     3841 tttctgtttc attttctccc ttaatactga atatttcttc tgcattcatg gcagggtcac
     3901 cagccatcat agacacttgg ttggtatcgg ttttgctgca gggacgaagt gtttgagtga
     3961 cacatgtggc tgttgccatt ctttctgcac cccagctccc aactgttccc accttcaacc
     4021 ctctttccca ttccaacgct gctctgtcct atagcttcac aaaacaggag cgtgtggggc
     4081 tgaggtcagg actgtacctt gggcactatt ccttatacaa aatattaaat attttttttc
     4141 ctcagtaaaa
//
