LOCUS       NM_008826               3752 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Mus musculus phosphofructokinase, liver, B-type (Pfkl), transcript
            variant 1, mRNA.
ACCESSION   NM_008826
VERSION     NM_008826.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3752)
  AUTHORS   Buth,J.E., Dyevich,C.E., Rubin,A., Wang,C., Gao,L., Marks,T.,
            Harrison,M.R., Kong,J.H., Ross,M.E., Novitch,B.G. and Pearson,C.A.
  TITLE     Foxp1 suppresses cortical angiogenesis and attenuates HIF-1alpha
            signaling to promote neural progenitor cell maintenance
  JOURNAL   EMBO Rep 25 (5), 2202-2219 (2024)
   PUBMED   38600346
REFERENCE   2  (bases 1 to 3752)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3752)
  AUTHORS   Kawakami,H., Chen,K.Q., Zhang,R., Pappas,M.P., Bailey,A.,
            Reisz,J.A., Corcoran,D., Nishinakamura,R., D'Alessandro,A. and
            Kawakami,Y.
  TITLE     Sall4 restricts glycolytic metabolism in limb buds through
            transcriptional regulation of glycolytic enzyme genes
  JOURNAL   Dev Biol 501, 28-38 (2023)
   PUBMED   37301463
REFERENCE   4  (bases 1 to 3752)
  AUTHORS   Zhang,Y., Zhang,Y., Chen,T., Lin,Y., Gong,J., Xu,Q., Wang,J.,
            Li,J., Meng,Y., Li,Y. and Li,X.
  TITLE     Caveolin-1 depletion attenuates hepatic fibrosis via promoting
            SQSTM1-mediated PFKL degradation in HSCs
  JOURNAL   Free Radic Biol Med 204, 95-107 (2023)
   PUBMED   37116593
  REMARK    GeneRIF: Caveolin-1 depletion attenuates hepatic fibrosis via
            promoting SQSTM1-mediated PFKL degradation in HSCs.
REFERENCE   5  (bases 1 to 3752)
  AUTHORS   Wang,C., Qiao,S., Zhao,Y., Tian,H., Yan,W., Hou,X., Wang,R.,
            Zhang,B., Yang,C., Zhu,F., Jiao,Y., Jin,J., Chen,Y. and Tian,W.
  TITLE     The KLF7/PFKL/ACADL axis modulates cardiac metabolic remodelling
            during cardiac hypertrophy in male mice
  JOURNAL   Nat Commun 14 (1), 959 (2023)
   PUBMED   36810848
  REMARK    GeneRIF: The KLF7/PFKL/ACADL axis modulates cardiac metabolic
            remodelling during cardiac hypertrophy in male mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3752)
  AUTHORS   MacDonald,G., Chu,M.L. and Cox,D.R.
  TITLE     Fine structure physical mapping of the region of mouse chromosome
            10 homologous to human chromosome 21
  JOURNAL   Genomics 11 (2), 317-323 (1991)
   PUBMED   1837533
REFERENCE   7  (bases 1 to 3752)
  AUTHORS   Rongnoparut,P., Verdon,C.P., Gehnrich,S.C. and Sul,H.S.
  TITLE     Isolation and characterization of the transcriptionally regulated
            mouse liver (B-type) phosphofructokinase gene and its promoter
  JOURNAL   J Biol Chem 266 (13), 8086-8091 (1991)
   PUBMED   1850735
REFERENCE   8  (bases 1 to 3752)
  AUTHORS   Levanon,D., Danciger,E., Dafni,N., Bernstein,Y., Elson,A.,
            Moens,W., Brandeis,M. and Groner,Y.
  TITLE     The primary structure of human liver type phosphofructokinase and
            its comparison with other types of PFK
  JOURNAL   DNA 8 (10), 733-743 (1989)
   PUBMED   2533063
REFERENCE   9  (bases 1 to 3752)
  AUTHORS   Gekakis,N., Gehnrich,S.C. and Sul,H.S.
