LOCUS       NM_008829               6889 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus progesterone receptor (Pgr), mRNA.
ACCESSION   NM_008829 NM_173017
VERSION     NM_008829.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6889)
  AUTHORS   Kawata,Y., Terakawa,J., Takeshita,A., Namiki,T., Kageyama,A.,
            Noguchi,M., Murakami,H., Fukada,T., Ito,J. and Kashiwazaki,N.
  TITLE     Endometrial zinc transporter Slc39a10/Zip10 is indispensable for
            progesterone responsiveness and successful pregnancy in mice
  JOURNAL   PNAS Nexus 4 (2), pgaf047 (2025)
   PUBMED   39967682
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6889)
  AUTHORS   Gutierrez-Castellanos,N., Husain,B.F.A., Dias,I.C., Nomoto,K.,
            Duarte,M.A., Ferreira,L., Lacoste,B. and Lima,S.Q.
  TITLE     A hypothalamic node for the cyclical control of female sexual
            rejection
  JOURNAL   Neuron 113 (2), 277-290 (2025)
   PUBMED   39591968
REFERENCE   3  (bases 1 to 6889)
  AUTHORS   Moldovan,G.E., Massri,N., Vegter,E.L., Pauneto-Delgado,I.N.,
            Burns,G.W., Joshi,N., Gu,B., Arora,R. and Fazleabas,A.T.
  TITLE     YAP1 and WWTR1 are required for murine pregnancy initiation
  JOURNAL   Reproduction 169 (1), e240355 (2025)
   PUBMED   39503541
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6889)
  AUTHORS   Dawson,C.A., Milevskiy,M.J.G., Capaldo,B.D., Yip,R.K.H., Song,X.,
            Vaillant,F., Prokopuk,L., Jackling,F.C., Smyth,G.K., Chen,Y.,
            Lindeman,G.J. and Visvader,J.E.
  TITLE     Hormone-responsive progenitors have a unique identity and exhibit
            high motility during mammary morphogenesis
  JOURNAL   Cell Rep 43 (12), 115073 (2024)
   PUBMED   39700014
REFERENCE   5  (bases 1 to 6889)
  AUTHORS   Aikawa,S., Matsuo,M., Akaeda,S., Sugimoto,Y., Arita,M., Isobe,Y.,
            Sugiura,Y., Taira,S., Maeda,R., Shimizu-Hirota,R., Takeda,N.,
            Hiratsuka,D., He,X., Ishizawa,C., Iida,R., Fukui,Y., Hiraoka,T.,
            Harada,M., Wada-Hiraike,O., Osuga,Y. and Hirota,Y.
  TITLE     Spatiotemporally distinct roles of cyclooxygenase-1 and
            cyclooxygenase-2 at fetomaternal interface in mice
  JOURNAL   JCI Insight 9 (19), e181865 (2024)
   PUBMED   39377223
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6889)
  AUTHORS   Lydon,J.P., DeMayo,F.J., Funk,C.R., Mani,S.K., Hughes,A.R.,
            Montgomery,C.A. Jr., Shyamala,G., Conneely,O.M. and O'Malley,B.W.
  TITLE     Mice lacking progesterone receptor exhibit pleiotropic reproductive
            abnormalities
  JOURNAL   Genes Dev 9 (18), 2266-2278 (1995)
   PUBMED   7557380
REFERENCE   7  (bases 1 to 6889)
  AUTHORS   Keeney,D.S., Ikeda,Y., Waterman,M.R. and Parker,K.L.
  TITLE     Cholesterol side-chain cleavage cytochrome P450 gene expression in
            the primitive gut of the mouse embryo does not require
            steroidogenic factor 1
  JOURNAL   Mol Endocrinol 9 (8), 1091-1098 (1995)
   PUBMED   7476982
REFERENCE   8  (bases 1 to 6889)
  AUTHORS   Schott,D.R., Shyamala,G., Schneider,W. and Parry,G.
