LOCUS       NM_025973               1384 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus progastricsin (pepsinogen C) (Pgc), mRNA.
ACCESSION   NM_025973
VERSION     NM_025973.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1384)
  AUTHORS   E,Y., Yu,Q., Sun,T., Xue,H., Zhao,X.R. and Zheng,H.C.
  TITLE     The relationship between pepsinogen C and gastric carcinogenesis: a
            transgene and population study
  JOURNAL   BMC Cancer 23 (1), 520 (2023)
   PUBMED   37291517
  REMARK    GeneRIF: The relationship between pepsinogen C and gastric
            carcinogenesis: a transgene and population study.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1384)
  AUTHORS   Ng,L., Liu,H., Liu,Y. and Forrest,D.
  TITLE     Biphasic expression of thyroid hormone receptor TRbeta1 in
            mammalian retina and anterior ocular tissues
  JOURNAL   Front Endocrinol (Lausanne) 14, 1174600 (2023)
   PUBMED   37033230
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1384)
  AUTHORS   Lee,J.H., Kim,S., Han,S., Min,J., Caldwell,B., Bamford,A.D.,
            Rocha,A.S.B., Park,J., Lee,S., Wu,S.S., Lee,H., Fink,J.,
            Pilat-Carotta,S., Kim,J., Josserand,M., Szep-Bakonyi,R., An,Y.,
            Ju,Y.S., Philpott,A., Simons,B.D., Stange,D.E., Choi,E., Koo,B.K.
            and Kim,J.K.
  TITLE     p57Kip2 imposes the reserve stem cell state of gastric chief cells
  JOURNAL   Cell Stem Cell 29 (5), 826-839 (2022)
   PUBMED   35523142
REFERENCE   4  (bases 1 to 1384)
  AUTHORS   Douchi,D., Yamamura,A., Matsuo,J., Melissa Lim,Y.H.,
            Nuttonmanit,N., Shimura,M., Suda,K., Chen,S., Pang,S., Kohu,K.,
            Abe,T., Shioi,G., Kim,G., Shabbir,A., Srivastava,S., Unno,M.,
            Bok-Yan So,J., Teh,M., Yeoh,K.G., Chuang,L.S.H. and Ito,Y.
  TITLE     Induction of Gastric Cancer by Successive Oncogenic Activation in
            the Corpus
  JOURNAL   Gastroenterology 161 (6), 1907-1923 (2021)
   PUBMED   34391772
REFERENCE   5  (bases 1 to 1384)
  AUTHORS   Sayols,S., Klassek,J., Werner,C., Mockel,S., Ritz,S.,
            Mendez-Lago,M. and Soshnikova,N.
  TITLE     Signalling codes for the maintenance and lineage commitment of
            embryonic gastric epithelial progenitors
  JOURNAL   Development 147 (18) (2020)
   PUBMED   32878924
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1384)
  AUTHORS   Nadeau,J.H., Herrmann,B., Bucan,M., Burkart,D., Crosby,J.L.,
            Erhart,M.A., Kosowsky,M., Kraus,J.P., Michiels,F., Schnattinger,A.
            et al.
  TITLE     Genetic maps of mouse chromosome 17 including 12 new anonymous DNA
            loci and 25 anchor loci
  JOURNAL   Genomics 9 (1), 78-89 (1991)
   PUBMED   1672293
REFERENCE   7  (bases 1 to 1384)
  AUTHORS   Sertic,J., Vincek,V., Ledley,F.D., Figueroa,F. and Klein,J.
  TITLE     Mapping of the L-methylmalonyl-CoA mutase gene to mouse chromosome
            17
  JOURNAL   Genomics 6 (3), 560-564 (1990)
   PUBMED   1970332
REFERENCE   8  (bases 1 to 1384)
  AUTHORS   Richards,S., Bucan,M., Brorson,K., Kiefer,M.C., Hunt,S.W. 3rd,
            Lehrach,H. and Lindahl,K.F.
  TITLE     Genetic and molecular mapping of the Hmt region of mouse
  JOURNAL   EMBO J 8 (12), 3749-3757 (1989)
   PUBMED   2573520
REFERENCE   9  (bases 1 to 1384)
  AUTHORS   Vincek,V., Kawaguchi,H., Mizuno,K., Zaleska-Rutczynska,Z.,
            Kasahara,M., Forejt,J., Figueroa,F. and Klein,J.
  TITLE     Linkage map of mouse chromosome 17: localization of 27 new DNA
            markers
  JOURNAL   Genomics 5 (4), 773-786 (1989)
   PUBMED   2574145
REFERENCE   10 (bases 1 to 1384)
  AUTHORS   Skow,L.C. and Donner,M.E.
  TITLE     The locus encoding alpha A-crystallin is closely linked to H-2K on
            mouse chromosome 17
  JOURNAL   Genetics 110 (4), 723-732 (1985)
   PUBMED   2993101
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK008959.1.
