LOCUS       NM_171824               3379 bp    mRNA    linear   ROD 15-OCT-2024
DEFINITION  Mus musculus piggyBac transposable element derived 5 (Pgbd5), mRNA.
ACCESSION   NM_171824
VERSION     NM_171824.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3379)
  AUTHORS   Zapater,L.J., Lewis,S.A., Gutierrez,R.L., Yamada,M.,
            Rodriguez-Fos,E., Planas-Felix,M., Cameron,D., Demarest,P.,
            Nabila,A., Mueller,H., Zhao,J., Bergin,P., Reed,C.,
            Chwat-Edelstein,T., Pagnozzi,A., Nava,C., Bourel-Ponchel,E.,
            Cornejo,P., Dursun,A., Ozgul,R.K., Akar,H.T., Maroofian,R.,
            Houlden,H., Cheema,H.A., Anjum,M.N., Zifarelli,G., Essid,M., Ben
            Hafsa,M., Benrhouma,H., Montoya,C.I.G., Proekt,A., Zhao,X.,
            Socci,N.D., Hayes,M., Bigot,Y., Rabadan,R., Torrents,D.,
            Kleinmann,C.L., Kruer,M.C., Toth,M. and Kentsis,A.
  TITLE     A transposase-derived gene required for human brain development
  JOURNAL   bioRxiv (2024)
   PUBMED   37163102
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3379)
  AUTHORS   Luo,P., Yang,J., Jian,L., Dong,J., Yin,S., Luo,C. and Zhou,S.
  TITLE     Knockdown of PGBD5 inhibits the malignant progression of glioma
            through upregulation of the PPAR pathway
  JOURNAL   Int J Oncol 64 (5) (2024)
   PUBMED   38577941
  REMARK    GeneRIF: Knockdown of PGBD5 inhibits the malignant progression of
            glioma through upregulation of the PPAR pathway.
REFERENCE   3  (bases 1 to 3379)
  AUTHORS   Yamada,M., Keller,R.R., Gutierrez,R.L., Cameron,D., Suzuki,H.,
            Sanghrajka,R., Vaynshteyn,J., Gerwin,J., Maura,F., Hooper,W.,
            Shah,M., Robine,N., Demarest,P., Bayin,N.S., Zapater,L.J., Reed,C.,
            Hebert,S., Masilionis,I., Chaligne,R., Socci,N.D., Taylor,M.D.,
            Kleinman,C.L., Joyner,A.L., Raju,G.P. and Kentsis,A.
  TITLE     Childhood cancer mutagenesis caused by transposase-derived PGBD5
  JOURNAL   Sci Adv 10 (12), eadn4649 (2024)
   PUBMED   38517960
  REMARK    GeneRIF: Childhood cancer mutagenesis caused by transposase-derived
            PGBD5.
REFERENCE   4  (bases 1 to 3379)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 3379)
  AUTHORS   Isbel,L., Srivastava,R., Oey,H., Spurling,A., Daxinger,L.,
            Puthalakath,H. and Whitelaw,E.
  TITLE     Trim33 Binds and Silences a Class of Young Endogenous Retroviruses
            in the Mouse Testis; a Novel Component of the Arms Race between
            Retrotransposons and the Host Genome
  JOURNAL   PLoS Genet 11 (12), e1005693 (2015)
   PUBMED   26624618
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3379)
  AUTHORS   Pavelitz,T., Gray,L.T., Padilla,S.L., Bailey,A.D. and Weiner,A.M.
  TITLE     PGBD5: a neural-specific intron-containing piggyBac transposase
            domesticated over 500 million years ago and conserved from
            cephalochordates to humans
  JOURNAL   Mob DNA 4 (1), 23 (2013)
   PUBMED   24180413
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3379)
  AUTHORS   Sarkar,A., Sim,C., Hong,Y.S., Hogan,J.R., Fraser,M.J.,
            Robertson,H.M. and Collins,F.H.
  TITLE     Molecular evolutionary analysis of the widespread piggyBac
            transposon family and related 'domesticated' sequences
  JOURNAL   Mol Genet Genomics 270 (2), 173-180 (2003)
   PUBMED   12955498
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. This record has been curated by NCBI staff in
            collaboration with Hugh Robertson. The reference sequence was
            derived from AC126930.4 and AC114005.5.
            
            On Jun 17, 2022 this sequence version replaced NM_171824.2.
            
            Summary: The piggyBac family of proteins, found in diverse animals,
            are transposases related to the transposase of the canonical
            piggyBac transposon from the moth, Trichoplusia ni. This family
            also includes genes in several genomes that appear to have been
            derived from the piggyBac transposons. This gene belongs to the
            subfamily of piggyBac transposable element derived (PGBD) genes.