  TITLE     Molecular cloning, sequence analyses, and expression of
            complementary DNA encoding murine progesterone receptor
  JOURNAL   Biochemistry 30 (28), 7014-7020 (1991)
   PUBMED   2069958
REFERENCE   9  (bases 1 to 6889)
  AUTHORS   Charmley,P., Nguyen,J., Wei,S. and Gatti,R.A.
  TITLE     Genetic linkage analysis and homology relationships of genes
            located on human chromosome 11q
  JOURNAL   Genomics 10 (3), 608-617 (1991)
   PUBMED   1679745
REFERENCE   10 (bases 1 to 6889)
  AUTHORS   Shyamala,G., Schneider,W. and Schott,D.
  TITLE     Developmental regulation of murine mammary progesterone receptor
            gene expression
  JOURNAL   Endocrinology 126 (6), 2882-2889 (1990)
   PUBMED   2190799
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC113506.12, AK054117.1,
            AC160964.1 and BB149371.1.
            
            On Aug 16, 2006 this sequence version replaced NM_008829.1.
            
            Summary: This gene encodes a member of the steroid receptor
            superfamily. The encoded protein mediates the physiological effects
            of progesterone, which plays a central role in reproductive events
            associated with the establishment and maintenance of pregnancy.
            [provided by RefSeq, Sep 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC145807.1, AK054117.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1319              AC113506.12        111002-112320
            1320-3703           AK054117.1         1-2384
            3704-6750           AC160964.1         107770-110816       c
            6751-6889           BB149371.1         49-187
FEATURES             Location/Qualifiers
     source          1..6889
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 2.46 cM"
     gene            1..6889
                     /gene="Pgr"
                     /gene_synonym="9930019P03Rik; NR3C3; PR; PR-A; PR-B"
                     /note="progesterone receptor"
                     /db_xref="GeneID:18667"
                     /db_xref="MGI:MGI:97567"
     exon            1..2251
                     /gene="Pgr"
                     /gene_synonym="9930019P03Rik; NR3C3; PR; PR-A; PR-B"
                     /inference="alignment:Splign:2.1.0"
     CDS             636..3416
                     /gene="Pgr"
                     /gene_synonym="9930019P03Rik; NR3C3; PR; PR-A; PR-B"
                     /note="nuclear receptor subfamily 3 group C member 3"
                     /codon_start=1
                     /product="progesterone receptor"
                     /protein_id="NP_032855.2"
                     /db_xref="CCDS:CCDS22816.1"
                     /db_xref="GeneID:18667"
                     /db_xref="MGI:MGI:97567"
                     /translation="MTELQAKDPQVLHTSGASPSPPHIGSPLLARLDSGPFQGSQHSD
                     VSSVVSPIPISLDGLLFPRSCRGPELPDGKTGDQQSLSDVEGAFSGVEATHREGGRNS
