LOCUS       NM_001163538            2079 bp    mRNA    linear   ROD 03-SEP-2024
DEFINITION  Mus musculus phosphoglycerate mutase family member 5 (Pgam5),
            transcript variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001163538
VERSION     NM_001163538.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2079)
  AUTHORS   Du,Y., He,J., Xu,Y., Wu,X., Cheng,H., Yu,J., Wang,X., An,Y., Wu,Y.
            and Guo,W.
  TITLE     SIRT6 prevent chronic cerebral hypoperfusion induced cognitive
            impairment by remodeling mitochondrial dynamics in a
            STAT5-PGAM5-Drp1 dependent manner
  JOURNAL   J Transl Med 22 (1), 788 (2024)
   PUBMED   39183280
  REMARK    GeneRIF: SIRT6 prevent chronic cerebral hypoperfusion induced
            cognitive impairment by remodeling mitochondrial dynamics in a
            STAT5-PGAM5-Drp1 dependent manner.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2079)
  AUTHORS   Tang,H., Yu,Q., Chen,X., Zhang,J., Guo,D., Guo,W., Zhang,S. and
            Shi,X.
  TITLE     Phosphoglycerate mutase 5 exacerbates liver ischemia-reperfusion
            injury by activating mitochondrial fission
  JOURNAL   Sci Rep 14 (1), 8535 (2024)
   PUBMED   38609411
  REMARK    GeneRIF: Phosphoglycerate mutase 5 exacerbates liver
            ischemia-reperfusion injury by activating mitochondrial fission.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2079)
  AUTHORS   Liu,Y., Hao,R., Lv,J., Yuan,J., Wang,X., Xu,C., Ma,D., Duan,Z.,
            Zhang,B., Dai,L., Cheng,Y., Lu,W. and Zhang,X.
  TITLE     Targeted knockdown of PGAM5 in synovial macrophages efficiently
            alleviates osteoarthritis
  JOURNAL   Bone Res 12 (1), 15 (2024)
   PUBMED   38433252
  REMARK    GeneRIF: Targeted knockdown of PGAM5 in synovial macrophages
            efficiently alleviates osteoarthritis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2079)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 2079)
  AUTHORS   Xia,T., Yu,J., Chen,Y., Chang,X. and Meng,M.
  TITLE     Phosphoglycerate mutase 5 aggravates alcoholic liver disease
            through disrupting VDAC-1-dependent mitochondrial integrity
  JOURNAL   Int J Med Sci 21 (4), 755-764 (2024)
   PUBMED   38464835
  REMARK    GeneRIF: Phosphoglycerate mutase 5 aggravates alcoholic liver
            disease through disrupting VDAC-1-dependent mitochondrial
            integrity.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2079)
  AUTHORS   Kang,Y.J., Bang,B.R., Han,K.H., Hong,L., Shim,E.J., Ma,J.,
            Lerner,R.A. and Otsuka,M.
  TITLE     Regulation of NKT cell-mediated immune responses to tumours and
            liver inflammation by mitochondrial PGAM5-Drp1 signalling
  JOURNAL   Nat Commun 6, 8371 (2015)
   PUBMED   26381214
  REMARK    GeneRIF: Results identify a crucial role for RIPK3-PGAM5-Drp1/NFAT
            signalling in NKT cell activation, and further suggest that
            RIPK3-PGAM5 signalling may mediate crosstalk between mitochondrial
            function and immune signalling.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2079)
  AUTHORS   Lu,W., Karuppagounder,S.S., Springer,D.A., Allen,M.D., Zheng,L.,
            Chao,B., Zhang,Y., Dawson,V.L., Dawson,T.M. and Lenardo,M.
