LOCUS       NM_031190               1592 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus phosphoglycerate kinase 2 (Pgk2), mRNA.
ACCESSION   NM_031190
VERSION     NM_031190.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1592)
  AUTHORS   Park,H.J., Lee,W.Y., Park,C., Hong,K.H., Kim,J.H. and Song,H.
  TITLE     Species-specific expression of phosphoglycerate kinase 2 (PGK2) in
            the developing porcine testis
  JOURNAL   Theriogenology 110, 158-167 (2018)
   PUBMED   29407897
  REMARK    GeneRIF: PGK2 is expressed differently in the testes of mouse and
            pigs according to developmental stage.
REFERENCE   2  (bases 1 to 1592)
  AUTHORS   Huang,Z., Danshina,P.V., Mohr,K., Qu,W., Goodson,S.G.,
            O'Connell,T.M. and O'Brien,D.A.
  TITLE     Sperm function, protein phosphorylation, and metabolism differ in
            mice lacking successive sperm-specific glycolytic enzymes
  JOURNAL   Biol Reprod 97 (4), 586-597 (2017)
   PUBMED   29025010
  REMARK    GeneRIF: These results identify multiple signaling and metabolic
            defects that are likely contributors to male infertility and the
            absence of progressive sperm motility seen in mice lacking GAPDHS.
REFERENCE   3  (bases 1 to 1592)
  AUTHORS   Bulusu,V., Prior,N., Snaebjornsson,M.T., Kuehne,A., Sonnen,K.F.,
            Kress,J., Stein,F., Schultz,C., Sauer,U. and Aulehla,A.
  TITLE     Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to
            Mouse Embryo Mesoderm Development
  JOURNAL   Dev Cell 40 (4), 331-341 (2017)
   PUBMED   28245920
REFERENCE   4  (bases 1 to 1592)
  AUTHORS   Yang,Z., Yoshioka,H. and McCarrey,J.R.
  TITLE     Sequence-specific promoter elements regulate temporal-specific
            changes in chromatin required for testis-specific activation of the
            Pgk2 gene
  JOURNAL   Reproduction 146 (5), 501-516 (2013)
   PUBMED   24000349
  REMARK    GeneRIF: Data from studies in transgenic mice suggest that Pgk2
            core promoter elements are required to direct demethylation of DNA
            and reconfiguration of nucleosomes in testis during sexual
            maturation and spermatogenesis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1592)
  AUTHORS   Chauvin,T., Xie,F., Liu,T., Nicora,C.D., Yang,F., Camp,D.G. 2nd,
            Smith,R.D. and Roberts,K.P.
  TITLE     A systematic analysis of a deep mouse epididymal sperm proteome
  JOURNAL   Biol Reprod 87 (6), 141 (2012)
   PUBMED   23115268
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1592)
  AUTHORS   Lee,C.Y. and Pegoraro,B.
  TITLE     Biochemical and immunological studies of three genetic variants of
            3-phosphoglycerate kinase 2 from the mouse
  JOURNAL   Biochem Genet 17 (7-8), 631-634 (1979)
   PUBMED   94263
REFERENCE   7  (bases 1 to 1592)
  AUTHORS   Vandeberg,J.L. and Klein,J.
  TITLE     Localization of mouse Pgk-2 gene at the D end of the H-2 complex
            (1)
  JOURNAL   J Exp Zool 203 (2), 319-324 (1978)
   PUBMED   624931
REFERENCE   8  (bases 1 to 1592)
  AUTHORS   Eicher,E.M., Cherry,M. and Flaherty,L.
  TITLE     Autosomal phosphoglycerate kinase linked to mouse major
            histocompatibility complex
  JOURNAL   Mol Gen Genet 158 (3), 225-228 (1978)
   PUBMED   628373
REFERENCE   9  (bases 1 to 1592)
  AUTHORS   Womack,J.E. and Eicher,E.M.
  TITLE     Liver-specific lysosomal acid phosphatase deficiency (Apl) on mouse
            chromosome 17
  JOURNAL   Mol Gen Genet 155 (3), 315-317 (1977)
   PUBMED   600262
REFERENCE   10 (bases 1 to 1592)
  AUTHORS   Vandeberg,J.L. and Blohm,S.V.
  TITLE     An allelic isozyme of mouse PGK-2 with low activity
  JOURNAL   J Exp Zool 201 (3), 479-483 (1977)
   PUBMED   908917
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU937018.1 and BC061054.1.
