LOCUS       NM_027044                708 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus prefoldin 5 (Pfdn5), mRNA.
ACCESSION   NM_027044
VERSION     NM_027044.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 708)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 708)
  AUTHORS   Collin,G.B., Gogna,N., Chang,B., Damkham,N., Pinkney,J., Hyde,L.F.,
            Stone,L., Naggert,J.K., Nishina,P.M. and Krebs,M.P.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 708)
  AUTHORS   Kadoyama,K., Matsuura,K., Takano,M., Maekura,K., Inoue,Y. and
            Matsuyama,S.
  TITLE     Changes in the expression of prefoldin subunit 5 depending on
            synaptic plasticity in the mouse hippocampus
  JOURNAL   Neurosci Lett 712, 134484 (2019)
   PUBMED   31505240
  REMARK    GeneRIF: Changes in the expression of prefoldin subunit 5 depending
            on synaptic plasticity in the mouse hippocampus.
REFERENCE   4  (bases 1 to 708)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 708)
  AUTHORS   Abe,A., Takahashi-Niki,K., Takekoshi,Y., Shimizu,T., Kitaura,H.,
            Maita,H., Iguchi-Ariga,S.M. and Ariga,H.
  TITLE     Prefoldin plays a role as a clearance factor in preventing
            proteasome inhibitor-induced protein aggregation
  JOURNAL   J Biol Chem 288 (39), 27764-27776 (2013)
   PUBMED   23946485
REFERENCE   6  (bases 1 to 708)
  AUTHORS   Chen,J., Melton,C., Suh,N., Oh,J.S., Horner,K., Xie,F., Sette,C.,
            Blelloch,R. and Conti,M.
  TITLE     Genome-wide analysis of translation reveals a critical role for
            deleted in azoospermia-like (Dazl) at the oocyte-to-zygote
            transition
  JOURNAL   Genes Dev 25 (7), 755-766 (2011)
   PUBMED   21460039
REFERENCE   7  (bases 1 to 708)
  AUTHORS   Lee,Y., Smith,R.S., Jordan,W., King,B.L., Won,J., Valpuesta,J.M.,
            Naggert,J.K. and Nishina,P.M.
  TITLE     Prefoldin 5 is required for normal sensory and neuronal development
            in a murine model
  JOURNAL   J Biol Chem 286 (1), 726-736 (2011)
   PUBMED   20956523
  REMARK    GeneRIF: a genetic disruption in the murine Pfdn5 gene, a subunit
            of prefoldin, causes a syndrome characterized by photoreceptor
            degeneration, central nervous system abnormalities, and male
            infertility
REFERENCE   8  (bases 1 to 708)
  AUTHORS   Won,J., Shi,L.Y., Hicks,W., Wang,J., Hurd,R., Naggert,J.K.,
            Chang,B. and Nishina,P.M.
  TITLE     Mouse model resources for vision research
  JOURNAL   J Ophthalmol 2011, 391384 (2011)
   PUBMED   21052544
REFERENCE   9  (bases 1 to 708)
  AUTHORS   Yoshida,T., Kitaura,H., Hagio,Y., Sato,T., Iguchi-Ariga,S.M. and
            Ariga,H.
  TITLE     Negative regulation of the Wnt signal by MM-1 through inhibiting
            expression of the wnt4 gene
  JOURNAL   Exp Cell Res 314 (6), 1217-1228 (2008)
   PUBMED   18281035
REFERENCE   10 (bases 1 to 708)
  AUTHORS   Inazu,T., Myint,Z., Kuroiwa,A., Matsuda,Y. and Noguchi,T.
  TITLE     Molecular cloning, expression and chromosomal localization of mouse
            MM-1
  JOURNAL   Mol Biol Rep 32 (4), 273-279 (2005)
   PUBMED   16328889
  REMARK    GeneRIF: MM-1 may play a role in liver development and growth.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN835522.1 and AF108357.1.
