LOCUS       NM_019410               2020 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus profilin 2 (Pfn2), mRNA.
ACCESSION   NM_019410
VERSION     NM_019410.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2020)
  AUTHORS   Verma,P., Yevate,S., E,J.S. and Parte,P.
  TITLE     Upregulation of Profilin 2 on HDAC6 overexpression in mouse GC-1
            cells and its putative role in germ cell migration in the testis
  JOURNAL   Cell Tissue Res 392 (3), 779-791 (2023)
   PUBMED   36788143
  REMARK    GeneRIF: Upregulation of Profilin 2 on HDAC6 overexpression in
            mouse GC-1 cells and its putative role in germ cell migration in
            the testis.
REFERENCE   2  (bases 1 to 2020)
  AUTHORS   Di Domenico,M., Jokwitz,M., Witke,W. and Pilo Boyl,P.
  TITLE     Specificity and Redundancy of Profilin 1 and 2 Function in Brain
            Development and Neuronal Structure
  JOURNAL   Cells 10 (9), 2310 (2021)
   PUBMED   34571959
  REMARK    GeneRIF: Specificity and Redundancy of Profilin 1 and 2 Function in
            Brain Development and Neuronal Structure.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2020)
  AUTHORS   Zhao,Y., Zhong,R., Deng,C. and Zhou,Z.
  TITLE     Circle RNA circABCB10 Modulates PFN2 to Promote Breast Cancer
            Progression, as Well as Aggravate Radioresistance Through
            Facilitating Glycolytic Metabolism Via miR-223-3p
  JOURNAL   Cancer Biother Radiopharm 36 (6), 477-490 (2021)
   PUBMED   32522014
  REMARK    GeneRIF: Circle RNA circABCB10 Modulates PFN2 to Promote Breast
            Cancer Progression, as Well as Aggravate Radioresistance Through
            Facilitating Glycolytic Metabolism Via miR-223-3p.
REFERENCE   4  (bases 1 to 2020)
  AUTHORS   Gayle,P., McGaughey,V., Hernandez,R., Wylie,M., Colletti,R.C.,
            Nguyen,K.L., Arons,M., Padula,L., Strbo,N. and Schesser,K.
  TITLE     Maternal- and Fetal-Encoded Perforin-2 Limits Placental Infection
            by a Bloodborne Pathogen
  JOURNAL   J Immunol 205 (7), 1878-1885 (2020)
   PUBMED   32839236
  REMARK    GeneRIF: Maternal- and Fetal-Encoded Perforin-2 Limits Placental
            Infection by a Bloodborne Pathogen.
REFERENCE   5  (bases 1 to 2020)
  AUTHORS   Sangokoya,C. and Blelloch,R.
  TITLE     MicroRNA-dependent inhibition of PFN2 orchestrates ERK activation
            and pluripotent state transitions by regulating endocytosis
  JOURNAL   Proc Natl Acad Sci U S A 117 (34), 20625-20635 (2020)
   PUBMED   32788350
  REMARK    GeneRIF: MicroRNA-dependent inhibition of PFN2 orchestrates ERK
            activation and pluripotent state transitions by regulating
            endocytosis.
REFERENCE   6  (bases 1 to 2020)
  AUTHORS   Lambrechts,A., Kwiatkowski,A.V., Lanier,L.M., Bear,J.E.,
            Vandekerckhove,J., Ampe,C. and Gertler,F.B.
  TITLE     cAMP-dependent protein kinase phosphorylation of EVL, a Mena/VASP
            relative, regulates its interaction with actin and SH3 domains
  JOURNAL   J Biol Chem 275 (46), 36143-36151 (2000)
   PUBMED   10945997
REFERENCE   7  (bases 1 to 2020)
  AUTHORS   Wang,X., Kibschull,M., Laue,M.M., Lichte,B., Petrasch-Parwez,E. and
            Kilimann,M.W.
  TITLE     Aczonin, a 550-kD putative scaffolding protein of presynaptic
            active zones, shares homology regions with Rim and Bassoon and
            binds profilin
  JOURNAL   J Cell Biol 147 (1), 151-162 (1999)
   PUBMED   10508862
REFERENCE   8  (bases 1 to 2020)
  AUTHORS   Joensuu,T., Blanco,G., Pakarinen,L., Sistonen,P., Kaariainen,H.,
            Brown,S., Chapelle,A. and Sankila,E.M.
  TITLE     Refined mapping of the Usher syndrome type III locus on chromosome
            3, exclusion of candidate genes, and identification of the putative
            mouse homologous region
  JOURNAL   Genomics 38 (3), 255-263 (1996)
   PUBMED   8975700
REFERENCE   9  (bases 1 to 2020)
  AUTHORS   Morris,D.J., Adler,I.D. and Robinson,T.J.
  TITLE     Somatic cell hybrid mapping on mouse chromosome 11 (MMU11):
            assignment of markers relative to two breakpoints in band D
  JOURNAL   Genomics 15 (2), 323-331 (1993)
   PUBMED   8449498
REFERENCE   10 (bases 1 to 2020)
  AUTHORS   Widada,J.S., Ferraz,C. and Liautard,J.P.
  TITLE     Total coding sequence of profilin cDNA from Mus musculus macrophage
  JOURNAL   Nucleic Acids Res 17 (7), 2855 (1989)
   PUBMED   2717414
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC165888.18 and AK132651.1.
