LOCUS       NM_027558               2958 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus progesterone receptor membrane component 2 (Pgrmc2),
            mRNA.
ACCESSION   NM_027558 XM_130859 XM_911696
VERSION     NM_027558.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2958)
  AUTHORS   Zhou,C., Zhu,T., Ni,W., Zhou,H., Song,J., Wang,M., Jin,G., Zhou,Y.,
            Han,J. and Hua,F.
  TITLE     Gain-of-function of progesterone receptor membrane component 2
            ameliorates ischemic brain injury
  JOURNAL   CNS Neurosci Ther 29 (6), 1585-1601 (2023)
   PUBMED   36794556
  REMARK    GeneRIF: Gain-of-function of progesterone receptor membrane
            component 2 ameliorates ischemic brain injury.
REFERENCE   2  (bases 1 to 2958)
  AUTHORS   Galmozzi,A., Kok,B.P., Kim,A.S., Montenegro-Burke,J.R., Lee,J.Y.,
            Spreafico,R., Mosure,S., Albert,V., Cintron-Colon,R., Godio,C.,
            Webb,W.R., Conti,B., Solt,L.A., Kojetin,D., Parker,C.G.,
            Peluso,J.J., Pru,J.K., Siuzdak,G., Cravatt,B.F. and Saez,E.
  TITLE     PGRMC2 is an intracellular haem chaperone critical for adipocyte
            function
  JOURNAL   Nature 576 (7785), 138-142 (2019)
   PUBMED   31748741
  REMARK    GeneRIF: Ensuing alterations in gene expression caused severe
            mitochondrial defects that rendered adipose-specific PGRMC2-null
            mice unable to activate adaptive thermogenesis and prone to greater
            metabolic deterioration when fed a high-fat diet
REFERENCE   3  (bases 1 to 2958)
  AUTHORS   Koopmans,F., van Nierop,P., Andres-Alonso,M., Byrnes,A.,
            Cijsouw,T., Coba,M.P., Cornelisse,L.N., Farrell,R.J.,
            Goldschmidt,H.L., Howrigan,D.P., Hussain,N.K., Imig,C., de
            Jong,A.P.H., Jung,H., Kohansalnodehi,M., Kramarz,B., Lipstein,N.,
            Lovering,R.C., MacGillavry,H., Mariano,V., Mi,H., Ninov,M.,
            Osumi-Sutherland,D., Pielot,R., Smalla,K.H., Tang,H., Tashman,K.,
            Toonen,R.F.G., Verpelli,C., Reig-Viader,R., Watanabe,K., van
            Weering,J., Achsel,T., Ashrafi,G., Asi,N., Brown,T.C., De
            Camilli,P., Feuermann,M., Foulger,R.E., Gaudet,P., Joglekar,A.,
            Kanellopoulos,A., Malenka,R., Nicoll,R.A., Pulido,C., de
            Juan-Sanz,J., Sheng,M., Sudhof,T.C., Tilgner,H.U., Bagni,C.,
            Bayes,A., Biederer,T., Brose,N., Chua,J.J.E., Dieterich,D.C.,
            Gundelfinger,E.D., Hoogenraad,C., Huganir,R.L., Jahn,R.,
            Kaeser,P.S., Kim,E., Kreutz,M.R., McPherson,P.S., Neale,B.M.,
            O'Connor,V., Posthuma,D., Ryan,T.A., Sala,C., Feng,G., Hyman,S.E.,
            Thomas,P.D., Smit,A.B. and Verhage,M.
  TITLE     SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the
            Synapse
  JOURNAL   Neuron 103 (2), 217-234 (2019)
   PUBMED   31171447
REFERENCE   4  (bases 1 to 2958)
  AUTHORS   Peluso,J.J., Liu,X., Uliasz,T., Pru,C.A., Kelp,N.C. and Pru,J.K.
  TITLE     PGRMC1/2 promotes luteal vascularization and maintains the
            primordial follicles of mice
  JOURNAL   Reproduction 156 (4), 365-373 (2018)
   PUBMED   30306772
  REMARK    GeneRIF: survival of adult primordial ovarian follicles dependent
            in part on progesterone receptor membrane component 1 and 2
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2958)
  AUTHORS   Clark,N.C., Pru,C.A., Yee,S.P., Lydon,J.P., Peluso,J.J. and
            Pru,J.K.
  TITLE     Conditional Ablation of Progesterone Receptor Membrane Component 2
            Causes Female Premature Reproductive Senescence
  JOURNAL   Endocrinology 158 (3), 640-651 (2017)
   PUBMED   28005395
  REMARK    GeneRIF: required for the maintenance of uterine histoarchitecture
            and normal female reproductive lifespan.
REFERENCE   6  (bases 1 to 2958)
  AUTHORS   Juhlen,R., Landgraf,D., Huebner,A. and Koehler,K.
