LOCUS       NM_008827               1599 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus placental growth factor (Pgf), transcript variant 1,
            mRNA.
ACCESSION   NM_008827
VERSION     NM_008827.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1599)
  AUTHORS   Sekimoto,A., Takaso,Y., Saruyama,H., Ookawa,M., Yamamoto,M.,
            Toyohara,T., Saigusa,D., Fukuuchi,T., Otsuka,M., Fushiki,Y.,
            Yamakoshi,S., Tanaka,K., Ikeda,T., Tanaka,T., Takahashi,N.,
            Mishima,E. and Sato,E.
  TITLE     Impacts of low birthweight on kidney development and
            intergenerational growth of the offspring
  JOURNAL   iScience 27 (11), 111159 (2024)
   PUBMED   39524353
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1599)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1599)
  AUTHORS   Zhao,H., Wong,R.J. and Stevenson,D.K.
  TITLE     The placental vasculature is affected by changes in gene expression
            and glycogen-rich cells in a diet-induced obesity mouse model
  JOURNAL   PLoS One 18 (11), e0294185 (2023)
   PUBMED   37948457
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1599)
  AUTHORS   Rusidze,M., Faure,M.C., Sicard,P., Raymond-Letron,I., Giton,F.,
            Vessieres,E., Prevot,V., Henrion,D., Arnal,J.F., Cornil,C.A. and
            Lenfant,F.
  TITLE     Loss of function of the maternal membrane oestrogen receptor
            ERalpha alters expansion of trophoblast cells and impacts mouse
            fertility
  JOURNAL   Development 149 (19) (2022)
   PUBMED   36239412
REFERENCE   5  (bases 1 to 1599)
  AUTHORS   Wilson,R.L., Troja,W., Courtney,J., Williams,A. and Jones,H.N.
  TITLE     Placental and fetal characteristics of the Ohia mouse line
            recapitulate outcomes in human hypoplastic left heart syndrome
  JOURNAL   Placenta 117, 131-138 (2022)
   PUBMED   34890862
REFERENCE   6  (bases 1 to 1599)
  AUTHORS   Maes,C., Carmeliet,P., Moermans,K., Stockmans,I., Smets,N.,
            Collen,D., Bouillon,R. and Carmeliet,G.
  TITLE     Impaired angiogenesis and endochondral bone formation in mice
            lacking the vascular endothelial growth factor isoforms VEGF164 and
            VEGF188
  JOURNAL   Mech Dev 111 (1-2), 61-73 (2002)
   PUBMED   11804779
REFERENCE   7  (bases 1 to 1599)
  AUTHORS   Carmeliet,P., Moons,L., Luttun,A., Vincenti,V., Compernolle,V., De
            Mol,M., Wu,Y., Bono,F., Devy,L., Beck,H., Scholz,D., Acker,T.,
            DiPalma,T., Dewerchin,M., Noel,A., Stalmans,I., Barra,A.,
            Blacher,S., VandenDriessche,T., Ponten,A., Eriksson,U., Plate,K.H.,
            Foidart,J.M., Schaper,W., Charnock-Jones,D.S., Hicklin,D.J.,
            Herbert,J.M., Collen,D. and Persico,M.G.
  TITLE     Synergism between vascular endothelial growth factor and placental
            growth factor contributes to angiogenesis and plasma extravasation
            in pathological conditions
  JOURNAL   Nat Med 7 (5), 575-583 (2001)
   PUBMED   11329059
REFERENCE   8  (bases 1 to 1599)
  AUTHORS   Yonekura,H., Sakurai,S., Liu,X., Migita,H., Wang,H., Yamagishi,S.,
            Nomura,M., Abedin,M.J., Unoki,H., Yamamoto,Y. and Yamamoto,H.
  TITLE     Placenta growth factor and vascular endothelial growth factor B and
            C expression in microvascular endothelial cells and pericytes.
            Implication in autocrine and paracrine regulation of angiogenesis
  JOURNAL   J Biol Chem 274 (49), 35172-35178 (1999)
   PUBMED   10575000
REFERENCE   9  (bases 1 to 1599)
  AUTHORS   Achen,M.G., Gad,J.M., Stacker,S.A. and Wilks,A.F.
  TITLE     Placenta growth factor and vascular endothelial growth factor are
            co-expressed during early embryonic development
  JOURNAL   Growth Factors 15 (1), 69-80 (1997)
   PUBMED   9401819
REFERENCE   10 (bases 1 to 1599)
  AUTHORS   DiPalma,T., Tucci,M., Russo,G., Maglione,D., Lago,C.T., Romano,A.,
            Saccone,S., Della Valle,G., De Gregorio,L., Dragani,T.A.,
            Viglietto,G. and Persico,M.G.
  TITLE     The placenta growth factor gene of the mouse
  JOURNAL   Mamm Genome 7 (1), 6-12 (1996)
   PUBMED   8903720
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127582.4.