            
            On Apr 2, 2009 this sequence version replaced NM_031190.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC061054.1, AK015016.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 BU937018.1         3-11
            10-1592             BC061054.1         1-1583
FEATURES             Location/Qualifiers
     source          1..1592
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 19.44 cM"
     gene            1..1592
                     /gene="Pgk2"
                     /gene_synonym="Pgk-2; Tcp-2"
                     /note="phosphoglycerate kinase 2"
                     /db_xref="GeneID:18663"
                     /db_xref="MGI:MGI:97563"
     exon            1..1592
                     /gene="Pgk2"
                     /gene_synonym="Pgk-2; Tcp-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..1328
                     /gene="Pgk2"
                     /gene_synonym="Pgk-2; Tcp-2"
                     /EC_number="2.7.2.3"
                     /note="phosphoglycerate kinase, testis specific"
                     /codon_start=1
                     /product="phosphoglycerate kinase 2"
                     /protein_id="NP_112467.2"
                     /db_xref="CCDS:CCDS28782.1"
                     /db_xref="GeneID:18663"
                     /db_xref="MGI:MGI:97563"
                     /translation="MALSAKLTLDKVDLKGKRVIMRVDFNVPMKNNQITNNQRIKAAI
                     PSIKHCLDNGAKSVVLMSHLGRPDGIPMPDKYSLEPVADELKSLLNKDVIFLKDCVGP
                     EVEQACANPDNGSIILLENLRFHVEEEGKGKDSSGKKISADPAKVEAFQASLSKLGDV
                     YVNDAFGTAHRAHSSTVGVNLPQKASGFLMKKELDYFSKALEKPERPFLAILGGAKVK
                     DKIQLIKNMLDKVNFMIIGGGMAYTFLKELKNMQIGASLFDEEGATIVKEIMEKAEKN
                     GVKIVFPVDFVTGDKFDENAKVGQATIESGIPSGWMGLDCGPESIKINAQIVAQAKLI
                     VWNGPIGVFEWDAFAKGTKALMDEVVKATSNGCVTIIGGGDTATCCAKWGTEDKVSHV
                     STGGGASLELLEGKILPGVEALSNM"
     regulatory      1568..1573
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pgk2"
                     /gene_synonym="Pgk-2; Tcp-2"
                     /note="hexamer: ATTAAA"
     polyA_site      1589
                     /gene="Pgk2"
                     /gene_synonym="Pgk-2; Tcp-2"
                     /note="major polyA site"
ORIGIN      
        1 gacttaagcg ttaaaaatca ccaccaagcc agcctcccag cagcagtaaa gaggctgttg
       61 tgcataccat caagatggct ctttctgcta agttgactct ggacaaagtg gatcttaagg
      121 gaaaaagagt aatcatgaga gtagacttca acgttcccat gaagaataac caaattacaa
      181 acaaccagag aatcaaggct gccatcccaa gtatcaagca ctgtctggac aatggagcca
      241 agtccgtagt tctcatgagt cacctcggtc ggcctgatgg tatccctatg ccagacaagt
      301 attcattaga gcctgttgct gatgagctca agtccctgct gaacaaggac gtcatattct
      361 tgaaggactg tgtgggccct gaagtagagc aagcctgtgc caacccagat aatgggtcta
      421 tcatcctgct ggagaacctg cgcttccatg tggaggaaga aggtaagggt aaagattctt
      481 ctggaaaaaa gattagtgct gaccctgcta aagtagaagc cttccaagca tcactgtcta
      541 aacttggcga tgtctatgtc aacgatgcat ttggcactgc acatcgggct cacagttcta
      601 cggtcggagt aaatttgccc cagaaggcat ctggtttcct tatgaagaag gaactggatt
      661 atttttccaa ggctttagaa aagccagaga ggcccttcct ggctatcctt ggtggagcca
      721 aagtgaaaga caagatccaa ctcattaaaa atatgttaga caaagtcaat ttcatgatta
      781 ttggtggtgg aatggcttac accttcctga aagaactcaa gaacatgcag attggtgctt
      841 ccttgtttga tgaagaggga gccacgattg ttaaagagat catggaaaaa gcagaaaaga
      901 atggtgtaaa gatagttttt cctgttgact ttgttactgg tgacaagttt gatgagaatg
      961 ctaaagttgg acaagccact atagaatctg gtataccatc tggttggatg ggcttggact
     1021 gtggccctga gagcattaaa atcaatgctc aaattgtggc ccaagcaaag ctgatagttt
     1081 ggaatggacc tattggggta tttgaatggg atgcctttgc taaaggaacc aaagctctca
     1141 tggatgaagt tgtaaaggcc acctccaatg gctgtgtcac cattatagga ggcggagata
     1201 ctgctacttg ctgcgccaaa tggggcactg aagacaaggt cagccatgtg agcacaggag
     1261 gtggggcaag tcttgagctt ctggaaggta aaatccttcc aggggtagag gccctcagca
     1321 acatgtaatt gtcataatgt acttgcttcc tgtttcctgc gcacaggacc agaaccaact
     1381 caacctaacc tatatctcaa catttgttaa cctctactat gaatcaagac ccaggtaatg
     1441 agctagcagt gagccatcaa tatcacatca gcaagtctta attctgtcac acatttgtta
     1501 gtctcttcaa gatctcatca ggatttccca cagtccttcc tagggaggaa acattctcat
     1561 gtcaactatt aaagaagtga gctaagtaag tt
//
