LOCUS       NM_008828               1840 bp    mRNA    linear   ROD 16-FEB-2025
DEFINITION  Mus musculus phosphoglycerate kinase 1 (Pgk1), mRNA.
ACCESSION   NM_008828
VERSION     NM_008828.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1840)
  AUTHORS   Zhu,G., Yu,H., Peng,T., Yang,K., Xu,X. and Gu,W.
  TITLE     Glycolytic enzyme PGK1 promotes M1 macrophage polarization and
            induces pyroptosis of acute lung injury via regulation of NLRP3
  JOURNAL   Respir Res 25 (1), 291 (2024)
   PUBMED   39080660
  REMARK    GeneRIF: Glycolytic enzyme PGK1 promotes M1 macrophage polarization
            and induces pyroptosis of acute lung injury via regulation of
            NLRP3.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1840)
  AUTHORS   Kawakami,H., Chen,K.Q., Zhang,R., Pappas,M.P., Bailey,A.,
            Reisz,J.A., Corcoran,D., Nishinakamura,R., D'Alessandro,A. and
            Kawakami,Y.
  TITLE     Sall4 restricts glycolytic metabolism in limb buds through
            transcriptional regulation of glycolytic enzyme genes
  JOURNAL   Dev Biol 501, 28-38 (2023)
   PUBMED   37301463
REFERENCE   3  (bases 1 to 1840)
  AUTHORS   Chen,H., Li,Y., Gao,J., Cheng,Q., Liu,L. and Cai,R.
  TITLE     Activation of Pgk1 Results in Reduced Protein Aggregation in
            Diverse Neurodegenerative Conditions
  JOURNAL   Mol Neurobiol 60 (9), 5090-5101 (2023)
   PUBMED   37249790
  REMARK    GeneRIF: Activation of Pgk1 Results in Reduced Protein Aggregation
            in Diverse Neurodegenerative Conditions.
REFERENCE   4  (bases 1 to 1840)
  AUTHORS   Xu,T., Gao,P., Huang,Y., Wu,M., Yi,J., Zhou,Z., Zhao,X., Jiang,T.,
            Liu,H., Qin,T., Yang,Z., Wang,X., Bao,T., Chen,J., Zhao,S. and
            Yin,G.
  TITLE     Git1-PGK1 interaction achieves self-protection against spinal cord
            ischemia-reperfusion injury by modulating Keap1/Nrf2 signaling
  JOURNAL   Redox Biol 62, 102682 (2023)
   PUBMED   36963288
  REMARK    GeneRIF: Git1-PGK1 interaction achieves self-protection against
            spinal cord ischemia-reperfusion injury by modulating Keap1/Nrf2
            signaling.
REFERENCE   5  (bases 1 to 1840)
  AUTHORS   Lay,A.J., Jiang,X.M., Kisker,O., Flynn,E., Underwood,A., Condron,R.
            and Hogg,P.J.
  TITLE     Phosphoglycerate kinase acts in tumour angiogenesis as a disulphide
            reductase
  JOURNAL   Nature 408 (6814), 869-873 (2000)
   PUBMED   11130727
  REMARK    GeneRIF: Phosphoglycerate kinase is a moonlighting protein that
            functions as both a glycolytic enzyme and a disulfide reductase.
REFERENCE   6  (bases 1 to 1840)
  AUTHORS   Adra,C.N., Boer,P.H. and McBurney,M.W.
  TITLE     Cloning and expression of the mouse pgk-1 gene and the nucleotide
            sequence of its promoter
  JOURNAL   Gene 60 (1), 65-74 (1987)
   PUBMED   3440520
REFERENCE   7  (bases 1 to 1840)
  AUTHORS   West,J.D. and Chapman,V.M.
  TITLE     Variation for X chromosome expression in mice detected by
            electrophoresis of phosphoglycerate kinase
  JOURNAL   Genet Res 32 (1), 91-102 (1978)
   PUBMED   710889
REFERENCE   8  (bases 1 to 1840)
  AUTHORS   West,J.D., Frels,W.I., Chapman,V.M. and Papaioannou,V.E.
