LOCUS       NP_032855                926 aa            linear   ROD 11-MAR-2025
DEFINITION  progesterone receptor [Mus musculus].
ACCESSION   NP_032855 NP_766605
VERSION     NP_032855.2
DBSOURCE    REFSEQ: accession NM_008829.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 926)
  AUTHORS   Kawata,Y., Terakawa,J., Takeshita,A., Namiki,T., Kageyama,A.,
            Noguchi,M., Murakami,H., Fukada,T., Ito,J. and Kashiwazaki,N.
  TITLE     Endometrial zinc transporter Slc39a10/Zip10 is indispensable for
            progesterone responsiveness and successful pregnancy in mice
  JOURNAL   PNAS Nexus 4 (2), pgaf047 (2025)
   PUBMED   39967682
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 926)
  AUTHORS   Gutierrez-Castellanos,N., Husain,B.F.A., Dias,I.C., Nomoto,K.,
            Duarte,M.A., Ferreira,L., Lacoste,B. and Lima,S.Q.
  TITLE     A hypothalamic node for the cyclical control of female sexual
            rejection
  JOURNAL   Neuron 113 (2), 277-290 (2025)
   PUBMED   39591968
REFERENCE   3  (residues 1 to 926)
  AUTHORS   Moldovan,G.E., Massri,N., Vegter,E.L., Pauneto-Delgado,I.N.,
            Burns,G.W., Joshi,N., Gu,B., Arora,R. and Fazleabas,A.T.
  TITLE     YAP1 and WWTR1 are required for murine pregnancy initiation
  JOURNAL   Reproduction 169 (1), e240355 (2025)
   PUBMED   39503541
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 926)
  AUTHORS   Dawson,C.A., Milevskiy,M.J.G., Capaldo,B.D., Yip,R.K.H., Song,X.,
            Vaillant,F., Prokopuk,L., Jackling,F.C., Smyth,G.K., Chen,Y.,
            Lindeman,G.J. and Visvader,J.E.
  TITLE     Hormone-responsive progenitors have a unique identity and exhibit
            high motility during mammary morphogenesis
  JOURNAL   Cell Rep 43 (12), 115073 (2024)
   PUBMED   39700014
REFERENCE   5  (residues 1 to 926)
  AUTHORS   Aikawa,S., Matsuo,M., Akaeda,S., Sugimoto,Y., Arita,M., Isobe,Y.,
            Sugiura,Y., Taira,S., Maeda,R., Shimizu-Hirota,R., Takeda,N.,
            Hiratsuka,D., He,X., Ishizawa,C., Iida,R., Fukui,Y., Hiraoka,T.,
            Harada,M., Wada-Hiraike,O., Osuga,Y. and Hirota,Y.
  TITLE     Spatiotemporally distinct roles of cyclooxygenase-1 and
            cyclooxygenase-2 at fetomaternal interface in mice
  JOURNAL   JCI Insight 9 (19), e181865 (2024)
   PUBMED   39377223
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 926)
  AUTHORS   Lydon,J.P., DeMayo,F.J., Funk,C.R., Mani,S.K., Hughes,A.R.,
            Montgomery,C.A. Jr., Shyamala,G., Conneely,O.M. and O'Malley,B.W.
  TITLE     Mice lacking progesterone receptor exhibit pleiotropic reproductive
            abnormalities
  JOURNAL   Genes Dev 9 (18), 2266-2278 (1995)
   PUBMED   7557380
REFERENCE   7  (residues 1 to 926)
  AUTHORS   Keeney,D.S., Ikeda,Y., Waterman,M.R. and Parker,K.L.
  TITLE     Cholesterol side-chain cleavage cytochrome P450 gene expression in
            the primitive gut of the mouse embryo does not require
            steroidogenic factor 1
  JOURNAL   Mol Endocrinol 9 (8), 1091-1098 (1995)
   PUBMED   7476982
REFERENCE   8  (residues 1 to 926)
  AUTHORS   Schott,D.R., Shyamala,G., Schneider,W. and Parry,G.
