LOCUS       NM_028352               4582 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus phosphoglucomutase 3 (Pgm3), transcript variant 1,
            mRNA.
ACCESSION   NM_028352
VERSION     NM_028352.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4582)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4582)
  AUTHORS   Roberts,G.A.G. and Tunster,S.J.
  TITLE     Characterising the dynamics of placental glycogen stores in the
            mouse
  JOURNAL   Placenta 99, 131-140 (2020)
   PUBMED   32798765
REFERENCE   3  (bases 1 to 4582)
  AUTHORS   Uijtdewilligen,P.J.E., Versteeg,E.M., van de Westerlo,E.M.A., van
            der Vlag,J., Daamen,W.F. and van Kuppevelt,T.H.
  TITLE     Dynamic Expression of Genes Involved in
            Proteoglycan/Glycosaminoglycan Metabolism during Skin Development
  JOURNAL   Biomed Res Int 2018, 9873471 (2018)
   PUBMED   30228991
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4582)
  AUTHORS   Bowman,C.E., Zhao,L., Hartung,T. and Wolfgang,M.J.
  TITLE     Requirement for the Mitochondrial Pyruvate Carrier in Mammalian
            Development Revealed by a Hypomorphic Allelic Series
  JOURNAL   Mol Cell Biol 36 (15), 2089-2104 (2016)
   PUBMED   27215380
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4582)
  AUTHORS   Greig,K.T., Antonchuk,J., Metcalf,D., Morgan,P.O., Krebs,D.L.,
            Zhang,J.G., Hacking,D.F., Bode,L., Robb,L., Kranz,C., de Graaf,C.,
            Bahlo,M., Nicola,N.A., Nutt,S.L., Freeze,H.H., Alexander,W.S.,
            Hilton,D.J. and Kile,B.T.
  TITLE     Agm1/Pgm3-mediated sugar nucleotide synthesis is essential for
            hematopoiesis and development
  JOURNAL   Mol Cell Biol 27 (16), 5849-5859 (2007)
   PUBMED   17548465
  REMARK    GeneRIF: Two hypomorphic alleles of mouse Pgm3 are described and
            specific physiological consequences of a graded reduction in Pgm3
            activity and global UDP-GlcNAc levels, are shown.
REFERENCE   6  (bases 1 to 4582)
  AUTHORS   Johnson,F.M., Hendren,R.W., Chasalow,F., Barnett,L.B. and
            Lewis,S.E.
  TITLE     A null mutation at the mouse Phosphoglucomutase-1 locus and a new
            locus Pgm-3
  JOURNAL   Biochem Genet 19 (5-6), 599-615 (1981)
   PUBMED   6457600
REFERENCE   7  (bases 1 to 4582)
  AUTHORS   Nadeau,J.H., Kompf,J., Siebert,G. and Taylor,B.A.
  TITLE     Linkage of Pgm-3 in the house mouse and homologies of three
            phosphoglucomutase loci in mouse and man
  JOURNAL   Biochem Genet 19 (5-6), 465-474 (1981)
   PUBMED   6457599
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK043547.1, AK160913.1, AK028066.1 and AC157998.2.