  TITLE     Phosphofructokinase isozyme expression during myoblast
            differentiation
  JOURNAL   J Biol Chem 264 (7), 3658-3661 (1989)
   PUBMED   2521854
REFERENCE   10 (bases 1 to 3752)
  AUTHORS   Gehnrich,S.C., Gekakis,N. and Sul,H.S.
  TITLE     Liver (B-type) phosphofructokinase mRNA. Cloning, structure, and
            expression
  JOURNAL   J Biol Chem 263 (24), 11755-11759 (1988)
   PUBMED   2969893
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY070321.1, AK081313.1, AK030892.1 and BP766623.1.
            
            On Dec 9, 2017 this sequence version replaced NM_008826.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.270417.1, AK030511.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                BY070321.1         2-62
            62-2785             AK081313.1         2-2725
            2786-3291           AK030892.1         1874-2379
            3292-3752           BP766623.1         24-484              c
FEATURES             Location/Qualifiers
     source          1..3752
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..3752
                     /gene="Pfkl"
                     /gene_synonym="ATP-PFK; PFK-B; PFK-L"
                     /note="phosphofructokinase, liver, B-type"
                     /db_xref="GeneID:18641"
                     /db_xref="MGI:MGI:97547"
     exon            1..209
                     /gene="Pfkl"
                     /gene_synonym="ATP-PFK; PFK-B; PFK-L"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..2467
                     /gene="Pfkl"
                     /gene_synonym="ATP-PFK; PFK-B; PFK-L"
                     /EC_number="2.7.1.11"
                     /note="isoform 1 is encoded by transcript variant 1;
                     6-phosphofructokinase, liver type; phosphohexokinase;
                     phosphofructokinase 1; phosphofructo-1-kinase isozyme B;
                     6-phosphofructokinase type B; ATP-dependent
                     6-phosphofructokinase, liver type"
                     /codon_start=1
                     /product="ATP-dependent 6-phosphofructokinase, liver type
                     isoform 1"
                     /protein_id="NP_032852.2"
                     /db_xref="CCDS:CCDS35955.1"
                     /db_xref="GeneID:18641"
                     /db_xref="MGI:MGI:97547"
                     /translation="MATVDLEKLRMSGAGKAIGVLTSGGDAQGMNAAVRAVTRMGIYV
                     GAKVFLIYEGYEGLVEGGENIKPANWLSVSNIIQLGGTIIGSARCKAFTTREGRLAAA
                     YNLLQHGITNLCVIGGDGSLTGANIFRNEWGSLLEELVKEGKISESTAQNYAHLTIAG
                     LVGSIDNDFCGTDMTIGTDSALHRIMEVIDAITTTAQSHQRTFVLEVMGRHCGYLALV
                     SALASGADWLFIPEAPPEDGWENFMCERLGETRSRGSRLNIIIIAEGAIDRHGKPISS
                     SYVKDLVVQRLGFDTRVTVLGHVQRGGTPSAFDRILSSKMGMEAVMALLEATPDTPAC
                     VVSLSGNQSVRLPLMECVQVTKDVQKAMDEERFDEAIQLRGRSFENNWKIYKLLAHQK
                     VSKEKSNFSLAILNVGAPAAGMNAAVRSAVRTGISEGHTVYIVHDGFEGLAKGQVQEV
                     GWHDVAGWLGRGGSMLGTKRTLPKPHLEAIVENLRTYNIHALLVIGGFEAYEGVLQLV
                     EARGRYEELCIVMCVIPATISNNVPGTDFSLGSDTAVNAAMESCDRIKQSASGTKRRV
                     FIVETMGGYCGYLATVTGIAVGADAAYVFEDPFNIHDLKANVEHMTEKMKTDIQRGLV
