LOCUS       NM_023418               1855 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus phosphoglycerate mutase 1 (Pgam1), mRNA.
ACCESSION   NM_023418
VERSION     NM_023418.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1855)
  AUTHORS   Okamoto,M., Omori-Miyake,M., Kuwahara,M., Okabe,M., Eguchi,M. and
            Yamashita,M.
  TITLE     The Inhibition of Glycolysis in T Cells by a Jak Inhibitor
            Ameliorates the Pathogenesis of Allergic Contact Dermatitis in Mice
  JOURNAL   J Invest Dermatol 143 (10), 1973-1982 (2023)
   PUBMED   37028703
REFERENCE   2  (bases 1 to 1855)
  AUTHORS   Yoshida,Y., Shimizu,I., Hsiao,Y.T., Suda,M., Katsuumi,G., Seki,M.,
            Suzuki,Y., Okuda,S., Soga,T. and Minamino,T.
  TITLE     Differing impact of phosphoglycerate mutase 1-deficiency on brown
            and white adipose tissue
  JOURNAL   iScience 25 (5), 104268 (2022)
   PUBMED   35521515
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1855)
  AUTHORS   Mikawa,T., Shibata,E., Shimada,M., Ito,K., Ito,T., Kanda,H.,
            Takubo,K., Shimada,A., Lleonart,M.E., Inagaki,N., Yokode,M. and
            Kondoh,H.
  TITLE     Characterization of genetically modified mice for phosphoglycerate
            mutase, a vitally-essential enzyme in glycolysis
  JOURNAL   PLoS One 16 (4), e0250856 (2021)
   PUBMED   33914812
  REMARK    GeneRIF: Characterization of genetically modified mice for
            phosphoglycerate mutase, a vitally-essential enzyme in glycolysis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1855)
  AUTHORS   Wu,Y., Chen,S., Wen,P., Wu,M., Wu,Y., Mai,M. and Huang,J.
  TITLE     PGAM1 deficiency ameliorates myocardial infarction remodeling by
            targeting TGF-beta via the suppression of inflammation, apoptosis
            and fibrosis
  JOURNAL   Biochem Biophys Res Commun 534, 933-940 (2021)
   PUBMED   33168191
  REMARK    GeneRIF: PGAM1 deficiency ameliorates myocardial infarction
            remodeling by targeting TGF-beta via the suppression of
            inflammation, apoptosis and fibrosis.
REFERENCE   5  (bases 1 to 1855)
  AUTHORS   Markiewicz-Potoczny,M., Lobanova,A., Loeb,A.M., Kirak,O.,
            Olbrich,T., Ruiz,S. and Lazzerini Denchi,E.
  TITLE     TRF2-mediated telomere protection is dispensable in pluripotent
            stem cells
  JOURNAL   Nature 589 (7840), 110-115 (2021)
   PUBMED   33239785
REFERENCE   6  (bases 1 to 1855)
  AUTHORS   Easterday,M.C., Dougherty,J.D., Jackson,R.L., Ou,J., Nakano,I.,
            Paucar,A.A., Roobini,B., Dianati,M., Irvin,D.K., Weissman,I.L.,
            Terskikh,A.V., Geschwind,D.H. and Kornblum,H.I.
  TITLE     Neural progenitor genes. Germinal zone expression and analysis of
            genetic overlap in stem cell populations
  JOURNAL   Dev Biol 264 (2), 309-322 (2003)
   PUBMED   14651920
REFERENCE   7  (bases 1 to 1855)
  AUTHORS   Zhang,J., Yu,L., Fu,Q., Gao,J., Xie,Y., Chen,J., Zhang,P., Liu,Q.
            and Zhao,S.
  TITLE     Mouse phosphoglycerate mutase M and B isozymes: cDNA cloning,
            enzyme activity assay and mapping
  JOURNAL   Gene 264 (2), 273-279 (2001)
   PUBMED   11250083
REFERENCE   8  (bases 1 to 1855)
  AUTHORS   Pretsch,W. and Favor,J.
  TITLE     A precise localization of a mouse gene encoding increased
            phosphoglycerate mutase activity (Pgam1e1) on chromosome 19
  JOURNAL   Mamm Genome 7 (8), 619 (1996)
   PUBMED   8829551
REFERENCE   9  (bases 1 to 1855)
  AUTHORS   Le Boulch,P., Joulin,V., Garel,M.C., Rosa,J. and Cohen-Solal,M.
  TITLE     Molecular cloning and nucleotide sequence of murine
            2,3-bisphosphoglycerate mutase cDNA
  JOURNAL   Biochem Biophys Res Commun 156 (2), 874-881 (1988)
   PUBMED   2847721
REFERENCE   10 (bases 1 to 1855)
  AUTHORS   Fundele,R., Winking,H., Illmensee,K. and Jagerbauer,E.M.
  TITLE     Developmental activation of phosphoglycerate mutase-2 in the testis
            of the mouse
  JOURNAL   Dev Biol 124 (2), 562-566 (1987)
   PUBMED   2824255
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC140193.3, AK159305.1 and BP769634.1.
