LOCUS       NM_018870                906 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus phosphoglycerate mutase 2 (Pgam2), mRNA.
ACCESSION   NM_018870
VERSION     NM_018870.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 906)
  AUTHORS   Bejarano,E., Whitcomb,E.A., Pfeiffer,R.L., Rose,K.L., Asensio,M.J.,
            Rodriguez-Navarro,J.A., Ponce-Mora,A., Canto,A., Almansa,I.,
            Schey,K.L., Jones,B.W., Taylor,A. and Rowan,S.
  TITLE     Unbalanced redox status network as an early pathological event in
            congenital cataracts
  JOURNAL   Redox Biol 66, 102869 (2023)
   PUBMED   37677999
REFERENCE   2  (bases 1 to 906)
  AUTHORS   Mikawa,T., Shibata,E., Shimada,M., Ito,K., Ito,T., Kanda,H.,
            Takubo,K., Shimada,A., Lleonart,M.E., Inagaki,N., Yokode,M. and
            Kondoh,H.
  TITLE     Characterization of genetically modified mice for phosphoglycerate
            mutase, a vitally-essential enzyme in glycolysis
  JOURNAL   PLoS One 16 (4), e0250856 (2021)
   PUBMED   33914812
  REMARK    GeneRIF: Characterization of genetically modified mice for
            phosphoglycerate mutase, a vitally-essential enzyme in glycolysis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 906)
  AUTHORS   Mikawa,T., Shibata,E., Shimada,M., Ito,K., Ito,T., Kanda,H.,
            Takubo,K., Lleonart,M.E., Inagaki,N., Yokode,M. and Kondoh,H.
  TITLE     Phosphoglycerate Mutase Cooperates with Chk1 Kinase to Regulate
            Glycolysis
  JOURNAL   iScience 23 (7), 101306 (2020)
   PUBMED   32634742
REFERENCE   4  (bases 1 to 906)
  AUTHORS   Gizak,A., McCubrey,J.A. and Rakus,D.
  TITLE     Cell-to-cell lactate shuttle operates in heart and is important in
            age-related heart failure
  JOURNAL   Aging (Albany NY) 12 (4), 3388-3406 (2020)
   PUBMED   32035422
REFERENCE   5  (bases 1 to 906)
  AUTHORS   Martynova,E., Zhao,Y., Xie,Q., Zheng,D. and Cvekl,A.
  TITLE     Transcriptomic analysis and novel insights into lens fibre cell
            differentiation regulated by Gata3
  JOURNAL   Open Biol 9 (12), 190220 (2019)
   PUBMED   31847788
REFERENCE   6  (bases 1 to 906)
  AUTHORS   Kondoh,H., Lleonart,M.E., Gil,J., Wang,J., Degan,P., Peters,G.,
            Martinez,D., Carnero,A. and Beach,D.
  TITLE     Glycolytic enzymes can modulate cellular life span
  JOURNAL   Cancer Res 65 (1), 177-185 (2005)
   PUBMED   15665293
REFERENCE   7  (bases 1 to 906)
  AUTHORS   Danik,S.B., Liu,F., Zhang,J., Suk,H.J., Morley,G.E., Fishman,G.I.
            and Gutstein,D.E.
  TITLE     Modulation of cardiac gap junction expression and arrhythmic
            susceptibility
  JOURNAL   Circ Res 95 (10), 1035-1041 (2004)
   PUBMED   15499029
REFERENCE   8  (bases 1 to 906)
  AUTHORS   Masino,A.M., Gallardo,T.D., Wilcox,C.A., Olson,E.N., Williams,R.S.
            and Garry,D.J.
  TITLE     Transcriptional regulation of cardiac progenitor cell populations
  JOURNAL   Circ Res 95 (4), 389-397 (2004)
   PUBMED   15242968
REFERENCE   9  (bases 1 to 906)
  AUTHORS   Zhang,J., Yu,L., Fu,Q., Gao,J., Xie,Y., Chen,J., Zhang,P., Liu,Q.
            and Zhao,S.
  TITLE     Mouse phosphoglycerate mutase M and B isozymes: cDNA cloning,
            enzyme activity assay and mapping
  JOURNAL   Gene 264 (2), 273-279 (2001)
   PUBMED   11250083
REFERENCE   10 (bases 1 to 906)
  AUTHORS   Fundele,R., Winking,H., Illmensee,K. and Jagerbauer,E.M.