                     RAPEKDSRLLDSVLDSLLTPSGTEQSHASPPACEAITSWCLFGPELPEDPRSVPATKG
                     LLSPLMSRPEIKAGDSSGTGAGQKVLPKGLSPPRQLLLPTSGSAHWPGAGVKPSPQPA
                     AGEVEEDSGLETEGSAAPLLKSKPRALEGTGSGGGVAANAASAAPGGVTLVPKEDSRF
                     SAPRVSLEQDSPIAPGRSPLATTVVDFIHVPILPLNHALLAARTRQLLEGDSYDGGAT
                     AQGPFAPPRGSPSAPSPPVPCGDFPDCTYPLEGDPKEDVFPLYGDFQTPGLKIKEEEE
                     GADAAVRSPRPYLSAGASSSTFPDFPLAPAPQRAPSSRPGEAAVAGGPSSAAVSPASS
                     SGSALECILYKAEGAPPTQGSFAPLPCKPPAAGSCLLPRDSLPAAPATAAAPAIYQPL
                     GLNGLPQLGYQAAVLKDSLPQVYPPYLNYLRPDSEASQSPQYGFDSLPQKICLICGDE
                     ASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIRRKNCPACRLRKCCQAG
                     MVLGGRKFKKFNKVRVMRTLDGVALPQSVGLPNESQALGQRITFSPNQEIQLVPPLIN
                     LLMSIEPDVVYAGHDNTKPDTSSSLLTSLNQLGERQLLSVVKWSKSLPGFRNLHIDDQ
                     ITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNEQRMKELSFYSLCLTMWQIP
                     QEFVKLQVTHEEFLCMKVLLLLNTIPLEGLRSQSQFEEMRSSYIRELIKAIGLRQKGV
                     VPSSQRFYQLTKLLDSLHDLVKQLHLYCLNTFIQSRTLAVEFPEMMSEVIAAQLPKIL
                     AGMVKPLLFHKK"
     exon            2252..2403
                     /gene="Pgr"
                     /gene_synonym="9930019P03Rik; NR3C3; PR; PR-A; PR-B"
                     /inference="alignment:Splign:2.1.0"
     exon            2404..2520
                     /gene="Pgr"
                     /gene_synonym="9930019P03Rik; NR3C3; PR; PR-A; PR-B"
                     /inference="alignment:Splign:2.1.0"
     exon            2521..2826
                     /gene="Pgr"
                     /gene_synonym="9930019P03Rik; NR3C3; PR; PR-A; PR-B"
                     /inference="alignment:Splign:2.1.0"
     exon            2827..2971
                     /gene="Pgr"
                     /gene_synonym="9930019P03Rik; NR3C3; PR; PR-A; PR-B"
                     /inference="alignment:Splign:2.1.0"
     exon            2972..3102
                     /gene="Pgr"
                     /gene_synonym="9930019P03Rik; NR3C3; PR; PR-A; PR-B"
                     /inference="alignment:Splign:2.1.0"
     exon            3103..3260
                     /gene="Pgr"
                     /gene_synonym="9930019P03Rik; NR3C3; PR; PR-A; PR-B"
                     /inference="alignment:Splign:2.1.0"
     exon            3261..6889
                     /gene="Pgr"
                     /gene_synonym="9930019P03Rik; NR3C3; PR; PR-A; PR-B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6863..6868
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pgr"
                     /gene_synonym="9930019P03Rik; NR3C3; PR; PR-A; PR-B"
     polyA_site      6889
                     /gene="Pgr"
                     /gene_synonym="9930019P03Rik; NR3C3; PR; PR-A; PR-B"
ORIGIN      
