LOCUS       NM_016783               1890 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus progesterone receptor membrane component 1 (Pgrmc1),
            mRNA.
ACCESSION   NM_016783
VERSION     NM_016783.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1890)
  AUTHORS   Jo,S.L., Baek,I.J., Ko,J.W., Kwun,H.J., Shin,H.J. and Hong,E.J.
  TITLE     Hepatic progesterone receptor membrane component 1 attenuates
            ethanol-induced liver injury by reducing acetaldehyde production
            and oxidative stress
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 324 (6), G442-G451 (2023)
   PUBMED   37070746
  REMARK    GeneRIF: Hepatic progesterone receptor membrane component 1
            attenuates ethanol-induced liver injury by reducing acetaldehyde
            production and oxidative stress.
REFERENCE   2  (bases 1 to 1890)
  AUTHORS   McGuire,M.R., Mukhopadhyay,D., Myers,S.L., Mosher,E.P.,
            Brookheart,R.T., Kammers,K., Sehgal,A., Selen,E.S., Wolfgang,M.J.,
            Bumpus,N.N. and Espenshade,P.J.
  TITLE     Progesterone receptor membrane component 1 (PGRMC1) binds and
            stabilizes cytochromes P450 through a heme-independent mechanism
  JOURNAL   J Biol Chem 297 (5), 101316 (2021)
   PUBMED   34678314
  REMARK    GeneRIF: Progesterone receptor membrane component 1 (PGRMC1) binds
            and stabilizes cytochromes P450 through a heme-independent
            mechanism.
REFERENCE   3  (bases 1 to 1890)
  AUTHORS   Huang,K., Zhang,Y., Gong,W., Yang,Y., Jiang,L., Zhao,L., Yang,Y.,
            Wei,Y., Li,C., He,X., Sun,X., Zou,Z. and Jin,M.
  TITLE     PGRMC1 Exerts Its Function of Anti-Influenza Virus in the Central
            Nervous System
  JOURNAL   Microbiol Spectr 9 (2), e0073421 (2021)
   PUBMED   34585989
  REMARK    GeneRIF: PGRMC1 Exerts Its Function of Anti-Influenza Virus in the
            Central Nervous System.
REFERENCE   4  (bases 1 to 1890)
  AUTHORS   Chen,Y.J., Knupp,J., Arunagiri,A., Haataja,L., Arvan,P. and Tsai,B.
  TITLE     PGRMC1 acts as a size-selective cargo receptor to drive ER-phagic
            clearance of mutant prohormones
  JOURNAL   Nat Commun 12 (1), 5991 (2021)
   PUBMED   34645803
  REMARK    GeneRIF: PGRMC1 acts as a size-selective cargo receptor to drive
            ER-phagic clearance of mutant prohormones.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1890)
  AUTHORS   Lee,S.R., Heo,J.H., Jo,S.L., Kim,G., Kim,S.J., Yoo,H.J., Lee,K.P.,
            Kwun,H.J., Shin,H.J., Baek,I.J. and Hong,E.J.
  TITLE     Progesterone receptor membrane component 1 reduces cardiac
            steatosis and lipotoxicity via activation of fatty acid oxidation
            and mitochondrial respiration
  JOURNAL   Sci Rep 11 (1), 8781 (2021)
   PUBMED   33888830
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1890)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
REFERENCE   7  (bases 1 to 1890)
  AUTHORS   Jin,W.H., Dai,J., Zhou,H., Xia,Q.C., Zou,H.F. and Zeng,R.
  TITLE     Phosphoproteome analysis of mouse liver using immobilized metal
            affinity purification and linear ion trap mass spectrometry
  JOURNAL   Rapid Commun Mass Spectrom 18 (18), 2169-2176 (2004)
   PUBMED   15378723
REFERENCE   8  (bases 1 to 1890)
  AUTHORS   Runko,E. and Kaprielian,Z.
  TITLE     Expression of Vema in the developing mouse spinal cord and optic
            chiasm
  JOURNAL   J Comp Neurol 451 (3), 289-299 (2002)
   PUBMED   12210140
REFERENCE   9  (bases 1 to 1890)
  AUTHORS   Raza,F.S., Takemori,H., Tojo,H., Okamoto,M. and Vinson,G.P.
  TITLE     Identification of the rat adrenal zona fasciculata/reticularis
            specific protein, inner zone antigen (IZAg), as the putative
            membrane progesterone receptor
  JOURNAL   Eur J Biochem 268 (7), 2141-2147 (2001)
   PUBMED   11277938
REFERENCE   10 (bases 1 to 1890)
  AUTHORS   Nolte,I., Jeckel,D., Wieland,F.T. and Sohn,K.
  TITLE     Localization and topology of ratp28, a member of a novel family of
            putative steroid-binding proteins
  JOURNAL   Biochim Biophys Acta 1543 (1), 123-130 (2000)
   PUBMED   11087948
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK618071.1, AK153272.1 and BP770245.1.
