LOCUS       NM_145488               3189 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus peroxisomal biogenesis factor 6 (Pex6), transcript
            variant 1, mRNA.
ACCESSION   NM_145488
VERSION     NM_145488.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3189)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3189)
  AUTHORS   Zaki,M.S., Heller,R., Thoenes,M., Nurnberg,G., Stern-Schneider,G.,
            Nurnberg,P., Karnati,S., Swan,D., Fateen,E., Nagel-Wolfrum,K.,
            Mostafa,M.I., Thiele,H., Wolfrum,U., Baumgart-Vogt,E. and Bolz,H.J.
  TITLE     PEX6 is Expressed in Photoreceptor Cilia and Mutated in
            Deafblindness with Enamel Dysplasia and Microcephaly
  JOURNAL   Hum Mutat 37 (2), 170-174 (2016)
   PUBMED   26593283
REFERENCE   3  (bases 1 to 3189)
  AUTHORS   Liu,S.P., Li,Y.S., Chen,Y.J., Chiang,E.P., Li,A.F., Lee,Y.H.,
            Tsai,T.F., Hsiao,M., Huang,S.F. and Chen,Y.M.
  TITLE     Glycine N-methyltransferase-/- mice develop chronic hepatitis and
            glycogen storage disease in the liver
  JOURNAL   Hepatology 46 (5), 1413-1425 (2007)
   PUBMED   17937387
  REMARK    Erratum:[Hepatology. 2008 Feb;47(2):769. Hwang, Shiu-Feng
            [corrected to Huang, Shiu-Feng]]
REFERENCE   4  (bases 1 to 3189)
  AUTHORS   Warner,D.R., Roberts,E.A., Greene,R.M. and Pisano,M.M.
  TITLE     Identification of novel Smad binding proteins
  JOURNAL   Biochem Biophys Res Commun 312 (4), 1185-1190 (2003)
   PUBMED   14651998
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT030702.11.
            
            On Jul 18, 2018 this sequence version replaced NM_145488.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC003424.1, SRR11927933.444111.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-909               CT030702.11        157479-158387       c
            910-1073            CT030702.11        155792-155955       c
            1074-1157           CT030702.11        155319-155402       c
            1158-1260           CT030702.11        149433-149535       c
            1261-1394           CT030702.11        149218-149351       c
            1395-1506           CT030702.11        148569-148680       c
            1507-1715           CT030702.11        147985-148193       c
            1716-1911           CT030702.11        147424-147619       c
            1912-1988           CT030702.11        147165-147241       c
            1989-2121           CT030702.11        146619-146751       c
            2122-2327           CT030702.11        146334-146539       c
            2328-2389           CT030702.11        146128-146189       c
            2390-2498           CT030702.11        145836-145944       c
            2499-2615           CT030702.11        145356-145472       c
            2616-2693           CT030702.11        145159-145236       c
            2694-2833           CT030702.11        144899-145038       c
            2834-3189           CT030702.11        144320-144675       c
FEATURES             Location/Qualifiers
     source          1..3189
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 22.9 cM"
     gene            1..3189
                     /gene="Pex6"
                     /gene_synonym="D130055I09Rik; PAF-2"
                     /note="peroxisomal biogenesis factor 6"
                     /db_xref="GeneID:224824"
                     /db_xref="MGI:MGI:2385054"
     exon            1..909
                     /gene="Pex6"
                     /gene_synonym="D130055I09Rik; PAF-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..2970
                     /gene="Pex6"
                     /gene_synonym="D130055I09Rik; PAF-2"
                     /note="peroxisome assembly factor 2; peroxin-6;
                     peroxisomal-type ATPase 1"
                     /codon_start=1
                     /product="peroxisomal ATPase PEX6"
                     /protein_id="NP_663463.1"
                     /db_xref="CCDS:CCDS28837.1"
                     /db_xref="GeneID:224824"
                     /db_xref="MGI:MGI:2385054"