  TITLE     Developmental activation of phosphoglycerate mutase-2 in the testis
            of the mouse
  JOURNAL   Dev Biol 124 (2), 562-566 (1987)
   PUBMED   2824255
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BE650074.1, AK169019.1 and AV041299.2.
            
            On Apr 7, 2009 this sequence version replaced NM_018870.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BE456792.1, AF029843.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                BE650074.1         1-74
            75-900              AK169019.1         2-827
            901-906             AV041299.2         285-290
FEATURES             Location/Qualifiers
     source          1..906
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 3.87 cM"
     gene            1..906
                     /gene="Pgam2"
                     /note="phosphoglycerate mutase 2"
                     /db_xref="GeneID:56012"
                     /db_xref="MGI:MGI:1933118"
     exon            1..522
                     /gene="Pgam2"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..870
                     /gene="Pgam2"
                     /EC_number="5.4.2.4"
                     /EC_number="5.4.2.11"
                     /note="phosphoglycerate mutase muscle-specific subunit;
                     PGAM-M; BPG-dependent PGAM 2; phosphoglycerate mutase
                     isozyme M; muscle-specific phosphoglycerate mutase"
                     /codon_start=1
                     /product="phosphoglycerate mutase 2"
                     /protein_id="NP_061358.1"
                     /db_xref="CCDS:CCDS24404.1"
                     /db_xref="GeneID:56012"
                     /db_xref="MGI:MGI:1933118"
                     /translation="MTTHRLVMVRHGESLWNQENRFCGWFDAELSEKGAEEAKRGATA
                     IKDAKIEFDICYTSVLKRAIRTLWTILDVTDQMWVPVVRTWRLNERHYGGLTGLNKAE
                     TAAKHGEEQVKIWRRSFDTPPPPMDEKHNYYTSISKDRRYAGLKPEELPTCESLKDTI
                     ARALPFWNEEIAPKIKAGQRVLIAAHGNSLRGIVKHLEGMSDQAIMELNLPTGIPIVY
                     ELDQNLKPTKPMRFLGDEETVRKAMEAVAAQGKAK"
     exon            523..703
                     /gene="Pgam2"
                     /inference="alignment:Splign:2.1.0"
     exon            704..906
                     /gene="Pgam2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      884..889
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pgam2"
                     /note="hexamer: AATAAA"
     polyA_site      906
                     /gene="Pgam2"
                     /note="major polyA site"
ORIGIN      
        1 gaatgctgat tggcagttag ggctggggtg ggggctggga aaactgttat aaagcctaaa
       61 gggccaagca agcagctgcc acctagagtt cctgtgtccc ccgccaccat gaccacccac
      121 cgcctagtaa tggttcgcca cggtgagagc ttatggaacc aagagaaccg tttctgtggc
      181 tggtttgatg cagagctgag tgagaaggga gcagaggagg ccaagcgggg ggccaccgct
      241 atcaaagatg ccaagataga gtttgacatc tgctacacgt cggtgctgaa gcgggcaatc
      301 cgcacccttt ggaccatcct ggatgttacg gaccaaatgt gggtgcccgt ggtgcgtacc
      361 tggcgcctca atgagcggca ctatggtggc ctcacaggcc tcaataaggc tgagacggct
      421 gcaaagcacg gggaggagca ggtgaagatc tggaggcgtt cctttgacac cccaccacca
      481 cccatggatg agaaacacaa ctactacacc tccatcagca aggaccgccg ctatgcaggc
      541 ttgaagcctg aggagctgcc tacctgtgaa agtctcaagg acaccattgc ccgggctttg
      601 cccttctgga atgaggagat cgcacctaag attaaggctg gccagagagt gcttattgca
      661 gcccatggga acagccttcg gggcattgtg aaacatctgg aagggatgtc cgaccaggcc
      721 atcatggagc tgaacctgcc cactggaatc cccattgtgt atgagctgga ccagaacctg
      781 aagcccacca agcccatgag gttcctggga gacgaagaga cggttcggaa ggccatggaa
      841 gctgttgctg cccagggaaa ggcgaagtga gggtggacgg ggcaataaag ttacttccgc
      901 acagcg
//
