LOCUS       NM_008831               1815 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus prohibitin 1 (Phb1), mRNA.
ACCESSION   NM_008831
VERSION     NM_008831.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1815)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1815)
  AUTHORS   Guo,Y., Xiang,P., Sun,X., Liu,W., Zhou,J., Yin,B., Hou,L.,
            Qiang,B., Li,H., Shu,P. and Peng,X.
  TITLE     Docking protein 6 (DOK6) selectively docks the neurotrophic
            signaling transduction to restrain peripheral neuropathy
  JOURNAL   Signal Transduct Target Ther 9 (1), 32 (2024)
   PUBMED   38351062
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1815)
  AUTHORS   Barbier-Torres,L., Chhimwal,J., Kim,S.Y., Ramani,K., Robinson,A.,
            Yang,H., Van Eyk,J., Liangpunsakul,S., Seki,E., Mato,J.M. and
            Lu,S.C.
  TITLE     S-Adenosylmethionine Negatively Regulates the Mitochondrial
            Respiratory Chain Repressor MCJ in the Liver
  JOURNAL   Int J Biol Sci 20 (4), 1218-1237 (2024)
   PUBMED   38385082
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1815)
  AUTHORS   Alula,K.M., Delgado-Deida,Y., Callahan,R., Till,A., Underwood,L.,
            Thompson,W.E., Souza,R.F., Dassopoulos,T., Onyiah,J., Venuprasad,K.
            and Theiss,A.L.
  TITLE     Inner mitochondrial membrane protein Prohibitin 1 mediates
            Nix-induced, Parkin-independent mitophagy
  JOURNAL   Sci Rep 13 (1), 18 (2023)
   PUBMED   36593241
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1815)
  AUTHORS   Liu,H., Fan,H., He,P., Zhuang,H., Liu,X., Chen,M., Zhong,W.,
            Zhang,Y., Zhen,C., Li,Y., Jiang,H., Meng,T., Xu,Y., Zhao,G. and
            Feng,D.
  TITLE     Prohibitin 1 regulates mtDNA release and downstream inflammatory
            responses
  JOURNAL   EMBO J 41 (24), e111173 (2022)
   PUBMED   36245295
  REMARK    GeneRIF: Prohibitin 1 regulates mtDNA release and downstream
            inflammatory responses.
REFERENCE   6  (bases 1 to 1815)
  AUTHORS   Calvo,S.E., Pagliarini,D.J. and Mootha,V.K.
  TITLE     Upstream open reading frames cause widespread reduction of protein
            expression and are polymorphic among humans
  JOURNAL   Proc Natl Acad Sci U S A 106 (18), 7507-7512 (2009)
   PUBMED   19372376
  REMARK    GeneRIF: Includes the study of an upstream ORF in this gene, and
            shows that it functions to reduce protein levels by ~58%.
REFERENCE   7  (bases 1 to 1815)
  AUTHORS   Altus,M.S., Wood,C.M., Stewart,D.A., Roskams,A.J., Friedman,V.,
            Henderson,T., Owens,G.A., Danner,D.B., Jupe,E.R., Dell'Orco,R.T. et
            al.
  TITLE     Regions of evolutionary conservation between the rat and human
            prohibitin-encoding genes
  JOURNAL   Gene 158 (2), 291-294 (1995)
   PUBMED   7607556
REFERENCE   8  (bases 1 to 1815)
  AUTHORS   Terashima,M., Kim,K.M., Adachi,T., Nielsen,P.J., Reth,M., Kohler,G.
            and Lamers,M.C.
  TITLE     The IgM antigen receptor of B lymphocytes is associated with
            prohibitin and a prohibitin-related protein
  JOURNAL   EMBO J 13 (16), 3782-3792 (1994)
   PUBMED   8070406
REFERENCE   9  (bases 1 to 1815)
  AUTHORS   Morris,D.J., Adler,I.D. and Robinson,T.J.
