LOCUS       NM_007531               1360 bp    mRNA    linear   ROD 11-SEP-2024
DEFINITION  Mus musculus prohibitin 2 (Phb2), mRNA.
ACCESSION   NM_007531
VERSION     NM_007531.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1360)
  AUTHORS   Zuo,H., Han,W., Wu,K., Yang,H., Song,H., Zhang,Z., Lai,Y., Pan,Z.,
            Li,W. and Zhao,L.
  TITLE     Prohibitin 2 deficiency in photoreceptors leads to progressive
            retinal degeneration and facilitated Muller glia engulfing
            microglia debris
  JOURNAL   Exp Eye Res 244, 109935 (2024)
   PUBMED   38763352
  REMARK    GeneRIF: Prohibitin 2 deficiency in photoreceptors leads to
            progressive retinal degeneration and facilitated Muller glia
            engulfing microglia debris.
REFERENCE   2  (bases 1 to 1360)
  AUTHORS   Du,Y., Li,J., Dai,Z., Chen,Y., Zhao,Y., Liu,X., Xia,T., Zhu,P. and
            Wang,Y.
  TITLE     Pyruvate kinase M2 sustains cardiac mitochondrial quality
            surveillance in septic cardiomyopathy by regulating prohibitin 2
            abundance via S91 phosphorylation
  JOURNAL   Cell Mol Life Sci 81 (1), 254 (2024)
   PUBMED   38856931
  REMARK    GeneRIF: Pyruvate kinase M2 sustains cardiac mitochondrial quality
            surveillance in septic cardiomyopathy by regulating prohibitin 2
            abundance via S91 phosphorylation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1360)
  AUTHORS   Guo,Y., Xiang,P., Sun,X., Liu,W., Zhou,J., Yin,B., Hou,L.,
            Qiang,B., Li,H., Shu,P. and Peng,X.
  TITLE     Docking protein 6 (DOK6) selectively docks the neurotrophic
            signaling transduction to restrain peripheral neuropathy
  JOURNAL   Signal Transduct Target Ther 9 (1), 32 (2024)
   PUBMED   38351062
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1360)
  AUTHORS   Zhao,Y., Pan,Y., Chen,M., Tan,Y., Chang,X., Li,H. and Zhi,Y.
  TITLE     PKM2 interacts with and phosphorylates PHB2 to sustain
            mitochondrial quality control against septic cerebral-cardiac
            injury
  JOURNAL   Int J Med Sci 21 (4), 633-643 (2024)
   PUBMED   38464826
  REMARK    GeneRIF: PKM2 interacts with and phosphorylates PHB2 to sustain
            mitochondrial quality control against septic cerebral-cardiac
            injury.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1360)
  AUTHORS   Liu,N., Ding,Y., Zhou,H., Chang,X. and Lou,L.
  TITLE     Dual-specificity phosphatase 1 interacts with prohibitin 2 to
            improve mitochondrial quality control against type-3 cardiorenal
            syndrome
  JOURNAL   Int J Med Sci 21 (3), 547-561 (2024)
   PUBMED   38322592
  REMARK    GeneRIF: Dual-specificity phosphatase 1 interacts with prohibitin 2
            to improve mitochondrial quality control against type-3 cardiorenal
            syndrome.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1360)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   7  (bases 1 to 1360)
  AUTHORS   Coates,P.J., Nenutil,R., McGregor,A., Picksley,S.M., Crouch,D.H.,
            Hall,P.A. and Wright,E.G.
  TITLE     Mammalian prohibitin proteins respond to mitochondrial stress and
            decrease during cellular senescence
  JOURNAL   Exp Cell Res 265 (2), 262-273 (2001)
   PUBMED   11302691
REFERENCE   8  (bases 1 to 1360)
  AUTHORS   Chu,C.C. and Paul,W.E.
  TITLE     Expressed genes in interleukin-4 treated B cells identified by cDNA
            representational difference analysis
  JOURNAL   Mol Immunol 35 (8), 487-502 (1998)
   PUBMED   9798653
REFERENCE   9  (bases 1 to 1360)
  AUTHORS   Ansari-Lari,M.A., Oeltjen,J.C., Schwartz,S., Zhang,Z., Muzny,D.M.,
            Lu,J., Gorrell,J.H., Chinault,A.C., Belmont,J.W., Miller,W. and
            Gibbs,R.A.
  TITLE     Comparative sequence analysis of a gene-rich cluster at human
            chromosome 12p13 and its syntenic region in mouse chromosome 6
  JOURNAL   Genome Res 8 (1), 29-40 (1998)
   PUBMED   9445485
REFERENCE   10 (bases 1 to 1360)
  AUTHORS   Terashima,M., Kim,K.M., Adachi,T., Nielsen,P.J., Reth,M., Kohler,G.
            and Lamers,M.C.
  TITLE     The IgM antigen receptor of B lymphocytes is associated with
            prohibitin and a prohibitin-related protein
  JOURNAL   EMBO J 13 (16), 3782-3792 (1994)
   PUBMED   8070406
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB595613.1, AK132058.1, AK152375.1 and AK002334.1.
