LOCUS       NM_001410279            3188 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Mus musculus peroxisomal biogenesis factor 5 (Pex5), transcript
            variant 7, mRNA.
ACCESSION   NM_001410279 XM_006505759
VERSION     NM_001410279.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3188)
  AUTHORS   Choi,J., Smith,D.M., Lee,Y.J., Cai,D., Hossain,M.J., O'Connor,T.J.,
            Deme,P., Haughey,N.J., Scafidi,S., Riddle,R.C. and Wolfgang,M.J.
  TITLE     Etomoxir repurposed as a promiscuous fatty acid mimetic
            chemoproteomic probe
  JOURNAL   iScience 27 (9), 110642 (2024)
   PUBMED   39252970
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3188)
  AUTHORS   Wang,M., Ding,Y., Hu,Y., Li,Z., Luo,W., Liu,P. and Li,Z.
  TITLE     SIRT3 improved peroxisomes-mitochondria interplay and prevented
            cardiac hypertrophy via preserving PEX5 expression
  JOURNAL   Redox Biol 62, 102652 (2023)
   PUBMED   36906951
  REMARK    GeneRIF: SIRT3 improved peroxisomes-mitochondria interplay and
            prevented cardiac hypertrophy via preserving PEX5 expression.
REFERENCE   3  (bases 1 to 3188)
  AUTHORS   Liu,M., Liu,S., Song,C., Zhu,H., Wu,B., Zhang,A., Zhao,H., Wen,Z.
            and Gao,J.
  TITLE     Pre-meiotic deletion of PEX5 causes spermatogenesis failure and
            infertility in mice
  JOURNAL   Cell Prolif 56 (3), e13365 (2023)
   PUBMED   36433756
  REMARK    GeneRIF: Pre-meiotic deletion of PEX5 causes spermatogenesis
            failure and infertility in mice.
REFERENCE   4  (bases 1 to 3188)
  AUTHORS   Werner,E.R., Swinkels,D., Juric,V., Dorninger,F., Baes,M.,
            Keller,M.A., Berger,J. and Watschinger,K.
  TITLE     Normal plasmalogen levels are maintained in tissues from mice with
            hepatocyte-specific deletion in peroxin 5
  JOURNAL   Brain Res Bull 193, 158-165 (2023)
   PUBMED   36584717
  REMARK    GeneRIF: Normal plasmalogen levels are maintained in tissues from
            mice with hepatocyte-specific deletion in peroxin 5.
            Review article
REFERENCE   5  (bases 1 to 3188)
  AUTHORS   Ansermet,C., Centeno,G., Pradervand,S., Harmacek,D., Garcia,A.,
            Daraspe,J., Kocherlakota,S., Baes,M., Bignon,Y. and Firsov,D.
  TITLE     Renal tubular peroxisomes are dispensable for normal kidney
            function
  JOURNAL   JCI Insight 7 (4), e155836 (2022)
   PUBMED   35191396
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3188)
  AUTHORS   Huyghe,S., Casteels,M., Janssen,A., Meulders,L., Mannaerts,G.P.,
            Declercq,P.E., Van Veldhoven,P.P. and Baes,M.
  TITLE     Prenatal and postnatal development of peroxisomal
            lipid-metabolizing pathways in the mouse
  JOURNAL   Biochem J 353 (Pt 3), 673-680 (2001)
   PUBMED   11171065
REFERENCE   7  (bases 1 to 3188)
  AUTHORS   Infante,J.P. and Huszagh,V.A.
  TITLE     Zellweger syndrome knockout mouse models challenge putative
            peroxisomal beta-oxidation involvement in docosahexaenoic acid
            (22:6n-3) biosynthesis
  JOURNAL   Mol Genet Metab 72 (1), 1-7 (2001)
   PUBMED   11161822
  REMARK    Review article
REFERENCE   8  (bases 1 to 3188)
  AUTHORS   Janssen,A., Baes,M., Gressens,P., Mannaerts,G.P., Declercq,P. and
            Van Veldhoven,P.P.
  TITLE     Docosahexaenoic acid deficit is not a major pathogenic factor in
            peroxisome-deficient mice
  JOURNAL   Lab Invest 80 (1), 31-35 (2000)
   PUBMED   10653000
REFERENCE   9  (bases 1 to 3188)
  AUTHORS   Braverman,N., Dodt,G., Gould,S.J. and Valle,D.