                     LRNEKCHEHYTTEFLYNLYSSEGRGVFDCRTNVLGHLQQGGAPTPFDRNYGTKLGVKA
                     MLWVSEKLRDVYRKGRVFANAPDSACVIGLRKKVVAFSPVTELKKETDFEHRMPREQW
                     WLNLRLMLKMLAHYRISMADYVSGELEHVTRRTLSIDKGF"
     exon            210..283
                     /gene="Pfkl"
                     /gene_synonym="ATP-PFK; PFK-B; PFK-L"
                     /inference="alignment:Splign:2.1.0"
     exon            284..361
                     /gene="Pfkl"
                     /gene_synonym="ATP-PFK; PFK-B; PFK-L"
                     /inference="alignment:Splign:2.1.0"
     exon            362..551
                     /gene="Pfkl"
                     /gene_synonym="ATP-PFK; PFK-B; PFK-L"
                     /inference="alignment:Splign:2.1.0"
     exon            552..717
                     /gene="Pfkl"
                     /gene_synonym="ATP-PFK; PFK-B; PFK-L"
                     /inference="alignment:Splign:2.1.0"
     exon            718..762
                     /gene="Pfkl"
                     /gene_synonym="ATP-PFK; PFK-B; PFK-L"
                     /inference="alignment:Splign:2.1.0"
     exon            763..871
                     /gene="Pfkl"
                     /gene_synonym="ATP-PFK; PFK-B; PFK-L"
                     /inference="alignment:Splign:2.1.0"
     exon            872..967
                     /gene="Pfkl"
                     /gene_synonym="ATP-PFK; PFK-B; PFK-L"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1060
                     /gene="Pfkl"
                     /gene_synonym="ATP-PFK; PFK-B; PFK-L"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1186
                     /gene="Pfkl"
                     /gene_synonym="ATP-PFK; PFK-B; PFK-L"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1251
                     /gene="Pfkl"
                     /gene_synonym="ATP-PFK; PFK-B; PFK-L"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1315
                     /gene="Pfkl"
                     /gene_synonym="ATP-PFK; PFK-B; PFK-L"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1462
                     /gene="Pfkl"
                     /gene_synonym="ATP-PFK; PFK-B; PFK-L"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1533
                     /gene="Pfkl"
                     /gene_synonym="ATP-PFK; PFK-B; PFK-L"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1621
                     /gene="Pfkl"
                     /gene_synonym="ATP-PFK; PFK-B; PFK-L"
                     /inference="alignment:Splign:2.1.0"
     exon            1622..1774
                     /gene="Pfkl"
                     /gene_synonym="ATP-PFK; PFK-B; PFK-L"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..1939
                     /gene="Pfkl"
                     /gene_synonym="ATP-PFK; PFK-B; PFK-L"
                     /inference="alignment:Splign:2.1.0"
     exon            1940..2001
                     /gene="Pfkl"
                     /gene_synonym="ATP-PFK; PFK-B; PFK-L"
                     /inference="alignment:Splign:2.1.0"
     exon            2002..2113
                     /gene="Pfkl"
                     /gene_synonym="ATP-PFK; PFK-B; PFK-L"