  TITLE     Molecular cloning, sequence analyses, and expression of
            complementary DNA encoding murine progesterone receptor
  JOURNAL   Biochemistry 30 (28), 7014-7020 (1991)
   PUBMED   2069958
REFERENCE   9  (residues 1 to 926)
  AUTHORS   Charmley,P., Nguyen,J., Wei,S. and Gatti,R.A.
  TITLE     Genetic linkage analysis and homology relationships of genes
            located on human chromosome 11q
  JOURNAL   Genomics 10 (3), 608-617 (1991)
   PUBMED   1679745
REFERENCE   10 (residues 1 to 926)
  AUTHORS   Shyamala,G., Schneider,W. and Schott,D.
  TITLE     Developmental regulation of murine mammary progesterone receptor
            gene expression
  JOURNAL   Endocrinology 126 (6), 2882-2889 (1990)
   PUBMED   2190799
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC113506.12, AK054117.1,
            AC160964.1 and BB149371.1.
            
            On Aug 16, 2006 this sequence version replaced NP_032855.1.
            
            Summary: This gene encodes a member of the steroid receptor
            superfamily. The encoded protein mediates the physiological effects
            of progesterone, which plays a central role in reproductive events
            associated with the establishment and maintenance of pregnancy.
            [provided by RefSeq, Sep 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC145807.1, AK054117.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..926
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 2.46 cM"
     Protein         1..926
                     /product="progesterone receptor"
                     /note="nuclear receptor subfamily 3 group C member 3"
                     /calculated_mol_wt=98851
     Region          1..559
                     /region_name="Modulating, Pro-Rich"
                     /note="propagated from UniProtKB/Swiss-Prot (Q00175.2)"
     Region          1..557
                     /region_name="Prog_receptor"
                     /note="Progesterone receptor; pfam02161"
                     /db_xref="CDD:460470"
     Region          1..165
                     /region_name="AF3, mediates transcriptional activation (in
                     isoform B). /evidence=ECO:0000250|UniProtKB:P06401"
                     /note="propagated from UniProtKB/Swiss-Prot (Q00175.2)"
     Region          1..48
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q00175.2)"
     Site            20
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P06401; propagated from
                     UniProtKB/Swiss-Prot (Q00175.2)"
     Region          56..60
                     /region_name="LXXL motif 1.
                     /evidence=ECO:0000250|UniProtKB:P06401"
                     /note="propagated from UniProtKB/Swiss-Prot (Q00175.2)"
     Site            82
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P06401; propagated from
                     UniProtKB/Swiss-Prot (Q00175.2)"
     Region          116..120
                     /region_name="LXXL motif 1.
                     /evidence=ECO:0000250|UniProtKB:P06401"
                     /note="propagated from UniProtKB/Swiss-Prot (Q00175.2)"
     Site            131
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P06401; propagated from
                     UniProtKB/Swiss-Prot (Q00175.2)"
     Site            163
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P06401; propagated from
                     UniProtKB/Swiss-Prot (Q00175.2)"
     Region          166..305
                     /region_name="Mediates transcriptional transrepression (in
                     isoform A). /evidence=ECO:0000250|UniProtKB:P06401"
                     /note="propagated from UniProtKB/Swiss-Prot (Q00175.2)"
     Region          168..256
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q00175.2)"
     Region          184..188
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q00175.2)"
     Site            191
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P06401; propagated from
                     UniProtKB/Swiss-Prot (Q00175.2)"
     Site            214
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P06401; propagated from
                     UniProtKB/Swiss-Prot (Q00175.2)"
     Site            294
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by MAPK1.
                     /evidence=ECO:0000250|UniProtKB:P06401; propagated from
                     UniProtKB/Swiss-Prot (Q00175.2)"
     Region          327..364
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q00175.2)"
     Site            345
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by MAPK.
                     /evidence=ECO:0000250|UniProtKB:P06401; propagated from
                     UniProtKB/Swiss-Prot (Q00175.2)"
     Region          391..447
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q00175.2)"
     Site            400
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CDK2.
                     /evidence=ECO:0000250|UniProtKB:P06401; propagated from
                     UniProtKB/Swiss-Prot (Q00175.2)"
     Region          453..539
                     /region_name="AF1, mediates transcriptional activation.
