LOCUS       NM_019932                520 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Mus musculus platelet factor 4 (Pf4), mRNA.
ACCESSION   NM_019932
VERSION     NM_019932.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 520)
  AUTHORS   Wei,J., Peng,M.Y., Wang,S.N. and Lu,H.X.
  TITLE     CXCL4:NLRP3-mediated pyroptosis product that regulates cardiac
            fibrosis
  JOURNAL   Int Immunopharmacol 133, 112096 (2024)
   PUBMED   38657496
  REMARK    GeneRIF: CXCL4:NLRP3-mediated pyroptosis product that regulates
            cardiac fibrosis.
REFERENCE   2  (bases 1 to 520)
  AUTHORS   Li,W., Chi,D., Ju,S., Zhao,X., Li,X., Zhao,J., Xie,H., Li,Y.,
            Jin,J., Mang,G. and Dong,Z.
  TITLE     Platelet factor 4 promotes deep venous thrombosis by regulating the
            formation of neutrophil extracellular traps
  JOURNAL   Thromb Res 237, 52-63 (2024)
   PUBMED   38547695
  REMARK    GeneRIF: Platelet factor 4 promotes deep venous thrombosis by
            regulating the formation of neutrophil extracellular traps.
REFERENCE   3  (bases 1 to 520)
  AUTHORS   Wei,J., Wang,D.F., Cui,C.C., Tan,J.J., Peng,M.Y. and Lu,H.X.
  TITLE     CXCL4/CXCR3 axis regulates cardiac fibrosis by activating
            TGF-beta1/Smad2/3 signaling in mouse viral myocarditis
  JOURNAL   Immun Inflamm Dis 12 (4), e1237 (2024)
   PUBMED   38577984
  REMARK    GeneRIF: CXCL4/CXCR3 axis regulates cardiac fibrosis by activating
            TGF-beta1/Smad2/3 signaling in mouse viral myocarditis.
REFERENCE   4  (bases 1 to 520)
  AUTHORS   Singh,A., Ghosh,R., Asuru,T.R., Prajapat,S.K., Joshi,G., Gaur,K.K.,
            Shrimali,N.M., Ojha,A., Vikram,N.K., Poncz,M., Kalia,M. and
            Guchhait,P.
  TITLE     Inhibition of cellular activation induced by platelet factor 4 via
            the CXCR3 pathway ameliorates Japanese encephalitis and dengue
            viral infections
  JOURNAL   J Thromb Haemost 22 (3), 818-833 (2024)
   PUBMED   38029855
  REMARK    GeneRIF: Inhibition of cellular activation induced by platelet
            factor 4 via the CXCR3 pathway ameliorates Japanese encephalitis
            and dengue viral infections.
REFERENCE   5  (bases 1 to 520)
  AUTHORS   Ngo,A.T., Skidmore,A., Oberg,J., Yarovoi,I., Sarkar,A., Levine,N.,
            Bochenek,V., Zhao,G., Rauova,L., Kowalska,M.A., Eckart,K.,
            Mangalmurti,N.S., Rux,A., Cines,D.B., Poncz,M. and Gollomp,K.
  TITLE     Platelet factor 4 limits neutrophil extracellular trap- and
            cell-free DNA-induced thrombogenicity and endothelial injury
  JOURNAL   JCI Insight 8 (22), e171054 (2023)
   PUBMED   37991024
  REMARK    GeneRIF: Platelet factor 4 limits neutrophil extracellular trap-
            and cell-free DNA-induced thrombogenicity and endothelial injury.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 520)
  AUTHORS   Zhang,C., Thornton,M.A., Kowalska,M.A., Sachis,B.S., Feldman,M.,
            Poncz,M., McKenzie,S.E. and Reilly,M.P.
  TITLE     Localization of distal regulatory domains in the
            megakaryocyte-specific platelet basic protein/platelet factor 4
            gene locus
  JOURNAL   Blood 98 (3), 610-617 (2001)
   PUBMED   11468158
REFERENCE   7  (bases 1 to 520)
  AUTHORS   Keith Ho,H.C., McGrath,K.E., Brodbeck,K.C., Palis,J. and
            Schick,B.P.
  TITLE     Serglycin proteoglycan synthesis in the murine uterine decidua and
            early embryo
  JOURNAL   Biol Reprod 64 (6), 1667-1676 (2001)
   PUBMED   11369593
REFERENCE   8  (bases 1 to 520)
  AUTHORS   Kitajima,K., Kojima,M., Kondo,S. and Takeuchi,T.