  TITLE     Identification of a novel putative interaction partner of the
            nucleoporin ALADIN
  JOURNAL   Biol Open 5 (11), 1697-1705 (2016)
   PUBMED   27754849
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2958)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   8  (bases 1 to 2958)
  AUTHORS   Suzuki,H., Fukunishi,Y., Kagawa,I., Saito,R., Oda,H., Endo,T.,
            Kondo,S., Bono,H., Okazaki,Y. and Hayashizaki,Y.
  TITLE     Protein-protein interaction panel using mouse full-length cDNAs
  JOURNAL   Genome Res 11 (10), 1758-1765 (2001)
   PUBMED   11591653
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC100511.12.
            
            On Jan 24, 2023 this sequence version replaced NM_027558.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC044759.2, AK140064.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164132, SAMN01164136
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-414               AC100511.12        55121-55534         c
            415-570             AC100511.12        42806-42961         c
            571-2958            AC100511.12        38863-41250         c
FEATURES             Location/Qualifiers
     source          1..2958
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 19.66 cM"
     gene            1..2958
                     /gene="Pgrmc2"
                     /gene_synonym="4631434O19Rik; 5730409G06Rik; DG6; PMBP"
                     /note="progesterone receptor membrane component 2"
                     /db_xref="GeneID:70804"
                     /db_xref="MGI:MGI:1918054"
     exon            1..414
                     /gene="Pgrmc2"
                     /gene_synonym="4631434O19Rik; 5730409G06Rik; DG6; PMBP"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..668
                     /gene="Pgrmc2"
                     /gene_synonym="4631434O19Rik; 5730409G06Rik; DG6; PMBP"
                     /note="progesterone membrane binding protein"
                     /codon_start=1
                     /product="membrane-associated progesterone receptor
                     component 2"
                     /protein_id="NP_081834.1"
                     /db_xref="CCDS:CCDS50899.1"
                     /db_xref="GeneID:70804"
                     /db_xref="MGI:MGI:1918054"
                     /translation="MAAGDGDVKLSTLGSGGESGGDGSPGGAGATAARSSWVAALLAT
                     GGEMLLNVALVALVLLGAYRLWVRWGRRGLCSGPGAGEESPAATLPRMKKRDFSLEQL
                     RQYDGARTPRILLAVNGKVFDVTKGSKFYGPAGPYGIFAGRDASRGLATFCLDKDALR
                     DEYDDLSDLNAVQMESVREWEMQFKEKYDYVGRLLKPGEEPSEYTDEEDTKDHSKQD"
     exon            415..570
                     /gene="Pgrmc2"
                     /gene_synonym="4631434O19Rik; 5730409G06Rik; DG6; PMBP"
                     /inference="alignment:Splign:2.1.0"
     exon            571..2958
                     /gene="Pgrmc2"
                     /gene_synonym="4631434O19Rik; 5730409G06Rik; DG6; PMBP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1791..1796
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pgrmc2"
                     /gene_synonym="4631434O19Rik; 5730409G06Rik; DG6; PMBP"
                     /note="hexamer: AATAAA"
     polyA_site      1801
                     /gene="Pgrmc2"
                     /gene_synonym="4631434O19Rik; 5730409G06Rik; DG6; PMBP"
                     /note="major polyA site"
     regulatory      2594..2599
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pgrmc2"
                     /gene_synonym="4631434O19Rik; 5730409G06Rik; DG6; PMBP"
                     /note="hexamer: AATAAA"
     polyA_site      2615
                     /gene="Pgrmc2"
                     /gene_synonym="4631434O19Rik; 5730409G06Rik; DG6; PMBP"
     regulatory      2939..2944
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pgrmc2"
                     /gene_synonym="4631434O19Rik; 5730409G06Rik; DG6; PMBP"