  TITLE     Preferential expression of the maternally derived X chromosome in
            the mouse yolk sac
  JOURNAL   Cell 12 (4), 873-882 (1977)
   PUBMED   597862
REFERENCE   9  (bases 1 to 1840)
  AUTHORS   Chapman,V.M. and Shows,T.B.
  TITLE     Somatic cell genetic evidence for X-chromosome linkage of three
            enzymes in the mouse
  JOURNAL   Nature 259 (5545), 665-667 (1976)
   PUBMED   943046
REFERENCE   10 (bases 1 to 1840)
  AUTHORS   Kozak,L.P. and Quinn,P.J.
  TITLE     Evidence for dosage compensation of an X-linked gene in the 6-day
            embryo of the mouse
  JOURNAL   Dev Biol 45 (1), 65-73 (1975)
   PUBMED   1181221
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY292706.1, AK133877.1 and
            BE986846.1.
            
            On Feb 1, 2014 this sequence version replaced NM_008828.2.
            
            Summary: The protein encoded by this gene is a glycolytic enzyme
            that catalyzes the conversion of 1,3-diphosphoglycerate to
            3-phosphoglycerate. Additionally, this protein is secreted by tumor
            cells where it participates in angiogenesis by functioning to
            reduce disulfide bonds in the serine protease, plasmin, which
            consequently leads to the release of the tumor blood vessel
            inhibitor angiostatin. The encoded protein has been identified as a
            moonlighting protein based on its ability to perform
            mechanistically distinct functions. Many pseudogenes of this gene
            are found throughout the mouse genome. [provided by RefSeq, Jan
            2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC108372.1, SRR1660815.59351.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            multifunctional gene product(s) :: PMID: 11130727
            RefSeq Select criteria          :: based on single protein-coding
                                               transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-79                BY292706.1         2-80
            80-1822             AK133877.1         2-1744
            1823-1840           BE986846.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..1840
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 47.36 cM"
     gene            1..1840
                     /gene="Pgk1"
                     /gene_synonym="Pgk-1"
                     /note="phosphoglycerate kinase 1"
                     /db_xref="GeneID:18655"
                     /db_xref="MGI:MGI:97555"
     exon            1..216
                     /gene="Pgk1"
                     /gene_synonym="Pgk-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..1405
                     /gene="Pgk1"
                     /gene_synonym="Pgk-1"
                     /EC_number="2.7.2.3"
                     /EC_number="2.7.11.1"
                     /codon_start=1
                     /product="phosphoglycerate kinase 1"
                     /protein_id="NP_032854.2"
                     /db_xref="CCDS:CCDS30339.1"
                     /db_xref="GeneID:18655"
                     /db_xref="MGI:MGI:97555"
                     /translation="MSLSNKLTLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAV
                     PSIKFCLDNGAKSVVLMSHLGRPDGVPMPDKYSLEPVAAELKSLLGKDVLFLKDCVGP
                     EVENACANPAAGTVILLENLRFHVEEEGKGKDASGNKVKAEPAKIDAFRASLSKLGDV
                     YVNDAFGTAHRAHSSMVGVNLPQKAGGFLMKKELNYFAKALESPERPFLAILGGAKVA
                     DKIQLINNMLDKVNEMIIGGGMAFTFLKVLNNMEIGTSLYDEEGAKIVKDLMSKAEKN
                     GVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMGLDCGTESSKKYAEAVGRAKQI
                     VWNGPVGVFEWEAFARGTKSLMDEVVKATSRGCITIIGGGDTATCCAKWNTEDKVSHV
                     STGGGASLELLEGKVLPGVDALSNV"
     exon            217..267
                     /gene="Pgk1"
                     /gene_synonym="Pgk-1"
                     /inference="alignment:Splign:2.1.0"
     exon            268..423