        1 cagtctagac tgtcactatc agtctttgta gtatttacgg gtgcgaggat tctgacattc
       61 tgctaacttc tcttagcttt actagagcaa cctgcaacca gaactcgctg ggattgtaga
      121 gaacctaggg agccatagag actgtcgctg caggagaacg agtaagaatg ggctacgtct
      181 tagccccagg tttttggtga ggactgtaaa gcaaacttcc taggatgtct aggtttcaac
      241 aaacataaga agtccggaga tagcgggagt cctttttttc agcaccggcc acaccagttc
      301 cgggtctccc attcaagaag aaacacgaaa aaaagtctct cgaataactc ccagttctca
      361 gaccagacca gcttgctcca gctacttctt cctgtcctca ccccaccgcg accgggacag
      421 cgcgactacc acccttcctc tgcgtctggg tggagggtaa ggacaggagc tgaccaagac
      481 cgcccctccc aaccaggagg tggagatccc acgggtcctg cgactctaca cccacttcct
      541 cctccctctg cccctatatc accggcaccc cctcctcctt cccttttccc tcctcccagg
      601 agacagggga ggagaaaagg ggagcttggg tcgtcatgac tgagctgcag gcaaaggatc
      661 cgcaggttct ccacacgtct ggcgcttcgc cctccccccc acacatcggg tcccccttgc
      721 ttgcacgctt ggactcaggt cccttccaag ggagccagca ctcggacgtg tcgtctgtag
      781 tctcgcctat accgatctcc ctggacgggc tgctttttcc tcggtcctgc cggggtcccg
      841 agctcccaga cggaaagaca ggggaccagc agtcgctgtc cgacgtggag ggagctttct
      901 ctggggtaga agccactcat agggaaggag gcagaaattc cagagccccg gagaaggaca
      961 gcagactctt agacagtgtc ttagactcgt tgttgactcc ctccgggacc gaacagagtc
     1021 acgccagccc tccagcctgc gaggccatca cttcctggtg tctctttggg ccagagcttc
     1081 cagaagaccc ccgcagtgtc cctgctacca aagggttgtt gtccccgctc atgagtcggc
     1141 cagagatcaa ggctggcgac agctccggga caggagcagg acagaaggtg ctgcccaaag
     1201 gactgtcacc acccaggcag ctgttgctcc ctacctcggg gagtgctcac tggcccgggg
     1261 caggggtgaa gccgtccccg cagccagctg caggggaggt ggaagaggac agtggcctgg
     1321 agaccgaggg ctctgcagct ccgcttctaa agagcaaacc tcgagcactg gaaggcaccg
     1381 gcagcggagg aggagtcgca gccaacgcgg cctcagcggc cccaggcggt gtcactctgg
     1441 tcccaaagga agattcacgg ttttctgctc ctagggtctc cttggagcaa gactctccca
     1501 ttgcccccgg gcgctcccca ctggccacca cagtggtgga tttcatccat gtgcccatcc
     1561 tgcctctgaa ccacgcactc ctggccgccc gcacccggca gctgctggag ggggacagct
     1621 acgacggcgg ggccacagcc cagggccctt ttgccccgcc taggggctcg ccctccgcgc
     1681 catccccgcc ggtgccctgc ggtgacttcc cagactgcac ctaccctctg gaaggcgacc
     1741 ccaaagagga cgtgttccct ctttacggcg acttccagac gcctggcttg aagatcaagg
     1801 aggaggagga gggcgcggat gctgctgtgc gctcgccgcg cccctacctg tcggctggag
     1861 ccagctcctc caccttccca gacttcccgc tggcacccgc gccgcagcga gcgccatcct
     1921 ccaggcccgg agaagcggcg gtggccggcg gacccagcag cgccgcggtg tcgccagcgt
     1981 cctcctccgg ctccgcgctg gagtgcatcc tgtacaaagc ggagggcgcg ccgcccacgc
     2041 agggttcgtt cgcgccactg ccgtgcaagc ccccagccgc cggctcctgc ctactacccc
     2101 gggacagcct gccggccgcc ccggccaccg ccgcagcacc cgccatctac cagccgctcg
     2161 gcctcaatgg gctcccgcag ctgggctacc aggccgcggt gctcaaggac agcctgcccc
     2221 aggtctaccc gccatacctt aactacctga ggccagattc agaagccagc cagagcccac
     2281 agtatggctt tgattcctta cctcagaaga tctgcttaat ctgcggggat gaagcatctg