            
            On Aug 6, 2009 this sequence version replaced NM_028352.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK036561.1, AK028066.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AK043547.1         2-2
            2-2056              AK160913.1         3-2057
            2057-4113           AK028066.1         2047-4103
            4114-4582           AC157998.2         26752-27220
FEATURES             Location/Qualifiers
     source          1..4582
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 46.58 cM"
     gene            1..4582
                     /gene="Pgm3"
                     /gene_synonym="2810473H05Rik; Agm1; PAGM; Pgm-3"
                     /note="phosphoglucomutase 3"
                     /db_xref="GeneID:109785"
                     /db_xref="MGI:MGI:97566"
     exon            1..113
                     /gene="Pgm3"
                     /gene_synonym="2810473H05Rik; Agm1; PAGM; Pgm-3"
                     /inference="alignment:Splign:2.1.0"
     exon            114..319
                     /gene="Pgm3"
                     /gene_synonym="2810473H05Rik; Agm1; PAGM; Pgm-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..1744
                     /gene="Pgm3"
                     /gene_synonym="2810473H05Rik; Agm1; PAGM; Pgm-3"
                     /EC_number="5.4.2.3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     N-acetylglucosamine-phosphate mutase;
                     phosphoacetylglucosamine mutase; PGM 3; acetylglucosamine
                     phosphomutase; GlcNAc-P mutase"
                     /codon_start=1
                     /product="phosphoacetylglucosamine mutase isoform 1"
                     /protein_id="NP_082628.3"
                     /db_xref="CCDS:CCDS23381.1"
                     /db_xref="GeneID:109785"
                     /db_xref="MGI:MGI:97566"
                     /translation="MDLEAVCKRSALHAKPQGLILQYGTAGFRTNAQHLDHIMFRMGL
                     LAVLRSKQTRSTIGVMVTASHNPEEDNGVKLVDPLGEMLAPSWEEHATCLASAEEQDV
                     RQVLAAIVEKEAVDLTQTAFVVIARDTRPSSEKLSQSVIDGVTVLGGQFHDYGLLTTP
                     QLHYMVYCRNSGGRYGQATVEGYCQKLSKAFVDLTNQVSCSGDVKRSVKVDCANGIGA
                     LKLREMEHYFSRGLSVLLFNDGTQGRLNHLCGADFVKSQQKPPQGIEMKSGERCCSFD
                     GDADRIVYYYCDADGHFHLIDGDKIATLISSFLKELLLEIGESVNLGVVQTAYANGSS
                     TRYLEEVMKVPVYCTKTGVKHLHHKAQEFDIGVYFEANGHGTALFSEAVEVKIKRLAQ
                     ELDDGKGKAARTLASIIDLFNQAAGDAISDMLVIEAILALKGLTVQQWDAIYVDLPNR
                     QLKVKVADRRVISTTDAERQAVTPPGLQEAINDLVKKYTLARAFVRPSGTEDIVRVYA
                     EANSQESADRLAYEVSLLVFQLAGGIGERPQPTF"
     exon            320..504
                     /gene="Pgm3"
                     /gene_synonym="2810473H05Rik; Agm1; PAGM; Pgm-3"
                     /inference="alignment:Splign:2.1.0"
     exon            505..572
                     /gene="Pgm3"
                     /gene_synonym="2810473H05Rik; Agm1; PAGM; Pgm-3"
                     /inference="alignment:Splign:2.1.0"
     exon            573..706
                     /gene="Pgm3"
                     /gene_synonym="2810473H05Rik; Agm1; PAGM; Pgm-3"
                     /inference="alignment:Splign:2.1.0"
     exon            707..902
                     /gene="Pgm3"
                     /gene_synonym="2810473H05Rik; Agm1; PAGM; Pgm-3"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1060
                     /gene="Pgm3"
                     /gene_synonym="2810473H05Rik; Agm1; PAGM; Pgm-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1144
                     /gene="Pgm3"
                     /gene_synonym="2810473H05Rik; Agm1; PAGM; Pgm-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1243
                     /gene="Pgm3"
