LOCUS       NM_001356332            2171 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus phosphogluconate dehydrogenase (Pgd), transcript
            variant 2, mRNA.
ACCESSION   NM_001356332 XM_017319917
VERSION     NM_001356332.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2171)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2171)
  AUTHORS   Facchinello,N., Astone,M., Audano,M., Oberkersch,R.E.,
            Spizzotin,M., Calura,E., Marques,M., Crisan,M., Mitro,N. and
            Santoro,M.M.
  TITLE     Oxidative pentose phosphate pathway controls vascular mural cell
            coverage by regulating extracellular matrix composition
  JOURNAL   Nat Metab 4 (1), 123-140 (2022)
   PUBMED   35102339
REFERENCE   3  (bases 1 to 2171)
  AUTHORS   Daneshmandi,S., Cassel,T., Higashi,R.M., Fan,T.W. and Seth,P.
  TITLE     6-Phosphogluconate dehydrogenase (6PGD), a key checkpoint in
            reprogramming of regulatory T cells metabolism and function
  JOURNAL   Elife 10, e67476 (2021)
   PUBMED   34709178
  REMARK    GeneRIF: 6-Phosphogluconate dehydrogenase (6PGD), a key checkpoint
            in reprogramming of regulatory T cells metabolism and function.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2171)
  AUTHORS   Daneshmandi,S., Cassel,T., Lin,P., Higashi,R.M., Wulf,G.M.,
            Boussiotis,V.A., Fan,T.W. and Seth,P.
  TITLE     Blockade of 6-phosphogluconate dehydrogenase generates CD8+
            effector T cells with enhanced anti-tumor function
  JOURNAL   Cell Rep 34 (10), 108831 (2021)
   PUBMED   33691103
  REMARK    GeneRIF: Blockade of 6-phosphogluconate dehydrogenase generates
            CD8(+) effector T cells with enhanced anti-tumor function.
REFERENCE   5  (bases 1 to 2171)
  AUTHORS   Gao,X., Zhao,L., Liu,S., Li,Y., Xia,S., Chen,D., Wang,M., Wu,S.,
            Dai,Q., Vu,H., Zacharias,L., DeBerardinis,R., Lim,E., Metallo,C.,
            Boggon,T.J., Lonial,S., Lin,R., Mao,H., Pan,Y., Shan,C. and Chen,J.
  TITLE     gamma-6-Phosphogluconolactone, a Byproduct of the Oxidative Pentose
            Phosphate Pathway, Contributes to AMPK Activation through
            Inhibition of PP2A
  JOURNAL   Mol Cell 76 (6), 857-871 (2019)
   PUBMED   31586547
REFERENCE   6  (bases 1 to 2171)
  AUTHORS   Lalley,P.A., Minna,J.D. and Francke,U.
  TITLE     Conservation of autosomal gene synteny groups in mouse and man
  JOURNAL   Nature 274 (5667), 160-163 (1978)
   PUBMED   662012
REFERENCE   7  (bases 1 to 2171)
  AUTHORS   Lalley,P.A., Francke,U. and Minna,J.D.
  TITLE     Homologous genes for enolase, phosphogluconate dehydrogenase,
            phosphoglucomutase, and adenylate kinase are syntenic on mouse
            chromosome 4 and human chromosome 1p
  JOURNAL   Proc Natl Acad Sci U S A 75 (5), 2382-2386 (1978)
   PUBMED   209463
REFERENCE   8  (bases 1 to 2171)
  AUTHORS   Kozak,C.A. and Ruddle,F.H.
  TITLE     Assignment of the genes for thymidine kinase and galactokinase to
            Mus musculus chromosome 11 and the preferential segregation of this
            chromosome in Chinese hamster/mouse somatic cell hybrids
  JOURNAL   Somatic Cell Genet 3 (2), 121-133 (1977)
   PUBMED   204065
REFERENCE   9  (bases 1 to 2171)
  AUTHORS   Francke,U., Lalley,P.A., Moss,W., Ivy,J. and Minna,J.D.
