LOCUS       NM_019703               4033 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus phosphofructokinase, platelet (Pfkp), transcript
            variant 1, mRNA.
ACCESSION   NM_019703
VERSION     NM_019703.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4033)
  AUTHORS   Cao,L., Wang,R., Liu,G., Zhang,Y., Thorne,R.F., Zhang,X.D., Li,J.,
            Xia,Y., Guo,L., Shao,F., Gu,H. and Wu,M.
  TITLE     Glycolytic Pfkp acts as a Lin41 protein kinase to promote
            endodermal differentiation of embryonic stem cells
  JOURNAL   EMBO Rep 24 (3), e55683 (2023)
   PUBMED   36660859
  REMARK    GeneRIF: Glycolytic Pfkp acts as a Lin41 protein kinase to promote
            endodermal differentiation of embryonic stem cells.
REFERENCE   2  (bases 1 to 4033)
  AUTHORS   Gandhirajan,A., Roychowdhury,S., Kibler,C., Cross,E., Abraham,S.,
            Bellar,A., Nagy,L.E., Scheraga,R.G. and Vachharajani,V.
  TITLE     SIRT2-PFKP interaction dysregulates phagocytosis in macrophages
            with acute ethanol-exposure
  JOURNAL   Front Immunol 13, 1079962 (2023)
   PUBMED   36865524
  REMARK    GeneRIF: SIRT2-PFKP interaction dysregulates phagocytosis in
            macrophages with acute ethanol-exposure.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4033)
  AUTHORS   Chong,D., Gu,Y., Zhang,T., Xu,Y., Bu,D., Chen,Z., Xu,N., Li,L.,
            Zhu,X., Wang,H., Li,Y., Zheng,F., Wang,D., Li,P., Xu,L., Hu,Z. and
            Li,C.
  TITLE     Neonatal ketone body elevation regulates postnatal heart
            development by promoting cardiomyocyte mitochondrial maturation and
            metabolic reprogramming
  JOURNAL   Cell Discov 8 (1), 106 (2022)
   PUBMED   36220812
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4033)
  AUTHORS   Zhao,K., Huang,X., Zhao,W., Lu,B. and Yang,Z.
  TITLE     LONP1-mediated mitochondrial quality control safeguards metabolic
            shifts in heart development
  JOURNAL   Development 149 (6) (2022)
   PUBMED   35237793
REFERENCE   5  (bases 1 to 4033)
  AUTHORS   Zhang,Z., Liang,W., Luo,Q., Hu,H., Yang,K., Hu,J., Chen,Z., Zhu,J.,
            Feng,J., Zhu,Z., Chi,Q. and Ding,G.
  TITLE     PFKP Activation Ameliorates Foot Process Fusion in Podocytes in
            Diabetic Kidney Disease
  JOURNAL   Front Endocrinol (Lausanne) 12, 797025 (2022)
   PUBMED   35095764
  REMARK    GeneRIF: PFKP Activation Ameliorates Foot Process Fusion in
            Podocytes in Diabetic Kidney Disease.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4033)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 4033)
  AUTHORS   Gunasekera,D. and Kemp,R.G.
  TITLE     Genomic organization, 5'flanking region and tissue-specific
            expression of mouse phosphofructokinase C gene
  JOURNAL   Gene 260 (1-2), 103-112 (2000)
   PUBMED   11137296
REFERENCE   8  (bases 1 to 4033)
  AUTHORS   Sanchez-Martinez,C., Estevez,A.M. and Aragon,J.J.
  TITLE     Phosphofructokinase C isozyme from ascites tumor cells: cloning,
            expression, and properties
  JOURNAL   Biochem Biophys Res Commun 271 (3), 635-640 (2000)
   PUBMED   10814514
REFERENCE   9  (bases 1 to 4033)
  AUTHORS   Gunasekera,D. and Kemp,R.G.
  TITLE     Cloning, sequencing, expression, and purification of the C isozyme
            of mouse phosphofructokinase
  JOURNAL   Protein Expr Purif 16 (3), 448-453 (1999)
   PUBMED   10425167
REFERENCE   10 (bases 1 to 4033)
  AUTHORS   Gekakis,N., Gehnrich,S.C. and Sul,H.S.