                     /gene_synonym="2810473H05Rik; Agm1; PAGM; Pgm-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1357
                     /gene="Pgm3"
                     /gene_synonym="2810473H05Rik; Agm1; PAGM; Pgm-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1480
                     /gene="Pgm3"
                     /gene_synonym="2810473H05Rik; Agm1; PAGM; Pgm-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1481..1654
                     /gene="Pgm3"
                     /gene_synonym="2810473H05Rik; Agm1; PAGM; Pgm-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..4582
                     /gene="Pgm3"
                     /gene_synonym="2810473H05Rik; Agm1; PAGM; Pgm-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2033..2038
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pgm3"
                     /gene_synonym="2810473H05Rik; Agm1; PAGM; Pgm-3"
                     /note="hexamer: ATTAAA"
     polyA_site      2057
                     /gene="Pgm3"
                     /gene_synonym="2810473H05Rik; Agm1; PAGM; Pgm-3"
                     /note="major polyA site"
     regulatory      2657..2662
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pgm3"
                     /gene_synonym="2810473H05Rik; Agm1; PAGM; Pgm-3"
                     /note="hexamer: TATAAA"
     polyA_site      2678
                     /gene="Pgm3"
                     /gene_synonym="2810473H05Rik; Agm1; PAGM; Pgm-3"
     regulatory      4517..4522
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pgm3"
                     /gene_synonym="2810473H05Rik; Agm1; PAGM; Pgm-3"
                     /note="hexamer: ATTAAA"
     polyA_site      4550
                     /gene="Pgm3"
                     /gene_synonym="2810473H05Rik; Agm1; PAGM; Pgm-3"
ORIGIN      
        1 gtcgggccgg aagcaaagct gggccacgtc tgcgaggtct gagagagttg gtttggtgcg
       61 cactgcgcgg ccgcgtctcg cctgtggaga gaacgttctt gctccagatc taggcatgga
      121 tctggaggct gtgtgtaagc gctcggcact ccatgccaag ccccaggggc tcattcttca
      181 gtatgggact gctggatttc ggaccaatgc ccagcatctc gatcatatca tgtttcgaat
      241 gggattgcta gctgtcctgc ggtcaaagca aacaagatct accattggag tcatggttac
      301 ggcctcacat aaccctgagg aagacaatgg tgtgaaattg gttgatcctt tgggggaaat
      361 gttggcccct tcctgggagg agcatgccac ctgtctggcc agtgcggagg agcaggacgt
      421 gcggcaagtg cttgctgcca tcgtggagaa agaagctgtg gatctgacac agaccgcctt
      481 cgtagtcatt gccagagaca ccaggcccag cagtgagaaa ctttcacaat ctgtgataga
      541 tggcgtgact gttttaggag gtcaattcca tgattacggc ctgttgacga cacctcagtt
      601 gcactacatg gtgtattgcc ggaattccgg aggccggtat ggacaggcca ccgtagaagg
      661 ctactgccag aagctctcca aggctttcgt agaccttacg aatcaggttt cctgcagtgg
      721 agatgtaaag aggtcagtta aggttgactg tgccaacggc ataggggcct tgaagctaag
      781 agaaatggaa cactacttct cccggggcct gtcggttctg ctgtttaatg atgggaccca
      841 agggcggctc aatcacctgt gcggtgctga ctttgtgaaa agtcaacaga aacccccaca
      901 gggaattgaa atgaagtccg gtgagagatg ctgctccttc gatggggatg cggacaggat
      961 cgtgtattac tactgtgatg cagatggtca ctttcatctc atagatggag acaagatagc
     1021 gacgttaatt agcagtttcc ttaaagagct actgttggag attggagaaa gtgtgaacct
     1081 cggagtcgta cagacagcat atgcaaatgg aagttccacg cggtaccttg aagaagttat
     1141 gaaggtacct gtgtattgca ccaaaactgg tgttaaacat ttgcatcaca aggctcaaga
     1201 gtttgacatc ggagtttatt ttgaagcgaa cgggcatgga acagcactgt tcagtgaagc
     1261 agttgaagtg aagataaaaa gactagccca agaactagac gatggaaaag gaaaagcagc
     1321 caggacgctt gcgagcatca tcgacttatt caaccaggca gctggagatg ctatttctga
     1381 catgttggtg attgaggcta tcctggctct gaaggggctg actgtacagc agtgggatgc
     1441 tatttatgtc gatcttccta acagacaact caaagttaag gtcgcggaca ggagagttat
     1501 tagcaccacg gatgctgaga gacaagcagt cactccacca ggactccaag aggcaatcaa
     1561 tgacctggtg aagaaataca cacttgcccg agcttttgta cggccctctg gtactgaaga
