LOCUS       NM_021483               4903 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus peroxisomal biogenesis factor 5-like (Pex5l),
            transcript variant 1, mRNA.
ACCESSION   NM_021483
VERSION     NM_021483.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4903)
  AUTHORS   Lo Giudice,Q., Wagener,R.J., Abe,P., Frangeul,L. and Jabaudon,D.
  TITLE     Developmental emergence of first- and higher-order thalamic neuron
            molecular identities
  JOURNAL   Development 151 (18) (2024)
   PUBMED   39348458
REFERENCE   2  (bases 1 to 4903)
  AUTHORS   Di Bella,D.J., Habibi,E., Stickels,R.R., Scalia,G., Brown,J.,
            Yadollahpour,P., Yang,S.M., Abbate,C., Biancalani,T., Macosko,E.Z.,
            Chen,F., Regev,A. and Arlotta,P.
  TITLE     Molecular logic of cellular diversification in the mouse cerebral
            cortex
  JOURNAL   Nature 595 (7868), 554-559 (2021)
   PUBMED   34163074
  REMARK    Erratum:[Nature. 2021 Aug;596(7873):E11. doi:
            10.1038/s41586-021-03797-5.. PMID: 34341543]
REFERENCE   3  (bases 1 to 4903)
  AUTHORS   Scherschel,K., Brauninger,H., Molders,A., Erlenhardt,N., Amin,E.,
            Jungen,C., Pape,U., Lindner,D., Chetkovich,D.M., Klocker,N. and
            Meyer,C.
  TITLE     Characterization of the HCN Interaction Partner TRIP8b/PEX5R in the
            Intracardiac Nervous System of TRIP8b-Deficient and Wild-Type Mice
  JOURNAL   Int J Mol Sci 22 (9), 4772 (2021)
   PUBMED   33946275
  REMARK    GeneRIF: Characterization of the HCN Interaction Partner
            TRIP8b/PEX5R in the Intracardiac Nervous System of TRIP8b-Deficient
            and Wild-Type Mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4903)
  AUTHORS   Munn,R.G.K., Mallory,C.S., Hardcastle,K., Chetkovich,D.M. and
            Giocomo,L.M.
  TITLE     Entorhinal velocity signals reflect environmental geometry
  JOURNAL   Nat Neurosci 23 (2), 239-251 (2020)
   PUBMED   31932764
REFERENCE   5  (bases 1 to 4903)
  AUTHORS   Foote,K.M., Lyman,K.A., Han,Y., Michailidis,I.E., Heuermann,R.J.,
            Mandikian,D., Trimmer,J.S., Swanson,G.T. and Chetkovich,D.M.
  TITLE     Phosphorylation of the HCN channel auxiliary subunit TRIP8b is
            altered in an animal model of temporal lobe epilepsy and modulates
            channel function
  JOURNAL   J Biol Chem 294 (43), 15743-15758 (2019)
   PUBMED   31492750
  REMARK    GeneRIF: loss of TRIP8b phosphorylation may affect HCN channel
            properties during epileptogenesis.
REFERENCE   6  (bases 1 to 4903)
  AUTHORS   Keane,M.H., Overmars,H., Wikander,T.M., Ferdinandusse,S., Duran,M.,
            Wanders,R.J. and Faust,P.L.
  TITLE     Bile acid treatment alters hepatic disease and bile acid transport
            in peroxisome-deficient PEX2 Zellweger mice
  JOURNAL   Hepatology 45 (4), 982-997 (2007)
   PUBMED   17393522
  REMARK    GeneRIF: Both untreated and bile acid-fed PEX2(-/-) mice
            accumulated high levels of predominantly unconjugated bile acids in
            plasma because of altered expression of hepatocyte bile acid
            transporters.
REFERENCE   7  (bases 1 to 4903)
  AUTHORS   Munton,R.P., Tweedie-Cullen,R., Livingstone-Zatchej,M.,
            Weinandy,F., Waidelich,M., Longo,D., Gehrig,P., Potthast,F.,
            Rutishauser,D., Gerrits,B., Panse,C., Schlapbach,R. and Mansuy,I.M.
  TITLE     Qualitative and quantitative analyses of protein phosphorylation in
            naive and stimulated mouse synaptosomal preparations
  JOURNAL   Mol Cell Proteomics 6 (2), 283-293 (2007)
   PUBMED   17114649
REFERENCE   8  (bases 1 to 4903)
  AUTHORS   Trinidad,J.C., Specht,C.G., Thalhammer,A., Schoepfer,R. and
            Burlingame,A.L.