  TITLE     Phosphofructokinase isozyme expression during myoblast
            differentiation
  JOURNAL   J Biol Chem 264 (7), 3658-3661 (1989)
   PUBMED   2521854
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY243493.1 and AK049841.1.
            
            On Mar 22, 2014 this sequence version replaced NM_019703.3.
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK049841.1, SRR1660817.158337.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                BY243493.1         1-47
            48-4033             AK049841.1         2-3987
FEATURES             Location/Qualifiers
     source          1..4033
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 3.25 cM"
     gene            1..4033
                     /gene="Pfkp"
                     /gene_synonym="1200015H23Rik; 9330125N24Rik; ATP-PFK;
                     PFK-C; PFK-P"
                     /note="phosphofructokinase, platelet"
                     /db_xref="GeneID:56421"
                     /db_xref="MGI:MGI:1891833"
     exon            1..201
                     /gene="Pfkp"
                     /gene_synonym="1200015H23Rik; 9330125N24Rik; ATP-PFK;
                     PFK-C; PFK-P"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..2447
                     /gene="Pfkp"
                     /gene_synonym="1200015H23Rik; 9330125N24Rik; ATP-PFK;
                     PFK-C; PFK-P"
                     /EC_number="2.7.1.11"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ATP:D-fructose 6-phosphate 1-phosphotransferase;
                     6-phosphofructokinase type C; phosphohexokinase;
                     phosphofructokinase 1; phosphofructo-1-kinase isozyme C;
                     ATP-dependent 6-phosphofructokinase, platelet type"
                     /codon_start=1
                     /product="ATP-dependent 6-phosphofructokinase, platelet
                     type isoform 1"
                     /protein_id="NP_062677.1"
                     /db_xref="CCDS:CCDS26230.1"
                     /db_xref="GeneID:56421"
                     /db_xref="MGI:MGI:1891833"
                     /translation="MSDLDSSSSSAYPKYLEHLSGDGKAIGVLTSGGDAQGMNAAVRA
                     VVRMGIYTGAKVYFIYEGYQGLVDGGSNIVEAKWDCVSSILQVGGTIIGSARCKAFRS
                     REGRLKAACNLARLGITNLCVIGGDGSLTGANLFRKEWSGLLEELARNGDIDNDTVQK
                     YSYLNVVGMVGSIDNDFCGTDMTIGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGR
                     HCGYLALVSALTCGADWVFLPESPPEEDWEENMCLKLSENRARKKRLNIIIVSEGAID
                     MQNKPITSEKIKELVVKNLGFDTRVTILGHVQRGGTPSAFDRILASRMGVEAVIALLE
                     ATPETPACVVSLRGNQAVRLPLMECVQMTQDVQKAMDERRFKEAVKLRGRRFEGNLNT
                     YKRLAIKLPDEKIVKSNCNVAVINVGAPAAGMNAAVRSAVRVGIADGHKMFAIYDGFE
                     GFANGQIKEIGWADVGGWTGQGGSILGTKRTLPGKYLEKIAEQMHSHSINALLIIGGF
                     EAYLGLLELAAAREKHEAFCVPMVMVPATVSNNVPGSDFSIGADTALNTITDTCDRIK
                     QSASGTKRRVFIIETMGGYCGYLANMGALAAGADAAYIFEEPFDIGDLQSNVVHLTEK
                     MKTSIQRGLVLRNESCSVNYTTDFIYQLYSEEGKGVFDCRKNVLGHMQQGGAPSPFDR
                     NFGTKISAKAMEWISAKLKGSQGTGKKFVSDDSICVLGICKRDLLFQPVAELKKVTDF
                     EHRIPKEQWWLKLRPIMKILAKYEASYDMSDSGKLESLQHHEEL"
     exon            202..275
                     /gene="Pfkp"
                     /gene_synonym="1200015H23Rik; 9330125N24Rik; ATP-PFK;