     1621 cattgtccga gtatatgcag aagccaactc acaagaaagc gcagacaggc ttgcctatga
     1681 agtgagtttg ctggtgttcc agctggctgg aggcattgga gaaagaccac aaccaacttt
     1741 ctgaagataa attttatatt ctggagaagt ggacttctaa aatgtttcta taacacttta
     1801 taatattggc agtactaggg catttgtaat catgacatca acatgtcatg catgttaatg
     1861 gattatttct agataggttt ttaaatgcta ccaggaaaaa aatgtttaga agctcaaaat
     1921 cttagacttg ggaatgaagc ttacctctga ttttaatctg tattaagttt taatagttca
     1981 agtgtcatta attttacagg gtatgaagtg aattcatgaa gggtactggg aaattaaact
     2041 ttactaactt ctttgcagcc cctttcgatt gcttacctaa ccaagatgtt ttgtagcact
     2101 gacctacctg gttcaaatgg ggagatttcg tatgaaccaa tttcccatgc ggatctcaat
     2161 gtgaggaaga aatgactgac tggtttgctt agcagcatca gaactggcag gtggcccatc
     2221 tttcattgta ctggcagagc tctgtgctgt gcccactaga gtgtgtggtc caggcttcag
     2281 ctactcttta gtgctcagcg aagggacaca gctccatctg atacctgaag cctctgacaa
     2341 ccaagtgacc attctgatac taggacatta ttaaccacag aaagaagaaa aacaacaatt
     2401 aacaattaaa tgaggcttga gaccaagcag gaaaaaagaa aacgtggtgt gtattttgca
     2461 ggtttaagac aacccaagac agtgaaacaa tggactatat atgcaaatat agaccttgta
     2521 ggcaccatca tcagtatgag ccacctatat atttaaactt gattcaggcc acattcagac
     2581 ataagctctt atttacaaat atttaaatta aatacaacct gaataatgct ttgttacata
     2641 tacacatata tatatatata aaagaaaaag aaactataca actcagcagt gtgttttaag
     2701 tattccattt aggctctgga gaaccactgg tggtggtcaa gtctttatga ctccttctag
     2761 aaagtccttt tctatcatct cttcaatttt ttgcctggct ttgctggaaa aggctttgtg
     2821 attctccagt ttcatgtcct tgtttgggaa ggagtttggg tagaggacgg ggctccctga
     2881 gtgtccgcca cagcggcttg tgactttgct gttgaagact tggctgagga cattgaagaa
     2941 aggcagaagc tgctccatgt tgcgcatggt gcagagcgtc agcagcaagt gccctggctc
     3001 ccagcccagt gtcctccccg agcagtcttc ctctgggttt ttctgcaaaa cacaaaaagg
     3061 agttgttact aataggtaac gtatgttatg tgagaagtgg agacaaatgc cagcatcaag
     3121 tcttcactgc agacttgacg aagtccactg gttctgaagc cttttagccg ccaatctaaa
     3181 tgaaaagtta accatggact ttcattatta acaaatgctg tcacacagtt taccatattg
     3241 cctctagtct cctaaaaatc aaaccaaatc aaatcaattt atcctgaaag aaagtaaatg
     3301 atgcttacag cctttatagc taattttgaa atacaagaca atcatggtaa aattactttt
     3361 tatattccta tggagatttt tcctttaaaa gtgtgaccct tccctcacag ccctgagctc
     3421 ttaaccaaga aaagcacagt ttcagtggtc ttttgttctt atgtacctgc cctccatact
     3481 aaataaccaa atatctccat atgaccattt cctcctctga cttcacaagt ctacaggtgt
     3541 gtgccttcct tcctgtttac ctgtcattgc ttttgctgcc atatcatatg catcaatagc
     3601 caccctcacc tgatgcttgg ccatctccaa tccctccaaa atcttaaagt cctcctcgtc
     3661 ctgtggaagg aaagaggaga actcatagcc cctgttcgag taacaagtgt gtttggccat
     3721 gaaggccttg tttaaaggga tggggatggg agatcctttc tggtgcagat ggctgccgta
     3781 tctgtggtca ttgtggagga cagcagaggg cacaggccta cagtcgtatg aatggtcact
     3841 gtatctgcat ttcctcctca aatcctgtga caaaaaagga atgcttttgt ccttaagtcc
     3901 tggatggact tttggtccat aactttgtcc ttttatttgg ctcctaaaga agcaagttcc
     3961 tcatgtcctt taagtaaagc tcctaattgc tttcttccct tttgctctgt agagaatcga
     4021 gtacagcttc attactgctg aaacaaatcg tgtgagttca cacagacctg gtctcacatg
     4081 agccctaact ctatgtactg ttaagattct gcacttagac aggtattaac acaggcccaa
     4141 tggtgaaatg ccattttcat ttacccctct gcttcagggc caagattggc ccgaaggtta
     4201 gcctgatcct tacttaatta taaaggattc aaggcatgta taaactacag aatttaactt
     4261 ctacacttta ttcatgagac agattttggt aattctcatt ttctcttgat ttcctttata
     4321 tagatggttt tttaaaaaat gttttagaca tttgtatttt tgagttcttc cactaacttt
     4381 ctgattagta gtcacattta gtagatggct ttattctcag cagtgtttct aaaactacag
     4441 ggagcagcag tagggtggat atgcaaaact gaaacatggc ataacaagag ttttatagaa
     4501 aatattagga aatattatta aagaagtcta tctagctaat tcaattttga taaagtattt
     4561 ctgtcaagtt tattgaaact tt
//
