LOCUS       NM_001081274            2227 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus phosphogluconate dehydrogenase (Pgd), transcript
            variant 1, mRNA.
ACCESSION   NM_001081274 XM_622094
VERSION     NM_001081274.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2227)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2227)
  AUTHORS   Facchinello,N., Astone,M., Audano,M., Oberkersch,R.E.,
            Spizzotin,M., Calura,E., Marques,M., Crisan,M., Mitro,N. and
            Santoro,M.M.
  TITLE     Oxidative pentose phosphate pathway controls vascular mural cell
            coverage by regulating extracellular matrix composition
  JOURNAL   Nat Metab 4 (1), 123-140 (2022)
   PUBMED   35102339
REFERENCE   3  (bases 1 to 2227)
  AUTHORS   Daneshmandi,S., Cassel,T., Higashi,R.M., Fan,T.W. and Seth,P.
  TITLE     6-Phosphogluconate dehydrogenase (6PGD), a key checkpoint in
            reprogramming of regulatory T cells metabolism and function
  JOURNAL   Elife 10, e67476 (2021)
   PUBMED   34709178
  REMARK    GeneRIF: 6-Phosphogluconate dehydrogenase (6PGD), a key checkpoint
            in reprogramming of regulatory T cells metabolism and function.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2227)
  AUTHORS   Daneshmandi,S., Cassel,T., Lin,P., Higashi,R.M., Wulf,G.M.,
            Boussiotis,V.A., Fan,T.W. and Seth,P.
  TITLE     Blockade of 6-phosphogluconate dehydrogenase generates CD8+
            effector T cells with enhanced anti-tumor function
  JOURNAL   Cell Rep 34 (10), 108831 (2021)
   PUBMED   33691103
  REMARK    GeneRIF: Blockade of 6-phosphogluconate dehydrogenase generates
            CD8(+) effector T cells with enhanced anti-tumor function.
REFERENCE   5  (bases 1 to 2227)
  AUTHORS   Gao,X., Zhao,L., Liu,S., Li,Y., Xia,S., Chen,D., Wang,M., Wu,S.,
            Dai,Q., Vu,H., Zacharias,L., DeBerardinis,R., Lim,E., Metallo,C.,
            Boggon,T.J., Lonial,S., Lin,R., Mao,H., Pan,Y., Shan,C. and Chen,J.
  TITLE     gamma-6-Phosphogluconolactone, a Byproduct of the Oxidative Pentose
            Phosphate Pathway, Contributes to AMPK Activation through
            Inhibition of PP2A
  JOURNAL   Mol Cell 76 (6), 857-871 (2019)
   PUBMED   31586547
REFERENCE   6  (bases 1 to 2227)
  AUTHORS   Lalley,P.A., Minna,J.D. and Francke,U.
  TITLE     Conservation of autosomal gene synteny groups in mouse and man
  JOURNAL   Nature 274 (5667), 160-163 (1978)
   PUBMED   662012
REFERENCE   7  (bases 1 to 2227)
  AUTHORS   Lalley,P.A., Francke,U. and Minna,J.D.
  TITLE     Homologous genes for enolase, phosphogluconate dehydrogenase,
            phosphoglucomutase, and adenylate kinase are syntenic on mouse
            chromosome 4 and human chromosome 1p
  JOURNAL   Proc Natl Acad Sci U S A 75 (5), 2382-2386 (1978)
   PUBMED   209463
REFERENCE   8  (bases 1 to 2227)
  AUTHORS   Kozak,C.A. and Ruddle,F.H.
  TITLE     Assignment of the genes for thymidine kinase and galactokinase to
            Mus musculus chromosome 11 and the preferential segregation of this
            chromosome in Chinese hamster/mouse somatic cell hybrids
  JOURNAL   Somatic Cell Genet 3 (2), 121-133 (1977)
   PUBMED   204065
REFERENCE   9  (bases 1 to 2227)
  AUTHORS   Francke,U., Lalley,P.A., Moss,W., Ivy,J. and Minna,J.D.
  TITLE     Gene mapping in Mus musculus by interspecific cell hybridization:
            assignment of the genes for tripeptidase-1 to chromosome 10,
            dipeptidase-2 to chromosome 18, acid phosphatase-1 to chromosome
            12, and adenylate kinase-1 to chromosome 2
  JOURNAL   Cytogenet Cell Genet 19 (2-3), 57-84 (1977)
   PUBMED   198184
REFERENCE   10 (bases 1 to 2227)
  AUTHORS   Krog,H.H., Wysocka,M., Kisielow,P. and Radzikowski,C.
  TITLE     Genetic characterization of important mouse strains used in cancer
            research
  JOURNAL   Hereditas 87 (2), 201-204 (1977)
   PUBMED   75870
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX215938.1, AK145602.1, CX212251.1 and AI834806.1.