  TITLE     Comprehensive identification of phosphorylation sites in
            postsynaptic density preparations
  JOURNAL   Mol Cell Proteomics 5 (5), 914-922 (2006)
   PUBMED   16452087
REFERENCE   9  (bases 1 to 4903)
  AUTHORS   Santoro,B., Wainger,B.J. and Siegelbaum,S.A.
  TITLE     Regulation of HCN channel surface expression by a novel C-terminal
            protein-protein interaction
  JOURNAL   J Neurosci 24 (47), 10750-10762 (2004)
   PUBMED   15564593
  REMARK    GeneRIF: These data suggest a possible role for TRIP8b in
            regulating HCN channel density in the plasma membrane. [TRIP8b]
REFERENCE   10 (bases 1 to 4903)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HQ646192.1, AC116723.13, AK039764.1, AC119877.9 and CB519585.1.
            
            On Jul 14, 2015 this sequence version replaced NM_021483.4.
            
            Transcript Variant: This variant (1) differs in the 5' UTR and
            lacks an alternate in-frame exon in the 5' coding region compared
            to variant 5. The encoded isoform (1) is shorter than isoform 5.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: HQ646194.1, AB032591.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-245               HQ646192.1         1-245
            246-377             AC116723.13        106069-106200
            378-435             AK039764.1         222-279
            436-436             AC116723.13        107698-107698
            437-784             AK039764.1         280-627
            785-2875            AK039764.1         631-2721
            2876-3421           HQ646192.1         3075-3620
            3422-4218           AC119877.9         53869-54665         c
            4219-4758           CB519585.1         1-540
            4759-4903           AC119877.9         53184-53328         c
FEATURES             Location/Qualifiers
     source          1..4903
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 15.94 cM"
     gene            1..4903
                     /gene="Pex5l"
                     /gene_synonym="1700016J08Rik; Pex2; pex5Rp; PXR2; TRIP8b"
                     /note="peroxisomal biogenesis factor 5-like"
                     /db_xref="GeneID:58869"
                     /db_xref="MGI:MGI:1916672"
     exon            1..245
                     /gene="Pex5l"
                     /gene_synonym="1700016J08Rik; Pex2; pex5Rp; PXR2; TRIP8b"
                     /inference="alignment:Splign:2.1.0"
     exon            246..405
                     /gene="Pex5l"
                     /gene_synonym="1700016J08Rik; Pex2; pex5Rp; PXR2; TRIP8b"
                     /inference="alignment:Splign:2.1.0"
     CDS             313..2160
                     /gene="Pex5l"
                     /gene_synonym="1700016J08Rik; Pex2; pex5Rp; PXR2; TRIP8b"
                     /note="isoform 1 is encoded by transcript variant 1;
                     peroxin 2; peroxisomal targeting signal 1 receptor-like;
                     PEX5-related protein; PEX5-like protein; PEX2-related
                     protein; peroxin-5-related protein; tetratricopeptide
                     repeat-containing Rab8b-interacting protein"
                     /codon_start=1
                     /product="PEX5-related protein isoform 1"
                     /protein_id="NP_067458.2"
                     /db_xref="CCDS:CCDS17302.1"
                     /db_xref="GeneID:58869"
                     /db_xref="MGI:MGI:1916672"
                     /translation="MSDSEMDGRTHIPSLLNALLSRNRVMQMSYLKSKEQGYGKLSSD
