LOCUS       NM_001165968            2434 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus peptidoglycan recognition protein 4 (Pglyrp4),
            transcript variant 1, mRNA.
ACCESSION   NM_001165968
VERSION     NM_001165968.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2434)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2434)
  AUTHORS   Dziarski,R., Park,S.Y., Kashyap,D.R., Dowd,S.E. and Gupta,D.
  TITLE     Pglyrp-Regulated Gut Microflora Prevotella falsenii,
            Parabacteroides distasonis and Bacteroides eggerthii Enhance and
            Alistipes finegoldii Attenuates Colitis in Mice
  JOURNAL   PLoS One 11 (1), e0146162 (2016)
   PUBMED   26727498
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2434)
  AUTHORS   Gowda,R.N., Redfern,R., Frikeche,J., Pinglay,S., Foster,J.W.,
            Lema,C., Cope,L. and Chakravarti,S.
  TITLE     Functions of Peptidoglycan Recognition Proteins (Pglyrps) at the
            Ocular Surface: Bacterial Keratitis in Gene-Targeted Mice Deficient
            in Pglyrp-2, -3 and -4
  JOURNAL   PLoS One 10 (9), e0137129 (2015)
   PUBMED   26332373
  REMARK    GeneRIF: Pglyrp-2 expression was induced after infection in WT
            mice. Pglyrp-3 expression was low before and after infection in WT
            mice, while Pglyrp-4 expression was slightly elevated after
            infection in WT, Pglyrp-2 and -3 null mice
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2434)
  AUTHORS   Park,S.Y., Gupta,D., Hurwich,R., Kim,C.H. and Dziarski,R.
  TITLE     Peptidoglycan recognition protein Pglyrp2 protects mice from
            psoriasis-like skin inflammation by promoting regulatory T cells
            and limiting Th17 responses
  JOURNAL   J Immunol 187 (11), 5813-5823 (2011)
   PUBMED   22048773
REFERENCE   5  (bases 1 to 2434)
  AUTHORS   Park,S.Y., Gupta,D., Kim,C.H. and Dziarski,R.
  TITLE     Differential effects of peptidoglycan recognition proteins on
            experimental atopic and contact dermatitis mediated by Treg and
            Th17 cells
  JOURNAL   PLoS One 6 (9), e24961 (2011)
   PUBMED   21949809
REFERENCE   6  (bases 1 to 2434)
  AUTHORS   Saha,S., Jing,X., Park,S.Y., Wang,S., Li,X., Gupta,D. and
            Dziarski,R.
  TITLE     Peptidoglycan recognition proteins protect mice from experimental
            colitis by promoting normal gut flora and preventing induction of
            interferon-gamma
  JOURNAL   Cell Host Microbe 8 (2), 147-162 (2010)
   PUBMED   20709292
REFERENCE   7  (bases 1 to 2434)
  AUTHORS   Saha,S., Qi,J., Wang,S., Wang,M., Li,X., Kim,Y.G., Nunez,G.,
            Gupta,D. and Dziarski,R.
  TITLE     PGLYRP-2 and Nod2 are both required for peptidoglycan-induced
            arthritis and local inflammation
  JOURNAL   Cell Host Microbe 5 (2), 137-150 (2009)
   PUBMED   19218085
REFERENCE   8  (bases 1 to 2434)
  AUTHORS   Mathur,P., Murray,B., Crowell,T., Gardner,H., Allaire,N., Hsu,Y.M.,
            Thill,G. and Carulli,J.P.
  TITLE     Murine peptidoglycan recognition proteins PglyrpIalpha and
            PglyrpIbeta are encoded in the epidermal differentiation complex
            and are expressed in epidermal and hematopoietic tissues
  JOURNAL   Genomics 83 (6), 1151-1163 (2004)
   PUBMED   15177568
REFERENCE   9  (bases 1 to 2434)
  AUTHORS   Liu,C., Xu,Z., Gupta,D. and Dziarski,R.
  TITLE     Peptidoglycan recognition proteins: a novel family of four human
            innate immunity pattern recognition molecules
  JOURNAL   J Biol Chem 276 (37), 34686-34694 (2001)
   PUBMED   11461926
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122425.5.
