LOCUS       NM_021319               2709 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus peptidoglycan recognition protein 2 (Pglyrp2),
            transcript variant 1, mRNA.
ACCESSION   NM_021319 XM_888081 XM_992832
VERSION     NM_021319.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2709)
  AUTHORS   Basu,P., Das,A.A., Siddiqui,K.N., Mondal,P.C. and Bandyopadhyay,A.
  TITLE     Novel role of peptidoglycan recognition protein 2 in activating
            NOD2-NFkappaB inflammatory axis in coronary artery disease
  JOURNAL   Atherosclerosis 389, 117436 (2024)
   PUBMED   38277990
  REMARK    GeneRIF: Novel role of peptidoglycan recognition protein 2 in
            activating NOD2-NFkappaB inflammatory axis in coronary artery
            disease.
REFERENCE   2  (bases 1 to 2709)
  AUTHORS   Dabrowski,A.N., Conrad,C., Behrendt,U., Shrivastav,A., Baal,N.,
            Wienhold,S.M., Hackstein,H., N'Guessan,P.D., Aly,S., Reppe,K.,
            Suttorp,N. and Zahlten,J.
  TITLE     Peptidoglycan Recognition Protein 2 Regulates Neutrophil
            Recruitment Into the Lungs After Streptococcus pneumoniae Infection
  JOURNAL   Front Microbiol 10, 199 (2019)
   PUBMED   30837960
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2709)
  AUTHORS   Arentsen,T., Khalid,R., Qian,Y. and Diaz Heijtz,R.
  TITLE     Sex-dependent alterations in motor and anxiety-like behavior of
            aged bacterial peptidoglycan sensing molecule 2 knockout mice
  JOURNAL   Brain Behav Immun 67, 345-354 (2018)
   PUBMED   28951252
  REMARK    GeneRIF: Study shows sex-dependent alterations in motor and
            anxiety-like behavior of aged bacterial peptidoglycan sensing
            molecule 2 (Pglyrp2) knockout mice. The findings suggest a novel
            role for Pglyrp2 as a key regulator of motor and anxiety-like
            behavior in late life.
REFERENCE   4  (bases 1 to 2709)
  AUTHORS   Dziarski,R., Park,S.Y., Kashyap,D.R., Dowd,S.E. and Gupta,D.
  TITLE     Pglyrp-Regulated Gut Microflora Prevotella falsenii,
            Parabacteroides distasonis and Bacteroides eggerthii Enhance and
            Alistipes finegoldii Attenuates Colitis in Mice
  JOURNAL   PLoS One 11 (1), e0146162 (2016)
   PUBMED   26727498
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2709)
  AUTHORS   Gowda,R.N., Redfern,R., Frikeche,J., Pinglay,S., Foster,J.W.,
            Lema,C., Cope,L. and Chakravarti,S.
  TITLE     Functions of Peptidoglycan Recognition Proteins (Pglyrps) at the
            Ocular Surface: Bacterial Keratitis in Gene-Targeted Mice Deficient
            in Pglyrp-2, -3 and -4
  JOURNAL   PLoS One 10 (9), e0137129 (2015)
   PUBMED   26332373
  REMARK    GeneRIF: Pglyrp-2 expression was induced after infection in WT
            mice. Pglyrp-3 expression was low before and after infection in WT
            mice, while Pglyrp-4 expression was slightly elevated after
            infection in WT, Pglyrp-2 and -3 null mice
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2709)
  AUTHORS   Xu,M., Wang,Z. and Locksley,R.M.
  TITLE     Innate immune responses in peptidoglycan recognition protein
            L-deficient mice
  JOURNAL   Mol Cell Biol 24 (18), 7949-7957 (2004)
   PUBMED   15340057
  REMARK    GeneRIF: In contrast to its critical role in immunity in flies,
            PGRP-L is largely dispensable for mammalian immunity against
            bacteria and fungi.
REFERENCE   7  (bases 1 to 2709)
  AUTHORS   Gelius,E., Persson,C., Karlsson,J. and Steiner,H.
  TITLE     A mammalian peptidoglycan recognition protein with
            N-acetylmuramoyl-L-alanine amidase activity
  JOURNAL   Biochem Biophys Res Commun 306 (4), 988-994 (2003)
   PUBMED   12821140
REFERENCE   8  (bases 1 to 2709)
  AUTHORS   Kibardin,A.V., Mirkina,I.I., Baranova,E.V., Zakeyeva,I.R.,
            Georgiev,G.P. and Kiselev,S.L.