                     EDLEIIVDQKQLVNEQQESRPLLSPSIDDFLCETKSEAIAKPVTSNTAVLTTGLDLLD
                     LSEPVSQTQTKAKKSEPSSKSSSLKKKADGSDLISADAEQRAQALRGPETSSLDLDIQ
                     TQLEKWDDVKFHGDRTSKGHLMAERKSCSSRTGSKELLWSAEHRSQPELSTGKSALNS
                     ESASELELVAPAQARLTKEHRWGSALLSRNHSLEEEFERAKAAVESDTEFWDKMQAEW
                     EEMARRNWISENQEAQNQVTVSASEKGYYFHTENPFKDWPGAFEEGLKRLKEGDLPVT
                     ILFMEAAILQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVS
                     YTNTSHQQDACEALKNWIKQNPKYKYLVKNKKGSPGLTRRMSKSPVDSSVLEGVKELY
                     LEAAHQNGDMIDPDLQTGLGVLFHLSGEFNRAIDAFNAALTVRPEDYSLWNRLGATLA
                     NGDRSEEAVEAYTRALEIQPGFIRSRYNLGISCINLGAYREAVSNFLTALSLQRKSRN
                     QQQVPHPAISGNIWAALRIALSLMDQPELFQAANLGDLDVLLRAFNLDP"
     exon            406..477
                     /gene="Pex5l"
                     /gene_synonym="1700016J08Rik; Pex2; pex5Rp; PXR2; TRIP8b"
                     /inference="alignment:Splign:2.1.0"
     exon            478..589
                     /gene="Pex5l"
                     /gene_synonym="1700016J08Rik; Pex2; pex5Rp; PXR2; TRIP8b"
                     /inference="alignment:Splign:2.1.0"
     exon            590..784
                     /gene="Pex5l"
                     /gene_synonym="1700016J08Rik; Pex2; pex5Rp; PXR2; TRIP8b"
                     /inference="alignment:Splign:2.1.0"
     exon            785..908
                     /gene="Pex5l"
                     /gene_synonym="1700016J08Rik; Pex2; pex5Rp; PXR2; TRIP8b"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1005
                     /gene="Pex5l"
                     /gene_synonym="1700016J08Rik; Pex2; pex5Rp; PXR2; TRIP8b"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1101
                     /gene="Pex5l"
                     /gene_synonym="1700016J08Rik; Pex2; pex5Rp; PXR2; TRIP8b"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1218
                     /gene="Pex5l"
                     /gene_synonym="1700016J08Rik; Pex2; pex5Rp; PXR2; TRIP8b"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1362
                     /gene="Pex5l"
                     /gene_synonym="1700016J08Rik; Pex2; pex5Rp; PXR2; TRIP8b"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1433
                     /gene="Pex5l"
                     /gene_synonym="1700016J08Rik; Pex2; pex5Rp; PXR2; TRIP8b"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1631
                     /gene="Pex5l"
                     /gene_synonym="1700016J08Rik; Pex2; pex5Rp; PXR2; TRIP8b"
                     /inference="alignment:Splign:2.1.0"
     exon            1632..1797
                     /gene="Pex5l"
                     /gene_synonym="1700016J08Rik; Pex2; pex5Rp; PXR2; TRIP8b"
                     /inference="alignment:Splign:2.1.0"
     exon            1798..1955
                     /gene="Pex5l"
                     /gene_synonym="1700016J08Rik; Pex2; pex5Rp; PXR2; TRIP8b"
                     /inference="alignment:Splign:2.1.0"
     exon            1956..4903
                     /gene="Pex5l"
                     /gene_synonym="1700016J08Rik; Pex2; pex5Rp; PXR2; TRIP8b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3176..3181
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pex5l"
                     /gene_synonym="1700016J08Rik; Pex2; pex5Rp; PXR2; TRIP8b"
                     /note="hexamer: AATACA"
     polyA_site      3198
                     /gene="Pex5l"
