LOCUS       NM_025954               2593 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus phosphoglycolate phosphatase (Pgp), mRNA.
ACCESSION   NM_025954
VERSION     NM_025954.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2593)
  AUTHORS   Oppong,A., Leung,Y.H., Ghosh,A., Peyot,M.L., Paquet,M., Morales,C.,
            Clarke,H.J., Al-Mulla,F., Boyer,A., Madiraju,S.R.M., Boerboom,D.,
            O'Flaherty,C. and Prentki,M.
  TITLE     Essential role of germ cell glycerol-3-phosphate phosphatase for
            sperm health, oxidative stress control and male fertility in mice
  JOURNAL   Mol Metab 90, 102063 (2024)
   PUBMED   39542419
REFERENCE   2  (bases 1 to 2593)
  AUTHORS   Zhang,D., Deng,W., Jiang,T., Zhao,Y., Bai,D., Tian,Y., Kong,S.,
            Zhang,L., Wang,H., Gao,S. and Lu,Z.
  TITLE     Maternal Ezh1/2 deficiency impairs the function of mitochondria in
            mouse oocytes and early embryos
  JOURNAL   J Cell Physiol 239 (6), e31244 (2024)
   PUBMED   38529784
REFERENCE   3  (bases 1 to 2593)
  AUTHORS   Sun,A. and Wang,J.
  TITLE     Functional Evaluation of P-gp and Bcrp at the Murine
            Blood-Cerebrospinal Fluid Barrier
  JOURNAL   Pharm Res 40 (11), 2667-2675 (2023)
   PUBMED   37704894
  REMARK    GeneRIF: Functional Evaluation of P-gp and Bcrp at the Murine
            Blood-Cerebrospinal Fluid Barrier.
REFERENCE   4  (bases 1 to 2593)
  AUTHORS   Al-Mass,A., Poursharifi,P., Peyot,M.L., Lussier,R., Chenier,I.,
            Leung,Y.H., Ghosh,A., Oppong,A., Possik,E., Mugabo,Y., Ahmad,R.,
            Sladek,R., Murthy Madiraju,S.R., Al-Mulla,F. and Prentki,M.
  TITLE     Hepatic glycerol shunt and glycerol-3-phosphate phosphatase control
            liver metabolism and glucodetoxification under hyperglycemia
  JOURNAL   Mol Metab 66, 101609 (2022)
   PUBMED   36198384
REFERENCE   5  (bases 1 to 2593)
  AUTHORS   Al-Mass,A., Poursharifi,P., Peyot,M.L., Lussier,R., Levens,E.J.,
            Guida,J., Mugabo,Y., Possik,E., Ahmad,R., Al-Mulla,F., Sladek,R.,
            Madiraju,S.R.M. and Prentki,M.
  TITLE     Glycerol-3-phosphate phosphatase operates a glycerol shunt in
            pancreatic beta-cells that controls insulin secretion and metabolic
            stress
  JOURNAL   Mol Metab 60, 101471 (2022)
   PUBMED   35272070
REFERENCE   6  (bases 1 to 2593)
  AUTHORS   Segerer,G., Hadamek,K., Zundler,M., Fekete,A., Seifried,A.,
            Mueller,M.J., Koentgen,F., Gessler,M., Jeanclos,E. and Gohla,A.
  TITLE     An essential developmental function for murine phosphoglycolate
            phosphatase in safeguarding cell proliferation
  JOURNAL   Sci Rep 6, 35160 (2016)
   PUBMED   27731369
  REMARK    GeneRIF: Knockin replacement of Pgp with its phosphatase-inactive
            Pgp(D34N) mutant is embryonically lethal due to intrauterine growth
            arrest and developmental delay in midgestation. PGP inactivation
            attenuated triosephosphate isomerase activity, increased
            triglyceride levels at the expense of the cellular
            phosphatidylcholine content, and inhibited cell proliferation.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2593)
  AUTHORS   Seifried,A., Bergeron,A., Boivin,B. and Gohla,A.
  TITLE     Reversible oxidation controls the activity and oligomeric state of
            the mammalian phosphoglycolate phosphatase AUM
  JOURNAL   Free Radic Biol Med 97, 75-84 (2016)
   PUBMED   27179418
  REMARK    GeneRIF: our findings establish that PGP, an aspartate-dependent
            HAD phosphatase, is transiently inactivated by reversible oxidation
            in cells
REFERENCE   8  (bases 1 to 2593)
  AUTHORS   Mugabo,Y., Zhao,S., Seifried,A., Gezzar,S., Al-Mass,A., Zhang,D.,
            Lamontagne,J., Attane,C., Poursharifi,P., Iglesias,J., Joly,E.,
            Peyot,M.L., Gohla,A., Madiraju,S.R. and Prentki,M.