            
            On Jul 19, 2006 this sequence version replaced NM_027044.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CN834584.1, BU526013.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                CN835522.1         4-43
            41-708              AF108357.1         1-668
FEATURES             Location/Qualifiers
     source          1..708
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 57.48 cM"
     gene            1..708
                     /gene="Pfdn5"
                     /gene_synonym="1190001O17Rik; 1700010A06Rik; D15Ertd697e;
                     Eig1; MM-1"
                     /note="prefoldin 5"
                     /db_xref="GeneID:56612"
                     /db_xref="MGI:MGI:1928753"
     exon            1..145
                     /gene="Pfdn5"
                     /gene_synonym="1190001O17Rik; 1700010A06Rik; D15Ertd697e;
                     Eig1; MM-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..538
                     /gene="Pfdn5"
                     /gene_synonym="1190001O17Rik; 1700010A06Rik; D15Ertd697e;
                     Eig1; MM-1"
                     /note="EIG-1; myc modulator 1; C-myc-binding protein Mm-1;
                     c-myc binding protein MM-1"
                     /codon_start=1
                     /product="prefoldin subunit 5"
                     /protein_id="NP_081320.2"
                     /db_xref="CCDS:CCDS37227.1"
                     /db_xref="GeneID:56612"
                     /db_xref="MGI:MGI:1928753"
                     /translation="MAQSINITELNLPQLEMLKNQLDQEVEFLSTSIAQLKVVQTKYV
                     EAKDCLNVLNKSNEGKELLVPLTSSMYVPGKLHDVEHVLIDVGTGYYVEKTAEDAKDF
                     FKRKIDFLTKQMEKIQPALQEKHAMKQAVMEMMSQKIQQLTALGAAQATVKA"
     exon            146..248
                     /gene="Pfdn5"
                     /gene_synonym="1190001O17Rik; 1700010A06Rik; D15Ertd697e;
                     Eig1; MM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            249..280
                     /gene="Pfdn5"
                     /gene_synonym="1190001O17Rik; 1700010A06Rik; D15Ertd697e;
                     Eig1; MM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            281..355
                     /gene="Pfdn5"
                     /gene_synonym="1190001O17Rik; 1700010A06Rik; D15Ertd697e;
                     Eig1; MM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            356..461
                     /gene="Pfdn5"
                     /gene_synonym="1190001O17Rik; 1700010A06Rik; D15Ertd697e;
                     Eig1; MM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            462..679
                     /gene="Pfdn5"
                     /gene_synonym="1190001O17Rik; 1700010A06Rik; D15Ertd697e;
                     Eig1; MM-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      657..662
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pfdn5"
                     /gene_synonym="1190001O17Rik; 1700010A06Rik; D15Ertd697e;
                     Eig1; MM-1"
                     /note="hexamer: AATAAA"
     polyA_site      679
                     /gene="Pfdn5"
                     /gene_synonym="1190001O17Rik; 1700010A06Rik; D15Ertd697e;
                     Eig1; MM-1"
                     /note="major polyA site"
ORIGIN      
        1 ggaggtaacg cggagggcgg ctagagcgtc actcgcccag gcggcttcct cttcggcagt
       61 cctccttccc aacatggcgc agtcgattaa catcacggag ctgaatctgc cacaactgga
      121 aatgctcaag aaccagctgg accaggaagt ggagtttttg tccacgtcca ttgctcagct
      181 caaggtggtc cagaccaagt acgtggaagc caaggactgt ctgaacgtgc tgaacaagag
      241 caacgaggga aaagaattac tggtcccact gacgagttct atgtacgtcc ccgggaagct
      301 acacgatgtg gagcatgtgc ttattgatgt gggaaccggc tactacgtgg agaagacagc
      361 tgaggacgcc aaggacttct tcaaaaggaa gatagacttc ctcaccaaac agatggagaa
      421 aatccagcca gcgctgcagg agaagcatgc catgaagcag gctgtcatgg aaatgatgag
      481 ccagaagatt cagcagctca cagccctggg ggcagcgcag gccacggtca aagcctgaga
      541 gtgcactgca gaaatgaagc agagtgaggg acccttcttc aaggggcctg ggactttttc
      601 cggcaatggc ctcctgggaa agtggcctgg gaagagagtg ttttgtgttt aatgttaata
      661 aatgtgaccg ctgcgcaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa
//