  TITLE     Somatic cell hybrid mapping on mouse chromosome 11 (MMU11):
            assignment of markers relative to two breakpoints in band D
  JOURNAL   Genomics 15 (2), 323-331 (1993)
   PUBMED   8449498
REFERENCE   10 (bases 1 to 1815)
  AUTHORS   White,J.J., Ledbetter,D.H., Eddy,R.L. Jr., Shows,T.B.,
            Stewart,D.A., Nuell,M.J., Friedman,V., Wood,C.M., Owens,G.A.,
            McClung,J.K. et al.
  TITLE     Assignment of the human prohibitin gene (PHB) to chromosome 17 and
            identification of a DNA polymorphism
  JOURNAL   Genomics 11 (1), 228-230 (1991)
   PUBMED   1684951
  REMARK    Erratum:[Genomics 1991 Nov;11(3):782]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL732490.10, AK010619.1 and AW457788.1.
            
            [WARNING] On May 3, 2024 this sequence was replaced by NM_008831.5.
            
            On May 5, 2010 this sequence version replaced NM_008831.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK010619.1, SRR7652917.917472.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            regulatory uORF        :: PMID: 19372376
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                AL732490.10        41563-41620
            59-1789             AK010619.1         2-1732
            1790-1815           AW457788.1         1-26                c
FEATURES             Location/Qualifiers
     source          1..1815
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 59.01 cM"
     gene            1..1815
                     /gene="Phb1"
                     /gene_synonym="Bap32; Phb"
                     /note="prohibitin 1"
                     /db_xref="GeneID:18673"
                     /db_xref="MGI:MGI:97572"
     exon            1..86
                     /gene="Phb1"
                     /gene_synonym="Bap32; Phb"
                     /inference="alignment:Splign:2.1.0"
     regulatory      63..80
                     /regulatory_class="uORF"
                     /gene="Phb1"
                     /gene_synonym="Bap32; Phb"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:19372376]"
                     /note="this uORF is predicted to encode a 5 aa peptide
                     (PMID:19372376)"
     exon            87..201
                     /gene="Phb1"
                     /gene_synonym="Bap32; Phb"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..932
                     /gene="Phb1"
                     /gene_synonym="Bap32; Phb"
                     /note="B-cell receptor-associated protein 32; prohibitin"
                     /codon_start=1
                     /product="prohibitin 1"
                     /protein_id="NP_032857.1"
                     /db_xref="CCDS:CCDS25280.1"
                     /db_xref="GeneID:18673"
                     /db_xref="MGI:MGI:97572"
                     /translation="MAAKVFESIGKFGLALAVAGGVVNSALYNVDAGHRAVIFDRFRG
                     VQDIVVGEGTHFLIPWVQKPIIFDCRSRPRNVPVITGSKDLQNVNITLRILFRPVASQ
                     LPRIYTSIGEDYDERVLPSITTEILKSVVARFDAGELITQRELVSRQVSDDLTERAAT
                     FGLILDDVSLTHLTFGKEFTEAVEAKQVAQQEAERARFVVEKAEQQKKAAIISAEGDS
                     KAAELIANSLATAGDGLIELRKLEAAEDIAYQLSRSRNITYLPAGQSVLLQLPQ"
     exon            202..363
                     /gene="Phb1"
                     /gene_synonym="Bap32; Phb"
                     /inference="alignment:Splign:2.1.0"
     exon            364..506
                     /gene="Phb1"
                     /gene_synonym="Bap32; Phb"
