LOCUS       NM_009402                681 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus peptidoglycan recognition protein 1 (Pglyrp1), mRNA.
ACCESSION   NM_009402 XM_904961
VERSION     NM_009402.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 681)
  AUTHORS   Lopez-Gil,J.C., Garcia-Silva,S., Ruiz-Canas,L., Navarro,D.,
            Palencia-Campos,A., Giraldez-Trujillo,A., Earl,J., Dorado,J.,
            Gomez-Lopez,G., Monfort-Vengut,A., Alcala,S., Gaida,M.M.,
            Garcia-Mulero,S., Cabezas-Sainz,P., Batres-Ramos,S., Barreto,E.,
            Sanchez-Tomero,P., Vallespinos,M., Ambler,L., Lin,M.L., Aicher,A.,
            Garcia Garcia de Paredes,A., de la Pinta,C., Sanjuanbenito,A.,
            Ruz-Caracuel,I., Rodriguez-Garrote,M., Guerra,C., Carrato,A., de
            Carcer,G., Sanchez,L., Nombela-Arrieta,C., Espinet,E.,
            Sanchez-Arevalo Lobo,V.J., Heeschen,C. and Sainz,B. Jr.
  TITLE     The Peptidoglycan Recognition Protein 1 confers immune evasive
            properties on pancreatic cancer stem cells
  JOURNAL   Gut 73 (9), 1489-1508 (2024)
   PUBMED   38754953
  REMARK    GeneRIF: The Peptidoglycan Recognition Protein 1 confers immune
            evasive properties on pancreatic cancer stem cells.
            Erratum:[Gut. 2024 Dec 10;74(1):e11. doi:
            10.1136/gutjnl-2023-330995corr1.. PMID: 39658261]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 681)
  AUTHORS   Bhusal,A., Kim,J.H., Kim,S.C., Hwang,E.M., Ryu,H., Ali,M.S.,
            Park,S.C., Lee,W.H. and Suk,K.
  TITLE     The microglial innate immune protein PGLYRP1 mediates
            neuroinflammation and consequent behavioral changes
  JOURNAL   Cell Rep 43 (3), 113813 (2024)
   PUBMED   38393947
  REMARK    GeneRIF: The microglial innate immune protein PGLYRP1 mediates
            neuroinflammation and consequent behavioral changes.
REFERENCE   3  (bases 1 to 681)
  AUTHORS   Schnell,A., Huang,L., Regan,B.M.L., Singh,V., Vonficht,D.,
            Bollhagen,A., Wang,M., Hou,Y., Bod,L., Sobel,R.A., Chihara,N.,
            Madi,A., Anderson,A.C., Regev,A. and Kuchroo,V.K.
  TITLE     Targeting PGLYRP1 promotes antitumor immunity while inhibiting
            autoimmune neuroinflammation
  JOURNAL   Nat Immunol 24 (11), 1908-1920 (2023)
   PUBMED   37828379
  REMARK    GeneRIF: Targeting PGLYRP1 promotes antitumor immunity while
            inhibiting autoimmune neuroinflammation.
REFERENCE   4  (bases 1 to 681)
  AUTHORS   Telegin,G.B., Chernov,A.S., Minakov,A.N., Balmasova,I.P.,
            Romanova,E.A., Sharapova,T.N., Sashchenko,L.P. and Yashin,D.V.
  TITLE     Short Peptides of Innate Immunity Protein Tag7 Inhibit the
            Production of Cytokines in CFA-Induced Arthritis
  JOURNAL   Int J Mol Sci 23 (20), 12435 (2022)
   PUBMED   36293292
  REMARK    GeneRIF: Short Peptides of Innate Immunity Protein Tag7 Inhibit the
            Production of Cytokines in CFA-Induced Arthritis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 681)
  AUTHORS   Li,H., Bradbury,J.A., Edin,M.L., Graves,J.P., Gruzdev,A., Cheng,J.,
            Hoopes,S.L., DeGraff,L.M., Fessler,M.B., Garantziotis,S.,
            Schurman,S.H. and Zeldin,D.C.
  TITLE     sEH promotes macrophage phagocytosis and lung clearance of
            Streptococcus pneumoniae
  JOURNAL   J Clin Invest 131 (22) (2021)
   PUBMED   34591792
REFERENCE   6  (bases 1 to 681)
  AUTHORS   Liu,C., Xu,Z., Gupta,D. and Dziarski,R.
  TITLE     Peptidoglycan recognition proteins: a novel family of four human
            innate immunity pattern recognition molecules
  JOURNAL   J Biol Chem 276 (37), 34686-34694 (2001)
   PUBMED   11461926
REFERENCE   7  (bases 1 to 681)
  AUTHORS   Mirkina,I.I., Kibardin,A.V., Korneeva,E.A., Gnuchev,N.V.,
            Georgiev,G.P. and Kiselev,S.L.