  TITLE     Identification of a mammalian glycerol-3-phosphate phosphatase:
            Role in metabolism and signaling in pancreatic beta-cells and
            hepatocytes
  JOURNAL   Proc Natl Acad Sci U S A 113 (4), E430-E439 (2016)
   PUBMED   26755581
  REMARK    GeneRIF: A previously known phosphoglycolate phosphatase (PGP) with
            an uncertain function acts as a specific glycerol-3-phosphate
            phosphatase and plays a role in the glucose and lipid metabolism
            and signaling, and the response to metabolic stress.
REFERENCE   9  (bases 1 to 2593)
  AUTHORS   Seifried,A., Knobloch,G., Duraphe,P.S., Segerer,G., Manhard,J.,
            Schindelin,H., Schultz,J. and Gohla,A.
  TITLE     Evolutionary and structural analyses of mammalian haloacid
            dehalogenase-type phosphatases AUM and chronophin provide insight
            into the basis of their different substrate specificities
  JOURNAL   J Biol Chem 289 (6), 3416-3431 (2014)
   PUBMED   24338473
  REMARK    GeneRIF: Evolutionary and structural analyses of mammalian haloacid
            dehalogenase-type phosphatases AUM and chronophin provide insight
            into the basis of their different substrate specificities.
REFERENCE   10 (bases 1 to 2593)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154237.1.
            
            On Feb 9, 2019 this sequence version replaced NM_025954.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR3363658.5642255.1, BC040100.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-724               AC154237.1         130505-131228
            725-2593            AC154237.1         131321-133189
FEATURES             Location/Qualifiers
     source          1..2593
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 12.39 cM"
     gene            1..2593
                     /gene="Pgp"
                     /gene_synonym="1700012G19Rik; AUM; G3PP"
                     /note="phosphoglycolate phosphatase"
                     /db_xref="GeneID:67078"
                     /db_xref="MGI:MGI:1914328"
     exon            1..724
                     /gene="Pgp"
                     /gene_synonym="1700012G19Rik; AUM; G3PP"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..1050
                     /gene="Pgp"
                     /gene_synonym="1700012G19Rik; AUM; G3PP"
                     /EC_number="3.1.3.48"
                     /EC_number="3.1.3.21"
                     /note="PGPase; aspartate-based ubiquitous Mg(2+)-dependent
                     phosphatase"
                     /codon_start=1
                     /product="glycerol-3-phosphate phosphatase"
                     /protein_id="NP_080230.2"
                     /db_xref="CCDS:CCDS28482.1"
                     /db_xref="GeneID:67078"
                     /db_xref="MGI:MGI:1914328"
                     /translation="MAEAEAGGDEARCVRLSAERAKLLLAEVDTLLFDCDGVLWRGET
                     AVPGAPETLRALRARGKRLGFITNNSSKTRTAYAEKLRRLGFGGPVGPEAGLEVFGTA
                     YCSALYLRQRLAGVPDPKAYVLGSPALAAELEAVGVTSVGVGPDVLHGDGPSDWLAVP
                     LEPDVRAVVVGFDPHFSYMKLTKAVRYLQQPDCLLVGTNMDNRLPLENGRFIAGTGCL
                     VRAVEMAAQRQADIIGKPSRFIFDCVSQEYGINPERTVMVGDRLDTDILLGSTCSLKT
                     ILTLTGVSSLEDVKSNQESDCMFKKKMVPDFYVDSIADLLPALQG"
     exon            725..2593
                     /gene="Pgp"
                     /gene_synonym="1700012G19Rik; AUM; G3PP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1075..1080
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pgp"
                     /gene_synonym="1700012G19Rik; AUM; G3PP"
                     /note="hexamer: AATAAA"
     polyA_site      1096
                     /gene="Pgp"
                     /gene_synonym="1700012G19Rik; AUM; G3PP"