            
            On Oct 5, 2022 this sequence version replaced NM_001165968.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC144902.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-300               AC122425.5         99639-99938
            301-408             AC122425.5         100837-100944
            409-607             AC122425.5         101565-101763
            608-726             AC122425.5         103675-103793
            727-879             AC122425.5         105858-106010
            880-1081            AC122425.5         108380-108581
            1082-1200           AC122425.5         111929-112047
            1201-2434           AC122425.5         113222-114455
FEATURES             Location/Qualifiers
     source          1..2434
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 39.96 cM"
     gene            1..2434
                     /gene="Pglyrp4"
                     /gene_synonym="Gm1478; Gm413"
                     /note="peptidoglycan recognition protein 4"
                     /db_xref="GeneID:384997"
                     /db_xref="MGI:MGI:2686324"
     exon            1..300
                     /gene="Pglyrp4"
                     /gene_synonym="Gm1478; Gm413"
                     /inference="alignment:Splign:2.1.0"
     exon            301..408
                     /gene="Pglyrp4"
                     /gene_synonym="Gm1478; Gm413"
                     /inference="alignment:Splign:2.1.0"
     exon            409..607
                     /gene="Pglyrp4"
                     /gene_synonym="Gm1478; Gm413"
                     /inference="alignment:Splign:2.1.0"
     exon            608..726
                     /gene="Pglyrp4"
                     /gene_synonym="Gm1478; Gm413"
                     /inference="alignment:Splign:2.1.0"
     exon            727..879
                     /gene="Pglyrp4"
                     /gene_synonym="Gm1478; Gm413"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1081
                     /gene="Pglyrp4"
                     /gene_synonym="Gm1478; Gm413"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1200
                     /gene="Pglyrp4"
                     /gene_synonym="Gm1478; Gm413"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..2434
                     /gene="Pglyrp4"
                     /gene_synonym="Gm1478; Gm413"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2412..2417
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pglyrp4"
                     /gene_synonym="Gm1478; Gm413"
                     /note="hexamer: AATAAA"
     polyA_site      2433
                     /gene="Pglyrp4"
                     /gene_synonym="Gm1478; Gm413"
                     /note="major polyA site"
ORIGIN      
        1 acacggcacc agtaaaatag agtagctagg agtctgtact aggatgttgg gcaccagctg
       61 tgtacagggc acccagagga gccttagcca ggtgccgggc cttagaaggc ccacagcaag
      121 gcagtagata gacagggtta cacacagtca ggtggcatgt cattggcagc tggcacagtc
      181 atgttaattg tcagtgtctc tcctagggtt gcttatcatt ccccgtgtag gtgtcctggg
      241 gccacctgag gatgctgtcc tggcttcttg tcttctctat cttggttctt ctggcacagg
      301 gtgtttcctc ctgggaaaat ccacaaactg atcaggtgtc agaagggctg cagcaactgt
      361 ttggcaacat atcccaactc tttgagaaag gcatactagg ccgtgatgat gtcttcacta
      421 tggtttctcg tgaggaatgg ggggcagaag caattggttg cagctctaag ctgagcaggc
      481 cagtggatgt ccttgtcata caccatatcc ctggactaga gtgccacaac aaaactgtct
      541 gtagccagaa gcttcgggaa ctacaggcct accacatcca caacagctgg tgtgatgtgg
      601 cttacaattt cctggttggg gatgatggca gagtatatga aggtgttggt tggaatgtcc
      661 aaggctctca cgaccagggc tacaagaaca tctccttagg tgttgccttc tttggtaccc
      721 aagaaggcca tagtcccagc cctgttgctc tgtcagccat gaagggcctg atttcctatg
      781 ctgtgaagaa gggacacttg tcatccaagt acatccagcc attgcttgcg aaaagtgaag
      841 actgcctggt ccctccacag aaggggaaac agaagaaagc agcttgtccc cacatagttc
      901 cacggtctgt ttggggcgcg agagactccc actgctccag aatgactctc cctgcgaagt
      961 atgccatcat tcttcatact gctgggagaa catgcagtca gcctgatgag tgccgcctgc
     1021 tggtccgaga tctccagtcg ttcttcatga acaggctaaa tgcatgtgac attgggtata
     1081 acttcctcgt gggccaggat ggtggtgttt atgaaggagt gggctggaat aaccaaggtt
     1141 ccaaaactga tagctacaat gacatctctt tgagtatcac cttcatgggc accttcacag
     1201 gttccccacc caatgcagct gcactggagg cagcccagga cttgatccgg tgtgctgtgg
     1261 tcaaggggta cctgaccccc aactacctgc taatgggcca cagtgatgtg tccaacactc
     1321 tgtcccctgg gcaggcactg tacaacatta tcaagacgtg gccccatttc aagcactgag
     1381 ggaagcccta tccctatctg aggatgctct tcctcctgct gggtgtctgt ctttaccttt
     1441 caccttggat tagtatatct gtcctctcat ttcaaaaact ttaccttgtt catttcctag
     1501 attgggatga ccttgtcctc tcttggtgac atttaccagt ttcccccaag ttttgcactt
     1561 atagtccctt gagcctgagc caaggctctt ctctcctagg tacttgtctg ctcaaccagg
     1621 ccaggtaatg gtctgattct tgtcatacct tattccctag ttatctgccc ccctgtctgg
     1681 tacctatggc ctgtctggta cctatggcct gtctggtacc tatggcctgt ctggtagttc
     1741 ccagctctca tccgtagccc agggagagtg ccctcacctc ctctgctcac acatccactt
     1801 gtgcatatgt ggatgccccc ttgcagacat ccaggtcctc ttctagatta tgagttttcc
     1861 agaacagccg cagaattttc tttcccacta ggtagcctgt gtcagctcct gatctgtgtt
     1921 taaatgtttc tagatattat agatgtttgt tggagaaatg gaggaacaag ttaaaggccc
     1981 cagtcctttt ccaaaggttt gccatcaccc ctctgtggaa accttgctgt ccagtttccc
     2041 atcctgccat tattcttggc actggtactt cttggttgga ggctcagagc tgtggtgact
     2101 tatgtgtcca taacacatgc catgtctctg aagtcctgtg ccattgtatc catagagcac
     2161 cctgagtgcc aggaccatat gttcttccaa gggcaaggca gactgacaac acttgctgcc
     2221 tagtactgtg gtctcctgaa tgagtcttgc tggtctctga aaccctccct accttcataa
     2281 tttgttgtaa gcacatgaag ccttatctta ctctgtgttg ttctgaaaaa tggatgggag
     2341 agtaagagga aaagaggaga gatgaataaa aggaatatag tatagagatt gtcttgttaa
     2401 aattttcata aaataaagtt ttatcttatt ttat
//