                     /translation="MALAVLRVLDPFPTETPPLAVLLPPGGPWPATGLGLVLALRPAS
                     ESPAKPALLVAAVEGSGAQGEQRGPGPPPLLVSRALLRVLALGPGARVRARLVRRPPA
                     LGWALLATAPGPGLGPRVGPLLVRRGETLPVPGSRVLETRPALQGLLGPGTRLAVTEL
                     RGRAKLGQESRDHSHPPPPPVVSSFAASHSVRRLRGVLGGTGDALGVSRSCLRSLGLF
                     QGEWVWVAQVAELPNSSQPRLAQVQVLEPRWELSERLGPNSGQQPGEPLADGLVFLPA
                     TLAFNLGCDPLEVGELRIQRYLEGSIAPENKGSCSPLPGPPFARELHIEILSSPHYSA
                     NGNYDHVLYRHFQTPRVVQEGDVLCVSTAGQVEILEGSLERLPRWREMFFKVKKTVGE
                     APEGPASAFLADTTHTSLYLAGTALSHVPSLPSGRSPPWDSLSPPGLEALVNELCAIL
                     KPHLQPGGTLLTGTSCVLLQGPPGSGKTTAVTAACSRLGLHLLKVPCSSLCADSSRAV
                     ETKLQATFSRARRCRPAVLLLTAVDLLGRDRDGLGEDARVAATLRHLLLDEDALSRCP
                     PLMVVATTSRVQDLPTDVQTAFPHELEVPVLSEAQRLSILQALTAHLPLGQEVNLPQL
                     ARRCAGFVVGDLYALLTHTCRAACTRIRASGSAGGLSEEDEGDLCVAGFPLLAEDFGQ
                     ALDQLQTAHSQAVGAPRIPSVSWHDVGGLQDVKKEILETIQLPLEHPELLSLGLRRSG
                     LLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQSEENVREVFARARAAAP
                     CIIFFDELDSLAPSRGRSGDSGGVMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLD
                     PALLRPGRFDKLVFVGASEDRASQLRVLSAITRKFKLEASVSLANVLDCCPPQLTGAD
                     LYSLCSDAMMTALKRRVRDLEEGLELRSSALLLTMEDLLQAAARLQPSVSEQELLRYK
                     RIQRKFAAC"
     exon            910..1073
                     /gene="Pex6"
                     /gene_synonym="D130055I09Rik; PAF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1157
                     /gene="Pex6"
                     /gene_synonym="D130055I09Rik; PAF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1260
                     /gene="Pex6"
                     /gene_synonym="D130055I09Rik; PAF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1394
                     /gene="Pex6"
                     /gene_synonym="D130055I09Rik; PAF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1506
                     /gene="Pex6"
                     /gene_synonym="D130055I09Rik; PAF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1715
                     /gene="Pex6"
                     /gene_synonym="D130055I09Rik; PAF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1716..1911
                     /gene="Pex6"
                     /gene_synonym="D130055I09Rik; PAF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1912..1988
                     /gene="Pex6"
                     /gene_synonym="D130055I09Rik; PAF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1989..2121
                     /gene="Pex6"
                     /gene_synonym="D130055I09Rik; PAF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2122..2327
                     /gene="Pex6"
                     /gene_synonym="D130055I09Rik; PAF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2328..2389
                     /gene="Pex6"
                     /gene_synonym="D130055I09Rik; PAF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2390..2498
                     /gene="Pex6"
                     /gene_synonym="D130055I09Rik; PAF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2499..2615
                     /gene="Pex6"
                     /gene_synonym="D130055I09Rik; PAF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2616..2693
                     /gene="Pex6"
                     /gene_synonym="D130055I09Rik; PAF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2694..2833
                     /gene="Pex6"
                     /gene_synonym="D130055I09Rik; PAF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2834..3189
                     /gene="Pex6"
                     /gene_synonym="D130055I09Rik; PAF-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3165..3170
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pex6"
                     /gene_synonym="D130055I09Rik; PAF-2"
                     /note="hexamer: AATAAA"
     polyA_site      3187
                     /gene="Pex6"
                     /gene_synonym="D130055I09Rik; PAF-2"