                     /gene_synonym="1700016J08Rik; Pex2; pex5Rp; PXR2; TRIP8b"
                     /note="major polyA site"
     regulatory      4329..4334
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pex5l"
                     /gene_synonym="1700016J08Rik; Pex2; pex5Rp; PXR2; TRIP8b"
                     /note="hexamer: AATACA"
     polyA_site      4350
                     /gene="Pex5l"
                     /gene_synonym="1700016J08Rik; Pex2; pex5Rp; PXR2; TRIP8b"
     regulatory      4426..4431
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pex5l"
                     /gene_synonym="1700016J08Rik; Pex2; pex5Rp; PXR2; TRIP8b"
                     /note="hexamer: AATAAA"
     polyA_site      4444
                     /gene="Pex5l"
                     /gene_synonym="1700016J08Rik; Pex2; pex5Rp; PXR2; TRIP8b"
ORIGIN      
        1 gaagattagc tttcttcctc ctcctagttc actcctctga ctgatgtgca aggtcttgca
       61 gaagccaggg acttgcattc tgggcttggc aaagtgctta ggaagacgac agggcttccc
      121 ggctgggagg agggaggaga gaggagagct gaagatcccc gcctgggctg gctcagctaa
      181 gcaaagtggg cagctcagta cttgaaagag gactgtgctc actcgctcgc tcgcactaga
      241 tatcaatctg tggttctctg gtcagcaagt tctggcaatg aagccactgc cgctggtgca
      301 aagaattctg ggatgtctga cagtgaaatg gatggaagga ctcacattcc atctctactt
      361 aatgcccttt tgtccagaaa tcgggtcatg cagatgagct acttgaaaag taaagaacaa
      421 ggctatggca agctaagcag tgacgaggac ctggaaataa ttgttgacca gaagcagctg
      481 gtgaatgagc aacaagagag cagacccctc ctgagcccct ccatcgacga cttcctctgc
      541 gaaaccaaat cggaggccat tgcaaagcca gtgacatcca acacagccgt gttgaccact
      601 ggcttggatc tccttgacct gagtgaaccc gtctctcaaa cccaaaccaa agccaagaaa
      661 tctgagccct catcaaagag ctcgtccctc aagaagaaag ctgatggctc cgacctcatc
      721 agtgcagatg ctgagcagag agcacaggct ctccgagggc cagagacatc atccttagat
      781 ttagacattc aaacacaact ggaaaaatgg gatgatgtca agtttcacgg tgaccgaaca
      841 agcaaggggc atctcatggc agaaaggaaa tcatgctctt ccagaactgg gtccaaagag
      901 cttctttggt ccgcagaaca cagatctcag ccagagctga gtactgggaa aagcgccctc
      961 aactctgagt cggcttccga gttggaactt gtagctccag cacaggctcg gctgaccaaa
     1021 gagcatcgct ggggaagtgc cctgctctcc aggaaccatt ccttggaaga ggagtttgaa
     1081 agggcaaaag cggcagtaga gtcagataca gagttctggg ataagatgca ggcagaatgg
     1141 gaggaaatgg cccggaggaa ctggatatcc gagaaccagg aagctcagaa ccaagtcacc
     1201 gtctcggcca gtgagaaggg atattacttc cacactgaaa atcccttcaa ggactggcct
     1261 ggagcatttg aagaaggctt aaaaaggttg aaggaagggg acctgcctgt caccatcctg
     1321 ttcatggaag ctgcaattct tcaggaccct ggagacgctg aggcatggca gtttcttggt
     1381 ataacccagg ctgagaatga aaatgagcag gcagctattg tcgccctcca gaggtgcctg
     1441 gagttgcagc ccaacaactt gaaggctctg atggccttgg ctgtaagtta caccaacacc
     1501 agccaccagc aggatgcttg tgaggcactg aagaactgga ttaagcaaaa cccaaagtac
     1561 aagtaccttg tgaagaacaa gaaaggctct ccaggcctca cacggcggat gtctaaatcc
     1621 ccagttgaca gctctgttct ggaaggagtg aaggagttgt acctggaagc tgcccaccaa
     1681 aatggtgaca tgattgaccc agacctgcag acaggtctgg gagttctgtt ccacctgagt
     1741 ggagagttca atagagcaat cgatgcattt aatgctgcct taacagttcg gccagaggat
     1801 tactcactgt ggaaccgtct tggggcaacc ttggcaaatg gagaccgcag tgaggaagct
     1861 gtggaggcct acacgagagc actggagatc cagccaggtt tcatccgctc cagatacaac
     1921 ctggggatca gctgcatcaa cctgggtgcc tacagagaag cggtcagcaa cttcctcact
     1981 gccctcagct tgcagaggaa gagcaggaac cagcagcaag tccctcaccc tgccatctcc
     2041 gggaacatct gggccgccct caggattgcc ctgtcgctga tggaccagcc ggagctcttc