            
            On Sep 29, 2017 this sequence version replaced NM_001081274.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK145602.1, BC011329.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                CX215938.1         1-34
            35-132              AK145602.1         1-98
            133-133             CX212251.1         74-74
            134-2212            AK145602.1         100-2178
            2213-2227           AI834806.1         7-21                c
FEATURES             Location/Qualifiers
     source          1..2227
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 78.96 cM"
     gene            1..2227
                     /gene="Pgd"
                     /gene_synonym="0610042A05Rik"
                     /note="phosphogluconate dehydrogenase"
                     /db_xref="GeneID:110208"
                     /db_xref="MGI:MGI:97553"
     exon            1..119
                     /gene="Pgd"
                     /gene_synonym="0610042A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            120..195
                     /gene="Pgd"
                     /gene_synonym="0610042A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            196..375
                     /gene="Pgd"
                     /gene_synonym="0610042A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            376..441
                     /gene="Pgd"
                     /gene_synonym="0610042A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            442..560
                     /gene="Pgd"
                     /gene_synonym="0610042A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            561..630
                     /gene="Pgd"
                     /gene_synonym="0610042A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            631..765
                     /gene="Pgd"
                     /gene_synonym="0610042A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            766..955
                     /gene="Pgd"
                     /gene_synonym="0610042A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1086
                     /gene="Pgd"
                     /gene_synonym="0610042A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1220
                     /gene="Pgd"
                     /gene_synonym="0610042A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1320
                     /gene="Pgd"
                     /gene_synonym="0610042A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1443
                     /gene="Pgd"
                     /gene_synonym="0610042A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..2216
                     /gene="Pgd"
                     /gene_synonym="0610042A05Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2196..2201
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pgd"
                     /gene_synonym="0610042A05Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2214
                     /gene="Pgd"
                     /gene_synonym="0610042A05Rik"
                     /note="major polyA site"
ORIGIN      
        1 cgtctctgta agcctctcga ggcgccggga gccggacttc actgtacttg cctcggagcg
       61 ctcggtcctt cgcgtttctt cctcctcgac tctgcttcgt ctgcctccgc catggcccaa
      121 gctgacattg cactgatcgg actggctgtc atgggccaga acttaatttt gaacatgaat
      181 gatcatggat ttgtggtctg tgctttcaat aggacagtct ccaaagtcga tgacttcttg
      241 gccaacgagg cgaagggcac caaggtggtt ggtgcacagt ccttaaagga catggtctcc
      301 aaactaaaga agccccgccg ggtcatcctg cttgtgaagg ccgggcaagc cgtggatgat
      361 ttcatcgaga aattagtacc cttgttggac acgggtgaca tcatcatcga tggaggaaat
      421 tctgaatacc gggacacgac aagaagatgc cgggacctca aggccaaggg catcttgttt
      481 gtggggagcg gagtcagtgg tggtgaggaa ggggctcggt acgggccgtc actcatgcca
      541 ggagggaaca aagaggcttg gccccacatc aaggcgatct tccaagccat cgctgcaaaa
      601 gtgggaaccg gagaaccctg ctgtgactgg gtgggagatg agggggcggg gcactttgtg
      661 aagatggtgc acaacgggat agagtatgga gacatgcagc tcatctgtga ggcttaccat
      721 ttgatgaagg atgttctggg catgcggcat gaggagatgg ctcaggcatt tgaagaatgg
      781 aacaagacag agctggactc attcctgatt gaaatcactg ctaacattct caagtaccgg
      841 gacactgacg gcaaagagct gttgccaaag atccgggaca gtgctgggca gaagggcact
      901 gggaagtgga ccgccatctc ggcgctggag tacggcatgc ccgtcaccct cattggagaa
      961 gctgtctttg ctcggtgctt gtcctctctg aaggaggagc gggttcaggc cagccaaaag
     1021 ctgaagggtc ctaaggtggt ccagctggaa ggcagtaaga agtcattcct ggaggacatc
     1081 cgtaaggccc tctatgcttc caagatcatc tcctacgccc aaggctttat gctgctcaga
     1141 caggcagcca ctgagtttgg ctggaccctc aattatggcg gcattgccct gatgtggaga
     1201 gggggctgca tcatccgaag tgtgttcctg ggaaaaatta aagatgcatt tgagcgaaac
     1261 ccagaacttc agaacctact gctagatgac ttctttaagt cagcagttga caactgccag
     1321 gactcctggc ggcgggtgat cagcactggg gtgcaagcag gcattcccat gccctgcttc
     1381 actactgccc tctccttcta tgatgggtac agacacgaga tgctgccagc aaacctcatc
     1441 caggctcaac gggattactt tggggctcac acctatgaac tcttaaccaa accgggagaa
     1501 tttatccaca ccaactggac gggccacggg ggcagtgtgt catcctcttc atacaatgcc
     1561 tagtaggcct gtggcttgcc ctccctccca gcaataggac agccccgtgg cgctcagcac
     1621 cccccctttg ccctagttcc tgctcttagc caagtgttgg ctgtgattgc tgaagaagtc
     1681 accgaggtct atagtttctg aaccaccaca tgctccacct ccgtctctgt gctgcccagg
     1741 acctgaccct gtgctgccac tgcgtgacct gaccctgtgc gccactgcgt gaccactccc
     1801 tgactgagcc gtgccatgtg gaccagacaa gctgcagctc ttagctcaca gagggggtgg
     1861 gtgtgtggga tcgtacaacc tggacgtgga ccatgcgtgt gggctctgct gtcctccagt
     1921 cagtgaagtg tatatggtta cactctctgg gtgtgcctgg cagaacgatc tgcactgagt
     1981 tcactattgc aaattgattt gttttccttt agccttgttc acttttaact ccggcttttt
     2041 ttaaagactc caaataaaac aggacaggta gtgagtaaat ctggagggag gtgcagagcc
     2101 gaggagtcgg tgggcagagg ctctcctgtc gggtatttct tactggcaca gtaggtacct
     2161 ggatgttcac agagcatccg ccccgtccca cttgtaataa acttttagac tggtttaaaa
     2221 aaaaaaa
//