            
            On Jun 16, 2009 this sequence version replaced NM_019410.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC024363.1, AK132651.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-193               AC165888.18        30385-30577
            194-1445            AK132651.1         2-1253
            1446-2020           AC165888.18        35673-36247
FEATURES             Location/Qualifiers
     source          1..2020
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 28.15 cM"
     gene            1..2020
                     /gene="Pfn2"
                     /gene_synonym="Pfn"
                     /note="profilin 2"
                     /db_xref="GeneID:18645"
                     /db_xref="MGI:MGI:97550"
     exon            1..407
                     /gene="Pfn2"
                     /gene_synonym="Pfn"
                     /inference="alignment:Splign:2.1.0"
     CDS             276..698
                     /gene="Pfn2"
                     /gene_synonym="Pfn"
                     /note="profilin II"
                     /codon_start=1
                     /product="profilin-2"
                     /protein_id="NP_062283.1"
                     /db_xref="CCDS:CCDS17364.1"
                     /db_xref="GeneID:18645"
                     /db_xref="MGI:MGI:97550"
                     /translation="MAGWQSYVDNLMCDGCCQEAAIVGYCDAKYVWAATAGGVFQSIT
                     PVEIDMIVGKDREGFFTNGLTLGAKKCSVIRDSLYVDGDCTMDIRTKSQGGEPTYNVA
                     VGRAGRVLVFVMGKEGVHGGGLNKKAYSMAKYLRDSGF"
     exon            408..600
                     /gene="Pfn2"
                     /gene_synonym="Pfn"
                     /inference="alignment:Splign:2.1.0"
     exon            601..2020
                     /gene="Pfn2"
                     /gene_synonym="Pfn"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1993..1998
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pfn2"
                     /gene_synonym="Pfn"
                     /note="hexamer: AATAAA"
     polyA_site      2013
                     /gene="Pfn2"
                     /gene_synonym="Pfn"
                     /note="major polyA site"
ORIGIN      
        1 gagctgcggc ggtgtgagac ggccgtcacc agccccgctg ccagcgtcgc tccgccgccg
       61 gctcctgagc cccgcggccg cggccgcccg gcgctccccg ctgcgggtcc tgtcaccgcc
      121 cgccgcagtt ccccggagag gggcggtcgg tgcctgcgca gagccgcctc ctccccgccc
      181 ccgccccgcc tccaccgccg ccgccgccgc cgccgccgct gccgctgctg cgcctctgct
      241 cctgccgtcc ccgctgcagt gcgaagggct cgaagatggc cggttggcag agctacgtgg
      301 ataacctgat gtgcgatggc tgctgccagg aggccgccat tgtcggctac tgcgacgcca
      361 aatacgtctg ggcagccacg gccgggggcg tcttccagag catcacgcca gtagaaatag
      421 atatgattgt aggaaaagac cgggaaggtt tctttaccaa cggtttgact cttggagcaa
      481 agaagtgttc tgtgatcaga gatagcctat acgttgatgg tgactgcaca atggacatcc
      541 ggacaaagag tcaaggtggg gagccaacat acaacgttgc tgttggcagg gccgggagag
      601 tcttggtctt tgtaatggga aaagaagggg tccatggagg cggattgaat aagaaggcat
      661 actcaatggc aaaatacttg agagactctg ggttctagct gctaggcaga ctgttaagta
      721 ttaggggaaa attgctctta aattttccta gctgtaagct taagtctcct ttgtatccct
      781 ctgttggtgg ggaaaggtgt ctttctttct gccccttccc cttaaataat tgtgttcatt
      841 tttgttttgt ttccttgtgt actccagcat tggttatagt catgggaaag gaaggtgtcc
      901 acgcaggcac aattaacaag aaaacatatg aactcgcttt atacctgaag aggtctgtaa
      961 ccaaccttta tctggcatca taattgcagc acaataatga tttgcatgat atcttgaaac
     1021 tgggggaagg gggcatgcca agttgggcat cacttcgtct tagcagttag tggattactg
     1081 attactaaaa taggttaata gtaagcaagg tgccggtgta cagtctctaa ctcgatcagt
     1141 gtcttttcag cactttggag catttccttg gctcatctag tcttcctttt gtagcgcatg
     1201 gttgggagga aaaagtgcat gcctctgtac gtcacacctt tctcacccct ccctaccaac
     1261 acgaggtgtt tggtctgctt ccattctctt ctgtgtagtg cctggtttat ttaactaatt
     1321 aatacctcct ctgttgatga gctattgaga gttgcagtgt tttacttttt aatacagtga
     1381 ctgcacttgg gacagactat ttgtagtgtc tataggacat gaagcgtgca gcttggagag
     1441 caaaggcact tcctcccacg accttactgc agtaaccata ccgatcaaat tcccagggac
     1501 attctgtcat tgcagtagct cagacctgtc ttttcttgca caccagctgt gctcttgaga
     1561 aaatgtaaag gctgccatta tggatattag gtatcccaac ataaccatct ggagtgtgtc
     1621 cagtttattt ttcataggac caatttttat ttgcagctta ggtttttata tgaagttgca
     1681 ttattgtgga cttggctgtc ttgtgatgta tttttttcat atgtatcctg tgccatacta
     1741 ttgttaaaat gaactgttgc tattgtgaga tggatttcct ttcgaatggc actaccttag
     1801 ggacattcta gtattgcttc tattgtttgg gcattgtgga taatgtacag atttaaaaac
     1861 aaatcttgtt gctgatttgt ccatttcttt ccctgcactt tgttacatct gggatacagt
     1921 ctaactcatc tgacttaata tgcatttaaa aaaatgccat aactattaaa caccttgttt
     1981 acagacagat gaaataaatt tattccaacc aaatactcca
//