  TITLE     The differentially spliced mouse tagL gene, homolog of tag7/PGRP
            gene family in mammals and Drosophila, can recognize Gram-positive
            and Gram-negative bacterial cell wall independently of T phage
            lysozyme homology domain
  JOURNAL   J Mol Biol 326 (2), 467-474 (2003)
   PUBMED   12559914
REFERENCE   9  (bases 1 to 2709)
  AUTHORS   Liu,C., Xu,Z., Gupta,D. and Dziarski,R.
  TITLE     Peptidoglycan recognition proteins: a novel family of four human
            innate immunity pattern recognition molecules
  JOURNAL   J Biol Chem 276 (37), 34686-34694 (2001)
   PUBMED   11461926
REFERENCE   10 (bases 1 to 2709)
  AUTHORS   Kibardin,A.V., Mirkina,I.I., Korneeva,E.A., Gnuchev,N.V.,
            Georgiev,G.P. and Kiselev,S.L.
  TITLE     Molecular cloning of a new mouse gene tagL containing a
            lysozyme-like domain
  JOURNAL   Dokl Biochem 372 (1-6), 103-105 (2000)
   PUBMED   10935177
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK050019.1, AY282722.1 and CT485616.11.
            
            On Sep 28, 2012 this sequence version replaced NM_021319.4.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a). Variants 1 and 2 encode the same isoform (a, also known as
            TagL-alpha).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF149837.1, SRR5189682.143816.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                AK050019.1         2-63
            63-1795             AY282722.1         1-1733
            1796-2709           CT485616.11        34731-35644         c
FEATURES             Location/Qualifiers
     source          1..2709
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 17.56 cM"
     gene            1..2709
                     /gene="Pglyrp2"
                     /gene_synonym="C730002N09Rik; Pglyrpl; PGRP-L; tagL"
                     /note="peptidoglycan recognition protein 2"
                     /db_xref="GeneID:57757"
                     /db_xref="MGI:MGI:1928099"
     exon            1..176
                     /gene="Pglyrp2"
                     /gene_synonym="C730002N09Rik; Pglyrpl; PGRP-L; tagL"
                     /inference="alignment:Splign:2.1.0"
     exon            177..1184
                     /gene="Pglyrp2"
                     /gene_synonym="C730002N09Rik; Pglyrpl; PGRP-L; tagL"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1395
                     /gene="Pglyrp2"
                     /gene_synonym="C730002N09Rik; Pglyrpl; PGRP-L; tagL"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1693
                     /gene="Pglyrp2"
                     /gene_synonym="C730002N09Rik; Pglyrpl; PGRP-L; tagL"
                     /inference="alignment:Splign:2.1.0"
     exon            1694..2709
                     /gene="Pglyrp2"
                     /gene_synonym="C730002N09Rik; Pglyrpl; PGRP-L; tagL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1780..1785
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pglyrp2"
                     /gene_synonym="C730002N09Rik; Pglyrpl; PGRP-L; tagL"
                     /note="hexamer: AATAAA"
     polyA_site      1803
                     /gene="Pglyrp2"
                     /gene_synonym="C730002N09Rik; Pglyrpl; PGRP-L; tagL"
                     /note="major polyA site"
     regulatory      2687..2692
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pglyrp2"
                     /gene_synonym="C730002N09Rik; Pglyrpl; PGRP-L; tagL"
                     /note="hexamer: AATAAA"
     polyA_site      2709