                     PFK-C; PFK-P"
                     /inference="alignment:Splign:2.1.0"
     exon            276..353
                     /gene="Pfkp"
                     /gene_synonym="1200015H23Rik; 9330125N24Rik; ATP-PFK;
                     PFK-C; PFK-P"
                     /inference="alignment:Splign:2.1.0"
     exon            354..543
                     /gene="Pfkp"
                     /gene_synonym="1200015H23Rik; 9330125N24Rik; ATP-PFK;
                     PFK-C; PFK-P"
                     /inference="alignment:Splign:2.1.0"
     exon            544..709
                     /gene="Pfkp"
                     /gene_synonym="1200015H23Rik; 9330125N24Rik; ATP-PFK;
                     PFK-C; PFK-P"
                     /inference="alignment:Splign:2.1.0"
     exon            710..754
                     /gene="Pfkp"
                     /gene_synonym="1200015H23Rik; 9330125N24Rik; ATP-PFK;
                     PFK-C; PFK-P"
                     /inference="alignment:Splign:2.1.0"
     exon            755..863
                     /gene="Pfkp"
                     /gene_synonym="1200015H23Rik; 9330125N24Rik; ATP-PFK;
                     PFK-C; PFK-P"
                     /inference="alignment:Splign:2.1.0"
     exon            864..959
                     /gene="Pfkp"
                     /gene_synonym="1200015H23Rik; 9330125N24Rik; ATP-PFK;
                     PFK-C; PFK-P"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1052
                     /gene="Pfkp"
                     /gene_synonym="1200015H23Rik; 9330125N24Rik; ATP-PFK;
                     PFK-C; PFK-P"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1178
                     /gene="Pfkp"
                     /gene_synonym="1200015H23Rik; 9330125N24Rik; ATP-PFK;
                     PFK-C; PFK-P"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1243
                     /gene="Pfkp"
                     /gene_synonym="1200015H23Rik; 9330125N24Rik; ATP-PFK;
                     PFK-C; PFK-P"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1313
                     /gene="Pfkp"
                     /gene_synonym="1200015H23Rik; 9330125N24Rik; ATP-PFK;
                     PFK-C; PFK-P"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1460
                     /gene="Pfkp"
                     /gene_synonym="1200015H23Rik; 9330125N24Rik; ATP-PFK;
                     PFK-C; PFK-P"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1531
                     /gene="Pfkp"
                     /gene_synonym="1200015H23Rik; 9330125N24Rik; ATP-PFK;
                     PFK-C; PFK-P"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..1619
                     /gene="Pfkp"
                     /gene_synonym="1200015H23Rik; 9330125N24Rik; ATP-PFK;
                     PFK-C; PFK-P"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1772
                     /gene="Pfkp"
                     /gene_synonym="1200015H23Rik; 9330125N24Rik; ATP-PFK;
                     PFK-C; PFK-P"
                     /inference="alignment:Splign:2.1.0"
     exon            1773..1937
                     /gene="Pfkp"
                     /gene_synonym="1200015H23Rik; 9330125N24Rik; ATP-PFK;
                     PFK-C; PFK-P"
                     /inference="alignment:Splign:2.1.0"
     exon            1938..1999
