LOCUS       NM_207247               1109 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus peptidoglycan recognition protein 3 (Pglyrp3), mRNA.
ACCESSION   NM_207247 XM_143385
VERSION     NM_207247.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1109)
  AUTHORS   Ghadimi,D., de Vrese,M., Ebsen,M., Rocken,C., Olaf Frahm,S.,
            Zahlten,J., Folster-Holst,R., Heller,K.J. and Bockelmann,W.
  TITLE     Study on the additive protective effect of PGLYRP3 and
            Bifidobacterium adolescentis Reuter 1963 on severity of DSS-induced
            colitis in Pglyrp3 knockout (Pglyrp3 -/-) and wild-type (WT) mice
  JOURNAL   Immunobiology 226 (1), 152028 (2021)
   PUBMED   33242664
  REMARK    GeneRIF: Study on the additive protective effect of PGLYRP3 and
            Bifidobacterium adolescentis Reuter 1963 on severity of DSS-induced
            colitis in Pglyrp3 knockout (Pglyrp3 -/-) and wild-type (WT) mice.
REFERENCE   2  (bases 1 to 1109)
  AUTHORS   Dziarski,R., Park,S.Y., Kashyap,D.R., Dowd,S.E. and Gupta,D.
  TITLE     Pglyrp-Regulated Gut Microflora Prevotella falsenii,
            Parabacteroides distasonis and Bacteroides eggerthii Enhance and
            Alistipes finegoldii Attenuates Colitis in Mice
  JOURNAL   PLoS One 11 (1), e0146162 (2016)
   PUBMED   26727498
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1109)
  AUTHORS   Gowda,R.N., Redfern,R., Frikeche,J., Pinglay,S., Foster,J.W.,
            Lema,C., Cope,L. and Chakravarti,S.
  TITLE     Functions of Peptidoglycan Recognition Proteins (Pglyrps) at the
            Ocular Surface: Bacterial Keratitis in Gene-Targeted Mice Deficient
            in Pglyrp-2, -3 and -4
  JOURNAL   PLoS One 10 (9), e0137129 (2015)
   PUBMED   26332373
  REMARK    GeneRIF: Pglyrp-2 expression was induced after infection in WT
            mice. Pglyrp-3 expression was low before and after infection in WT
            mice, while Pglyrp-4 expression was slightly elevated after
            infection in WT, Pglyrp-2 and -3 null mice
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1109)
  AUTHORS   Jing,X., Zulfiqar,F., Park,S.Y., Nunez,G., Dziarski,R. and Gupta,D.
  TITLE     Peptidoglycan recognition protein 3 and Nod2 synergistically
            protect mice from dextran sodium sulfate-induced colitis
  JOURNAL   J Immunol 193 (6), 3055-3069 (2014)
   PUBMED   25114103
  REMARK    GeneRIF: Pglyrp3 deficiency resulted in colitis-predisposing
            intestinal microflora and increased intestinal ATP
REFERENCE   5  (bases 1 to 1109)
  AUTHORS   Park,S.Y., Gupta,D., Hurwich,R., Kim,C.H. and Dziarski,R.
  TITLE     Peptidoglycan recognition protein Pglyrp2 protects mice from
            psoriasis-like skin inflammation by promoting regulatory T cells
            and limiting Th17 responses
  JOURNAL   J Immunol 187 (11), 5813-5823 (2011)
   PUBMED   22048773
REFERENCE   6  (bases 1 to 1109)
  AUTHORS   Park,S.Y., Gupta,D., Kim,C.H. and Dziarski,R.
  TITLE     Differential effects of peptidoglycan recognition proteins on
            experimental atopic and contact dermatitis mediated by Treg and
            Th17 cells
  JOURNAL   PLoS One 6 (9), e24961 (2011)
   PUBMED   21949809
REFERENCE   7  (bases 1 to 1109)
  AUTHORS   Saha,S., Jing,X., Park,S.Y., Wang,S., Li,X., Gupta,D. and
            Dziarski,R.
  TITLE     Peptidoglycan recognition proteins protect mice from experimental
            colitis by promoting normal gut flora and preventing induction of
            interferon-gamma
  JOURNAL   Cell Host Microbe 8 (2), 147-162 (2010)
   PUBMED   20709292
REFERENCE   8  (bases 1 to 1109)
  AUTHORS   Saha,S., Qi,J., Wang,S., Wang,M., Li,X., Kim,Y.G., Nunez,G.,
            Gupta,D. and Dziarski,R.
  TITLE     PGLYRP-2 and Nod2 are both required for peptidoglycan-induced
            arthritis and local inflammation
  JOURNAL   Cell Host Microbe 5 (2), 137-150 (2009)
   PUBMED   19218085
REFERENCE   9  (bases 1 to 1109)
  AUTHORS   Mathur,P., Murray,B., Crowell,T., Gardner,H., Allaire,N., Hsu,Y.M.,
            Thill,G. and Carulli,J.P.
