LOCUS       NM_011072                883 bp    mRNA    linear   ROD 07-AUG-2024
DEFINITION  Mus musculus profilin 1 (Pfn1), mRNA.
ACCESSION   NM_011072 XM_001471660
VERSION     NM_011072.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 883)
  AUTHORS   Cisterna,B.A., Skruber,K., Jane,M.L., Camesi,C.I., Nguyen,I.D.,
            Liu,T.M., Warp,P.V., Black,J.B., Butler,M.T., Bear,J.E., Mor,D.E.,
            Read,T.A. and Vitriol,E.A.
  TITLE     Prolonged depletion of profilin 1 or F-actin causes an adaptive
            response in microtubules
  JOURNAL   J Cell Biol 223 (7) (2024)
   PUBMED   38722279
  REMARK    GeneRIF: Prolonged depletion of profilin 1 or F-actin causes an
            adaptive response in microtubules.
REFERENCE   2  (bases 1 to 883)
  AUTHORS   Funes,S., Jung,J., Gadd,D.H., Mosqueda,M., Zhong,J.,
            Shankaracharya, Unger,M., Stallworth,K., Cameron,D., Rotunno,M.S.,
            Dawes,P., Fowler-Magaw,M., Keagle,P.J., McDonough,J.A.,
            Boopathy,S., Sena-Esteves,M., Nickerson,J.A., Lutz,C.,
            Skarnes,W.C., Lim,E.T., Schafer,D.P., Massi,F., Landers,J.E. and
            Bosco,D.A.
  TITLE     Expression of ALS-PFN1 impairs vesicular degradation in
            iPSC-derived microglia
  JOURNAL   Nat Commun 15 (1), 2497 (2024)
   PUBMED   38509062
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 883)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 883)
  AUTHORS   Tian,X., Pedigo,C.E., Li,K., Ma,X., Bunda,P., Pell,J., Lek,A.,
            Gu,J., Zhang,Y., Medina Rangel,P.X., Li,W., Schwartze,E.,
            Nagata,S., Lerner,G., Perincheri,S., Priyadarshini,A., Zhao,H.,
            Lek,M., Menon,M.C., Fu,R. and Ishibe,S.
  TITLE     Profilin1 is required for prevention of mitotic catastrophe in
            murine and human glomerular diseases
  JOURNAL   J Clin Invest 133 (24), e171237 (2023)
   PUBMED   37847555
  REMARK    GeneRIF: Profilin1 is required for prevention of mitotic
            catastrophe in murine and human glomerular diseases.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 883)
  AUTHORS   Gau,D., Daoud,A., Allen,A., Joy,M., Sagan,A., Lee,S., Lucas,P.C.,
            Duensing,S., Boone,D., Osmanbeyoglu,H.U. and Roy,P.
  TITLE     Vascular endothelial profilin-1 drives a protumorigenic tumor
            microenvironment and tumor progression in renal cancer
  JOURNAL   J Biol Chem 299 (8), 105044 (2023)
   PUBMED   37451478
  REMARK    GeneRIF: Vascular endothelial profilin-1 drives a protumorigenic
            tumor microenvironment and tumor progression in renal cancer.
REFERENCE   6  (bases 1 to 883)
  AUTHORS   Witke,W., Sharpe,A.H., Hartwig,J.H., Azuma,T., Stossel,T.P. and
            Kwiatkowski,D.J.
  TITLE     Hemostatic, inflammatory, and fibroblast responses are blunted in
            mice lacking gelsolin
  JOURNAL   Cell 81 (1), 41-51 (1995)
   PUBMED   7720072
REFERENCE   7  (bases 1 to 883)
  AUTHORS   Kwiatkowski,D.J., Aklog,L., Ledbetter,D.H. and Morton,C.C.
  TITLE     Identification of the functional profilin gene, its localization to
            chromosome subband 17p13.3, and demonstration of its deletion in
            some patients with Miller-Dieker syndrome
  JOURNAL   Am J Hum Genet 46 (3), 559-567 (1990)
   PUBMED   1968707
REFERENCE   8  (bases 1 to 883)
  AUTHORS   Widada,J.S., Ferraz,C. and Liautard,J.P.
  TITLE     Total coding sequence of profilin cDNA from Mus musculus macrophage
  JOURNAL   Nucleic Acids Res 17 (7), 2855 (1989)
   PUBMED   2717414
REFERENCE   9  (bases 1 to 883)
  AUTHORS   Kwiatkowski,D.J. and Bruns,G.A.