            
            On Sep 14, 2006 this sequence version replaced NM_023418.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF283667.1, BC002241.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-148               AC140193.3         84632-84779
            149-1823            AK159305.1         2-1676
            1824-1855           BP769634.1         1-32                c
FEATURES             Location/Qualifiers
     source          1..1855
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 35.44 cM"
     gene            1..1855
                     /gene="Pgam1"
                     /gene_synonym="2310050F24Rik; Pgam-1"
                     /note="phosphoglycerate mutase 1"
                     /db_xref="GeneID:18648"
                     /db_xref="MGI:MGI:97552"
     exon            1..316
                     /gene="Pgam1"
                     /gene_synonym="2310050F24Rik; Pgam-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             178..942
                     /gene="Pgam1"
                     /gene_synonym="2310050F24Rik; Pgam-1"
                     /EC_number="5.4.2.4"
                     /EC_number="5.4.2.11"
                     /note="PGAM-B; BPG-dependent PGAM 1; phosphoglycerate
                     mutase isozyme B"
                     /codon_start=1
                     /product="phosphoglycerate mutase 1"
                     /protein_id="NP_075907.2"
                     /db_xref="CCDS:CCDS29815.1"
                     /db_xref="GeneID:18648"
                     /db_xref="MGI:MGI:97552"
                     /translation="MAAYKLVLIRHGESAWNLENRFSGWYDADLSPAGHEEAKRGGQA
                     LRDAGYEFDICFTSVQKRAIRTLWTVLDAIDQMWLPVVRTWRLNERHYGGLTGLNKAE
                     TAAKHGEAQVKIWRRSYDVPPPPMEPDHPFYSNISKDRRYADLTEDQLPSCESLKDTI
                     ARALPFWNEEIVPQIKEGKRVLIAAHGNSLRGIVKHLEGLSEEAIMELNLPTGIPIVY
                     ELDKNLKPIKPMQFLGDEETVRKAMEAVAAQGKVKK"
     exon            317..591
                     /gene="Pgam1"
                     /gene_synonym="2310050F24Rik; Pgam-1"
                     /inference="alignment:Splign:2.1.0"
     exon            592..772
                     /gene="Pgam1"
                     /gene_synonym="2310050F24Rik; Pgam-1"
                     /inference="alignment:Splign:2.1.0"
     exon            773..1832
                     /gene="Pgam1"
                     /gene_synonym="2310050F24Rik; Pgam-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1806..1811
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pgam1"
                     /gene_synonym="2310050F24Rik; Pgam-1"
                     /note="hexamer: AATAAA"
     polyA_site      1832
                     /gene="Pgam1"
                     /gene_synonym="2310050F24Rik; Pgam-1"
                     /note="major polyA site"
ORIGIN      
        1 gcgcatgcgc acacggggcg ggcggcggtc tgtcgagcga gtggaaagat ttcggggaga
       61 aagtgcgcgg aagcggggcg ggagactgta agtgcgcagg cgcgaccggg gcggggggcg
      121 ggctgcgaag agaatctcgg cgatcctcag ttgctgctgc atcctctgcc cgtcgccatg
      181 gctgcctaca agctggtgct gatccggcat ggcgagagcg cctggaacct ggagaaccgc
      241 ttcagcggct ggtacgacgc cgacctgagc ccggcgggcc acgaggaggc gaagcgcggc
      301 gggcaggcgt tgcgagatgc tggctatgaa tttgacatct gcttcacctc tgtgcagaag
      361 agagcaatcc ggaccctctg gacagtcctg gatgccattg accagatgtg gttgccagtg
      421 gtcaggactt ggcgcctcaa tgagcgacac tatggcggtc tgacaggtct caacaaagca
      481 gaaactgctg ctaagcatgg tgaggcccag gtaaagatct ggagacgatc ttatgatgtc
      541 ccaccgcctc ccatggagcc tgatcacccc ttctacagca acatcagcaa ggatcgcagg
      601 tacgcagacc ttactgaaga ccagctcccc tcctgtgaga gcctgaagga cactattgcc
      661 agagcactgc ccttctggaa tgaagaaatt gtcccccaga tcaaagaggg gaaaagggtc
      721 ttgattgccg cccacggcaa cagccttcgg ggcatcgtta agcatctgga gggtctctca
      781 gaagaggcca tcatggagct gaacctgccc acgggcatcc ctatcgtcta tgaactggac
      841 aagaacttga agcccatcaa gcccatgcag ttcctgggag acgaggagac cgtgcgcaaa
      901 gccatggaag ctgtggctgc tcagggcaag gtgaagaagt gaaggcgaag aggcagactc
      961 ctaccccgac accctccctg cctgttcctg cctcctgcac cctccccagc acctgccaca
     1021 ctgactatgt ctttaggatt ttaagtttaa gttgtagctg cagatggggg cctgtggctc
     1081 ccgttttcat tgtagtattt tatcccctgc acccactccc ttcatagaat ctagtcagaa
     1141 taacgcctct gggggtgcag gttctcggac cacatcgagg gacagctccc tgtaccagga
     1201 gagttgagag atagtaacta tagtttttct taggtctttg tttactaagg gtctgcttag
     1261 gaagaattca gggaggaact gtgctgtggt gtgaccaatg aaaagctgca gtccagtttt
     1321 gtccctggaa cctgtcctgc actcttcctg cagttaggta actgggggca tagtcattcc
     1381 agtggagagt ggaagtaacc tcatggtgat ttttaaccct aatttctctc tgaccctaaa
     1441 ggagctgctg gccctagaag gttgggatca atcttgtcaa gtctatgtta cacttacttt
     1501 tacaaaaaaa agtatatata catattatca gcacacaaaa gcaactctga ggttgctagt
     1561 gacatttgaa acagtcctgt gtggtcacca gaaaataagc cattcctcat atcagtggga
     1621 taaactcctt gtacctcttg ctgtgtttgg atcccttggc cttgttttgt agaggtgaag
     1681 tacccctgga tcatgtccga gtttttgtct ttcactgtct gaatcatgtt ccagctgctt
     1741 gaccctaccg tgtgggttca gagctcgttt gggcgtaaca actaagtctc tttccagatc
     1801 agtataataa aggagtgatg tgcaatactt taaaaaaaaa aaaaaaaaaa aaaaa
//
