LOCUS       NP_001181994             626 aa            linear   ROD 30-APR-2024
DEFINITION  phosphatase and actin regulator 2 isoform A [Mus musculus].
ACCESSION   NP_001181994
VERSION     NP_001181994.1
DBSOURCE    REFSEQ: accession NM_001195065.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 626)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 626)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 626)
  AUTHORS   Jiang,W., Shi,J., Zhao,J., Wang,Q., Cong,D., Chen,F., Zhang,Y.,
            Liu,Y., Zhao,J., Chen,Q., Gu,L., Zhou,W., Wang,C., Fang,Z.,
            Geng,S., Xie,W., Chen,L.N., Yang,Y., Bai,Y., Lin,H. and Li,X.
  TITLE     ZFP57 dictates allelic expression switch of target imprinted genes
  JOURNAL   Proc Natl Acad Sci U S A 118 (5) (2021)
   PUBMED   33500348
REFERENCE   4  (residues 1 to 626)
  AUTHORS   Kim,J.Y., Choi,S.Y., Moon,Y., Kim,H.J., Chin,J.H., Kim,H. and
            Sun,W.
  TITLE     Different expression patterns of Phactr family members in normal
            and injured mouse brain
  JOURNAL   Neuroscience 221, 37-46 (2012)
   PUBMED   22766235
  REMARK    GeneRIF: This study demonistrated that the mRNA expression of
            phactr2 was progressively increased in the injury penumbra.
REFERENCE   5  (residues 1 to 626)
  AUTHORS   Wilson,C.H., Crombie,C., van der Weyden,L., Poulogiannis,G.,
            Rust,A.G., Pardo,M., Gracia,T., Yu,L., Choudhary,J., Poulin,G.B.,
            McIntyre,R.E., Winton,D.J., March,H.N., Arends,M.J., Fraser,A.G.
            and Adams,D.J.
  TITLE     Nuclear receptor binding protein 1 regulates intestinal progenitor
            cell homeostasis and tumour formation
  JOURNAL   EMBO J 31 (11), 2486-2497 (2012)
   PUBMED   22510880
REFERENCE   6  (residues 1 to 626)
  AUTHORS   Allen,P.B., Greenfield,A.T., Svenningsson,P., Haspeslagh,D.C. and
            Greengard,P.
  TITLE     Phactrs 1-4: A family of protein phosphatase 1 and actin regulatory
            proteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (18), 7187-7192 (2004)
   PUBMED   15107502
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC156949.9 and AL713985.10.
            
            Transcript Variant: This variant (A) represents the longest
            transcript and encodes the longest isoform (A).
            
            Sequence Note: This RefSeq record was created from genomic sequence
            data to make the sequence consistent with the reference genome
            assembly. The genomic coordinates used for the transcript record
            were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC012871.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..626
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 4.72 cM"
     Protein         1..626
                     /product="phosphatase and actin regulator 2 isoform A"
                     /calculated_mol_wt=68348
     Region          132..153
                     /region_name="RPEL"
                     /note="RPEL repeat; pfam02755"
                     /db_xref="CDD:460677"
     Region          469..494
                     /region_name="RPEL"
                     /note="Repeat in Drosophila CG10860, human KIAA0680 and C.
                     elegans F26H9.2; smart00707"
                     /db_xref="CDD:128947"
     Region          508..532
                     /region_name="RPEL"
                     /note="Repeat in Drosophila CG10860, human KIAA0680 and C.
                     elegans F26H9.2; smart00707"
                     /db_xref="CDD:128947"
     Region          545..570
                     /region_name="RPEL"
                     /note="Repeat in Drosophila CG10860, human KIAA0680 and C.
                     elegans F26H9.2; smart00707"
                     /db_xref="CDD:128947"
     CDS             1..626
                     /gene="Phactr2"
                     /coded_by="NM_001195065.1:119..1999"
                     /note="isoform A is encoded by transcript variant A"
                     /db_xref="CCDS:CCDS87962.1"
                     /db_xref="GeneID:215789"
                     /db_xref="MGI:MGI:2446138"
ORIGIN      
        1 maeagrspem spdqpagqea aaaealdpep eapgppvpsl rwlpgdpspr grsqsdlssa
       61 ssrgrplrvh isgsvdgldk asiansdgpp agsqtppfkr kgklstigki fkpwkwrkkk
      121 tsdkfretsa vlerkistrq sreelirrgl lkelpdqdgd vtvnfensng hmihigeeat
      181 qeenvgkpee gsdsvcektp preeqaeekt aasragsshp kkatgskasa spstsstssr
      241 prapkeslag kaglvgttrg kkkiskqpva srlspsttts dtpslkgels dtgiesltpe
      301 etvagaeeqa tskskaaial ppstappspp alllppedqc tialdtpmvl vsdgptlpvs
      361 aldtsqllwt eepssrtspy sstglggsre qakcfttkde lgpqlltpgq mgdssesfsa
      421 pedeapreyq andsdsdgpi lytddddeed ddddssgesa laskirrrdt laiklgnrps
      481 kkeledknil qrtseeerqe lrqqigtklv rrlsqrptte eleqrnilkq kneeeeqeak
      541 melkrrlsrk lslrptvael qarrilrfne yvevtdspdy drradkpwar ltpadkaair
      601 kelnefkste mevheesrqf trfhrp
//