                     /gene="Pfkp"
                     /gene_synonym="1200015H23Rik; 9330125N24Rik; ATP-PFK;
                     PFK-C; PFK-P"
                     /inference="alignment:Splign:2.1.0"
     exon            2000..2111
                     /gene="Pfkp"
                     /gene_synonym="1200015H23Rik; 9330125N24Rik; ATP-PFK;
                     PFK-C; PFK-P"
                     /inference="alignment:Splign:2.1.0"
     exon            2112..2211
                     /gene="Pfkp"
                     /gene_synonym="1200015H23Rik; 9330125N24Rik; ATP-PFK;
                     PFK-C; PFK-P"
                     /inference="alignment:Splign:2.1.0"
     exon            2212..2314
                     /gene="Pfkp"
                     /gene_synonym="1200015H23Rik; 9330125N24Rik; ATP-PFK;
                     PFK-C; PFK-P"
                     /inference="alignment:Splign:2.1.0"
     exon            2315..4033
                     /gene="Pfkp"
                     /gene_synonym="1200015H23Rik; 9330125N24Rik; ATP-PFK;
                     PFK-C; PFK-P"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2711..2716
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pfkp"
                     /gene_synonym="1200015H23Rik; 9330125N24Rik; ATP-PFK;
                     PFK-C; PFK-P"
                     /note="hexamer: ATTAAA"
     polyA_site      2733
                     /gene="Pfkp"
                     /gene_synonym="1200015H23Rik; 9330125N24Rik; ATP-PFK;
                     PFK-C; PFK-P"
                     /note="major polyA site"
ORIGIN      
        1 aggcggggca gcggttccaa ggctggcgcg cgtgggccag ggcttcagtg cttgctgagt
       61 acgggagtgt ctggcgtctc tacctcctca tcatgagtga cttggattct tcgagctcca
      121 gcgcctatcc gaagtacctg gagcacctct ctggggatgg caaagctatc ggtgtcctga
      181 ccagcggcgg ggatgcccaa ggcatgaatg ctgctgtccg cgctgtggtg cgcatgggaa
      241 tctacacggg ggccaaagtg tactttatat atgagggtta ccaaggcttg gtggatggag
      301 gctccaatat tgtggaagcc aaatgggact gtgtctccag cattctgcaa gtgggtggga
      361 ccatcatcgg tagtgcgcgc tgcaaagcct ttcgaagccg tgaagggcgc ctgaaagctg
      421 cctgtaactt ggcgcgcttg ggcataacca atctgtgcgt gatcggcggg gacggaagtc
      481 tcacgggagc caacctcttc cgaaaggagt ggagcggact tctggaagag ctggctcgga
      541 atggtgatat cgataacgac acagtgcaga agtattccta cctcaacgtg gtgggtatgg
      601 tgggctccat tgacaatgac ttctgtggca cagacatgac cattggtaca gattcagccc
      661 tgcaccgaat tattgaagtt gttgatgcca tcatgaccac tgctcagagc caccagagga
      721 ccttcgtcct ggaggtgatg gggagacact gtggttactt ggccttggtg agcgccttga
      781 cttgcggtgc cgactgggtg ttccttccgg agtctccacc tgaggaagat tgggaggaaa
      841 atatgtgcct caaactctca gagaaccgag cccgaaaaaa gaggctgaat atcatcattg
      901 tgtctgaagg agcaatcgac atgcaaaata agccaatcac ctctgagaaa atcaaggagc
      961 ttgtagtgaa gaatttggga tttgacaccc gggtcaccat ccttgggcat gtccaacgag
     1021 gagggacccc atctgcattt gacaggattt tggccagccg tatgggagtg gaggctgtca
     1081 ttgccttgct ggaagctacc cccgagaccc cagcctgtgt cgtgtcacta agaggaaacc
     1141 aagcagtgcg cctgccactg atggagtgtg tgcaaatgac ccaggatgta cagaaggcaa
     1201 tggatgaaag aagatttaag gaagccgtga aactccgagg aaggcgtttt gagggaaacc
     1261 tgaacaccta taagcgtctt gccattaaac tgcctgatga gaagattgtc aagagcaact
     1321 gcaatgtagc cgtcatcaat gtaggggcac ctgctgccgg aatgaatgca gccgtgcgct
