LOCUS       NM_133757               2298 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus phosphatidylglycerophosphate synthase 1 (Pgs1), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_133757 XM_895026 XM_911477 XM_993433
VERSION     NM_133757.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2298)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2298)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   3  (bases 1 to 2298)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 2298)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK049359.1.
            
            On Apr 6, 2007 this sequence version replaced NM_133757.1.
            
            Transcript Variant: This variant (1) represents the longer
            protein-coding transcript.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK049359.1, SRR1660815.159968.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2298              AK049359.1         2-2299
FEATURES             Location/Qualifiers
     source          1..2298
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 82.96 cM"
     gene            1..2298
                     /gene="Pgs1"
                     /gene_synonym="2610019F11Rik; 4933424M23Rik; SAF"
                     /note="phosphatidylglycerophosphate synthase 1"
                     /db_xref="GeneID:74451"
                     /db_xref="MGI:MGI:1921701"
     exon            1..157
                     /gene="Pgs1"
                     /gene_synonym="2610019F11Rik; 4933424M23Rik; SAF"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..1685
                     /gene="Pgs1"
                     /gene_synonym="2610019F11Rik; 4933424M23Rik; SAF"
                     /EC_number="2.7.8.5"
                     /note="PGP synthase 1; silencer-associated factor"
                     /codon_start=1
                     /product="CDP-diacylglycerol--glycerol-3-phosphate
                     3-phosphatidyltransferase, mitochondrial"
                     /protein_id="NP_598518.1"
                     /db_xref="CCDS:CCDS25698.1"
                     /db_xref="GeneID:74451"
                     /db_xref="MGI:MGI:1921701"
                     /translation="MAAPAAGPVFWRRLLGLLPGRPGLAALLGRLSDRLGRSRERRRR
                     RSPWLLLAPLLSPTVPQVTSPPCCLCPEGVHRFQWIRNLVPEFGVSSSHVRVLSSPAE
                     FFELMKGQIKIAKRRVVMASLYLGTGPLEQELVDCLESSLEKSLQAKFPSDLKVSILL
                     DFTRGSRGRKNSRTMLLPLLQRFPERVRVSLFHTPNLRGLLRLLIPERFNETIGLQHI
                     KVYLFDNNVILSGANLSDSYFTNRQDRYVFLQDCAEIADFFTELVDAVGDVSLQLQGD
                     DTVEVVDGMVHPYKGDRAAYCRAANKRVMDVIHSARARQQMLHAQTFHSDSLLSQEEA
                     AAAGDRRPAPDTWIYPLIQMKPFEIQIDEIVTETLLTEAERGAKVFLTTGYFNLTQAY
                     MDLVLGTRAEYQILLASPEVNGFFGAKGVAGAIPAAYVHIERQFYSEVCSLGQQDRVQ
                     LQEYWRRGWTFHAKGLWLYLAGSSLPCLTLIGSPNFGYRSVHRDLEAQIAIVTESRSL
                     QQQLHQEQEQLYLRSGVVTSATFEQPGRQVKLWVKMVTPLIKNFF"
     exon            158..347
                     /gene="Pgs1"
                     /gene_synonym="2610019F11Rik; 4933424M23Rik; SAF"
                     /inference="alignment:Splign:2.1.0"
     exon            348..425
                     /gene="Pgs1"
                     /gene_synonym="2610019F11Rik; 4933424M23Rik; SAF"
                     /inference="alignment:Splign:2.1.0"
     exon            426..525
                     /gene="Pgs1"
                     /gene_synonym="2610019F11Rik; 4933424M23Rik; SAF"
                     /inference="alignment:Splign:2.1.0"
     exon            526..715
                     /gene="Pgs1"
                     /gene_synonym="2610019F11Rik; 4933424M23Rik; SAF"
                     /inference="alignment:Splign:2.1.0"
     exon            716..894
                     /gene="Pgs1"
                     /gene_synonym="2610019F11Rik; 4933424M23Rik; SAF"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1416
                     /gene="Pgs1"
                     /gene_synonym="2610019F11Rik; 4933424M23Rik; SAF"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1565
                     /gene="Pgs1"
