LOCUS       NM_029303                574 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus profilin 3 (Pfn3), mRNA.
ACCESSION   NM_029303
VERSION     NM_029303.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 574)
  AUTHORS   Umer,N., Arevalo,L., Phadke,S., Lohanadan,K., Kirfel,G., Sons,D.,
            Sofia,D., Witke,W. and Schorle,H.
  TITLE     Loss of Profilin3 Impairs Spermiogenesis by Affecting Acrosome
            Biogenesis, Autophagy, Manchette Development and Mitochondrial
            Organization
  JOURNAL   Front Cell Dev Biol 9, 749559 (2021)
   PUBMED   34869336
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 574)
  AUTHORS   Hara,Y., Yamagata,K., Oguchi,K. and Baba,T.
  TITLE     Nuclear localization of profilin III-ArpM1 complex in mouse
            spermiogenesis
  JOURNAL   FEBS Lett 582 (20), 2998-3004 (2008)
   PUBMED   18692047
  REMARK    GeneRIF: These findings suggest that the testis-specific profilin
            III-ArpM1 complex may be involved in conformational changes in the
            organization of the sperm-specific nucleus.
REFERENCE   3  (bases 1 to 574)
  AUTHORS   Braun,A., Aszodi,A., Hellebrand,H., Berna,A., Fassler,R. and
            Brandau,O.
  TITLE     Genomic organization of profilin-III and evidence for a transcript
            expressed exclusively in testis
  JOURNAL   Gene 283 (1-2), 219-225 (2002)
   PUBMED   11867228
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC048629.1.
            
            On Jun 2, 2006 this sequence version replaced NM_029303.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC048629.1, BU963073.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..574
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 30.06 cM"
     gene            1..574
                     /gene="Pfn3"
                     /gene_synonym="1700012P12Rik"
                     /note="profilin 3"
                     /db_xref="GeneID:75477"
                     /db_xref="MGI:MGI:2178800"
     exon            1..545
                     /gene="Pfn3"
                     /gene_synonym="1700012P12Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..480
                     /gene="Pfn3"
                     /gene_synonym="1700012P12Rik"
                     /note="profilin III"
                     /codon_start=1
                     /product="profilin-3"
                     /protein_id="NP_083579.1"
                     /db_xref="CCDS:CCDS26545.1"
                     /db_xref="GeneID:75477"
                     /db_xref="MGI:MGI:2178800"
                     /translation="MSDWKGYISAVLRDQRIDDVAIVGHSDNRCVWASRPGGLLAAIS
                     PQEVGVLTGPDRHTFLQTGLSVAGRRCCVIRDYLLAEGDGVLDARTKGLDGRAICVGH
                     TPRALLVLMGRRGVHGGILNKTVHDLIGGLREQCS"
     regulatory      520..525
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pfn3"
                     /gene_synonym="1700012P12Rik"
                     /note="hexamer: AATAAA"
     polyA_site      545
                     /gene="Pfn3"
                     /gene_synonym="1700012P12Rik"
                     /note="major polyA site"
ORIGIN      
        1 agctctgaat gcagccggcc acccccccta atgcaagcac aagttgctgg gactgactga
       61 gcggagatga gtgactggaa gggctacatc agtgcagtgc tgcgggatca gcggatcgat
      121 gacgtggcta tcgtgggcca ctcggacaat cgctgtgtgt gggcatcacg gcctgggggt
      181 ctgctggctg ccatctcccc gcaggaggtg ggtgtgctca ccgggccaga ccggcacacc
      241 tttctgcaga cgggtctgag cgtggcaggc cgccgctgct gcgttatccg tgactacctg
      301 ctggccgagg gtgacggcgt actggatgcg cgcaccaagg ggctagacgg gcgtgcaatc
      361 tgtgtgggcc acacgccacg ggcgctcctg gtgctcatgg gcagacgagg cgtgcatgga
      421 ggcatcctca ataagacagt gcacgatctg attggtgggc tgcgtgagca gtgctcttag
      481 taggacagct agaccgcccg tggttggtag ggagaccaga ataaaccgtg aactgggtgc
      541 tctgaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa
//