            
            On Aug 27, 2015 this sequence version replaced NM_016783.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC006016.1, AK153272.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                CK618071.1         1-16
            17-1659             AK153272.1         2-1644
            1660-1890           BP770245.1         1-231               c
FEATURES             Location/Qualifiers
     source          1..1890
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 21.0 cM"
     gene            1..1890
                     /gene="Pgrmc1"
                     /gene_synonym="HPR6.6; mPR; PPMR; Vema"
                     /note="progesterone receptor membrane component 1"
                     /db_xref="GeneID:53328"
                     /db_xref="MGI:MGI:1858305"
     exon            1..422
                     /gene="Pgrmc1"
                     /gene_synonym="HPR6.6; mPR; PPMR; Vema"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..682
                     /gene="Pgrmc1"
                     /gene_synonym="HPR6.6; mPR; PPMR; Vema"
                     /codon_start=1
                     /product="membrane-associated progesterone receptor
                     component 1"
                     /protein_id="NP_058063.2"
                     /db_xref="CCDS:CCDS30060.1"
                     /db_xref="GeneID:53328"
                     /db_xref="MGI:MGI:1858305"
                     /translation="MAAEDVVATGADPSELEGGGLLHEIFTSPLNLLLLGLCIFLLYK
                     IVRGDQPGASGDNDDDEPPPLPRLKRRDFTPAELRRFDGVQDPRILMAINGKVFDVTK
                     GRKFYGPEGPYGVFAGRDASRGLATFCLDKEALKDEYDDLSDLTPAQQETLSDWDSQF
                     TFKYHHVGKLLKEGEEPTVYSDDEEPKDETARKNE"
     exon            423..578
                     /gene="Pgrmc1"
                     /gene_synonym="HPR6.6; mPR; PPMR; Vema"
                     /inference="alignment:Splign:2.1.0"
     exon            579..1870
                     /gene="Pgrmc1"
                     /gene_synonym="HPR6.6; mPR; PPMR; Vema"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1851..1856
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pgrmc1"
                     /gene_synonym="HPR6.6; mPR; PPMR; Vema"
                     /note="hexamer: AATAAA"
     polyA_site      1870
                     /gene="Pgrmc1"
                     /gene_synonym="HPR6.6; mPR; PPMR; Vema"
                     /note="major polyA site"
ORIGIN      
        1 aagaacgctg cgcgccactg ttcgctggga gggcggagga agcggactgt tccggagctc
       61 tgcctagccg ggcccaacct ttgctccaga gatcatggct gccgaggatg tggtggcgac
      121 tggcgccgac ccgagcgagc tagagggcgg cgggctgctg cacgagattt tcacgtctcc
      181 tctcaacctg ctcctcctgg gcctctgcat cttcctgctc tacaagatcg ttcgcgggga
      241 ccagcccggt gccagtggcg acaacgacga cgacgaacca cccccgctgc cccgcctcaa
      301 gcggcgcgac ttcacccctg ccgagctgag gcgtttcgat ggcgtccagg acccgcgcat
      361 tctcatggcc atcaacggca aggtgttcga cgtgaccaaa ggccgcaagt tctacgggcc
      421 tgaggggcca tatggggtct ttgccggaag agatgcatcc aggggccttg ccacattttg
      481 cctggacaaa gaagcactga aggatgagta tgacgacctt tctgacctca cccctgcaca
      541 gcaggagacc ctgagtgact gggactctca gttcactttc aagtatcatc acgtgggaaa
      601 actgctgaag gaaggggagg agcctactgt gtactcagat gatgaagaac caaaagacga
      661 gacagctcgg aagaatgaat gaagcattcg gtggagcata tctatttttg tattttgcaa
      721 aatcatttgt aacattccag tctgtcttta caacatggtg atttcaatat ttagaaaagt
      781 tttgaacttg ctgtaaattt tttaagtaac atcactagtg acaccgataa aatcaactcg
      841 tcttagaatg catgatgtgt ttgtatgtca caaatccaga aagtgaagtt cagtgctgta
      901 atgcaaatgg taaagctatt tctcttctat ctgtagttag aacaaactga attacaattt
      961 gattttcctg agagagggaa aacttgggta tttccacata ctggtcaaaa tggtaagtgc
     1021 acacacactg gtcaaaatgg taaatgtcct aagaatgaag aaggatcagc gtgtagccat
     1081 gctgtattct aaaacaagcc cattttaccc aactgactta actgcatgat ttttgtttta
     1141 tctaccccta aagcaaatct gcagtattcc aaaatctatg gtattgattc aaaacagaag
     1201 tccagtaaca aaatgaaacc tcaatactga actcagttag ggcaaaccca ttgcctgtgt
     1261 tcgtggactg atttatcatc catgtctgca tgtggacact ctcccacaca cagtaactct
     1321 cacacacatg gtcattgaca gttggaacta aaacagcatc ggaaaatcca aaggagaact
     1381 ttgcaaaaga aaattctctt gcttgtagca gggtgatggt tatgtggtta ttgaccagct
     1441 gtaaaatttg agaggaatta cagggcagga acaggtatgt gcttttccaa aagccttcac
     1501 tgacatctct gaagaatgag aaaacactac atggcactag ctgggtgagt ttgaaaggac
     1561 aatacattca ttcctaaggt aacacttaaa tccttctgtt gttacaagct tgtagtcact
     1621 tcaaaagtag tcgtcaggtg tctaggtctt gggtaatact cctttggtta atactaaacc
     1681 tagcttaagt agactctaca gttgtgtaaa tttgtaaaag tattatctga acaactagtg
     1741 aggtttcaaa ctcttgtaat tgtagttaaa tagtcattgt attttcttgt gagctgtgtt
     1801 taatggtttt acctcaaatc agaaaaaaaa atgaagtgct tgggtcagtt aataaaaagg
     1861 ttttacccaa aaaaaaaaaa aaaaaaaaaa
//