            The PGBD proteins appear to be novel, with no obvious relationship
            to other transposases, or other known protein families. The exact
            function of this gene is not known. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7974084.24513.1,
                                           SRR7345562.2945181.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-693               AC126930.4         149182-149874
            694-1121            AC114005.5         43197-43624
            1122-1256           AC114005.5         47501-47635
            1257-1437           AC114005.5         51529-51709
            1438-1635           AC114005.5         53376-53573
            1636-1741           AC114005.5         55862-55967
            1742-3379           AC114005.5         57133-58770
FEATURES             Location/Qualifiers
     source          1..3379
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 72.65 cM"
     gene            1..3379
                     /gene="Pgbd5"
                     /gene_synonym="2900019M05Rik"
                     /note="piggyBac transposable element derived 5"
                     /db_xref="GeneID:209966"
                     /db_xref="MGI:MGI:2429955"
     exon            1..693
                     /gene="Pgbd5"
                     /gene_synonym="2900019M05Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             366..1937
                     /gene="Pgbd5"
                     /gene_synonym="2900019M05Rik"
                     /note="piggyBac transposase 5"
                     /codon_start=1
                     /product="piggyBac transposable element-derived protein 5"
                     /protein_id="NP_741958.2"
                     /db_xref="CCDS:CCDS22770.1"
                     /db_xref="GeneID:209966"
                     /db_xref="MGI:MGI:2429955"
                     /translation="MAEGGGGSRRRAPALLEAARARYESLHISDDVFGESGPDSGGNP
                     FYSTSAASRSSSAASSDDERERPAPPGTAPPSYAADPLELEEDETGGGWSAVLRDRPS
                     PRFEDTGGPTRKMPPSASAVDFFQLFVPDNVLKNMVVQTNMYARKFQERFGSDGAWVE
                     VTLAEMKAFLGYVISTSVSHCESVLSIWSGGFYSNRSLALVMSQARFEKILKYFHVVA
                     FRSSQTTHGLYKVQPFLDSLQSGFDAAFRPSQTQVLHEPLIDEDPVFIATCTERELRK
                     RKKRKFSLWVRQCSSTGFIIQIYVHLKEGGGPDGLDALKNKPQLHSMVARSLCRNAAG
                     KNYIIFTGPSITSLNLFEEFEKQGIYCCGLLSSRKSDCTGLPPSMLTNPATPLARGQH
                     QIRTKGNMSLICWYNKGHFRFLTNAYSPVQKGVIIKRRSGEIPCPLAVEAFAAHLSYI
                     CRYDDKYSKYFISHKPNKTWQQVFWFAISIAVNNAYILYKMSDAYHVKKYSRAQFGER
                     LVRELLGLEDSSPAH"
     exon            694..1121
                     /gene="Pgbd5"
                     /gene_synonym="2900019M05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1256
                     /gene="Pgbd5"
                     /gene_synonym="2900019M05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1437
                     /gene="Pgbd5"
                     /gene_synonym="2900019M05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1635
                     /gene="Pgbd5"
                     /gene_synonym="2900019M05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1636..1741
                     /gene="Pgbd5"
                     /gene_synonym="2900019M05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1742..3379
                     /gene="Pgbd5"
                     /gene_synonym="2900019M05Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3357..3362
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pgbd5"
                     /gene_synonym="2900019M05Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3379
                     /gene="Pgbd5"
                     /gene_synonym="2900019M05Rik"
                     /note="major polyA site"
ORIGIN      
        1 gggcccggtc cacggctcgc gcccgggaag gtcggcggcg caacgcggtt gccgcgggga
       61 gggtgcgcgg ggacgcgacg gggccgggcg cggcggagac gcagcgggtg ggggcggcgg
      121 cggctctggg cagcggctga gtctcttccc gccgcggccg cagccagcgg cgcccgagct