  TITLE     Human profilin. Molecular cloning, sequence comparison, and
            chromosomal analysis
  JOURNAL   J Biol Chem 263 (12), 5910-5915 (1988)
   PUBMED   3356709
REFERENCE   10 (bases 1 to 883)
  AUTHORS   Gogstad,G.O., Hagen,I., Korsmo,R. and Solum,N.O.
  TITLE     Characterization of the proteins of isolated human platelet
            alpha-granules. Evidence for a separate alpha-granule-pool of the
            glycoproteins IIb and IIIa
  JOURNAL   Biochim Biophys Acta 670 (2), 150-162 (1981)
   PUBMED   6457647
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AV448567.1, AK150780.1, AK152491.1 and BX527156.1.
            
            On Apr 18, 2009 this sequence version replaced NM_011072.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC002080.1, AK011066.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                AV448567.1         2-45
            45-841              AK150780.1         2-798
            842-865             AK152491.1         828-851
            866-883             BX527156.1         184-201
FEATURES             Location/Qualifiers
     source          1..883
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 43.21 cM"
     gene            1..883
                     /gene="Pfn1"
                     /gene_synonym="Pfn"
                     /note="profilin 1"
                     /db_xref="GeneID:18643"
                     /db_xref="MGI:MGI:97549"
     exon            1..302
                     /gene="Pfn1"
                     /gene_synonym="Pfn"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..593
                     /gene="Pfn1"
                     /gene_synonym="Pfn"
                     /note="profilin I; actin binding protein"
                     /codon_start=1
                     /product="profilin-1"
                     /protein_id="NP_035202.1"
                     /db_xref="CCDS:CCDS24960.1"
                     /db_xref="GeneID:18643"
                     /db_xref="MGI:MGI:97549"
                     /translation="MAGWNAYIDSLMADGTCQDAAIVGYKDSPSVWAAVPGKTFVSIT
                     PAEVGVLVGKDRSSFFVNGLTLGGQKCSVIRDSLLQDGEFTMDLRTKSTGGAPTFNVT
                     VTMTAKTLVLLMGKEGVHGGLINKKCYEMASHLRRSQY"
     exon            303..495
                     /gene="Pfn1"
                     /gene_synonym="Pfn"
                     /inference="alignment:Splign:2.1.0"
     exon            496..870
                     /gene="Pfn1"
                     /gene_synonym="Pfn"
                     /inference="alignment:Splign:2.1.0"
     regulatory      847..852
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pfn1"
                     /gene_synonym="Pfn"
                     /note="hexamer: AATAAA"
     polyA_site      870
                     /gene="Pfn1"
                     /gene_synonym="Pfn"
                     /note="major polyA site"
ORIGIN      
        1 ggggggggga ggagcaggaa gtggcggtgc gagggctgct gcacagctaa cagagccgcg
       61 ttccggacgg cagcgcgtgc cccgagctct ctgccttccc ccgcccgcca gcccgagccc
      121 gagcccgcga tcccagcaac agcccgcaga gcagccccag cagcagcgcc atggccgggt
      181 ggaacgccta catcgacagc cttatggcgg acgggacctg tcaggacgcg gccatcgtag
      241 gctacaagga ctcgccctcc gtctgggccg ccgtccccgg gaagaccttc gttagcatta
      301 cgccagctga ggttggtgtc ctggtaggca aagaccggtc aagttttttc gtcaatgggc
      361 tgacacttgg gggccagaaa tgttctgtga tccgggactc actgctgcaa gacggggaat
      421 ttacaatgga tcttcgtacc aagagcaccg gaggagcccc caccttcaat gtcactgtca
      481 ccatgactgc caagacgcta gtcctgctga tgggcaaaga aggtgtccac ggtggtttga
      541 tcaacaagaa atgttatgaa atggcctctc acctgcggcg ttcccagtac tgacctcatc
      601 tgtcccttcc ccccaccgtt ccctttggct tttgcacccc cttctttcca tacacacaca
      661 taccattatt ttttgggcca ttaccccatt tcccttattg ctgccaaaac cacatgggct
      721 gggggctggg gctggatgga cagacacctc cccctaccca taccccctcc tgtgtgtgtt
      781 tggaaaattt ttgtttttgg gtttcatttt ttgttttttg gtcttttttt tttttttttt
      841 tttctgaata aaaaaagatt ctactaacaa aaaaaaaaaa aaa
//