  TITLE     Murine peptidoglycan recognition proteins PglyrpIalpha and
            PglyrpIbeta are encoded in the epidermal differentiation complex
            and are expressed in epidermal and hematopoietic tissues
  JOURNAL   Genomics 83 (6), 1151-1163 (2004)
   PUBMED   15177568
REFERENCE   10 (bases 1 to 1109)
  AUTHORS   Liu,C., Xu,Z., Gupta,D. and Dziarski,R.
  TITLE     Peptidoglycan recognition proteins: a novel family of four human
            innate immunity pattern recognition molecules
  JOURNAL   J Biol Chem 276 (37), 34686-34694 (2001)
   PUBMED   11461926
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB619146.1 and AC163215.4.
            
            On Oct 1, 2009 this sequence version replaced NM_207247.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC128291.1, AY518698.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-377               BB619146.1         174-550
            378-378             AC163215.4         70179-70179         c
            379-457             BB619146.1         552-630
            458-591             AC163215.4         69318-69451         c
            592-790             AC163215.4         67724-67922         c
            791-909             AC163215.4         65164-65282         c
            910-1109            AC163215.4         64330-64529         c
FEATURES             Location/Qualifiers
     source          1..1109
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 40.14 cM"
     gene            1..1109
                     /gene="Pglyrp3"
                     /gene_synonym="Gm420"
                     /note="peptidoglycan recognition protein 3"
                     /db_xref="GeneID:242100"
                     /db_xref="MGI:MGI:2685266"
     exon            1..120
                     /gene="Pglyrp3"
                     /gene_synonym="Gm420"
                     /inference="alignment:Splign:2.1.0"
     exon            121..322
                     /gene="Pglyrp3"
                     /gene_synonym="Gm420"
                     /inference="alignment:Splign:2.1.0"
     exon            323..441
                     /gene="Pglyrp3"
                     /gene_synonym="Gm420"
                     /inference="alignment:Splign:2.1.0"
     exon            442..591
                     /gene="Pglyrp3"
                     /gene_synonym="Gm420"
                     /inference="alignment:Splign:2.1.0"
     exon            592..790
                     /gene="Pglyrp3"
                     /gene_synonym="Gm420"
                     /inference="alignment:Splign:2.1.0"
     exon            791..909
                     /gene="Pglyrp3"
                     /gene_synonym="Gm420"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1109
                     /gene="Pglyrp3"
                     /gene_synonym="Gm420"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgttctctag gacctgtgcc ctccaggact gccagtcaga ctccatgttg gtgtcctggg
       61 accaccctaa gatgttgccc aggcttcttg gcttcttggc tctcagtctc ctggcctgtg
      121 gcaacccaac catagtttcc agaaaagagt ggggagcaag ttcacttacc tgcagagtac
      181 cactgagcct gcccgtaccc tacctcatca tagagcaagt taccaggatg caatgccaag
      241 atcagatcac ctgcagccag gtggtgcggg tcctacagtc ccaatatgtc cacaacaaag
      301 gctggtgtga cattgccttc aactttctgg ttggagatga tggcaaggtg tatgaaggtg
      361 tcggctggta tgtccaaggc ttgcacactc aaggctacaa taacgtttcc ctgggcattg
      421 ccttctttgg cagtaagata ggaagcccca gtcccgctgc tttatcagct acagaggatc
      481 tgatcttctt tgccatccag aatggctacc tgtcacccaa gtacattcag ccatttctct
      541 taaaagaaga gacctgtttg gttcctcaac actcagagat acccaaaaaa gcatgcccca
      601 atatcacacc acggtctgct tgggaagcca gagaaacaca ctgccctcag atgaaccttc
      661 cagccaaatt tgtcatcatc atccacactg ctgggaaaag ctgcaatgag tctgcagact
      721 gtttggttcg tgtaagagac acacagtcct ttcacataga taaccaagat ttctgcgaca
      781 ttgcatatca ctttctagtg ggccaggatg gtgaagtata tgaaggagtt ggctggaata
      841 ttgaaggctc tcatacctat ggatacaacg atattgctct aggaattgcc ttcatgggaa
      901 actttgtaga aaagcctcca aatgaagctt cactgaaggc agcccagagc ctgatccagt
      961 gtgctgtggc caaagggtac ctgacctcca actacctgct aatgggccac agtgatgtgt
     1021 ccaacatcct gtcccctgga caggcattgt acaacatcat caagacatgg cctcacttca
     1081 agcactgaaa aatgctacag tcccatcta
//