     2341 gctgtcacta tggcgtgctt acctgtggga gctgcaaggt cttctttaag agggcaatgg
     2401 aagggcagca taactattta tgtgctggaa gaaatgactg cattgttgat aaaattcgca
     2461 gaaaaaactg cccagcatgt cgtctgagaa agtgttgtca ggctggcatg gtccttggag
     2521 gtcgtaagtt taagaagttt aataaagtcc gagttatgag aacccttgac ggtgttgctc
     2581 tcccccagtc ggtgggcctt cctaacgaga gccaggccct gggccagaga atcacctttt
     2641 caccaaatca agaaattcaa ctggtcccgc cactcatcaa cctgctcatg agcattgagc
     2701 ctgatgtggt ctatgcaggg catgacaaca caaagcctga cacttccagc tctttgctga
     2761 ccagtctcaa ccaactaggc gagagacaac tgctttcagt agtcaaatgg tctaaatctc
     2821 tgccaggttt ccggaactta cacattgatg accagataac cctgattcag tactcctgga
     2881 tgagcctgat ggtgtttggc ctggggtgga ggtcgtacaa gcatgtcagt ggacagatgc
     2941 tatattttgc acctgatcta atcctaaatg agcagaggat gaaggagctg tcattctact
     3001 cgctgtgcct taccatgtgg caaatcccac aggagtttgt caaactccag gtgacccatg
     3061 aggaattcct ctgtatgaaa gtcttactac ttcttaacac aattcctttg gaaggactga
     3121 ggagtcaaag ccagtttgaa gagatgagat caagctatat ccgcgaattg atcaaggcaa
     3181 ttggtttaag acagaaaggg gttgtcccca gctcacagcg cttctaccaa ctcacaaaac
     3241 ttctcgacag cttgcatgat cttgtgaaac agctccacct gtactgcttg aatacattca
     3301 tccaatcccg gacactggct gtggaatttc cggaaatgat gtctgaagtt attgctgccc
     3361 agttgcccaa gatcctggcg ggcatggtga agccgctcct ctttcacaaa aagtgatgac
     3421 ttttctttgt tttctttgtg aaaattgaat cttgtggtgt gccatctttt tctcagtcag
     3481 gatggtcagg tcatgtgtct ttataatgcc tttctgatag ccttacatgt atgcactatc
     3541 acactgtaaa gttaggagaa aaccaatgac attctgactt tcttttgtaa tgtctaagca
     3601 gagttttttt ttaagtgttg tgtgcaccca tattttaaga gtttacatgg tttttaaaaa
     3661 atgactaaaa ttgattgtac gagtaaacta tatttcaccc attatttcaa acttttcaga
     3721 tgagtgtaat caactttttc atctgacaga tctccatgag aagggaagaa acacccctcc
     3781 ctacctttaa ttacaacagg ctactacaca ggctatggct atgtagttcc tttggtctcc
     3841 atgcttatat ttccaaaaat gactcttaaa atggcagtca aaatgtgatg tgcaatagat
     3901 tttcagaggg cttttagtga aaaacaaaac aaaacaaaca acaacaacaa caaaacagag
     3961 atgaaatggg ttgatgtttt taactctagg caaactgtgt tcagggtgcc tgcctgataa
     4021 cagattgatg acagagttaa tggcagctat acagttgctg tgacattatt gagggcaggt
     4081 ttagggggag gatgtcttta aataagacct gtgaatagac agaaattgtg agatctgttt
     4141 tctcattgga attcctgcgg ttggctgacc ttacaaagtc ggtctccatt ggtagttcca
     4201 tgtccttgct tttaaaaatg atatgcagca tttctcttga caaatgtttc tttggccata
     4261 tagtcttatt gaaatttacc aaagaagacg gggggggggg gaggagggag aaaggcaagg
     4321 gtgggagata aagacaattt ctttcttggg gatagtgttt ttctctagga aaatgtatag
     4381 agcgaatcag cgaatctcag gtggaaatta tttttagtgc ctctaaatct gagagatgct
     4441 ttagaaatag acaagtctca gtggaaagtt ttgagtgcct atgacccaat tctaagtgag
     4501 atacttcagg aaatcctaga tacttgctta aaaatcacac aaccaggtac aacacaacag
     4561 ataaaacaca gttccgtttg tcatttctac ttaaaatatt cctttgaaag acaaataata