                     /note="hexamer: AATAAA"
     polyA_site      2958
                     /gene="Pgrmc2"
                     /gene_synonym="4631434O19Rik; 5730409G06Rik; DG6; PMBP"
ORIGIN      
        1 gctggcgggc agtgatggcg gcgggtgatg gggacgtaaa gctaagcacc ctggggagcg
       61 gcggggagag tggcggcgac gggagcccgg gtggcgccgg agcgacggcg gcgaggagca
      121 gttgggtggc ggcgctgctg gcgacgggcg gggagatgct gctgaacgtg gcgctggtgg
      181 cgctggtgct gctgggggcc taccggctgt gggtgcgctg ggggcggcgt ggtctgtgct
      241 cgggacccgg ggcgggcgag gagagcccgg ccgccacgct gccgcgcatg aagaagcggg
      301 acttcagcct ggagcagctg cgccagtacg acggggcgcg cacgccgcgc atcctgctcg
      361 cggtcaatgg gaaagtcttc gacgtgacca aaggcagcaa gttctacggc cccgcgggtc
      421 catatggcat ctttgctggc agggacgcct ccagggggct ggcgacattc tgcctggata
      481 aggatgcact tagagatgaa tatgacgacc tctcagattt gaacgcagtg caaatggaga
      541 gtgttcgaga atgggaaatg cagtttaaag aaaaatatga ttatgtaggc agactcctaa
      601 agccagggga ggagccatca gagtacacag atgaggagga caccaaggat cacagtaaac
      661 aggactgaac tttgtgagca accaaagcca ggggccttca gaactgcagc tcgtacccct
      721 ttcagagaat gtccagtctt tgggtgtgat gctcctgctg tgagaaacac ctcaccagcg
      781 tgaacaagat aatctgcctg actgaagatc tgaggatgag gcgttggttg tgctgccagg
      841 tgaatttgtt gccgttggtt gtaatgtctg gtgggcttca tcatcctaaa caggagacag
      901 gaccttctta acagcaagaa agtcaccggg tcgtttttcc ccctcccctg ccccaccttc
      961 ccctcctccc cttctctctc tgccttcctt tctttccccc acccctccca tgtctctctt
     1021 aaaacaaaaa agtatcaaag acaaccagat aggtatttgc tactcagtgt gcagatctct
     1081 ggaaagcaag ggatactgtt tcacaggctg tgttttattt gtgttaaggg aagagccctg
     1141 ggcagggaag aggggttgca tattcattta agaagttcag gctactgaaa cattcaaacg
     1201 tgaattccca aacttttctt tccgggcttt gtcagagaag ggggtaaatg tccttctaag
     1261 aaagatctgg aagttagagg aatatccagc ggattgaagt cagcagttcc cagcaacgat
     1321 aatttgaaac cagttttatt tctttccctt ccttccgcta ggtcaaatca atattaattg
     1381 tgccttattt cacttccata aacttgaatt actttttggg aaagcccctc tgtgaattga
     1441 gaagtcacta caagcagcat tgagcctgag gctgatgtca ttctgtgtgt agaatggaag
     1501 aggagtactc agtgttaact gccatatgtt agaacacaaa catagctagc attgtgatgg
     1561 ccaaatgcat cccctgggct cttttctttt ccaagaaaaa ttgaaaaacc aactactctt
     1621 ccccaacagc tgcctaattt taggagtctg accctcactc gtcactggtg tgggtagcag
     1681 ggccgtggta tgaatgtctg tgtgagtgag tctggatgtc tgtgagagca ccttggggga
     1741 aacttcctgc gatgctgtaa atacgagtac cgttttaata aagcatgtac aataaaccaa
     1801 ataagctcga gtcggactct aaatacagag ccgtgagcca gtgtgtcatg tactaatact
     1861 gcatttgatt cacgatgagg gggaaaccct cttagaaatg aaaatcaggc cctgactagc
     1921 caagctgtcc gtgtcccatg ctcagtgtaa cttccaaggc aggtccacct ctgtgggtgg
     1981 ttcaggtaag aagggatatt acagtggaca gtgctctcag gcctcgctgc cactcagtgt
     2041 gctggaagca ccagccttcc aaagtaggaa ctgacataga aacacagtat tgtacccata
     2101 gccagtaaat cccgttcttg tcagttaaaa aagttctatt tcaaagcctg cttagtttgg
     2161 gttttggctt cattatggtg gactcttagt cagggacaga ttgctctcac agagaaaagc
     2221 cccaaggagg tggcattaaa gacgtgttcc tgacgggtgc agtgcaagca gaagctcggg
     2281 ttcgatggga agcagagggc gagcggtgct acactcgtag catgctggaa tagcctccag
     2341 aagtgtgctt gtcaccacat cctgtctgaa gaactcaagg agactgaaga gtgttgggaa
     2401 gtgcttcctt tatatgtaaa acactttcta aaagcaaatt gttatatatt atctatcctc
     2461 tggtgtagta aattggtgta tctgaaccat tgagcctaat aatctgcgat tgcgagaagc
     2521 cgcaggtatt catgcagtaa aaaacaatgc attttggttt ttaaaaggaa gtggttttgt
     2581 gttttggact ttaaataaac tgtgttcgta gataatttct taattccagt caaatgtctc
     2641 attgttaggt agtgtggtac ccagacctag agggtctgta accggcctga ctgatggggg
     2701 cggggggtta ggacacgttt cttttctttt ttttcttttt cttatccttc agtgttagaa
     2761 ttcagacaca gggcttcaca tattgctcaa ccatttacat cccagctcca aagtatacat
     2821 tcttcctatc cactgagcct aaatctgttt gtggttcctc caatcaaacg tacgattgga
     2881 catgtttgag aaacactgca tccacctttt gaagttgtgt ggtccatgtt tgccatacaa
     2941 taaaagttga acttataa
//
