LOCUS       NM_010385                728 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus prefoldin subunit 6 (Pfdn6), transcript variant 1,
            mRNA.
ACCESSION   NM_010385
VERSION     NM_010385.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 728)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 728)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   3  (bases 1 to 728)
  AUTHORS   Logunova,N., Korotetskaya,M., Polshakov,V. and Apt,A.
  TITLE     The QTL within the H2 Complex Involved in the Control of
            Tuberculosis Infection in Mice Is the Classical Class II H2-Ab1
            Gene
  JOURNAL   PLoS Genet 11 (11), e1005672 (2015)
   PUBMED   26618355
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 728)
  AUTHORS   Dai,N., Zhao,L., Wrighting,D., Kramer,D., Majithia,A., Wang,Y.,
            Cracan,V., Borges-Rivera,D., Mootha,V.K., Nahrendorf,M.,
            Thorburn,D.R., Minichiello,L., Altshuler,D. and Avruch,J.
  TITLE     IGF2BP2/IMP2-Deficient mice resist obesity through enhanced
            translation of Ucp1 mRNA and Other mRNAs encoding mitochondrial
            proteins
  JOURNAL   Cell Metab 21 (4), 609-621 (2015)
   PUBMED   25863250
REFERENCE   5  (bases 1 to 728)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 728)
  AUTHORS   Grandea,A.G. 3rd, Comber,P.G., Wenderfer,S.E., Schoenhals,G.,
            Fruh,K., Monaco,J.J. and Spies,T.
  TITLE     Sequence, linkage to H2-K, and function of mouse tapasin in MHC
            class I assembly
  JOURNAL   Immunogenetics 48 (4), 260-265 (1998)
   PUBMED   9716645
REFERENCE   7  (bases 1 to 728)
  AUTHORS   Ha,H., Abe,K. and Artzt,K.
  TITLE     Primary structure of the embryo-expressed gene KE2 from the mouse
            H-2K region
  JOURNAL   Gene 107 (2), 345-346 (1991)
   PUBMED   1748305
REFERENCE   8  (bases 1 to 728)
  AUTHORS   St-Jacques,B., Han,T.H., MacMurray,A. and Shin,H.S.
  TITLE     A putative transmembrane protein with histidine-rich charge
            clusters encoded in the H-2K/tw5 region of mice
  JOURNAL   Mol Cell Biol 10 (1), 138-145 (1990)
   PUBMED   2294398
REFERENCE   9  (bases 1 to 728)
  AUTHORS   Abe,K., Wei,J.F., Wei,F.S., Hsu,Y.C., Uehara,H., Artzt,K. and
            Bennett,D.
  TITLE     Searching for coding sequences in the mammalian genome: the H-2K
            region of the mouse MHC is replete with genes expressed in embryos
  JOURNAL   EMBO J 7 (11), 3441-3449 (1988)
   PUBMED   2463160
REFERENCE   10 (bases 1 to 728)
  AUTHORS   Uehara,H., Abe,K., Park,C.H., Shin,H.S., Bennett,D. and Artzt,K.
  TITLE     The molecular organization of the H-2K region of two t-haplotypes:
            implications for the evolution of genetic diversity
  JOURNAL   EMBO J 6 (1), 83-90 (1987)
   PUBMED   3034582
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY238879.1, AK010679.1 and AV446044.1.
            
            On Apr 20, 2007 this sequence version replaced NM_010385.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK010679.1, CF751669.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                BY238879.1         1-12
            13-707              AK010679.1         3-697
            708-728             AV446044.1         363-383
FEATURES             Location/Qualifiers
     source          1..728
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 17.98 cM"
     gene            1..728
                     /gene="Pfdn6"
                     /gene_synonym="H-2Ke2; H2-Ke2; Ke-2"
                     /note="prefoldin subunit 6"
                     /db_xref="GeneID:14976"
                     /db_xref="MGI:MGI:95908"
     exon            1..320
                     /gene="Pfdn6"
                     /gene_synonym="H-2Ke2; H2-Ke2; Ke-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             257..640
                     /gene="Pfdn6"
                     /gene_synonym="H-2Ke2; H2-Ke2; Ke-2"
                     /note="protein Ke2; H2-K region expressed gene 2"
                     /codon_start=1
                     /product="prefoldin subunit 6"
                     /protein_id="NP_034515.1"
                     /db_xref="CCDS:CCDS28636.1"
                     /db_xref="GeneID:14976"
                     /db_xref="MGI:MGI:95908"
                     /translation="MAELIQKKLQGEVEKYQQLQKDLSKSMSGRQKLEAQLTENNIVK
                     EELALLDGSNVVFKLLGPVLVKQELGEARATVGKRLDYITAEIKRYESQLRDLERQSE
                     QQRETLAQLQQEFQRAQAAKAPGKA"
     exon            321..391
                     /gene="Pfdn6"
                     /gene_synonym="H-2Ke2; H2-Ke2; Ke-2"
                     /inference="alignment:Splign:2.1.0"
     exon            392..516
                     /gene="Pfdn6"
                     /gene_synonym="H-2Ke2; H2-Ke2; Ke-2"
                     /inference="alignment:Splign:2.1.0"
     exon            517..719
                     /gene="Pfdn6"
                     /gene_synonym="H-2Ke2; H2-Ke2; Ke-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      688..693
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pfdn6"
                     /gene_synonym="H-2Ke2; H2-Ke2; Ke-2"
                     /note="hexamer: AATAAA"
     polyA_site      709
                     /gene="Pfdn6"
                     /gene_synonym="H-2Ke2; H2-Ke2; Ke-2"
                     /note="major polyA site"
ORIGIN      
        1 ttgtttactt ccgggtttat tgattacagc gggtagagcg tgaagaggtt agcgtttggc
       61 ttggagggtt cggggatctc ttctttcgct ctcctttgcc tagggagtgg ctattctgga
      121 cgaaaagagg ctgcggcgcc tcggagagtt gcgggtagaa agtgctgtcc ttctgcaggg
      181 tcagggaggg gggattcagg tgcctcccag agcttgagac ccagcgaccc ccgcccagga
      241 ggctttctcc ttcaccatgg ctgaactgat ccaaaagaag ctgcagggag aggtagagaa
      301 atatcaacag ctgcagaagg acttgagtaa atctatgtca gggaggcaga agctcgaagc
      361 acagctaacg gaaaacaata tcgtgaagga ggagctggcc ctgctggatg gatccaacgt
      421 ggtctttaag cttctgggac ccgtgcttgt caaacaggag ctgggggagg ctcgggccac
      481 agtagggaag aggctagact acatcacagc agaaatcaag cgctacgaat cacagcttcg
      541 ggacctcgag cggcagtcag agcaacagag ggaaaccctt gctcaactgc agcaggagtt
      601 tcagcgggcc caagctgcaa aggctcctgg gaaagcctga ccccgtggga gggggtcagg
      661 agggagggat gaggctaacc ctgagccaat aaaatgtaaa cagaaccaag cctactttaa
      721 aaaaaaaa
//