  TITLE     An isoform of pex5p, the human PTS1 receptor, is required for the
            import of PTS2 proteins into peroxisomes
  JOURNAL   Hum Mol Genet 7 (8), 1195-1205 (1998)
   PUBMED   9668159
REFERENCE   10 (bases 1 to 3188)
  AUTHORS   Baes,M., Gressens,P., Baumgart,E., Carmeliet,P., Casteels,M.,
            Fransen,M., Evrard,P., Fahimi,D., Declercq,P.E., Collen,D., van
            Veldhoven,P.P. and Mannaerts,G.P.
  TITLE     A mouse model for Zellweger syndrome
  JOURNAL   Nat Genet 17 (1), 49-57 (1997)
   PUBMED   9288097
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124470.4.
            
            On Aug 2, 2022 this sequence version replaced XM_006505759.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422597.118180.1,
                                           SRR17784646.62964.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-97                AC124470.4         13571-13667
            98-261              AC124470.4         13984-14147
            262-297             AC124470.4         14392-14427
            298-430             AC124470.4         14733-14865
            431-562             AC124470.4         15034-15165
            563-668             AC124470.4         23162-23267
            669-759             AC124470.4         23714-23804
            760-870             AC124470.4         24191-24301
            871-966             AC124470.4         24527-24622
            967-1086            AC124470.4         25199-25318
            1087-1230           AC124470.4         28203-28346
            1231-1301           AC124470.4         28505-28575
            1302-1508           AC124470.4         28980-29186
            1509-1674           AC124470.4         29488-29653
            1675-1832           AC124470.4         29933-30090
            1833-3188           AC124470.4         30264-31619
FEATURES             Location/Qualifiers
     source          1..3188
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 59.15 cM"
     gene            1..3188
                     /gene="Pex5"
                     /gene_synonym="ESTM1; PTS1-BP; PTS1R; Pxr1; PXR1P"
                     /note="peroxisomal biogenesis factor 5"
                     /db_xref="GeneID:19305"
                     /db_xref="MGI:MGI:1098808"
     exon            1..97
                     /gene="Pex5"
                     /gene_synonym="ESTM1; PTS1-BP; PTS1R; Pxr1; PXR1P"
                     /inference="alignment:Splign:2.1.0"
     exon            98..261
                     /gene="Pex5"
                     /gene_synonym="ESTM1; PTS1-BP; PTS1R; Pxr1; PXR1P"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..2034
                     /gene="Pex5"
                     /gene_synonym="ESTM1; PTS1-BP; PTS1R; Pxr1; PXR1P"
                     /note="isoform 1 is encoded by transcript variant 7;
                     peroxisome receptor 1; peroxin 5; peroxisome biogenesis
                     factor 5; peroxisomal targeting signal 1 receptor; PTS1
                     receptor; peroxisomal C-terminal targeting signal import
                     receptor"
                     /codon_start=1
                     /product="peroxisomal targeting signal 1 receptor isoform
                     1"
                     /protein_id="NP_001397208.1"
                     /db_xref="GeneID:19305"
                     /db_xref="MGI:MGI:1098808"
                     /translation="MAMRELVEGECGGANPLMKLATHFTQDKALRQEGLRPGPWPPGA
                     SAAETVSKPLGVGTEDELVSEFLQDQNATLVSRAPQTFKMDDLLAEMQEIEQSNFRQA
                     PQRAPGVADLALSENWAQEFLAAGDAVDVAQDYNETDWSQEFIAEVTDPLSVSPARWA
                     EEYLEQSEEKLWLGDQEGSSTADRWYDEYHPEEDLQHTASDFVSKVDDPKLANSEFLK
                     FVRQIGEGQVSLESAAGSGGAQAEQWAAEFIQQQGTSEAWVDQFTRPGNKIAALQVEF