  TITLE     Genetic deficiency of the mitochondrial protein PGAM5 causes a
            Parkinson's-like movement disorder
  JOURNAL   Nat Commun 5, 4930 (2014)
   PUBMED   25222142
  REMARK    GeneRIF: Loss of PGAM5 disables PINK1-mediated mitophagy in vitro
            and leads to dopaminergic neurodegeneration and mild dopamine loss
            in vivo causing a Parkinson's-like movement disorder.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2079)
  AUTHORS   Wilkins,J.M., McConnell,C., Tipton,P.A. and Hannink,M.
  TITLE     A conserved motif mediates both multimer formation and allosteric
            activation of phosphoglycerate mutase 5
  JOURNAL   J Biol Chem 289 (36), 25137-25148 (2014)
   PUBMED   25012655
  REMARK    GeneRIF: Data indicate that phosphoglycerate mutase 5 (PGAM5)
            contains an N-terminal WDXNWD motif required for multimerization
            and maximal phosphatase activity.
REFERENCE   9  (bases 1 to 2079)
  AUTHORS   Wang,Z., Jiang,H., Chen,S., Du,F. and Wang,X.
  TITLE     The mitochondrial phosphatase PGAM5 functions at the convergence
            point of multiple necrotic death pathways
  JOURNAL   Cell 148 (1-2), 228-243 (2012)
   PUBMED   22265414
  REMARK    GeneRIF: Experimental data indicate that the two splice variants of
            the mitochondrial protein phosphatase PGAM5 are at the convergent
            point of multiple necrosis pathways.
REFERENCE   10 (bases 1 to 2079)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY101410.1, BC052179.1 and BY620990.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146216.1, AK169643.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                BY101410.1         15-90
            77-2054             BC052179.1         1-1978
            2055-2079           BY620990.1         394-418
FEATURES             Location/Qualifiers
     source          1..2079
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 53.43 cM"
     gene            1..2079
                     /gene="Pgam5"
                     /gene_synonym="2610528A17Rik"
                     /note="phosphoglycerate mutase family member 5"
                     /db_xref="GeneID:72542"
                     /db_xref="MGI:MGI:1919792"
     exon            1..248
                     /gene="Pgam5"
                     /gene_synonym="2610528A17Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..927
                     /gene="Pgam5"
                     /gene_synonym="2610528A17Rik"
                     /EC_number="3.1.3.16"
                     /note="isoform 1 is encoded by transcript variant 1;
                     serine/threonine-protein phosphatase PGAM5, mitochondrial"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase PGAM5,
                     mitochondrial isoform 1"
                     /protein_id="NP_001157010.1"
                     /db_xref="CCDS:CCDS51606.1"
                     /db_xref="GeneID:72542"
                     /db_xref="MGI:MGI:1919792"
                     /translation="MAFRQALQLAACGLAGGSAAVLFSAVAVGKPRGGGDADTRATEP
                     PAWTGARAGRGVWDTNWDRREPLSLINLKKRNVESGEDELTSRLDHYKAKATRHIFLI
                     RHSQYHVDGSLEKDRTLTPLGREQAELTGLRLASLGLKFNKIVHSSMTRAVETTDIIS
                     KHLPGVSRVSTDLLREGAPIEPDPPVSHWKPEAVQYYEDGARIEAAFRNYIHRADARQ
                     EEDSYEIFICHANVIRYIVCRALQFPPEGWLRLSLNNGSITHLVIRPNGRVALRTLGD
                     TGFMPPDKITRS"
     exon            249..427
                     /gene="Pgam5"
                     /gene_synonym="2610528A17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            428..553