      181 ccaaggcgca tcccgggcgc gcggcccgag cggccaagac ggcgggccgg ccgggcgcgg
      241 ggcggcgcgc gctgtgctgc gggctgcgct ggtggggagc cacgggccgc ggcgggggtc
      301 ccgggcccgg cgtgtgcggc tgggaggcgc tgtggggtgt gggcgcgcgg gcggcggccg
      361 gggctatggc cgagggcggt gggggctcac ggaggagggc tccggcgctg ctggaggcag
      421 cccgtgcacg ctacgagagc ctgcacatct cggacgacgt gttcggcgag tcgggcccgg
      481 acagcggcgg gaaccccttt tacagcacct ccgcagcctc acgctcctcc tcggccgcct
      541 cctcggacga tgagcgtgag cgccccgcgc ctccggggac cgccccgcca tcctacgccg
      601 cggatccctt ggaactcgag gaggacgaga ccggtggggg ctggagcgcc gtgctgaggg
      661 atcgcccgtc cccgcgcttc gaggacaccg gtggtccaac cagaaagatg ccacccagcg
      721 ctagcgcggt ggacttcttc cagctcttcg tcccggacaa cgtgctcaag aacatggtgg
      781 tacagaccaa catgtatgcc aggaagttcc aggagcggtt tggcagtgac ggtgcctggg
      841 tggaggtgac gttggcagag atgaaggcct tcctgggcta tgtgatctcc accagcgtct
      901 cgcactgtga gtcggtactc agcatttgga gcggaggctt ctatagcaac cggagccttg
      961 ccctcgtcat gagccaggcc cgcttcgaga aaatcctcaa gtacttccat gttgtggcct
     1021 tccgatccag ccagaccacg catgggctct acaaggtcca gcccttcctc gactccctgc
     1081 agagtggctt tgatgctgct ttcaggccgt ctcagaccca ggtgctacat gaacccctga
     1141 ttgacgagga ccctgtgttc attgccacgt gcacggagcg agagctgcgg aagaggaaaa
     1201 agcggaaatt cagcctgtgg gtccgccagt gctcttcaac cgggttcatc atccagatct
     1261 acgtccacct aaaggaaggt ggtggcccag atggcctgga cgctctgaag aacaagccac
     1321 agctgcacag catggtggcc cggagcctgt gccggaacgc ggccggaaag aactatatca
     1381 tctttacagg gcccagcatc accagcctca atctgttcga agaatttgag aagcaaggga
     1441 tctactgctg tggcctcctc agctctagga agagtgactg cacaggtctc cctccatcca
     1501 tgttgaccaa ccctgccacc ccactcgccc ggggccagca ccagatcagg acaaagggca
     1561 acatgtcact gatctgctgg tacaacaagg ggcacttccg cttcctgacc aacgcctact
     1621 cccctgtgca gaaaggcgtc atcatcaaga ggaggagtgg ggaaatcccc tgccctctgg
     1681 ccgtggaggc ctttgcggct cacctcagct acatctgcag atatgacgat aagtacagca
     1741 agtatttcat ctctcacaag ccaaacaaga cgtggcagca agtgttctgg ttcgccatca
     1801 gcatcgccgt caacaacgcc tacatcctgt acaaaatgtc agacgcctac cacgtgaaga
     1861 agtacagccg ggcacagttc ggagagagac ttgtcaggga gttgctgggc ttggaggact
     1921 catcgccagc ccactgagac tgctggccca ggggtgtcag ggacaaggaa ggagcctgtc
     1981 acctgcctgc tggctggagg gctcatgtgt ggtcagaagt ctgctttcca catcaccccc
     2041 cacaaagggt ggctccccag agcctgatac aggtgacctc ggaaggtacc agcagtagga
     2101 ccagtggacc gtgctccgct ttccagagtg tgaaagatca tgacgggctc aagttcagac
     2161 caggcaagct tacaaaatgg acccctcggt gccaccccac agcatccggg gcatgggttc
     2221 ctagcactct cccatgagat cagcttagat ggctcccttg gaagaagaga tgcagtgtgg
     2281 tgccattaaa actcagagcc agggggggca ggggcggctg cagcttgctg actgtaaaca
     2341 gggtgctcct gttctgtcct ccacgggact gcagcgagca gggcgaggag gggagaacaa
     2401 tgccgggttt ttgttttttt tttttgtttt ggttggttgt tttgttttgt tttgttttca
     2461 atgtatcttc aggttaattc cctactgttg cttaaggtct actgtgaaca gatgtgcccc
     2521 ccactcccca ctctctgaca ccacatacct tcacagctcc ctgcatgatc acagttctgt
     2581 ttctggcctg tggcaggtta ggaagggccg ctggcttcca ggacagatgt agctagctat
     2641 ggctaccaag gcctggggag cctgcagact gaatactctg tcaccttgtc actgttggca
     2701 gaattacctg tcttgagaac tctatagcat catgaaaaca aaatccttca cctccctctg
     2761 tctgtgagaa tggggtcccc tagaaagtca cagcaggatt aggaggccct ggctggggac
     2821 tgaccctgtg ggatctccca taggcccagg tccttcccac cagaggttga catctctcca
     2881 tggagcctga gcctcaaggt gggcccactg tccccacaga tgggatacaa ggatttttcc
     2941 acaccttgca gcccttcctc ctgatctaat ggcacctaat gtccccagat gcagactgtc
     3001 ctcggcaggg gctttggggc acttcctcat cctttcagtg agccgaggcg tggctggcag
     3061 cagaatgctc tccacacctt gtcacatctg tgtccactct ctccacaagc accctcgcct
     3121 gcggtgggac ccgcaatgcc acagatcaca ggcccaactt cagtttgtgt ttaagataac
     3181 ctttgctgta cccttaatgg gatcaaaagc actttcacca cacggagaaa tatattttca
     3241 atttgtgatg cttttctaca aggcccactc ttcctgagtt caggtgtttc caacgcttag
     3301 ggagcctaat gaaggccaat gactttttct tttctgtcca aacaagaaaa ataaaaaata
     3361 aaagtctatt tagatgtcg
//