  TITLE     Gene mapping in Mus musculus by interspecific cell hybridization:
            assignment of the genes for tripeptidase-1 to chromosome 10,
            dipeptidase-2 to chromosome 18, acid phosphatase-1 to chromosome
            12, and adenylate kinase-1 to chromosome 2
  JOURNAL   Cytogenet Cell Genet 19 (2-3), 57-84 (1977)
   PUBMED   198184
REFERENCE   10 (bases 1 to 2171)
  AUTHORS   Krog,H.H., Wysocka,M., Kisielow,P. and Radzikowski,C.
  TITLE     Genetic characterization of important mouse strains used in cancer
            research
  JOURNAL   Hereditas 87 (2), 201-204 (1977)
   PUBMED   75870
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK145602.1, CX212251.1, AL731655.8 and AI834806.1.
            
            On Sep 29, 2017 this sequence version replaced XM_017319917.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.3600943.1,
                                           SRR7345562.4634325.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164132, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AK145602.1         86-98
            14-14               CX212251.1         74-74
            15-511              AK145602.1         100-596
            512-574             AL731655.8         39914-39976         c
            575-2156            AK145602.1         597-2178
            2157-2171           AI834806.1         7-21                c
FEATURES             Location/Qualifiers
     source          1..2171
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 78.96 cM"
     gene            1..2171
                     /gene="Pgd"
                     /gene_synonym="0610042A05Rik"
                     /note="phosphogluconate dehydrogenase"
                     /db_xref="GeneID:110208"
                     /db_xref="MGI:MGI:97553"
     exon            1..76
                     /gene="Pgd"
                     /gene_synonym="0610042A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            77..256
                     /gene="Pgd"
                     /gene_synonym="0610042A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            257..322
                     /gene="Pgd"
                     /gene_synonym="0610042A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            323..441
                     /gene="Pgd"
                     /gene_synonym="0610042A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            442..574
                     /gene="Pgd"
                     /gene_synonym="0610042A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            575..709
                     /gene="Pgd"
                     /gene_synonym="0610042A05Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             608..1507
                     /gene="Pgd"
                     /gene_synonym="0610042A05Rik"
                     /EC_number="1.1.1.44"
                     /note="isoform 2 is encoded by transcript variant 2;
                     6-phosphogluconate dehydrogenase, decarboxylating"
                     /codon_start=1
                     /product="6-phosphogluconate dehydrogenase,
                     decarboxylating isoform 2"
                     /protein_id="NP_001343261.1"
                     /db_xref="GeneID:110208"
                     /db_xref="MGI:MGI:97553"
                     /translation="MVHNGIEYGDMQLICEAYHLMKDVLGMRHEEMAQAFEEWNKTEL
                     DSFLIEITANILKYRDTDGKELLPKIRDSAGQKGTGKWTAISALEYGMPVTLIGEAVF
                     ARCLSSLKEERVQASQKLKGPKVVQLEGSKKSFLEDIRKALYASKIISYAQGFMLLRQ
                     AATEFGWTLNYGGIALMWRGGCIIRSVFLGKIKDAFERNPELQNLLLDDFFKSAVDNC
                     QDSWRRVISTGVQAGIPMPCFTTALSFYDGYRHEMLPANLIQAQRDYFGAHTYELLTK
                     PGEFIHTNWTGHGGSVSSSSYNA"
     exon            710..899
                     /gene="Pgd"