                     /gene="Pglyrp2"
                     /gene_synonym="C730002N09Rik; Pglyrpl; PGRP-L; tagL"
ORIGIN      
        1 acacaacctt acctcgctgg ggtgactgcg acaggttaat tctcatgctc ctatcctcct
       61 agggcctccg aggttctctg ctgggtctgt gccctggaac tggagaccca ccatgaaggc
      121 ctggggtgcc ctctggatcg tgcttggatt gctgctgtgg ccagagccag gggcagcctc
      181 ctccttgcct ctgctcatgg actccatcat ccaggccctt gctgaacttg agcaaaaggt
      241 accagtgact gaggccagca tcactgcctc tgcatggatt ctgtcagcca agaactccag
      301 cacccacaat tcccttcacc agcgcttgct gctgaaggca ccaagccaca acactacaga
      361 gccagatcct cactctctca gcccggagct tcaagcactg atttctgagg tggctcaaca
      421 cgatgtacag aatgggcggg aatatggagt ggtgctggca cctgatggct ccaccgtagc
      481 tgtgaagcct ctgctgtttg ggctagaggc cggtctacag gcacacagcg ttgctaactt
      541 gccttcagat tgtctggcta tcccctgtga tactggagac accttggcca atattagagc
      601 cacctggcca ggactcatgg atgcttttcc aaatgcctct tctccagatg ttggagccac
      661 tttaccaaac gacaaagcca agactcccac cactgtggac agactcctgg caatcacctt
      721 ggctggtgac ttaggtctga ccttcctcca caggtcccag acttggagtc ctccaggact
      781 gggaactgag ggctgctggg accagcttac tgcccccagg gtcttcacac tgttggaccc
      841 ccaggcatcc aggctcacca tggctttcct caatggtgcc ttagatggag ctctccttgg
      901 gaaccacttg agccaaatcc ctaggcccca cccacccctc agccacctgc taagagagta
      961 ctatggagct ggggtgaatg gagatccggt gttccgaagt aacttccgaa ggcagaacgg
     1021 tgctgctttg acttcagccc ctaccctggc ccagcaggta tgggaggccc ttgtcctgtt
     1081 acagaaactg gagccagaac acctacagtt gcagaacatt agccaagagc agctggctca
     1141 ggtagccacc ttggctacca aggagttcac tgaggctttc ctgggatgcc cagccattca
     1201 cccccgctgc cgttggggag cggctcccta ccgaggccac ccaacaccac tccggctgcc
     1261 acttggattc ttatatgtgc atcacacata cgtgccagcg ccaccctgca ccaccttcca
     1321 gagctgcgcc gccgatatgc gctccatgca gcgtttccac caggatgtgc gcaagtggga
     1381 tgacatcggc tacagtttcg tggtaggctc cgacggctat ctgtaccagg gccgtggctg
     1441 gcactgggta ggtgcgcaca cacgcggcta caactcccgc ggcttcggtg tggccttcgt
     1501 gggcaactac actgggtcac tgcccaacga agctgcgctg aacacggtgc gcgacgcgct
     1561 cccgagctgc gcaattcgcg caggtctctt gcggccagac tacaagctgc ttggccaccg
     1621 ccagctagtg ctcacccact gccccgggaa cgcgctcttc aacttgctgc gcacctggcc
     1681 tcacttcaca gaggttgaaa actaagaact cctttgagag acccttgaag atccaggagg
     1741 tattatccct gatgatcctt tgagcaacca cagacctcca ataaagggac cactgaaagg
     1801 aaatctctat gagtatcacc ttcctcagag accaaaatgc aagcaatgtg tgtgtggctc
     1861 agtgggagag aacctagttg acaagcaaga ggcttttagt tttgttttgt tttgtggttt
     1921 ttgtcttgtt ttgttttcct acagagtttc tctgtgtggc gtggctgtcc tggaacttgc
     1981 tctgcagacg gggctggcct tgaattcgca aagatctgcc tgcctctgcc ttcttagtgc
     2041 tgggattaaa ggcattgccg ccactgccca tccaaggctc tggatctcca ttctagcact
     2101 acaacagaaa tcaagctggc tatgggagct catacttgta atcatagcaa ctggaagata
     2161 gaggaaggag gggaggtttt cttggaagcc gtgggtctta gggactgatc cctcctgaca
     2221 atgagtacaa gagagtcggg atgacaaaaa ttgaggcagt ttattttacg accttgtaag
     2281 gtgaaatgcc aacaaaactg gcaatggcgc cccattggga aaaaactgtc cttttttatt
     2341 ttttttaatg gtcctaatca aaattccttt cccctgcttt gctgcatgtt gcctgagttc
     2401 cattatccat ccatctcccc cttttttcaa tgtttgctct tggtcatgat gctacctgta
     2461 ccctctcatc ctgtaaagat aaccttggtt tggaaagaag gttaactaaa aggccagaca
     2521 agaagaaggc acaagctgtt agggcaaaga agccaatgcc ttccttttgc ttacctgaaa
     2581 cctaagccca tctaagggac ttttgtactg aaaatggacc cttgcgtttt gtttgccacc
     2641 aaggctagag gttaacctgt gctacagaat cgagaaaaca aaaacaaata aattaatttc
     2701 agtacaaaa
//
