LOCUS       NM_025396                883 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus 6-phosphogluconolactonase (Pgls), transcript variant
            1, mRNA.
ACCESSION   NM_025396
VERSION     NM_025396.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 883)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 883)
  AUTHORS   Cao,J., Yao,Q.J., Wu,J., Chen,X., Huang,L., Liu,W., Qian,K.,
            Wan,J.J. and Zhou,B.O.
  TITLE     Deciphering the metabolic heterogeneity of hematopoietic stem cells
            with single-cell resolution
  JOURNAL   Cell Metab 36 (1), 209-221 (2024)
   PUBMED   38171334
REFERENCE   3  (bases 1 to 883)
  AUTHORS   Gao,X., Zhao,L., Liu,S., Li,Y., Xia,S., Chen,D., Wang,M., Wu,S.,
            Dai,Q., Vu,H., Zacharias,L., DeBerardinis,R., Lim,E., Metallo,C.,
            Boggon,T.J., Lonial,S., Lin,R., Mao,H., Pan,Y., Shan,C. and Chen,J.
  TITLE     gamma-6-Phosphogluconolactone, a Byproduct of the Oxidative Pentose
            Phosphate Pathway, Contributes to AMPK Activation through
            Inhibition of PP2A
  JOURNAL   Mol Cell 76 (6), 857-871 (2019)
   PUBMED   31586547
REFERENCE   4  (bases 1 to 883)
  AUTHORS   Li,M.L., Wu,S.H., Zhang,J.J., Tian,H.Y., Shao,Y., Wang,Z.B.,
            Irwin,D.M., Li,J.L., Hu,X.T. and Wu,D.D.
  TITLE     547 transcriptomes from 44 brain areas reveal features of the aging
            brain in non-human primates
  JOURNAL   Genome Biol 20 (1), 258 (2019)
   PUBMED   31779658
  REMARK    GeneRIF: hub gene underlying brain aging
            Erratum:[Genome Biol. 2020 Feb 24;21(1):46. doi:
            10.1186/s13059-020-01962-z.. PMID: 32093779]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 883)
  AUTHORS   Bulusu,V., Prior,N., Snaebjornsson,M.T., Kuehne,A., Sonnen,K.F.,
            Kress,J., Stein,F., Schultz,C., Sauer,U. and Aulehla,A.
  TITLE     Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to
            Mouse Embryo Mesoderm Development
  JOURNAL   Dev Cell 40 (4), 331-341 (2017)
   PUBMED   28245920
REFERENCE   6  (bases 1 to 883)
  AUTHORS   Miclet,E., Stoven,V., Michels,P.A., Opperdoes,F.R., Lallemand,J.Y.
            and Duffieux,F.
  TITLE     NMR spectroscopic analysis of the first two steps of the
            pentose-phosphate pathway elucidates the role of
            6-phosphogluconolactonase
  JOURNAL   J Biol Chem 276 (37), 34840-34846 (2001)
   PUBMED   11457850
REFERENCE   7  (bases 1 to 883)
  AUTHORS   Kagami,Y. and Furuichi,T.
  TITLE     Investigation of differentially expressed genes during the
            development of mouse cerebellum
  JOURNAL   Brain Res Gene Expr Patterns 1 (1), 39-59 (2001)
   PUBMED   15018818
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC162033.11.
            
            On Apr 29, 2007 this sequence version replaced NM_025396.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK172066.1, AK003985.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-321               AC162033.11        47787-48107
            322-429             AC162033.11        49687-49794
            430-531             AC162033.11        50272-50373
            532-672             AC162033.11        50664-50804
            673-883             AC162033.11        51660-51870
FEATURES             Location/Qualifiers
     source          1..883
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 34.43 cM"
     gene            1..883
                     /gene="Pgls"
                     /gene_synonym="1110030K05Rik; Plgs"
                     /note="6-phosphogluconolactonase"
                     /db_xref="GeneID:66171"
                     /db_xref="MGI:MGI:1913421"
     exon            1..321
                     /gene="Pgls"
                     /gene_synonym="1110030K05Rik; Plgs"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..807
                     /gene="Pgls"
                     /gene_synonym="1110030K05Rik; Plgs"
                     /EC_number="3.1.1.31"
                     /note="isoform 1 is encoded by transcript variant 1; 6PGL"
                     /codon_start=1
                     /product="6-phosphogluconolactonase isoform 1"
                     /protein_id="NP_079672.1"
                     /db_xref="CCDS:CCDS22400.1"
                     /db_xref="GeneID:66171"
                     /db_xref="MGI:MGI:1913421"
                     /translation="MAAPAPSLISVFSSPQELGASLAQLVAQRAASCLEGDRGRFALG
                     LSGGSLVSMLARDLPAAAAPAGPASFARWTLGFCDERLVPFDHAESTYGLYRTHLLSK
                     LPIPDSQVLTINPALPVEDAAEDYARKLRQALQGDAVPVFDLLILGVGPDGHTCSLFP
                     DHPLLQEREKIVAPISDSPKPPPQRVTLTLPVLNAAQSIIFVATGEGKAAVLKRILED
                     KEGTLPAALVQPRTGALCWFLDEAAARLLSVPFEKHSTL"
     exon            322..429
                     /gene="Pgls"
                     /gene_synonym="1110030K05Rik; Plgs"
                     /inference="alignment:Splign:2.1.0"
     exon            430..531
                     /gene="Pgls"
                     /gene_synonym="1110030K05Rik; Plgs"
                     /inference="alignment:Splign:2.1.0"
     exon            532..672
                     /gene="Pgls"
                     /gene_synonym="1110030K05Rik; Plgs"
                     /inference="alignment:Splign:2.1.0"
     exon            673..883
                     /gene="Pgls"
                     /gene_synonym="1110030K05Rik; Plgs"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctctgccggg agcgccgccg cctccccacc gccatggcag cacccgcgcc cagtctcatc
       61 tcggtcttct ccagcccgca agagctgggc gcgtcgctgg cgcagctggt ggcgcagcgg
      121 gccgcgagct gcctggaagg ggaccgtggc cgcttcgcgc ttggtctgtc aggcggcagc
      181 ctggtctcca tgctagcccg agacctgccc gccgccgccg ctcccgctgg accagccagc
      241 tttgcgcgct ggacgctcgg cttctgcgac gagcgcctcg tgcccttcga ccacgccgag
      301 agcacgtacg gcctctaccg gacacacctg ctctcaaagc tgcccatccc agacagccag
      361 gtccttacca tcaatcctgc cctacctgtg gaggatgctg cagaggacta tgccaggaaa
      421 ctgagacagg ccttgcaagg agacgctgtc cctgtgtttg acctgctgat cctgggagtg
      481 ggccctgacg gccatacctg ttcgctcttc cctgaccatc ccctcctaca ggagcgggag
      541 aagatcgtgg ctcccatcag tgactcccca aagccaccac cgcagagggt gaccctaacg
      601 cttcctgtgc tgaacgcagc ccaaagtatc atctttgtgg ccacggggga aggcaaggca
      661 gctgtgctga agcgcatcct ggaggacaag gagggcacgt tgcccgccgc cttggtgcag
      721 ccgcgcacgg gcgccctctg ctggttcctg gacgaggcag ctgcccggct gctgtctgtg
      781 cccttcgaga agcattccac attgtagggg gtgcgccatg cacgccgtgg gcacttcggg
      841 tgttgtggga gcggactagc tgcggattaa acagctttgc tgg
//