                     /inference="alignment:Splign:2.1.0"
     exon            2114..2213
                     /gene="Pfkl"
                     /gene_synonym="ATP-PFK; PFK-B; PFK-L"
                     /inference="alignment:Splign:2.1.0"
     exon            2214..2319
                     /gene="Pfkl"
                     /gene_synonym="ATP-PFK; PFK-B; PFK-L"
                     /inference="alignment:Splign:2.1.0"
     exon            2320..3730
                     /gene="Pfkl"
                     /gene_synonym="ATP-PFK; PFK-B; PFK-L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2752..2757
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pfkl"
                     /gene_synonym="ATP-PFK; PFK-B; PFK-L"
                     /note="hexamer: AATAAA"
     polyA_site      2774
                     /gene="Pfkl"
                     /gene_synonym="ATP-PFK; PFK-B; PFK-L"
                     /note="major polyA site"
     polyA_site      2842
                     /gene="Pfkl"
                     /gene_synonym="ATP-PFK; PFK-B; PFK-L"
     polyA_site      2847
                     /gene="Pfkl"
                     /gene_synonym="ATP-PFK; PFK-B; PFK-L"
     polyA_site      3407
                     /gene="Pfkl"
                     /gene_synonym="ATP-PFK; PFK-B; PFK-L"
     regulatory      3706..3711
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pfkl"
                     /gene_synonym="ATP-PFK; PFK-B; PFK-L"
                     /note="hexamer: AATAGA"
     polyA_site      3730
                     /gene="Pfkl"
                     /gene_synonym="ATP-PFK; PFK-B; PFK-L"
ORIGIN      
        1 ggagccgggg cggggcggga caaaccgggt acacaggcag gcgcacgggg cggggacagg
       61 cgacagcggc gcggaacgca gagcggcggg agaggagctt gggctcctgg tctccgctgc
      121 cgccatggct accgtggacc tggagaaact gcggatgtcg ggggctggca aggccattgg
      181 agtgctgacc agcggcggtg atgcgcaagg tatgaatgct gctgtcaggg ctgtgacccg
      241 tatgggcata tatgtggggg ccaaagtctt cctcatctat gagggctacg agggccttgt
      301 ggaaggaggc gagaacatca agccagccaa ctggctcagc gtttccaata tcatccagct
      361 gggtggcacc attattggca gtgcccgctg taaggccttc actacgaggg aaggccgcct
      421 ggctgcagcc tacaatctgc tccaacacgg catcaccaac ctgtgtgtca tcggtggcga
      481 cggcagcctc acgggggcca acatcttccg caacgagtgg ggcagcttgc tggaggagct
      541 ggtgaaggaa ggcaagatct cagagtccac agctcagaac tacgcacact tgaccatcgc
      601 cggtctggtg ggctccatcg ataacgactt ctgtggcact gacatgacca ttggcacaga
      661 ctcagccctg caccgcatta tggaggtcat tgacgccatc actaccactg cccaaagtca
      721 ccagaggacc tttgttttgg aggtgatggg acggcactgc gggtacctgg cgctggtgtc
      781 tgccctggct tccggggctg attggctatt cattcctgaa gcgccccctg aggatggctg
      841 ggagaacttc atgtgtgaga ggctgggcga gactcggagc cgaggctctc ggctgaacat
      901 catcatcatc gcagagggtg ccattgaccg gcatggaaag cctatctcat ccagctacgt
      961 gaaggatctg gtggttcaga ggctgggctt cgatacacga gtgactgtgc tgggtcatgt
     1021 acagcgagga gggacgcctt cagccttcga ccgaatcctg agtagcaaga tgggtatgga
     1081 ggccgtgatg gcgctgctag aggccacgcc tgacacgccg gcctgtgtgg tcagcctctc
     1141 cgggaaccag tctgtgaggc tacctctcat ggagtgtgtg caagtgacaa aggacgtgca
     1201 gaaggccatg gacgaggaga ggtttgacga ggccatccag ctccgtggca ggagctttga