            
            On Mar 8, 2007 this sequence version replaced NM_007531.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK151952.1, AK132058.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                BB595613.1         18-28
            12-13               AK132058.1         1-2
            14-625              AK152375.1         4-615
            626-1352            AK132058.1         615-1341
            1353-1360           AK002334.1         1319-1326
FEATURES             Location/Qualifiers
     source          1..1360
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 59.17 cM"
     gene            1..1360
                     /gene="Phb2"
                     /gene_synonym="BAP; Bap37; Bcap37; REA"
                     /note="prohibitin 2"
                     /db_xref="GeneID:12034"
                     /db_xref="MGI:MGI:102520"
     exon            1..275
                     /gene="Phb2"
                     /gene_synonym="BAP; Bap37; Bcap37; REA"
                     /inference="alignment:Splign:2.1.0"
     CDS             149..1048
                     /gene="Phb2"
                     /gene_synonym="BAP; Bap37; Bcap37; REA"
                     /note="repressor of estrogen receptor activity; B-cell
                     receptor-associated protein BAP37; B-cell
                     receptor-associated protein 37"
                     /codon_start=1
                     /product="prohibitin-2"
                     /protein_id="NP_031557.2"
                     /db_xref="CCDS:CCDS39627.1"
                     /db_xref="GeneID:12034"
                     /db_xref="MGI:MGI:102520"
                     /translation="MAQNLKDLAGRLPAGPRGMGTALKLLLGAGAVAYGVRESVFTVE
                     GGHRAIFFNRIGGVQQDTILAEGLHFRIPWFQYPIIYDIRARPRKISSPTGSKDLQMV
                     NISLRVLSRPNAQELPSMYQRLGLDYEERVLPSIVNEVLKSVVAKFNASQLITQRAQV
                     SLLIRRELTERAKDFSLILDDVAITELSFSREYTAAVEAKQVAQQEAQRAQFLVEKAK
                     QEQRQKIVQAEGEAEAAKMLGEALSKNPGYIKLRKIRAAQNISKTIATSQNRIYLTAD
                     NLVLNLQDESFTRGSDSLIKGKK"
     exon            276..360
                     /gene="Phb2"
                     /gene_synonym="BAP; Bap37; Bcap37; REA"
                     /inference="alignment:Splign:2.1.0"
     exon            361..440
                     /gene="Phb2"
                     /gene_synonym="BAP; Bap37; Bcap37; REA"
                     /inference="alignment:Splign:2.1.0"
     exon            441..625
                     /gene="Phb2"
                     /gene_synonym="BAP; Bap37; Bcap37; REA"
                     /inference="alignment:Splign:2.1.0"
     exon            626..755
                     /gene="Phb2"
                     /gene_synonym="BAP; Bap37; Bcap37; REA"
                     /inference="alignment:Splign:2.1.0"
     exon            756..859
                     /gene="Phb2"
                     /gene_synonym="BAP; Bap37; Bcap37; REA"
                     /inference="alignment:Splign:2.1.0"
     exon            860..937
                     /gene="Phb2"
                     /gene_synonym="BAP; Bap37; Bcap37; REA"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1014
                     /gene="Phb2"
                     /gene_synonym="BAP; Bap37; Bcap37; REA"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1020
                     /gene="Phb2"
                     /gene_synonym="BAP; Bap37; Bcap37; REA"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1360
                     /gene="Phb2"
                     /gene_synonym="BAP; Bap37; Bcap37; REA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1336..1341
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Phb2"
                     /gene_synonym="BAP; Bap37; Bcap37; REA"
                     /note="putative"
ORIGIN      
        1 gcacttccgg tgccctttct cccgcgagct ctaaggccgc cgatcctcgt gtgcaaggcg
       61 aggtctgtaa gctggagcgg ggcagaggct ggcgggcacc ccctcctgac cgctggtgcc
      121 gccgccgccg ccttcgggag gatcagacat ggcccagaac ttgaaggact tagctggacg
      181 cctgcccgcc gggcctcggg gcatgggcac ggcgctgaag ctgctgctgg gggccggggc
      241 ggtggcctac ggcgtccgcg aatccgtgtt caccgtggaa ggcggtcata gagccatctt
      301 ttttaatcgt attggtggcg tgcagcagga cacgatcctg gccgaaggcc ttcacttcag
      361 gatcccctgg ttccagtacc ccatcatcta tgacattcgg gccagacctc gaaaaatctc
      421 ctcccccaca ggctccaaag acctgcagat ggtgaacatc tccctgcgtg tgctgtcccg
      481 acccaatgcc caggagctcc ccagcatgta ccagcgtcta gggctggact atgaggagcg
      541 agtgctgccg tccattgtta atgaggtgct caagagtgtg gtggccaagt tcaatgcctc
      601 gcagctgatc acccagcggg ctcaggtgtc cctgttgatc cgaagagagc tgacagagcg
      661 cgccaaggac ttcagcctca tcctggatga tgtagctatc acagagctga gcttcagccg
      721 agagtacaca gctgctgtag aagccaagca agtggcccag caggaagccc agcgggccca
      781 gtttttggtg gagaaagcga agcaggaaca gcgacagaag attgtgcagg ctgaggggga
      841 ggcggaggct gccaagatgc ttggagaagc actgagcaag aatcctggct atatcaagct
      901 ccgaaagatc cgggccgccc agaacatctc taaaacgatc gccacatcac agaaccgaat
      961 ctatctcaca gctgacaacc ttgtgctgaa tctacaggat gaaagtttta ctcggggaag
     1021 tgacagcctc attaagggta agaaatgagt gtggacatca agaaccccac caccagagaa
     1081 gttggcacac ttgtccagct tggaggagcc agctcggggg tcaagcacag cccaccctgc
     1141 cccaggcatc atgtgatgga cttttctgta tctgccctct tggattaagg aagactgaga
     1201 ccagcccttt cagaggcttt cctccttcct gtgttggctg ggaagcgggg tgggacaatg
     1261 tgatttctcc gtgatttcct acagccttga gcctctccca gagtggggga gataaccacc
     1321 atgccaggaa ttctcaataa aatttttatt acttaaagcc
//
