LOCUS       NM_021453               1416 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Mus musculus pepsinogen 5, group I (Pga5), mRNA.
ACCESSION   NM_021453
VERSION     NM_021453.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1416)
  AUTHORS   Shi,W. and Filmus,J.
  TITLE     Glypican-6 and Glypican-4 stimulate embryonic stomach growth by
            regulating Hedgehog and noncanonical Wnt signaling
  JOURNAL   Dev Dyn 251 (12), 2015-2028 (2022)
   PUBMED   36057966
REFERENCE   2  (bases 1 to 1416)
  AUTHORS   Huang,M., He,H., Belenkaya,T. and Lin,X.
  TITLE     Multiple roles of epithelial heparan sulfate in stomach
            morphogenesis
  JOURNAL   J Cell Sci 131 (10) (2018)
   PUBMED   29700203
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1416)
  AUTHORS   Chang,I., Bramall,A.N., Baynash,A.G., Rattner,A., Rakheja,D.,
            Post,M., Joza,S., McKerlie,C., Stewart,D.J., McInnes,R.R. and
            Yanagisawa,M.
  TITLE     Endothelin-2 deficiency causes growth retardation, hypothermia, and
            emphysema in mice
  JOURNAL   J Clin Invest 123 (6), 2643-2653 (2013)
   PUBMED   23676500
REFERENCE   4  (bases 1 to 1416)
  AUTHORS   Ogaki,S., Harada,S., Shiraki,N., Kume,K. and Kume,S.
  TITLE     An expression profile analysis of ES cell-derived definitive
            endodermal cells and Pdx1-expressing cells
  JOURNAL   BMC Dev Biol 11, 13 (2011)
   PUBMED   21362171
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1416)
  AUTHORS   Kageyama,T.
  TITLE     Pepsinogens, progastricsins, and prochymosins: structure, function,
            evolution, and development
  JOURNAL   Cell Mol Life Sci 59 (2), 288-306 (2002)
   PUBMED   11915945
  REMARK    Review article
REFERENCE   6  (bases 1 to 1416)
  AUTHORS   Chen,X., Rosenfeld,C.S., Roberts,R.M. and Green,J.A.
  TITLE     An aspartic proteinase expressed in the yolk sac and neonatal
            stomach of the mouse
  JOURNAL   Biol Reprod 65 (4), 1092-1101 (2001)
   PUBMED   11566730
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK053965.1 and AK168924.1.
            
            On Oct 30, 2009 this sequence version replaced NM_021453.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK168924.1, AK053965.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849376 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                AK053965.1         2-63
            63-1416             AK168924.1         2-1355
FEATURES             Location/Qualifiers
     source          1..1416
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 7.12 cM"
     gene            1..1416
                     /gene="Pga5"
                     /gene_synonym="1110035E17Rik; Pepf"
                     /note="pepsinogen 5, group I"
                     /db_xref="GeneID:58803"
                     /db_xref="MGI:MGI:1915935"
     exon            1..153
                     /gene="Pga5"
                     /gene_synonym="1110035E17Rik; Pepf"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..1264
                     /gene="Pga5"
                     /gene_synonym="1110035E17Rik; Pepf"
                     /EC_number="3.4.23.1"
                     /note="pepsinogen F; pepsinogen A5; pepsin F; pepsin A-5"
                     /codon_start=1
                     /product="pepsin A-5 precursor"
                     /protein_id="NP_067428.2"
                     /db_xref="CCDS:CCDS29584.1"
                     /db_xref="GeneID:58803"
                     /db_xref="MGI:MGI:1915935"
                     /translation="MKWLWVLGLVALSECLVKIPLMKIKSMRENLRESQVLKDYLEKY