                     /gene_synonym="2610019F11Rik; 4933424M23Rik; SAF"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1691
                     /gene="Pgs1"
                     /gene_synonym="2610019F11Rik; 4933424M23Rik; SAF"
                     /inference="alignment:Splign:2.1.0"
     exon            1692..2298
                     /gene="Pgs1"
                     /gene_synonym="2610019F11Rik; 4933424M23Rik; SAF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2194..2199
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pgs1"
                     /gene_synonym="2610019F11Rik; 4933424M23Rik; SAF"
                     /note="hexamer: TATAAA"
     polyA_site      2214
                     /gene="Pgs1"
                     /gene_synonym="2610019F11Rik; 4933424M23Rik; SAF"
     regulatory      2280..2285
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pgs1"
                     /gene_synonym="2610019F11Rik; 4933424M23Rik; SAF"
                     /note="hexamer: AATAAA"
     polyA_site      2298
                     /gene="Pgs1"
                     /gene_synonym="2610019F11Rik; 4933424M23Rik; SAF"
                     /note="major polyA site"
ORIGIN      
        1 ggaagcggaa gcggcgggtc tccatggcgg cgccggcagc gggcccggtg ttctggaggc
       61 ggctgctggg cctgctgcct ggcaggcccg ggctggccgc gctcctgggc cgcctctccg
      121 accgtctggg caggagccgg gagcgccggc gccggaggtc accatggctg ttattggctc
      181 ccttgctgtc cccaaccgtt cctcaggtca cctccccacc ttgctgccta tgtcccgagg
      241 gtgtacacag gttccagtgg atcagaaacc tggttccaga gtttggagtc tccagctctc
      301 atgtcagggt actgtcttcc cctgcagagt tcttcgagct catgaagggg cagataaaaa
      361 tagccaagag gcgagttgtg atggcatccc tctacttggg gacaggacct ttggaacagg
      421 aactggtgga ttgtctggaa agttctctag aaaagtcact ccaagcgaag tttccttccg
      481 acctcaaggt ctccattctc ctggacttca ccagaggctc aagaggtagg aagaactctc
      541 gcactatgct gctcccactc ctgcagaggt ttccagagcg cgtgcgcgtc tccctcttcc
      601 acacaccaaa cctccgagga ctcctccgac tccttatccc tgagcgcttc aatgagacca
      661 tcggcctcca gcacatcaag gtgtacctct ttgacaacaa cgtcatcctg agtggtgcaa
      721 acctgagtga ctcatacttc accaaccgcc aggaccgcta cgtgttcttg caggactgcg
      781 ctgagattgc cgacttcttc acagagctgg tggacgccgt gggggatgta tccttgcagt
      841 tgcagggcga cgacacagtg gaggttgtgg atgggatggt gcacccttac aaaggtgacc
      901 gggctgcgta ctgcagagca gcgaacaagc gggtcatgga cgtcatccac tcggccaggg
      961 cccggcagca gatgctgcac gcacagacct ttcacagtga ttctctgctg agccaggaag
     1021 aggctgcagc tgccggggac cggaggccag cgcccgacac ctggatttac ccactgatcc
     1081 agatgaagcc ctttgagatt cagattgatg agatagtcac ggagacgctg ctgacggagg
     1141 ctgagcgcgg agctaaggtc ttcctcacca ctggctactt caacctgacc caggcctaca
     1201 tggacctggt gctaggcact cgagctgagt atcagatcct tctagcctca ccggaggtga
     1261 atggcttctt tggggctaag ggcgtggcgg gcgccatccc agccgcctat gtgcacattg
     1321 agcgacagtt ctacagtgag gtgtgtagcc tggggcagca ggatcgggtc cagctccagg
     1381 aatactggcg caggggttgg acctttcatg ccaaaggcct ctggctgtac ctggcaggga
     1441 gcagcctgcc ctgcctcacg ctgattggct ctcctaattt tgggtacagg tcagttcacc
     1501 gggacctgga agcccagatt gccatcgtga cggagagccg gtccctgcag cagcagcttc
     1561 atcaggagca agagcagctc tacctgcggt ctggtgtggt gacctccgca acctttgagc
     1621 agccagggcg gcaggtcaag ctgtgggtga agatggtgac cccgctaatc aagaacttct
     1681 tctgagaaca ggaatggcct tgatgaagat gacgggcatg actggggtca gatccttcaa
     1741 ccgggcttca gcaatgactc cggtctgggt gtcccagcga gctcctgtgg ggacaatgga
     1801 gctgagggtc tgggtgccct aggggaggca gaacccactg tttggatgct gaccgtgaaa
     1861 aagggaggca cggtagggag agaggcctgg cctccaacct ccccactctt ttcagagaca
     1921 ggccagtgac tgggagccat gaagcgttca ggccaggtgc cagggtctga gagtgccaaa
     1981 catggaggag tgtgaaccaa ggactccgag gtgactctgc atgccgtaat ggctctgagg
     2041 ctgcatcttc tcagagcttc atctcagcct tctcaatgtc agtggcagag aaaactgacc
     2101 gcagctcaga tcccagcaat gttccttcct gatccctcct gtgtaatgtc tactctctgt
     2161 gtacataggg aataagttat atatagatgc acatataaac actatctgcc cttagccaga
     2221 ctgctgttgt ctcttatcct agccaatggt gtttgtgtcc tgcgtggcat tggaatcaca
     2281 ataaacatgg agaatggc
//