                     ERAKSAIESDVDFWDKLQAELEEMAKRDAEAHPWLSDYDDLTSASYDKGYQFEEENPL
                     RDHPQPFEEGLHRLEEGDLPNAVLLFEAAVQQDPKHMEAWQYLGTTQAENEQELLAIS
                     ALRRCLELKPDNRTALMALAVSFTNESLQRQACETLRDWLRYSPAYAHLVAPGEEGAT
                     GAGPSKRILGSLLSDSLFLEVKDLFLAAVRLDPTSIDPDVQCGLGVLFNLSGEYDKAV
                     DCFTAALSVRPNDYLMWNKLGATLANGNQSEEAVAAYRRALELQPGYIRSRYNLGISC
                     INLGAHREAVEHFLEALNMQRKSRGPRGEGGAMSENIWSTLRLALSMLGQSDAYGAAD
                     ARDLSALLAMFGLPQ"
     exon            262..297
                     /gene="Pex5"
                     /gene_synonym="ESTM1; PTS1-BP; PTS1R; Pxr1; PXR1P"
                     /inference="alignment:Splign:2.1.0"
     exon            298..430
                     /gene="Pex5"
                     /gene_synonym="ESTM1; PTS1-BP; PTS1R; Pxr1; PXR1P"
                     /inference="alignment:Splign:2.1.0"
     exon            431..562
                     /gene="Pex5"
                     /gene_synonym="ESTM1; PTS1-BP; PTS1R; Pxr1; PXR1P"
                     /inference="alignment:Splign:2.1.0"
     exon            563..668
                     /gene="Pex5"
                     /gene_synonym="ESTM1; PTS1-BP; PTS1R; Pxr1; PXR1P"
                     /inference="alignment:Splign:2.1.0"
     exon            669..759
                     /gene="Pex5"
                     /gene_synonym="ESTM1; PTS1-BP; PTS1R; Pxr1; PXR1P"
                     /inference="alignment:Splign:2.1.0"
     exon            760..870
                     /gene="Pex5"
                     /gene_synonym="ESTM1; PTS1-BP; PTS1R; Pxr1; PXR1P"
                     /inference="alignment:Splign:2.1.0"
     exon            871..966
                     /gene="Pex5"
                     /gene_synonym="ESTM1; PTS1-BP; PTS1R; Pxr1; PXR1P"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1086
                     /gene="Pex5"
                     /gene_synonym="ESTM1; PTS1-BP; PTS1R; Pxr1; PXR1P"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1230
                     /gene="Pex5"
                     /gene_synonym="ESTM1; PTS1-BP; PTS1R; Pxr1; PXR1P"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1301
                     /gene="Pex5"
                     /gene_synonym="ESTM1; PTS1-BP; PTS1R; Pxr1; PXR1P"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1508
                     /gene="Pex5"
                     /gene_synonym="ESTM1; PTS1-BP; PTS1R; Pxr1; PXR1P"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1674
                     /gene="Pex5"
                     /gene_synonym="ESTM1; PTS1-BP; PTS1R; Pxr1; PXR1P"
                     /inference="alignment:Splign:2.1.0"
     exon            1675..1832
                     /gene="Pex5"
                     /gene_synonym="ESTM1; PTS1-BP; PTS1R; Pxr1; PXR1P"
                     /inference="alignment:Splign:2.1.0"
     exon            1833..3188
                     /gene="Pex5"
                     /gene_synonym="ESTM1; PTS1-BP; PTS1R; Pxr1; PXR1P"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3138..3143
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pex5"
                     /gene_synonym="ESTM1; PTS1-BP; PTS1R; Pxr1; PXR1P"
                     /note="hexamer: AATAAA"
     polyA_site      3188
                     /gene="Pex5"
                     /gene_synonym="ESTM1; PTS1-BP; PTS1R; Pxr1; PXR1P"
                     /note="major polyA site"
ORIGIN      
        1 aggtgacacg agctgggatc gggacccgca gctggcgcct gaccgggggt gtgggtcccg
       61 gtgtacggtg gaaggcgtcc ccgctgtccc tcgtcaggga agctgctggt caccatggca
      121 atgcgggagc tggtggaggg cgaatgtggg ggtgccaacc cgctgatgaa gctggccacc
      181 catttcaccc aggacaaggc ccttcggcag gagggactga ggcctggccc ctggcctccg