                     /note="major polyA site"
ORIGIN      
        1 ggagtggttt ccttctcctt cgccatggcg ttggctgtcc tgcgcgtcct ggaccccttc
       61 ccgacggaga caccaccgtt ggcggtgctg ttgcctcccg ggggcccgtg gccagcgacg
      121 gggctggggc tggtgctggc actgcggccg gcgagcgaga gtcccgcgaa gcccgcgctg
      181 ctcgtggcgg ccgtggaagg gtccggcgcc cagggcgagc agcgcgggcc ggggcctccg
      241 ccgctgctgg tgagccgcgc gctgctgcgg gtcctagcgc tggggcccgg ggcgcgagta
      301 cgagcgcggc ttgtgcggcg tcccccggcc ctgggctggg cgttgcttgc cacggctccg
      361 ggacccgggc tagggcctcg agtcgggccg ctgttggtgc gccgcgggga gaccctcccc
      421 gtgcccggat cgcgagtgtt ggagacgcga ccggccctgc aggggttgct gggcccgggg
      481 acacggctgg ccgtgactga gctccgcggg cgggccaaac tgggccagga gagtcgggat
      541 cacagccatc ccccgccccc gcccgtagtg tcgtcctttg cagcttccca ctcggtccgg
      601 cgactccgag gggttctggg agggactgga gatgcgctgg gtgtgagccg gagctgtctc
      661 cggagtctcg gactcttcca gggcgaatgg gtctgggtgg cccaggtcgc agagttaccc
      721 aactcctcgc agccgcgctt ggctcaagtc caggttctag aaccgcgctg ggagctgtct
      781 gagagactgg gacccaactc cgggcagcag ccgggagagc cactcgctga cggactggtg
      841 tttctgcccg ccactctggc ttttaatctc ggctgtgacc ccctggaagt gggagagctc
      901 agaattcaga ggtatttgga aggctccatc gccccagaga acaaaggaag ctgttcacca
      961 ctgcccgggc ctccgtttgc tcgagagtta cacattgaga ttctgtcctc gcctcactac
     1021 agtgctaatg gaaattatga ccatgtcctg taccggcact ttcagacacc cagggtggtc
     1081 caggaagggg atgtgttgtg tgtgtcaaca gctgggcaag ttgagatcct ggaaggaagc
     1141 ctggagagac tgcccaggtg gcgggagatg tttttcaaag tgaagaaaac ggttggagaa
     1201 gccccagagg ggccagccag tgcctttctg gctgatacca cccacacctc tttatacctg
     1261 gctggcaccg ccctgagtca tgtgccatcg ctgccttcag gaaggtcccc accctgggac
     1321 agcttgtctc ctccaggcct ggaggccttg gtaaatgagc tgtgtgctat cctgaagcct
     1381 cacctgcagc ccggaggaac attgctcaca ggaaccagct gtgtgcttct gcagggtccc
     1441 ccaggcagcg ggaagaccac agccgtcacg gctgcatgca gccgccttgg gctccatttg
     1501 ctgaaggtgc cctgctccag cctctgtgca gacagcagta gggccgtgga gacaaagctg
     1561 caggccacct tctcccgggc ccgccgctgc aggcctgcag tcctcctgtt gacagctgtg
     1621 gacctcctgg gccgggaccg agacggactg ggtgaggatg cccgtgttgc ggccacactc
     1681 cgtcatctcc tccttgatga ggacgctctc agcaggtgcc ctcctctcat ggtggtggct
     1741 accacaagcc gtgtccagga cctgcccacc gatgtgcaga cggcatttcc tcatgagcta
     1801 gaggtgccag tgctgtctga ggctcaacgg ctcagtatcc tgcaggccct cactgcccac
     1861 cttcccttag gccaggaggt taacctgccc cagctggcac ggcgctgtgc gggctttgtg
     1921 gtgggggacc tctatgccct tctgacccat acctgccggg cagcctgcac caggatcaga
     1981 gcctcgggct cggcaggtgg tttgagtgag gaggatgagg gggacctgtg tgtggctggc
     2041 tttcctttgc tggctgagga cttcgggcag gcattagatc aactgcagac agctcactcc
     2101 caagctgtgg gagcacccag gatcccttca gtgtcctggc acgacgtggg cgggctgcag
     2161 gatgtgaaga aggagatcct agaaaccatc cagctgcctc tggaacaccc tgagctgctc
     2221 agcctgggcc taagacgatc aggccttctg ctccatgggc ccccaggcac tggcaagacc
     2281 ctgctggcca aggccgtagc cactgagtgc agcctcacct tcctcagtgt aaagggaccg
     2341 gagctcatca acatgtatgt gggccaaagc gaggagaatg tccgggaagt gtttgccagg
     2401 gccagggctg ctgctccctg tatcatcttc tttgatgaac tggattcctt agctccaagc
     2461 cgcggacgga gtggagattc tggaggggtg atggacagag ttgtgtctca gctcctagcc
     2521 gagctggatg ggctccacag cacccaggat gtgtttgtga tcggagccac caacagacca
     2581 gacctcctgg accctgccct tctgcggcct ggcagatttg acaagctggt gtttgtaggg
     2641 gcgagtgagg accgggcctc ccagctgcgt gtgctgagcg ccatcacacg gaagttcaag
     2701 ctggaggcct ctgtgagcct ggcaaacgtg ctggattgct gcccacccca gctgactggt
     2761 gcagatctct attctctctg ctctgacgcc atgatgactg ccctcaaacg cagggttcga
     2821 gacctagagg aagggctaga gctgcggagc tcagcactgc tgctcaccat ggaggacctg
     2881 ttgcaggctg cagcccggct gcagccctca gtcagtgagc aggagctgtt gcgatacaag
     2941 cgcatccaac gcaagtttgc cgcctgctag gagctgcctg cctgccctct gcctatgccc
     3001 cctgactgaa ggtacctccc gcctgtcgcc tgaaggctgc ctcctcccag agatcccttg
     3061 tgagccctag tgggggcccc tagtgctcag gaggagaggc agggctggca gctaggggct
     3121 tggcagcctg tgacctgtgc ggagacacta gttctggagt agaaaataaa gtgtatactg
     3181 cctcctact
//