                     /inference="alignment:Splign:2.1.0"
     exon            507..623
                     /gene="Phb1"
                     /gene_synonym="Bap32; Phb"
                     /inference="alignment:Splign:2.1.0"
     exon            624..719
                     /gene="Phb1"
                     /gene_synonym="Bap32; Phb"
                     /inference="alignment:Splign:2.1.0"
     exon            720..1799
                     /gene="Phb1"
                     /gene_synonym="Bap32; Phb"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1034..1039
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Phb1"
                     /gene_synonym="Bap32; Phb"
                     /note="hexamer: AATAAA"
     polyA_site      1063
                     /gene="Phb1"
                     /gene_synonym="Bap32; Phb"
                     /note="major polyA site"
     regulatory      1770..1775
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Phb1"
                     /gene_synonym="Bap32; Phb"
                     /note="hexamer: AATAAA"
     polyA_site      1793
                     /gene="Phb1"
                     /gene_synonym="Bap32; Phb"
ORIGIN      
        1 gggggtcggg ggggggggag gagctgcctg gcgcacgcgc agtatccgga gctggggaat
       61 tcatgtggag gtcagagtga aagcaggtgt gagtggaagc aacagaagga gtcatggctg
      121 ccaaagtgtt tgagtccatt ggaaagttcg gcctggcgtt ggcagttgca ggaggcgtgg
      181 tgaactctgc tttgtataat gtggatgctg gacacagagc tgtcatcttt gaccgattcc
      241 gtggcgtaca ggacattgtg gtcggggaag ggactcattt cctcatccct tgggtacaga
      301 aaccaattat ctttgactgc cgctctcgac cacggaacgt accagtcatc actggtagca
      361 aagacttgca gaacgtcaat atcacactgc gaatcctctt ccggccggtg gccagccagc
      421 ttcctcgtat ctacaccagc attggcgagg actatgatga gcgggtcctg ccttctatca
      481 ccacagagat cctcaagtcg gtggtggctc gattcgatgc tggagaattg attacccagc
      541 gagagctggt ctccaggcag gtgagcgatg acctcacaga gcgagcggca acatttgggc
      601 ttatcctgga tgacgtgtcc ctgacacatc tgaccttcgg gaaggagttc acagaggcag
      661 tagaagccaa acaggtggct cagcaggaag cggagagagc cagatttgtg gtggaaaagg
      721 ctgagcagca gaagaaggca gccatcatct ctgctgaggg tgactccaag gccgctgagc
      781 tgatcgccaa ctcgctggcc acggcaggcg acggcctgat cgagctgcgg aagctggagg
      841 ccgccgagga cattgcgtac cagctctccc gctctcggaa catcacctac ctgccagcgg
      901 gccagtccgt gcttctccag cttccccagt gaggccagcc gggccacggc ctccatcatg
      961 ctgaatgacg ccttccttct gccccacccc agaaaatcac tgtgaaattt catgattggc
     1021 ttaaagtgaa ggaaataaag gtaaaatcac ttcagatctc taattatcaa gcgaagcttt
     1081 tattgttaca cttcttaccc tctttcatat ccaaaattgc caagtgcctc tgcagactgg
     1141 ccttccaccc taggcgcggg cagttggcag aagaaaggca gggcagtgtg tagtggatgg
     1201 gcagcctgct ggcagcctgc ataggcctag ggcctccatt ctgccgtata ttgaagattt
     1261 aaagacagtg gcacacacac ttgaacaaaa gcaagccctc agtgtttcca gccatttgaa
     1321 cctggacaga tgcagctggg gagggccaga ggaagtggtc tatctcaact gtaaggccca
     1381 tcccctctta accatgacca gcggaagcag gtgtgtgtga ccagggcacg gggtgaagaa
     1441 tctgcccatc aaggtgggtg ggcctcatgt cgctgccccc accagagtcc taaaacctgg
     1501 atggacttgg acgggacaag aggcctggac tgagatgtga gtcccatgga agacttcctc
     1561 tccacccccc acatcggtcc tctcaaatac ccaatgggat tccagcttga aggattgcat
     1621 cctgcaggga atgagcacac ctgccaagga cacgtgcgcc tgccttcccg ctccctctct
     1681 ctcagagatt gccctttctt cccgagggct gtgggccagc gctccgaagg aagcaatcaa
     1741 ggggagaaaa cacagtgtaa gccgctgtca ataaatgaca cccagacctt ccagctgcaa
     1801 aaaaaaaaaa aaaaa
//