                     PRSRAHVLLEQRRNPAVTYEPMRNYLDLVYIGIISIGTPPQEFRVVLDTGSSVLWVPS
                     IYCSSPACAHHKAFNPLRSSTFLVSGRPVNVAYGSGEMSGFLAYDTVRIGDLTVVAQA
                     FGLSLEEPGIFMEYAVFDGILGLGYPNLGLQGITPVFDNLWLQGLIPQNLFAFYLSSK
                     DEKGSMLMLGGVDPSYYHGELHWVPVSKPSYWQLAVDSISMNGEVIACDGGCQGIMDT
                     GTSLLTGPRSSIVNIQNLIGAKASGDGEYFLKCDTINTLPDIVFTIGSVTYPVPASAY
                     IRKDRSHNCRSNFEEGMDDPSDPEMWVLGDVFLRLYFTVFDRANNRIGLAPAA"
     exon            154..313
                     /gene="Pga5"
                     /gene_synonym="1110035E17Rik; Pepf"
                     /inference="alignment:Splign:2.1.0"
     exon            314..431
                     /gene="Pga5"
                     /gene_synonym="1110035E17Rik; Pepf"
                     /inference="alignment:Splign:2.1.0"
     exon            432..550
                     /gene="Pga5"
                     /gene_synonym="1110035E17Rik; Pepf"
                     /inference="alignment:Splign:2.1.0"
     exon            551..750
                     /gene="Pga5"
                     /gene_synonym="1110035E17Rik; Pepf"
                     /inference="alignment:Splign:2.1.0"
     exon            751..867
                     /gene="Pga5"
                     /gene_synonym="1110035E17Rik; Pepf"
                     /inference="alignment:Splign:2.1.0"
     exon            868..1012
                     /gene="Pga5"
                     /gene_synonym="1110035E17Rik; Pepf"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1111
                     /gene="Pga5"
                     /gene_synonym="1110035E17Rik; Pepf"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1416
                     /gene="Pga5"
                     /gene_synonym="1110035E17Rik; Pepf"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agggtctgat tagagcaggc cagacgaact taataagcag ttctccacac agcttcaggc
       61 ccagaacttc tccctagcac cttaagcctg agaagggatc atgaagtggc tctgggtcct
      121 tgggcttgtg gccctctcag agtgcttggt caaaatccct ctgatgaaga ttaagtccat
      181 gcgtgaaaac ctgcgggaaa gccaagtgct gaaggattac ctggagaagt accctcgaag
      241 ccgtgcccac gtgcttcttg agcagcgccg gaacccagcc gtaacttatg agcctatgag
      301 gaactaccta gacctggtct acattggcat catcagcatt ggcacgcccc ctcaggagtt
      361 cagggttgtc ttggatactg gatcttcagt cctgtgggta ccatccatct attgctccag
      421 cccagcctgc gctcaccaca aagccttcaa cccgcttcgg tcttccactt tcctggtctc
      481 aggccgacct gtgaatgttg cctatggctc aggagagatg tccggatttc ttgcctatga
      541 cactgtcagg attggggacc tcacggttgt ggcccaggcc tttggcctga gcctggaaga
      601 acctggcatt ttcatggaat atgctgtctt tgatggtatc ctggggctgg gataccccaa
      661 ccttggcctt cagggaatca cacccgtctt tgacaacctg tggctacaag gcctcatccc
      721 ccagaatctc tttgccttct acttgagcag caaggatgaa aagggcagca tgctgatgct
      781 aggtggagtg gatccctcct actaccatgg agagcttcac tgggtaccag tgtccaagcc
      841 cagctactgg caattagctg tggatagcat ctccatgaat ggggaggtca ttgcctgtga
      901 tggtggctgc caaggtatta tggacacagg gacctccttg ctgaccggcc cccgaagctc
      961 catcgttaac atccagaatc taattggtgc caaggcttct ggtgacggcg agtacttcct
     1021 caagtgtgac accatcaaca ccctgcctga tattgtcttc accatcggca gtgttaccta
     1081 cccagtgcca gccagtgcct acatccgaaa ggatcggtca cacaattgca ggagcaactt
     1141 tgaggagggc atggatgacc catcagaccc tgagatgtgg gtgctggggg atgtcttcct
     1201 gaggctgtat ttcaccgtgt ttgatcgggc aaataacagg attggtctgg ctcctgctgc
     1261 atgagtgttg agcctccttc agggaatggc ggggcatgcc cctcaacaca ctgagtgcac
     1321 acagggcata tttcatccag agagctgatc ccaggctatg gggagctctg caaagccctg
     1381 ttctgtgtaa ggaataaaga ctgcattcac aaagcc
//