     4621 gttcttttct aagatgagtc actggagata tattaattta aaaaataact caaacatata
     4681 aacatacacc attatggtat atacataaat agtgagttct ttagcacatt tggaaaaggg
     4741 attaaagtgg agtctaatca gaacccgtga cttgtgctcc cttcacgcat gtggaaatca
     4801 taatggcttt cctgcacagc agtaccttta ttagagcagt ccgagttttc cccaagtact
     4861 gcaatggtca gcactagtaa atagatgctc ttcctattgg tctacatgcc tcctacaatg
     4921 tgtctgaaat gcattatgtt ctttactggt gcttggctct tcgtaatctc catacacaca
     4981 agcatacttc atctttcagg ccaaaatgag atcagattcc ttgggctata tcctaagagt
     5041 tattttttta attcctcaac ttaccctgct gccattatgt tcctgctatg ccaatcttta
     5101 cgtaagaaaa agaaagaaag caattttcta ccagaacttg actccagact cttgcatgtg
     5161 ttgaccttca agatctgctt tatcactcct gtaaagtctt tctcagtctc tcatactgtg
     5221 atttgacccc tcatctgttt ccaagaagtt gtttaaatta cattagtatg tagctgcacc
     5281 attctaatgg tccacaggtc tagggctcgt gctaaggaaa gaccatagtg ttttgtgaca
     5341 gagttgactg tgacattcgt cctgctgagg gtcttctgag tgacattgat aaacctcttc
     5401 ttgtgtcttt attattcctt ttatctgcaa ctttgttttt cttcatttcc aagctatatt
     5461 ttccccatcc tgtggtaact tgcctttttt gactacgtca tgggagcaca ttttatatgc
     5521 aattagaaga aaacggtcca tttcctgttc tgagctgaat gaatggaata ttaattcctt
     5581 ccctataaaa gattctataa actctgacat gttttatatt gcaaacctca atgtaaaaat
     5641 ttccctgcat tttttttatt ttcttcaaca aatatttttg agtgtgtaat gtgagcacaa
     5701 gaaatcatat gaataagctt taatagaaac tggagctaaa ggaaattgta tataactcaa
     5761 gaagttatag cccaggagtt gtacaaatat gtctggtaag tgcagggtca ctagatattt
     5821 gtagtatata aactacatcg ttaaggttta atatgtgcaa ggcattacag cattacttat
     5881 atgcaacttg aatgagataa gtgctaaaaa atagtatttt aaaattaata attatttaat
     5941 ctaggcaact gccagcaatt aatttgcttt aaacttttgt gtatatttgt atattggaaa
     6001 agttttaata ccatttttca aaaatataaa taaaataaaa tatttttaag atctctcaaa
     6061 tagaatacct gggaactttt gttctgtggc agttgtattc gttgtgagag attggtgacc
     6121 caaaaacaat gtcatgagtc cttttagtaa agtaatgaac cctgaaacac tagatacaat
     6181 cattattcag ttattcatta ttcaattagt tttcctttga attaaaggat tagtttgata
     6241 gtagttatct ttgtatatca gcacagttta actttcaaaa taatgaaaag tttctaattt
     6301 catttaacag tgaggaaata gagtatgttg gccccaggac tgaattttat agtgtccctt
     6361 gttttggaac tgtctaaaaa cacttgacag tcttgacctt gatctccatg ggtagtttaa
     6421 atgtctaaac accaggtttt aatatttaag gctaagctta gaaagaaaaa tattcccaga
     6481 agaacatgac atgagcaaat ggaagttatc tcatctccaa atcttttaat ctacaattcc
     6541 aactgccgag actccatgcc tgtgtagtca tcataacctt tatctccact ctgaagacca
     6601 tgctctttgg gttgctctaa actaaaataa aagcttaaga acaaaggaaa tacttgaagc
     6661 ttagatgatt ttgtttactg acatatttaa aaaaaaaaaa aaagaaaaat gatttgtgtc
     6721 taaagagatg tcatgcccag tattgttttg tggaactatt ttgtttctgg tgtataaaca
     6781 catggcatgt ttagttaggc aatgcttttc cattgtactt tttcacactt aactttaagt
     6841 tttactattg tacattgtat gaaataaaat atttttaaat agccacagt
//