                     /note="major polyA site"
     regulatory      2567..2572
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pgp"
                     /gene_synonym="1700012G19Rik; AUM; G3PP"
                     /note="hexamer: ATTAAA"
     polyA_site      2584
                     /gene="Pgp"
                     /gene_synonym="1700012G19Rik; AUM; G3PP"
                     /note="major polyA site"
ORIGIN      
        1 gccgcggctg gcggctgcga ggagcggccg gtggtggcgg caggagcggc gggtggcggc
       61 ggcggcagcg gtcagcggtc gaccatggca gaggcggaag ccggtggcga cgaagcccgc
      121 tgcgtgcggc tgagcgccga gcgggccaag ttgctgctgg ccgaggtgga cacgctgctg
      181 ttcgactgcg atggcgtgct gtggcgcggt gagacggccg tgccgggcgc gccggagact
      241 ctgcgggctc tgcgggcccg cggcaagcga ctgggcttca tcaccaacaa cagcagcaag
      301 actcgcacgg cctacgcgga gaagctaagg cgcttgggtt tcggcggccc ggtggggccc
      361 gaagctggcc tcgaggtgtt cggcacggcc tattgcagcg cgctctatct gcgccaacgc
      421 ctggccggcg tgccggaccc caaggcctac gtgctgggca gcccggcctt agcagccgag
      481 ctggaggccg tgggtgtcac tagcgtgggc gtgggcccgg acgtgcttca cggcgatggc
      541 cccagcgact ggctagccgt gccgctcgaa cccgacgtgc gcgcggtagt ggtgggcttc
      601 gacccacact tcagctacat gaagctcacc aaggccgtgc ggtacctgca gcagcccgac
      661 tgtctgctcg tgggcaccaa catggacaac cggctcccgc tagagaacgg ccgtttcatt
      721 gcgggtaccg gctgtctggt gcgagccgtg gagatggccg cccagcgcca ggcggacatc
      781 atcgggaagc ctagccgctt catcttcgac tgcgtgtccc aggagtatgg tatcaacccg
      841 gagcgcaccg tcatggtggg agaccgcctg gacacagaca tcctcctggg ctccacctgt
      901 agcctgaaga ctatcctgac cctcaccgga gtctccagtc ttgaggatgt gaagagcaat
      961 caggaaagtg actgcatgtt caagaagaaa atggtccctg acttctatgt tgacagcatt
     1021 gccgacctct tgcctgccct tcaaggttaa agatctagtg tctttaatct ctggaataaa
     1081 aaaaagaaaa agaaaatcag ctacctaaat taatagtggg gcttagaaat tgctctgtta
     1141 ggtggctgca ggttaactga agttaataag caaaggcagt agttaatctt gtaagtaaac
     1201 gttggggggg gttgtttaca gagaattata ttttaagatg cacttttaag cttggaaggc
     1261 attatggggt gggcatagca tgtgcccaac attcaggtaa cctcaggccc tgttgctgag
     1321 actgaaatgg gtcaagggtt gtgtgtcatg ctttttactg aaatgtaatc agggatcagg
     1381 ccctaaggtg ggcagagtta aaaagggctc ttaatgacac agagaccaaa aactggggtt
     1441 tcccctaatg atcctgcggc agaggcgcct gctactgcgt cccagttcct cacctgtggg
     1501 gtgggagcgc tctatagctg gggtttggat gccaaccccg acagcctccg ctactctgcc
     1561 tctttgacat cacaattgtc tgttctgttt cagatgctca gtactgcaga ccctcatgca
     1621 cagtaacagc ccaactaaac ttgtcttttg tgaacttggc ctaggtgtct taagtgtggc
     1681 ctgctgagca gctcccaaca ccatgctgct ttcccgggag ctcagaacag ttgggttgtt
     1741 tggggttttg tttttttcaa actagtgaac aacactgtca agtgtgaaat tggatcttac
     1801 gcgtgtggat taatagttgt gctgtcgcaa cggtaaaccc cactaaagaa atctcctgtc
     1861 ccagtcagca gcatagccag tgtgctagcc gaggattgtc ttgtttccca gagtcctctg
     1921 ggtaggcagg agtcagtcct gaggatagtt aagtctctaa gaaagcagcc aacccccccc
     1981 cttgtccagg tcagttttgt tgtagacagg tggacttcct tgttggtggc cagccataag
     2041 acctactagc cagttggctt ctcagcatct ctggcctttt cccctgctct tccagtccct
     2101 gacctttcag tgttctgagc agactgggaa gttccttttg gctgactcct ttctggcacc
     2161 atgccctgta ccaagtggct atgctcatgg ccacaggact tcgcctgctc accaagttct
     2221 cagagcaata aaaggtattc atccatgccg gaagctgctc ccaggtcagg ggtgggagtg
     2281 gaatggtgcc atggatcaac aggacctact caccaagttc tcagagcaat aaaagatatc
     2341 tatccatgcc tgaagctgtt cccgggccag gggcgggagt ggaaggtgcc atagatcaac
     2401 acgactgtgg tagtgcctat gacattggtg gtgctgatcc ttggagtctg gataatgacc
     2461 aggcttggca ggtgcgtagc cagagagacc ctcctctgga caaacctgga gaacctgtgt
     2521 gtgtgtgaca tttctagctt gtcttgctgt gtgatctcaa atgcacatta aactctcaaa
     2581 cccatgatga tta
//