                     /gene="Pgam5"
                     /gene_synonym="2610528A17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            554..642
                     /gene="Pgam5"
                     /gene_synonym="2610528A17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            643..776
                     /gene="Pgam5"
                     /gene_synonym="2610528A17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            777..2079
                     /gene="Pgam5"
                     /gene_synonym="2610528A17Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2037..2042
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pgam5"
                     /gene_synonym="2610528A17Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2054
                     /gene="Pgam5"
                     /gene_synonym="2610528A17Rik"
                     /note="major polyA site"
ORIGIN      
        1 accagccgga agcggaagtc tgctcctggc gtcccgccgt caggtcgcgc gatttgcggc
       61 atggctttcc ggcaggcgct tcagctggcg gcctgtggtc tggccggtgg ctcggccgct
      121 gttctcttct cggcggtcgc ggtagggaag ccgcgaggtg gcggggatgc agacacgcgc
      181 gcgaccgagc cgccggcctg gacaggagcg cgagccgggc gcggcgtctg ggacaccaac
      241 tgggacaggc gagagccact gtcactcatt aacctgaaga aaaggaatgt ggaatctgga
      301 gaagacgagt tgacatccag gctggatcac tataaggcca aggccacaag gcacatcttc
      361 ctcatccggc attcccagta ccatgtggat ggctccctgg agaaggaccg caccctgaca
      421 ccattaggtc gggaacaggc tgaactcacg gggctccgac ttgcaagcct gggattaaag
      481 tttaataaaa ttgtccattc ctctatgacc cgtgcagtag agaccacaga catcatcagc
      541 aagcacctgc caggtgtctc cagagtcagc acagacttgc tacgggaagg tgcccccatt
      601 gaaccggatc cacctgtctc tcactggaag ccagaggctg tgcagtatta tgaagatgga
      661 gcccggattg aagctgcctt caggaactac atccaccgag ctgatgccag gcaggaggag
      721 gacagctatg agatcttcat atgccatgcc aatgtcatcc gctatattgt ttgtagagcg
      781 ttgcagtttc ccccagaagg ttggctccgc ctgtccctca acaacggcag tatcacccac
      841 ctggtgattc gacccaatgg tcgtgtggca ctcaggaccc ttggggacac agggttcatg
      901 cccccagaca agattactcg gtcctgaggc tgcctatcag actgcacgct gtcctctgct
      961 ggtggcctga ctacagcctt cccttgtctt ccacagctgt gctgtggctt catgttgtct
     1021 caaatgtcac atttgggtgc tttagttctg gctcatgctg aagaaggcaa cttaggagtt
     1081 agacggcctt tgtgaaagtt ttctccttta ccattaccac cagcacagcc ctatgaggtg
     1141 tgacaggaac cttcctaggt agaaggcagg cctgttatgg gtactggcct ggctgtactg
     1201 catcacgtga ttacagtaga ccagccaagc aatccataac atcgggcaga gacctgactg
     1261 gtagtatggt ggtttacagg tgacattaca tttcatatac tgcaatctaa gacctttggt
     1321 tgcttattta ttaaagattt tcatgtggtt tcttgctttg aaaaccaact tctcagctca
     1381 attaagagat cctatgttta ctgcatctga atgaaggaca aaggggctgg cttcctatat
     1441 gatagataaa agccatggaa gaagtggccc tgcaagaaga ctgtggtctg tataaggcaa
     1501 gtaggtgaca gtcctgtaag cgcttctttg gaggcaaaga tttagccccc gctgactgac
     1561 agaggaggca gcatgtactt gtaattctag catttgggag gcagaagcag gatcaggagt
     1621 tactatccag cctgagttat gtttaaagac ccagaaaaat atccttgttc aacagttcca
     1681 tcttagtttg ctactggcta ctgttaacct tggacttgta ggttatttag aaatgatgtg
     1741 tttactccag atagtctgat gacttaagaa aaaaactgtc ttttatgtat gtggtttttg
     1801 gttttgcttt ttgagacaga atcttaatta ttgcccaggc tggcttcaaa cttgagaccc
     1861 ttctccatct tgtaaatgtt gggattgcat gtatatacta ccatacctgc ttccctctcg
     1921 ccccctcaaa aacccaagta cagtttctat gaagtggttg tgagcatctt ctgtaatcaa
     1981 tgcaatgagt tggaatattt gatgtacctc tctgtcctct ttgggaataa gtatgtaata
     2041 aaattttact ttgttttgtt gtttatttgt tttaaaggg
//