      241 ggagcctcag cagcagagac cgtttccaag cctttgggag taggaactga agacgagttg
      301 gtgtcagaat tcctgcagga ccagaatgca actcttgtat cccgagcccc tcagaccttc
      361 aagatggatg acctcctggc agagatgcag gagattgaac agtcaaactt tcgccaggct
      421 cctcagagag cccctggtgt ggcagatttg gccttgtctg agaattgggc ccaggagttt
      481 cttgcagctg gagatgctgt ggatgtagct caagattata atgagaccga ctggtcccaa
      541 gaattcatcg ccgaagttac agacccactg tccgtgtccc ctgcccgatg ggctgaggag
      601 tatctggagc agtctgagga gaagctgtgg ttgggagacc aggaaggatc ctctaccgct
      661 gatcgatggt acgatgaata tcatcctgag gaggacctgc agcacacagc cagtgacttt
      721 gtgtccaagg tggacgaccc caaattggct aactctgagt tcctgaaatt cgtgcggcag
      781 attggcgagg ggcaggtgtc cctggagtcg gctgcagggt cgggcggagc tcaggcagaa
      841 cagtgggcag cagagtttat acagcagcag ggcacgtcag aggcctgggt tgatcagttt
      901 acaagaccag gaaacaaaat agctgccctt caggtggaat ttgaacgagc caagtcagct
      961 atagagtctg atgtcgattt ctgggacaag ttacaggcag agttggagga gatggccaag
     1021 cgggatgccg aggcgcaccc ctggctttct gactatgatg acctcacatc cgcttcctat
     1081 gacaagggtt accagtttga ggaggagaat cccttgcgtg accaccctca gccttttgaa
     1141 gaagggctgc atcgactgga ggagggagac ctgcccaatg ctgtgttgct cttcgaggct
     1201 gctgtgcagc aggatcctaa gcacatggaa gcttggcagt acctgggcac cacccaggcc
     1261 gagaatgagc aagagctctt ggctatcagt gccctgcgga ggtgtctgga actaaagcca
     1321 gataaccgga cagcactgat ggcgctggct gtgagcttta ccaatgagtc cctgcagcgc
     1381 caggcctgtg agacgttgag ggactggctg cgctactcac cggcctacgc tcatctggtg
     1441 gctcctgggg aagaaggggc gaccggggca ggccccagca agcgcatctt gggatctctg
     1501 ttgtctgact ccctgtttct tgaagtaaaa gatctcttcc tggcggctgt gcgtctggac
     1561 cctacatcca ttgaccctga tgtgcagtgt ggcctgggag tcctcttcaa cctgagcggg
     1621 gagtacgaca aggctgtgga ctgtttcaca gctgccctca gtgttcgccc caatgactat
     1681 ttgatgtgga acaagcttgg ggccaccctg gccaatggga accagagtga agaagcagtg
     1741 gctgcatacc gccgagccct tgaactacag cctgggtata ttcggtcccg gtataaccta
     1801 ggcatcagct gcatcaacct gggagctcac cgtgaggctg tggagcactt tctggaggct
     1861 ctgaacatgc agaggaagag ccggggccct cggggtgagg ggggcgccat gtctgagaac
     1921 atctggagta ccctgcgctt ggcgttatcc atgttaggcc agagcgatgc ctatggggca
     1981 gccgatgctc gggatctgtc tgccctccta gctatgtttg gcctgcccca gtgacagtgg
     2041 gatgggctgc cctgtgagtg tctgcttgga ggggtccgcg ctctgggtgt gactccctct
     2101 cctcaaacgg gcctaccaag ggggtgggct gatgaccaca agcggtacga cctctcagga
     2161 gctgcctcag agtaggggtg catagctgtg tcttaggtcc tacttaattg tagggatgag
     2221 ctgtctctgt cccttggtaa ttcaagggct gtctacccag ctacagatct ctttctgttc
     2281 atcaggccct ttcttggtgc tgcttcttgg gtcggaccca atgacatagg ggagttgtca
     2341 tctgccgttt ctgatagggt ctgccacatt tgtaagtctc tccttgcccc atcttcctgg
     2401 gaattggtaa cagtccagct tccttgggca gttgtgtgta agaggctccc ctgagcatct
     2461 gtgcgacgcc agctgggatg gatgttagga gctgccctgc tcgctgaaat ggtgatgcgg
     2521 ctccctagag ccgaacttgg aacaagtgct cgcagctcgg tcactccggg agcgagcatg
     2581 gatcttctgt gggtggacac tgaagcagca gatgctcatg tggttactgt actgtcctca
     2641 gggccagggc ttgtcactgc aggtggcctg gcctatgggg gagggaggtt catttgtgga
     2701 atgagcccag agatgcgaca gtagtgatac ggtcagcact gcagtcctct cttcttggga
     2761 gacttggaag taggaactaa acaaactctt gtagcaacct ggttcagaag ttgcattctt
     2821 gccaaattcc caaccaaggg agggttcagt gttaccataa gccttcttga aacctttata
     2881 ggggatatca ttgaaaaccc ccttcccctc gattacctcc acaaggtgaa gatgaaggga
     2941 ttctgaggga gcagctggag acgtctccac tgtttctgtg tggggagatg cacagacccc
     3001 cataaatgac tgctaagcct cttaccttgt cttcagtagc taatgatcag attttttttt
     3061 tttttaaact gccatggtcc caaaatccca tcctgaaatt tatttttctt tgtatgcata
     3121 tgtgtaaatg atttaaaaat aaaactgtaa aatatttgta tgaagaataa actggactga
     3181 cgtgggta
//