     1381 ctgctgttcg agtcgggatt gcagacggcc acaagatgtt tgcaatctat gacggctttg
     1441 aaggattcgc caatggccaa atcaaagaaa tcggctgggc agatgtcgga ggctggactg
     1501 gacaaggagg gtccattctt gggacaaaac gcaccctacc tggaaagtac ttggagaaga
     1561 tcgcagagca gatgcattcc catagtatca atgcccttct gatcattgga ggatttgagg
     1621 cctacctagg actcctagag ctggcagctg cccgggagaa acatgaggcg ttctgtgtcc
     1681 ccatggttat ggttcctgct actgtctcca acaatgtgcc gggttccgat ttcagcatcg
     1741 gggcagacac agctctgaac actatcacag acacgtgcga ccgcattaaa cagtcagcca
     1801 gtgggaccaa gcgccgggtg ttcatcattg agaccatggg tggatactgt ggctacctgg
     1861 ccaacatggg ggcccttgca gcaggagctg atgctgccta catctttgaa gagccatttg
     1921 atatcggaga tttgcagtcc aacgtcgtgc acttgacaga gaaaatgaag accagcatcc
     1981 agaggggcct cgtactcaga aacgaaagct gcagtgtaaa ttataccact gacttcatct
     2041 accagctcta ctcagaggag ggcaaaggag tgtttgactg caggaaaaac gtgctgggcc
     2101 atatgcagca ggggggagca ccgtctccat tcgataggaa ctttggaacc aagatttctg
     2161 ccaaagcaat ggagtggatc tcggccaaac tgaaggggtc ccagggcaca gggaaaaaat
     2221 ttgttagcga tgattccatt tgtgtcctgg gaatttgcaa gagagatctc ctgtttcaac
     2281 cagtggcaga gctgaagaaa gtcactgact ttgagcacag gatccccaag gagcagtggt
     2341 ggctgaaact gcggcccatc atgaagatct tggccaagta tgaggcgagc tatgacatgt
     2401 ctgattcagg caagctggag tccttgcagc accatgaaga actatgagcc atctcatcaa
     2461 gtctgccatc acctgacctg gaatgttctc cagggaccat ccttttttgt aacatagtta
     2521 tttatcagca ctttatggaa gcaagcattg ttgacggagt cagcagtaat aatcagagag
     2581 caccacttgc catcaccact gatgcagcag accctaagac atgaaaccca gcctcacgct
     2641 attgatcagg tgtcagtttt ctactgtatg ggatactgtc ttgtgcttta ccatgtgtat
     2701 gtcttgtggg attaaacatt tggttacaac tcccatggta cttggtttat tgttttaagt
     2761 aggagtctga aacaagatga tttttttcca tgccaccaaa ggtttccttc ctcagcagtc
     2821 ttgtggagat tagcaaagtc tccacagata ctccagggac accagggaca tgtagatagg
     2881 ggccccgcct acttcactac tgcaagctag gcttatgatc ttttccaatc agatcgcata
     2941 caaatgctaa aaggacaact atgaattagt gattctcaat tcccccttag tcgtatacag
     3001 cacagctgcc aaggcttaga aggagaagct ggtaccggcc tcttcttcaa aagcagccag
     3061 ggtgctgggt tttcaccctc tggaagattt tgactcactg tttagggtta atgattgggt
     3121 ccttggcaaa agcccatcca ctccgccctc ctccgcccca gactgatgag ccgtctgcag
     3181 gcaaagcatc cctgcctctt gtaaggagtc cgtgtgctcc cactctgcct gagcgtcctc
     3241 tagcatccac acagcaggga tgaggaaatg tttgcagaga cagggatgcc taaaggtcac
     3301 tagagcttga ggataaataa aagaaacaga cgctcagttt tctccctgtc tcagtaaaca
     3361 caggacaaaa gcctgaggta acaaccactt aacaagcact catggatgct cactgggcag
     3421 ctctgctaaa ctctgcattt acactctcct tcaggcctgt ggtgtgacca cacacacaca
     3481 cacactctct ctctctctcc tctctctctc cactccttgt atttattcta aacgatctat
     3541 ttgttcttag tttttatgtg tatgaatgtt ttgcctacat gcatgtctgt gcaccaaatg
     3601 catgcagtgg ccatagagtc ctgaagagga catcagatcc ctggaacctg cagttacaga
     3661 tggctgtgag ctgctgctag ttggaagcta acaacccaaa cctggtctct tgcaagagca
     3721 gcaagtgctt ttttgattta gcattttatt ttttttttta tttttttgat ttagattttg
     3781 atttgattta gccatttttc ttaagtgaag gtctaaacat tattgtcgta aattattgtt
     3841 tgaaaataat gagtaaaact cagacaggtt ggagttggct tttatattta aaatacatat
     3901 tctaggctta gtaatgtttc agaggcttaa tttgctcact gctgtcattt aatgcatgat
     3961 taatgatttc ttcatggtct cagaatttcc ttcagagttt ttgccagtca ataaacacct
     4021 ttggttggtt ttt
//