            
            On Apr 6, 2007 this sequence version replaced NM_025973.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK008959.1, AK008886.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1384              AK008959.1         2-1385
FEATURES             Location/Qualifiers
     source          1..1384
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 23.98 cM"
     gene            1..1384
                     /gene="Pgc"
                     /gene_synonym="2210410L06Rik; Upg-1; Upg1"
                     /note="progastricsin (pepsinogen C)"
                     /db_xref="GeneID:109820"
                     /db_xref="MGI:MGI:98909"
     exon            1..123
                     /gene="Pgc"
                     /gene_synonym="2210410L06Rik; Upg-1; Upg1"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..1243
                     /gene="Pgc"
                     /gene_synonym="2210410L06Rik; Upg-1; Upg1"
                     /EC_number="3.4.23.3"
                     /note="urinary pepsinogen 1; gastricsin; pepsinogen C"
                     /codon_start=1
                     /product="gastricsin precursor"
                     /protein_id="NP_080249.2"
                     /db_xref="CCDS:CCDS28855.1"
                     /db_xref="GeneID:109820"
                     /db_xref="MGI:MGI:98909"
                     /translation="MKWMVVALLCLPLLEAALIRVPLKKMKSIRETMKEQGVLKDFLK
                     NHKYDPGQKYHFGKFGDYSVLYEPMAYMDASYYGEISIGTPPQNFLVLFDTGSSNLWV
                     SSVYCQSEACTTHTRYNPSKSSTYYTQGQTFSLQYGTGSLTGFFGYDTLRVQSIQVPN
                     QEFGLSENEPGTNFVYAQFDGIMGLAYPGLSSGGATTALQGMLGEGALSQPLFGVYLG
                     SQQGSNGGQIVFGGVDENLYTGELTWIPVTQELYWQITIDDFLIGNQASGWCSSSGCQ
                     GIVDTGTSLLVMPAQYLNELLQTIGAQEGEYGQYFVSCDSVSSLPTLTFVLNGVQFPL
                     SPSSYIIQEEGSCMVGLESLSLNAESGQPLWILGDVFLRSYYAVFDMGNNRVGLAPSV
                     "
     exon            124..283
                     /gene="Pgc"
                     /gene_synonym="2210410L06Rik; Upg-1; Upg1"
                     /inference="alignment:Splign:2.1.0"
     exon            284..401
                     /gene="Pgc"
                     /gene_synonym="2210410L06Rik; Upg-1; Upg1"
                     /inference="alignment:Splign:2.1.0"
     exon            402..520
                     /gene="Pgc"
                     /gene_synonym="2210410L06Rik; Upg-1; Upg1"
                     /inference="alignment:Splign:2.1.0"
     exon            521..720
                     /gene="Pgc"
                     /gene_synonym="2210410L06Rik; Upg-1; Upg1"
                     /inference="alignment:Splign:2.1.0"
     exon            721..840
                     /gene="Pgc"
                     /gene_synonym="2210410L06Rik; Upg-1; Upg1"
                     /inference="alignment:Splign:2.1.0"
     exon            841..991
                     /gene="Pgc"
                     /gene_synonym="2210410L06Rik; Upg-1; Upg1"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1090
                     /gene="Pgc"
                     /gene_synonym="2210410L06Rik; Upg-1; Upg1"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1384
                     /gene="Pgc"
                     /gene_synonym="2210410L06Rik; Upg-1; Upg1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1384
                     /gene="Pgc"
                     /gene_synonym="2210410L06Rik; Upg-1; Upg1"
                     /note="putative"
ORIGIN      
        1 actccaccgc aacggtcgag ctcgaagtga tttcttccag tgagaccagc tgcaaaccgg
       61 catcatgaag tggatggtgg tcgccttgct ctgcctccca ctcctggagg cagctttgat
      121 cagggtcccc ctgaagaaaa tgaagagtat ccgggagacc atgaaggaac aaggtgtcct
      181 caaagacttt ctgaagaacc acaagtatga ccctggccag aaataccact ttggcaagtt
      241 tggtgactac agtgtactct atgagcccat ggcctatatg gatgcttcct actatggtga
      301 gatcagcatc gggactccac cccagaactt cctggtcctt ttcgacactg gctcctccaa
      361 cctgtgggtg tcttctgtct actgccagag cgaggcctgc accacacaca cccgctacaa
      421 ccccagcaag tcctccacct actacactca agggcagacc ttctccctgc agtacggcac
      481 cggcagcctt accggcttct tcggctatga cactctgaga gtccaaagca tccaggtccc
      541 taaccaggag ttcggcctga gtgagaatga gcctggcacc aattttgtct acgcccaatt
      601 tgacgggatc atgggcctgg cctaccccgg cctgtcttca gggggcgcca ccaccgcctt
      661 gcagggcatg ttgggggagg gcgctctgtc ccagcccctc ttcggtgtct accttggcag
      721 ccagcagggg tctaacggcg ggcagattgt gttcggtggc gtggacgaga acctgtacac
      781 tggcgagctc acctggattc ctgtcaccca ggagctttac tggcagatca ccattgacga
      841 cttccttatt ggcaaccagg cctctggctg gtgctcctcc tctggctgcc aaggcattgt
      901 agacacaggc acctctctgc tcgtcatgcc tgcccagtac ctgaatgaac ttctgcagac
      961 cataggagcc caggaaggag agtatggaca gtattttgtg agctgcgaca gcgtcagtag
     1021 cctgcctacc ctcacttttg tcctcaatgg tgtccagttc cccctgtcac cctcttccta
     1081 catcatccag gaggaaggct cctgcatggt gggtctggag agcctctccc tgaacgctga
     1141 gagtggccag cccctctgga tcctcgggga tgtcttcctc aggtcttact atgctgtctt
     1201 cgacatgggc aataacaggg tgggccttgc cccttctgtc tagacttgac atctagacaa
     1261 accccccccc cacccccgtg cccttccttc ttcccctcag cctgtcccat ctgccccgcc
     1321 tctctgtatc cagctttcct tttctggaaa cctagacatt ccctaataat aaatagtcct
     1381 ccat
//