                     /gene="Pgk1"
                     /gene_synonym="Pgk-1"
                     /inference="alignment:Splign:2.1.0"
     exon            424..568
                     /gene="Pgk1"
                     /gene_synonym="Pgk-1"
                     /inference="alignment:Splign:2.1.0"
     exon            569..672
                     /gene="Pgk1"
                     /gene_synonym="Pgk-1"
                     /inference="alignment:Splign:2.1.0"
     exon            673..792
                     /gene="Pgk1"
                     /gene_synonym="Pgk-1"
                     /inference="alignment:Splign:2.1.0"
     exon            793..907
                     /gene="Pgk1"
                     /gene_synonym="Pgk-1"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1087
                     /gene="Pgk1"
                     /gene_synonym="Pgk-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1265
                     /gene="Pgk1"
                     /gene_synonym="Pgk-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1364
                     /gene="Pgk1"
                     /gene_synonym="Pgk-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1825
                     /gene="Pgk1"
                     /gene_synonym="Pgk-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1801..1806
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pgk1"
                     /gene_synonym="Pgk-1"
                     /note="hexamer: AATAAA"
     polyA_site      1820
                     /gene="Pgk1"
                     /gene_synonym="Pgk-1"
                     /note="major polyA site"
ORIGIN      
        1 gggggcgggc tcaggggcgg gctcaggggc ggggcgggcg cccgaaggtc ctccggaggc
       61 ccggcattct gcacgcttca aaagcgcacg tctgccgcgc tgttctcctc ttcctcatct
      121 ccgggccttt cgacctcacg gtgttgccaa aatgtcgctt tccaacaagc tgactttgga
      181 caagctggac gtgaagggga agcgggtcgt gatgagggtg gacttcaacg ttcctatgaa
      241 gaacaaccag ataacaaaca accaaaggat caaggctgct gttccaagca tcaaattctg
      301 cttggacaat ggagccaagt ccgttgtcct tatgagccac ctgggccggc ctgatggtgt
      361 tcccatgcct gacaagtact ccttagagcc agttgctgct gaactcaaat ctctgctggg
      421 caaggatgtt ctgttcttga aggattgtgt gggcccagaa gtcgagaatg cctgtgccaa
      481 cccagcggct gggactgtca tcctgctgga aaacctccgc tttcatgtag aggaagaagg
      541 gaagggaaaa gatgcttctg gaaacaaggt taaagctgag ccggccaaaa ttgatgcttt
      601 ccgagcctca ctgtccaaac taggagatgt ctatgtcaat gatgcttttg ggactgcaca
      661 ccgagcccat agctccatgg tgggtgtgaa tctgccacag aaggctggtg gatttttgat
      721 gaagaaggag ctgaactact ttgccaaggc tttggagagt ccagagcgac ccttcctggc
      781 tatcttggga ggcgctaaag ttgcagacaa gatccagctg atcaataata tgctagacaa
      841 agtcaatgag atgatcattg gtggtggaat ggcctttacc ttccttaagg tgctcaacaa
      901 catggagatt ggcacatctc tgtatgatga agaaggagcc aagattgtca aagatctcat
      961 gtccaaagct gagaaaaatg gtgtgaagat taccttgcct gttgactttg tcactgctga
     1021 caaatttgat gagaatgcca agactggcca agctactgtg gcctctggta tacctgctgg
     1081 ctggatgggc ttggactgtg gtactgagag cagcaagaaa tatgccgagg ctgtgggtcg
     1141 agctaagcag attgtttgga atggtcctgt tggggtattt gaatgggaag cctttgccag
     1201 gggaaccaag tcactcatgg atgaggtggt gaaagccact tctaggggtt gcatcactat
     1261 cataggtggt ggagacactg ccacttgctg tgccaaatgg aacacagagg ataaagtcag
     1321 ccatgtgagc actgggggcg gtgccagtct agagctcctg gaaggtaaag tccttcctgg
     1381 ggtggatgct ctcagcaatg tttagtattt tctttcctgc ctttggttcc tgtgctccta
     1441 agtcaaccta gtgttttcca catctccatt tggtgttagc gcaagattca gctagtggct
     1501 gagatgtggc accaggaacc cttaaacagt tgcacagcat ctcagctcgt ctttactgca
     1561 tcaggatttg tctgtgttct tcaagatccc atttaaattc cttagtgact aaaaccattg
     1621 tgcattgtag agggcgtcta tttatattct gcctgagaaa ggaagtgagc tgtaaaggct
     1681 gagctctctc tctgacgtat gtagcctctg gttagcttcg tcactcactg ttcttgactc
     1741 agcatggcaa tctgatgaaa tcccagctgt aagtctgcag aaattgatga tctattaaac
     1801 aataaagatg tccactaaaa tggaaaaaaa aaaaaaaaaa
//