            
            On Nov 9, 2012 this sequence version replaced NM_008827.2.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK042891.1, BC016567.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-416               AC127582.4         21906-22321
            417-456             AC127582.4         23424-23463
            457-653             AC127582.4         27363-27559
            654-733             AC127582.4         27765-27844
            734-763             AC127582.4         29679-29708
            764-823             AC127582.4         29802-29861
            824-1599            AC127582.4         31805-32580
FEATURES             Location/Qualifiers
     source          1..1599
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 39.58 cM"
     gene            1..1599
                     /gene="Pgf"
                     /gene_synonym="PIGF; Plgf"
                     /note="placental growth factor"
                     /db_xref="GeneID:18654"
                     /db_xref="MGI:MGI:105095"
     exon            1..416
                     /gene="Pgf"
                     /gene_synonym="PIGF; Plgf"
                     /inference="alignment:Splign:2.1.0"
     CDS             351..827
                     /gene="Pgf"
                     /gene_synonym="PIGF; Plgf"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; placenta growth factor"
                     /codon_start=1
                     /product="placenta growth factor isoform 1 precursor"
                     /protein_id="NP_032853.1"
                     /db_xref="CCDS:CCDS49115.1"
                     /db_xref="GeneID:18654"
                     /db_xref="MGI:MGI:105095"
                     /translation="MLVMKLFTCFLQVLAGLAVHSQGALSAGNNSTEVEVVPFNEVWG
                     RSYCRPMEKLVYILDEYPDEVSHIFSPSCVLLSRCSGCCGDEGLHCVPIKTANITMQI
                     LKIPPNRDPHFYVEMTFSQDVLCECRPILETTKAERRKTKGKRKRSRNSQTEEPHP"
     exon            417..456
                     /gene="Pgf"
                     /gene_synonym="PIGF; Plgf"
                     /inference="alignment:Splign:2.1.0"
     exon            457..653
                     /gene="Pgf"
                     /gene_synonym="PIGF; Plgf"
                     /inference="alignment:Splign:2.1.0"
     exon            654..733
                     /gene="Pgf"
                     /gene_synonym="PIGF; Plgf"
                     /inference="alignment:Splign:2.1.0"
     exon            734..763
                     /gene="Pgf"
                     /gene_synonym="PIGF; Plgf"
                     /inference="alignment:Splign:2.1.0"
     exon            764..823
                     /gene="Pgf"
                     /gene_synonym="PIGF; Plgf"
                     /inference="alignment:Splign:2.1.0"
     exon            824..1599
                     /gene="Pgf"
                     /gene_synonym="PIGF; Plgf"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1576..1581
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pgf"
                     /gene_synonym="PIGF; Plgf"
                     /note="hexamer: AATAAA"
     polyA_site      1597
                     /gene="Pgf"
                     /gene_synonym="PIGF; Plgf"
                     /note="major polyA site"
ORIGIN      
        1 ccgactagct tcagttcgta gggaagctgc agtctgagaa ggaaaccgca tcttcagact
       61 tctgctcact cacgagagga gctagggtca tcggacccct aagatccttt cacatcgctc
      121 cgactcgccg gaacactcct caccagtttc ctcagccaca gccctacctg tgagctccgg
      181 acttccccgg ctttctgtgg atgctcaggc agactgcaga gacctagcct aggacagcag
      241 tgagggggac actcctctcc tctcctctcc tctggtatca gcgtctcccc caagggggac
      301 gagcatggtg attgtgcctt gaaggacctt ggctctggat gtctgagaag atgctggtca
      361 tgaagctgtt cacttgcttc ttacaggtcc tagctgggtt ggctgtgcat tcccaggggg
      421 ccctgtctgc tgggaacaac tcaacagaag tggaagtggt gcctttcaac gaagtgtggg
      481 gtcgcagcta ctgtcggccc atggagaagc tggtgtacat cttggatgaa taccctgatg
      541 aggtgtctca catattcagt ccgtcctgtg tccttctgag tcgctgtagt ggctgctgtg
      601 gtgatgaagg tctgcactgt gtgccgataa agacagccaa catcactatg cagatcttga
      661 agattccccc caatcgggat ccacatttct atgtggagat gacattttct caggatgtgc
      721 tctgtgaatg cagacctatt ctggagacga caaaggcaga aaggaggaaa accaagggga
      781 agaggaagag gagtagaaac tcacagactg aggaacccca cccgtgatgt catttcccgg
      841 aggtaaccag ccactcagag gagagcccca cacccagctc acgtatttat taccgtcacc
      901 ctctcagaac cctccctgct ggtacctacc ctctatttat tagccgactc gtccctgctg
      961 aatgacgtgc cccctccaag ataaggggca tggaaggaca agacgctcag gaattcagtg
     1021 ccttaaaaca gaacgagaga gaaagaaaga agccagccac ggatctgtgg gagcttcggc
     1081 ttgggaagaa gcaagacatg gacatggcct tacaaggggc aagccgcacc ccagaggccc
     1141 tggctctcca gggaactgga gaagagaaga ggaggcctag aacctgccct gattcccagc
     1201 tccacccaga gagcagctct ggccccggct gcattgaagg catgtagagg ggacccagtc
     1261 tactgtatcc tggagatggg acaggacatt cggctctgga gagcagagct tgcctgtgga
     1321 gtttgccctt cagcctagaa gtttatgctt caccctttgc aaaggtcctt tgtcccctct
     1381 ctggaacaca ggcagagtgg cctggggctg agcagagggc aggctggagg agcagtagcc
     1441 cgtggacttt gaccgataca agtctgggtt gtgtgtcttc gtggtacagc tacgggaagt
     1501 gagccgactc ctggagggcc cttgcagccc accggttgtc tctgccggga ctaactgcca
     1561 agccagattc tcttgaataa agcattctag tctggaacc
//