     2101 caggccgcca acctcggtga cttggatgtc ctcctgagag ctttcaattt ggatccttga
     2161 aggaaaagaa gacaagaata ataaaggata ctaatgtgtc ttctgtgtta ttatactaaa
     2221 aagggacaaa actattttat tatgaatttc caaaacacat tttttttaaa aaaggataaa
     2281 gctgagaggc aaaaggccat ggtcatataa gccaagggaa ttgatttcta cagatccagt
     2341 ctctgttcag acccaaaagc acaaagcgaa ggtcggggtc aagagaagaa ctgagattct
     2401 caggacaaac caagataagg taactgcact cgcttccaaa ttgcaagtgt actttgagtt
     2461 atattgttcc tgtcccagct ggtggcacat ctgagggaca ctcttgggac ataacatgac
     2521 aatttgtcca cagtcagtga actcaggctg tctttgtcta cccttttgca agactgaaca
     2581 tagtttgggc cactggcaaa tgtacacatg cagccattgc ttccctctcg cccactctaa
     2641 ccttgactgt aagcctttgt tttcagagac agagagcttt gctggcgaaa gcagtttttg
     2701 cactagaagt ttttgctgtt cccaatgaaa tcctttctag gattgtacat aagcacttta
     2761 atatcttatt tatgccttgc cgggcttctg gcttgctgct ccagtttcta acttgggggg
     2821 tagggaaggg tgggataaaa gacttcagaa ctcagagttg ttagctcagt ggaccaaata
     2881 aaaaaattat aagaatagtt tttcttagca gagggtttgg gaagtgtgtt tgcatagaat
     2941 gtaaatatgt taaacacaat tttctttgtg tgctttctgg gagcccatgg atctcttgtg
     3001 aagcaaagtt cccagggcgc tctccctgca gaagggagct tggcgattct gcaatttcta
     3061 atgagttgtg ttaaacttgt tttaatatcc tgttttcctg gctctctaac tgccttgcac
     3121 aatgatattt cctttaaact gttactattt caaatggtat ttcttaagcg tgttaaatac
     3181 aattttccta aagtcgaagt gtttcctgag ttccgtaaca accactacca cctcccgcca
     3241 ctgcacacac acccccaccc ccaccccaac tgtccacatc ctcacattgt aagtgacagg
     3301 agggtcacat ttgtaaccca gcagtacaga gcagcaggaa gacacatgca acactcagca
     3361 atagccagac cttctccact ggccgagaaa tctgacttca ctgttggcct cctacagatt
     3421 tcttcagatt acttagtggg tgtttgggcg cttagtggtc atttcaaaag atgcattcat
     3481 ttaaaaatta gaaaaatgtt ggcaaaacac tacaaaataa cactttgatt agctcaaatt
     3541 ttagtaaact gccctatttg tctcccctct gtagccttcc tgccttcaga gtcttcccga
     3601 aagtagtctg atcccaacac tttcatatcc gttgctcact aataactcac ttcactaaca
     3661 attgtagcgt ccagactttg ggtgaaagca gatatagact gtggagtcat ctactaatga
     3721 ttgaaaccat gccagaggca gactggacca ctctggttcc ctggtttggg agatgcctga
     3781 agttcatagg tcactacaag tccttgaagc ttagctgtca cctaagcttc ctggctctta
     3841 aggacaaggt gataagacca ctgtagtggc ctcaggcttt gctcttcatg gtcaatactc
     3901 cctatggcag agcagtagcc ccaggttggc agcaggcact gggaggcatc ggggcatcca
     3961 ctcctggaca cggaaacaag tcacactttc taatagtctg agcagcaaag aacagctcaa
     4021 gtgtattttg aggagcagaa ttttctagac tgctagaaac agattgggaa gacctcttcg
     4081 ggccagactg cagacagtgg cattgcctgc tgggacattg ctgatagtat agtgatcatt
     4141 cctattttct ttctcactcc aagtatcaca tactgacaag gtgatgtgaa cccctcagag
     4201 tcccttccaa gcttgtgaac caagggttca tgactcttct gctgatgata atgcttttcc
     4261 aggccctcag tagcacctga tgttgccagg atgctgaccc accataccct cctccatgtc
     4321 acttcacaaa tacagcccaa ctaatacaaa tatgagaagt ctgactttat ttgaatattg
     4381 ctgaactgtg ttgaatactg tggcccaagt ttatgttgcc gttagaataa aaagtaactt
     4441 caaactctgg ggagttattt taggggacag ttgacaattt tccactttac cattagggaa
     4501 caatttgtag ggcatttgat gggactttat ccactccatc agttctatcc atcacagtcc
     4561 agatgtttat aggctaccac ctgtcaggaa gttcaaaagt actgctaaga gggaaagagt
     4621 tgcaacccgt ggcattataa tgatagtaag taaaaaccaa taactgaaaa gtaaaaatgt
     4681 gtgaaataga gccctagcag acactaagca gtaaacttca atgtcttctt tgcttttttc
     4741 ccccctctat gctttttaaa tgcagaactg ttagtgcttc ttatggcaag aaattgcctg
     4801 ttcacttttg aaacactgag gcattctttt gaggccctgg gaggagtctg aggatggtat
     4861 tcattcatgc gatggccact cagtggcttc cctggactga ttt
//