     1261 gaacaactgg aaaatttaca agctccttgc ccaccagaag gtgtctaaag agaagtccaa
     1321 cttctccctg gccatcctga atgtgggggc tccagctgct ggcatgaatg cagctgtgcg
     1381 ctccgcagtg cgcactggta tctccgaggg acacacggta tacatcgtgc atgatggctt
     1441 tgagggtctg gccaagggtc aggtgcaaga agtgggctgg catgatgtgg caggctggct
     1501 gggacgtggt ggctcgatgc tggggaccaa gaggacactg cccaagcccc acctggaggc
     1561 cattgtggag aatctccgca cctacaacat ccacgccctg ctggtgattg gtggctttga
     1621 ggcctacgag ggtgtgctgc agctggtgga ggcccggggg cgctacgagg aactctgcat
     1681 tgtcatgtgt gtcatcccag ccaccatcag caacaatgtg cctggcactg acttcagcct
     1741 gggctcagac acggctgtca acgctgcaat ggagagttgt gatcgcatca agcagtcagc
     1801 ctcagggaca aagcggcgtg tgttcattgt agagaccatg gggggctact gtggctacct
     1861 ggctactgtg accggcattg ctgtgggtgc cgatgctgcc tacgtctttg aggacccttt
     1921 caacatccat gacttaaagg ccaatgtgga gcatatgaca gagaagatga agacagacat
     1981 ccagagggga ctggtgctcc ggaacgagaa gtgtcacgaa cactacacca cagagttcct
     2041 atacaacctg tactcctcag aaggcagggg cgtgtttgac tgcaggacca atgtgctggg
     2101 ccacttgcag cagggtggtg ctccaacccc tttcgaccgg aactatggga ccaaactggg
     2161 ggtgaaggcc atgttgtggg tgtctgagaa gctacgtgat gtctaccgta aagggcgggt
     2221 gtttgccaat gctccagact cagcctgtgt gatcggcctg cggaagaagg tagtggcctt
     2281 cagtccggtc acagaactca agaaagagac tgattttgag caccgcatgc cccgggagca
     2341 gtggtggctg aatctgcggc tgatgctgaa gatgctggca cactaccgca tcagcatggc
     2401 agactatgtg tctggggagc tggagcacgt cacacgccgc accttgagca tagacaaggg
     2461 tttctgagct tactgtcact actgttcctg cgttcccgga ctctcaccct cccagtgcta
     2521 gccacagatc ccagcaccga ggggaactca aggggaactc ggagcccgtg gctggctgag
     2581 ggatgtgggg gtctactgtg ctgctctggg gctcttccct tagccctccc cccaccccca
     2641 ggacagagag cctgtggggc ccctaccttc cagtcagacc cacattgcct ctccctcact
     2701 ggccagctgg ctgcctcacc acacggctga aaagagcctc acttttttag aaataaagtc
     2761 acctgtctag agcatggtca ctgggacaac atgaccagag gagtccaggg agagggttgt
     2821 caggactcag gtgcaaacct tacccaaggc tatagtttgt ttaatttata taagtacact
     2881 gtagctgtct tcagacacac cattagaggt catcagatcc cattgcagac cgttgtgagc
     2941 caccatgtgg ttgctgggat ttgaactcag gacctctgga agggcagttg gtgatcttaa
     3001 ccgctgagcc atctctccag tcctgcccac agctattcta caagactgga atttagggaa
     3061 ccctcccggg aagagactag ggagacctga gcccttagag agctactgag gctcgtgtga
     3121 gccccatacc tgccctggaa tggctggggt atcggcctgt gggcaatgtg ccccggtctg
     3181 gagaggagac tgtcattgtc agtatagtgt tcttggctga ttgctgccct tcaggaggtt
     3241 cttgaggtcg ggacgttggc tcctcagaga agtttatgaa gggctgagcc ctggccagcc
     3301 ccacctcaga tccctctcta agccccttat cagggtttct tacgtgagct gctgctgggt
     3361 ccatcctcta cagtgcctgg atttttacaa tatttacaat aggtggaggc tgtttctggt
     3421 ttctccgtgt atggaggtca agggttgtga ctttggctct gtggacctgc aggccgcatt
     3481 ggggcggtgg tttccttggg tagacgtctc cccccatggg tcactgtaag gcttctgtgg
     3541 gggtattgca ggccatgtac ccagctgctt catctggctg gagcccccaa agctgctggg
     3601 agcagagtcc tggagtgtaa gtgtcatatc acagcaccct ggagggtttg gtcttgagca
     3661 catggcaaca aggcctgtat attagggctc tagagaaaca gaaccaatag aatgtatata
     3721 tactgtaaaa aaaaaaaaaa aaaaaaaaaa aa
//