  TITLE     [Cloning and study of novel mammalian genes with structural
            homology with phage lysozyme]
  JOURNAL   Genetika 36 (11), 1492-1500 (2000)
   PUBMED   11094766
REFERENCE   8  (bases 1 to 681)
  AUTHORS   Kang,D., Liu,G., Lundstrom,A., Gelius,E. and Steiner,H.
  TITLE     A peptidoglycan recognition protein in innate immunity conserved
            from insects to humans
  JOURNAL   Proc Natl Acad Sci U S A 95 (17), 10078-10082 (1998)
   PUBMED   9707603
REFERENCE   9  (bases 1 to 681)
  AUTHORS   Kiselev,S.L., Kustikova,O.S., Korobko,E.V., Prokhortchouk,E.B.,
            Kabishev,A.A., Lukanidin,E.M. and Georgiev,G.P.
  TITLE     Molecular cloning and characterization of the mouse tag7 gene
            encoding a novel cytokine
  JOURNAL   J Biol Chem 273 (29), 18633-18639 (1998)
   PUBMED   9660837
REFERENCE   10 (bases 1 to 681)
  AUTHORS   Kustikova,O.S., Kiselev,S.L., Borodulina,O.R., Senin,V.M.,
            Afanas'eva,A.V. and Kabishev,A.A.
  TITLE     [Cloning of the tag7 gene expressed in metastatic mouse tumors]
  JOURNAL   Genetika 32 (5), 621-628 (1996)
   PUBMED   8755036
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC153651.4.
            
            On Nov 17, 2006 this sequence version replaced NM_009402.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK008335.1, AF076482.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-284               AC153651.4         49950-50233         c
            285-406             AC153651.4         45524-45645         c
            407-681             AC153651.4         44485-44759         c
FEATURES             Location/Qualifiers
     source          1..681
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 9.38 cM"
     gene            1..681
                     /gene="Pglyrp1"
                     /gene_synonym="Pglyrp; PGRP; PGRP-S; Tag7; Tasg7; Tnfsf3l"
                     /note="peptidoglycan recognition protein 1"
                     /db_xref="GeneID:21946"
                     /db_xref="MGI:MGI:1345092"
     exon            1..284
                     /gene="Pglyrp1"
                     /gene_synonym="Pglyrp; PGRP; PGRP-S; Tag7; Tasg7; Tnfsf3l"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..585
                     /gene="Pglyrp1"
                     /gene_synonym="Pglyrp; PGRP; PGRP-S; Tag7; Tasg7; Tnfsf3l"
                     /note="cytokine tag7"
                     /codon_start=1
                     /product="peptidoglycan recognition protein 1 precursor"
                     /protein_id="NP_033428.1"
                     /db_xref="CCDS:CCDS20881.1"
                     /db_xref="GeneID:21946"
                     /db_xref="MGI:MGI:1345092"
                     /translation="MLFACALLALLGLATSCSFIVPRSEWRALPSECSSRLGHPVRYV
                     VISHTAGSFCNSPDSCEQQARNVQHYHKNELGWCDVAYNFLIGEDGHVYEGRGWNIKG
                     DHTGPIWNPMSIGITFMGNFMDRVPAKRALRAALNLLECGVSRGFLRSNYEVKGHRDV
                     QSTLSPGDQLYQVIQSWEHYRE"
     exon            285..406
                     /gene="Pglyrp1"
                     /gene_synonym="Pglyrp; PGRP; PGRP-S; Tag7; Tasg7; Tnfsf3l"
                     /inference="alignment:Splign:2.1.0"
     exon            407..681
                     /gene="Pglyrp1"
                     /gene_synonym="Pglyrp; PGRP; PGRP-S; Tag7; Tasg7; Tnfsf3l"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      680
                     /gene="Pglyrp1"
                     /gene_synonym="Pglyrp; PGRP; PGRP-S; Tag7; Tasg7; Tnfsf3l"
ORIGIN      
        1 atacacagcc ctgcagtcct gtgcggcacg tccagcatgt tgtttgcctg tgctctcctt
       61 gccctcctgg gtctggcaac ctcctgcagt ttcatcgtgc cccgcagtga gtggagggcc
      121 ctgccatccg agtgctctag ccgcctgggg cacccagttc gctacgtggt gatctcacac
      181 acagccggca gcttctgcaa cagcccggac tcctgtgaac agcaggcccg caatgtgcag
      241 cattaccaca agaatgagct gggctggtgc gatgtagcct acaacttcct tattggagag
      301 gacggtcatg tctatgaagg ccgaggctgg aacatcaagg gtgaccacac agggcccatc
      361 tggaatccca tgtctattgg catcaccttc atggggaact tcatggaccg ggtacccgca
      421 aagcgggccc tccgtgctgc cctaaatctt ctggaatgtg gggtgtctcg gggcttcctg
      481 agatccaact atgaagtcaa aggacaccgg gatgtgcaaa gcactctctc tccaggtgac
      541 caactctatc aggtcatcca aagctgggaa cactaccgag agtgagagac cttgagacct
      601 agtgagaatc cccccccccc agcccgaaat ccctcctgcc acctgcttct tcccattgac
      661 ccccaataaa gactcagcac c
//