                     /gene_synonym="0610042A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1030
                     /gene="Pgd"
                     /gene_synonym="0610042A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1164
                     /gene="Pgd"
                     /gene_synonym="0610042A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1264
                     /gene="Pgd"
                     /gene_synonym="0610042A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1387
                     /gene="Pgd"
                     /gene_synonym="0610042A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..2160
                     /gene="Pgd"
                     /gene_synonym="0610042A05Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2140..2145
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pgd"
                     /gene_synonym="0610042A05Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2158
                     /gene="Pgd"
                     /gene_synonym="0610042A05Rik"
                     /note="major polyA site"
ORIGIN      
        1 agctgacatt gcactgatcg gactggctgt catgggccag aacttaattt tgaacatgaa
       61 tgatcatgga tttgtggtct gtgctttcaa taggacagtc tccaaagtcg atgacttctt
      121 ggccaacgag gcgaagggca ccaaggtggt tggtgcacag tccttaaagg acatggtctc
      181 caaactaaag aagccccgcc gggtcatcct gcttgtgaag gccgggcaag ccgtggatga
      241 tttcatcgag aaattagtac ccttgttgga cacgggtgac atcatcatcg atggaggaaa
      301 ttctgaatac cgggacacga caagaagatg ccgggacctc aaggccaagg gcatcttgtt
      361 tgtggggagc ggagtcagtg gtggtgagga aggggctcgg tacgggccgt cactcatgcc
      421 aggagggaac aaagaggctt ggccccacat caaggcgatc ttccaagcca tcgctgcaaa
      481 agtgggaacc ggagaaccct gctgtgactg ggcaagttct gggctaccct ttgacgacgt
      541 gcaccgctga agacagacca ccttggtccc agtggtggga gatgaggggg cggggcactt
      601 tgtgaagatg gtgcacaacg ggatagagta tggagacatg cagctcatct gtgaggctta
      661 ccatttgatg aaggatgttc tgggcatgcg gcatgaggag atggctcagg catttgaaga
      721 atggaacaag acagagctgg actcattcct gattgaaatc actgctaaca ttctcaagta
      781 ccgggacact gacggcaaag agctgttgcc aaagatccgg gacagtgctg ggcagaaggg
      841 cactgggaag tggaccgcca tctcggcgct ggagtacggc atgcccgtca ccctcattgg
      901 agaagctgtc tttgctcggt gcttgtcctc tctgaaggag gagcgggttc aggccagcca
      961 aaagctgaag ggtcctaagg tggtccagct ggaaggcagt aagaagtcat tcctggagga
     1021 catccgtaag gccctctatg cttccaagat catctcctac gcccaaggct ttatgctgct
     1081 cagacaggca gccactgagt ttggctggac cctcaattat ggcggcattg ccctgatgtg
     1141 gagagggggc tgcatcatcc gaagtgtgtt cctgggaaaa attaaagatg catttgagcg
     1201 aaacccagaa cttcagaacc tactgctaga tgacttcttt aagtcagcag ttgacaactg
     1261 ccaggactcc tggcggcggg tgatcagcac tggggtgcaa gcaggcattc ccatgccctg
     1321 cttcactact gccctctcct tctatgatgg gtacagacac gagatgctgc cagcaaacct
     1381 catccaggct caacgggatt actttggggc tcacacctat gaactcttaa ccaaaccggg
     1441 agaatttatc cacaccaact ggacgggcca cgggggcagt gtgtcatcct cttcatacaa
     1501 tgcctagtag gcctgtggct tgccctccct cccagcaata ggacagcccc gtggcgctca
     1561 gcaccccccc tttgccctag ttcctgctct tagccaagtg ttggctgtga ttgctgaaga
     1621 agtcaccgag gtctatagtt tctgaaccac cacatgctcc acctccgtct ctgtgctgcc
     1681 caggacctga ccctgtgctg ccactgcgtg acctgaccct gtgcgccact gcgtgaccac
     1741 tccctgactg agccgtgcca tgtggaccag acaagctgca gctcttagct cacagagggg
     1801 gtgggtgtgt gggatcgtac aacctggacg tggaccatgc gtgtgggctc tgctgtcctc
     1861 cagtcagtga agtgtatatg gttacactct ctgggtgtgc ctggcagaac gatctgcact
     1921 gagttcacta ttgcaaattg atttgttttc ctttagcctt gttcactttt aactccggct
     1981 ttttttaaag actccaaata aaacaggaca ggtagtgagt aaatctggag ggaggtgcag
     2041 agccgaggag tcggtgggca gaggctctcc tgtcgggtat ttcttactgg cacagtaggt
     2101 acctggatgt tcacagagca tccgccccgt cccacttgta ataaactttt agactggttt
     2161 aaaaaaaaaa a
//