                     /evidence=ECO:0000250|UniProtKB:P06401"
                     /note="propagated from UniProtKB/Swiss-Prot (Q00175.2)"
     Region          556..633
                     /region_name="NR_DBD_GR_PR"
                     /note="DNA-binding domain of glucocorticoid receptor (GR)
                     is composed of two C4-type zinc fingers; cd07172"
                     /db_xref="CDD:143546"
     Site            order(560,563,577,580,596,602,612,615)
                     /site_type="other"
                     /note="zinc binding site [ion binding]"
                     /db_xref="CDD:143546"
     Site            order(570..572,578..579,581..582,585..586,594,609..610,
                     616)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:143546"
     Site            order(595..597,599,602..603,607..608,611)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:143546"
     Site            669
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P06401; propagated from
                     UniProtKB/Swiss-Prot (Q00175.2)"
     Region          673..926
                     /region_name="AF2, mediates transcriptional activation.
                     /evidence=ECO:0000250|UniProtKB:P06401"
                     /note="propagated from UniProtKB/Swiss-Prot (Q00175.2)"
     Region          679..926
                     /region_name="NR_LBD_PR"
                     /note="Ligand binding domain of the progesterone receptor,
                     a member of the nuclear hormone receptor; cd07074"
                     /db_xref="CDD:132759"
     Site            order(708,711..712,714..715,718,749,752..753,759,771,787,
                     790..791,794,880,883..884,887,896,898,902)
                     /site_type="other"
                     /note="ligand binding site [chemical binding]"
                     /db_xref="CDD:132759"
     Site            order(723,727,737..738,741,901,904,908)
                     /site_type="active"
                     /note="putative coactivator recognition site [active]"
                     /db_xref="CDD:132759"
     Site            order(878,882,886,889..890,907,911,914..915)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:132759"
     CDS             1..926
                     /gene="Pgr"
                     /gene_synonym="9930019P03Rik; NR3C3; PR; PR-A; PR-B"
                     /coded_by="NM_008829.2:636..3416"
                     /db_xref="CCDS:CCDS22816.1"
                     /db_xref="GeneID:18667"
                     /db_xref="MGI:MGI:97567"
ORIGIN      
        1 mtelqakdpq vlhtsgasps pphigsplla rldsgpfqgs qhsdvssvvs pipisldgll
       61 fprscrgpel pdgktgdqqs lsdvegafsg veathreggr nsrapekdsr lldsvldsll
      121 tpsgteqsha sppaceaits wclfgpelpe dprsvpatkg llsplmsrpe ikagdssgtg
      181 agqkvlpkgl spprqlllpt sgsahwpgag vkpspqpaag eveedsglet egsaapllks
      241 kpralegtgs gggvaanaas aapggvtlvp kedsrfsapr vsleqdspia pgrsplattv
      301 vdfihvpilp lnhallaart rqllegdsyd ggataqgpfa pprgspsaps ppvpcgdfpd
      361 ctyplegdpk edvfplygdf qtpglkikee eegadaavrs prpylsagas sstfpdfpla
      421 papqrapssr pgeaavaggp ssaavspass sgsalecily kaegapptqg sfaplpckpp
      481 aagscllprd slpaapataa apaiyqplgl nglpqlgyqa avlkdslpqv yppylnylrp
      541 dseasqspqy gfdslpqkic licgdeasgc hygvltcgsc kvffkrameg qhnylcagrn
      601 dcivdkirrk ncpacrlrkc cqagmvlggr kfkkfnkvrv mrtldgvalp qsvglpnesq
      661 algqritfsp nqeiqlvppl inllmsiepd vvyaghdntk pdtsssllts lnqlgerqll
      721 svvkwskslp gfrnlhiddq itliqyswms lmvfglgwrs ykhvsgqmly fapdlilneq
      781 rmkelsfysl cltmwqipqe fvklqvthee flcmkvllll ntipleglrs qsqfeemrss
      841 yirelikaig lrqkgvvpss qrfyqltkll dslhdlvkql hlyclntfiq srtlavefpe
      901 mmseviaaql pkilagmvkp llfhkk
//