  TITLE     A role of jumonji gene in proliferation but not differentiation of
            megakaryocyte lineage cells
  JOURNAL   Exp Hematol 29 (4), 507-514 (2001)
   PUBMED   11301191
REFERENCE   9  (bases 1 to 520)
  AUTHORS   Watanabe,O., Natori,K., Tamari,M., Shiomoto,Y., Kubo,S. and
            Nakamura,Y.
  TITLE     Significantly elevated expression of PF4 (platelet factor 4) and
            eotaxin in the NOA mouse, a model for atopic dermatitis
  JOURNAL   J Hum Genet 44 (3), 173-176 (1999)
   PUBMED   10319581
REFERENCE   10 (bases 1 to 520)
  AUTHORS   Thomasset,N., Lochter,A., Sympson,C.J., Lund,L.R., Williams,D.R.,
            Behrendtsen,O., Werb,Z. and Bissell,M.J.
  TITLE     Expression of autoactivated stromelysin-1 in mammary glands of
            transgenic mice leads to a reactive stroma during early development
  JOURNAL   Am J Pathol 153 (2), 457-467 (1998)
   PUBMED   9708806
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC105995.9.
            
            On Oct 3, 2022 this sequence version replaced NM_019932.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061111.1, CB572082.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-176               AC105995.9         94329-94504
            177-309             AC105995.9         94738-94870
            310-520             AC105995.9         94999-95209
FEATURES             Location/Qualifiers
     source          1..520
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 44.78 cM"
     gene            1..520
                     /gene="Pf4"
                     /gene_synonym="Cxcl4; Scyb4"
                     /note="platelet factor 4"
                     /db_xref="GeneID:56744"
                     /db_xref="MGI:MGI:1888711"
     exon            1..176
                     /gene="Pf4"
                     /gene_synonym="Cxcl4; Scyb4"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..397
                     /gene="Pf4"
                     /gene_synonym="Cxcl4; Scyb4"
                     /note="chemokine (C-X-C motif) ligand 4; C-X-C motif
                     chemokine 4"
                     /codon_start=1
                     /product="platelet factor 4 precursor"
                     /protein_id="NP_064316.1"
                     /db_xref="CCDS:CCDS19416.1"
                     /db_xref="GeneID:56744"
                     /db_xref="MGI:MGI:1888711"
                     /translation="MSVAAVFRGLRPSPELLLLGLLFLPAVVAVTSAGPEESDGDLSC
                     VCVKTISSGIHLKHITSLEVIKAGRHCAVPQLIATLKNGRKICLDRQAPLYKKVIKKI
                     LES"
     exon            177..309
                     /gene="Pf4"
                     /gene_synonym="Cxcl4; Scyb4"
                     /inference="alignment:Splign:2.1.0"
     exon            310..520
                     /gene="Pf4"
                     /gene_synonym="Cxcl4; Scyb4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      502..507
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pf4"
                     /gene_synonym="Cxcl4; Scyb4"
                     /note="hexamer: AATAAA"
     polyA_site      520
                     /gene="Pf4"
                     /gene_synonym="Cxcl4; Scyb4"
                     /note="major polyA site"
ORIGIN      
        1 gctggcctgc acttaagagc cctagaccca tttcctcaag gtagaacttt atctttgggt
       61 ccagtggcac cctcttgaca tgagcgtcgc tgcggtgttt cgaggcctcc ggcccagtcc
      121 tgagctgctg cttctgggcc tgttgtttct gccagcggtg gttgctgtca ccagcgctgg
      181 tcccgaagaa agcgatggag atcttagctg tgtgtgtgtg aagaccatct cctctgggat
      241 ccatcttaag cacatcacca gcctggaggt gatcaaggca ggacgccact gtgcggttcc
      301 ccagctcata gccaccctga agaatgggag gaaaatttgc ctggaccggc aagcacccct
      361 atataagaaa gtaatcaaga aaatcctgga gagttaggta tcagctgcct aaatgtcaat
      421 tgtgttacaa gactcctgga atcttgtcta cttttaatgt aactgcaatc ttccgatgtt
      481 tatattatcc ttcaagattt aaataaatgc attgaaccaa
//
