LOCUS       NM_019961               2303 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus peroxisomal biogenesis factor 3 (Pex3), transcript
            variant 1, mRNA.
ACCESSION   NM_019961
VERSION     NM_019961.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2303)
  AUTHORS   Sun,J.T., Wang,Z.M., Zhou,L.H., Yang,T.T., Zhao,D., Bao,Y.L.,
            Wang,S.B., Gu,L.F., Chen,J.W., Shan,T.K., Wei,T.W., Wang,H.,
            Wang,Q.M., Kong,X.Q., Xie,L.P., Gu,A.H., Zhao,Y., Chen,F., Ji,Y.,
            Cui,Y.Q. and Wang,L.S.
  TITLE     PEX3 promotes regenerative repair after myocardial injury in mice
            through facilitating plasma membrane localization of ITGB3
  JOURNAL   Commun Biol 7 (1), 795 (2024)
   PUBMED   38951640
  REMARK    GeneRIF: PEX3 promotes regenerative repair after myocardial injury
            in mice through facilitating plasma membrane localization of ITGB3.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2303)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2303)
  AUTHORS   Yao,Y., Shi,B., Zhang,X., Wang,X., Li,S., Yao,Y., Guo,Y., Chen,D.,
            Wang,B., Yuan,Y., Sha,J. and Guo,X.
  TITLE     Germ cell-specific deletion of Pex3 reveals essential roles of
            PEX3-dependent peroxisomes in spermiogenesis
  JOURNAL   J Biomed Res 38 (1), 24-36 (2023)
   PUBMED   38062668
REFERENCE   4  (bases 1 to 2303)
  AUTHORS   Wu,C.C., Chen,W.C., Hsiao,W.P., Huang,K.F., Liao,Y.S., Lin,H.B.,
            Wu,Y.J., Kao,C.H. and Chen,S.L.
  TITLE     Reciprocal Regulation of Peroxisome Biogenesis and Myogenic Factors
            Is Critical for Myogenesis
  JOURNAL   Int J Mol Sci 24 (15), 12262 (2023)
   PUBMED   37569637
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2303)
  AUTHORS   Kochaj,R.M., Martelletti,E., Ingham,N.J., Buniello,A., Sousa,B.C.,
            Wakelam,M.J.O., Lopez-Clavijo,A.F. and Steel,K.P.
  TITLE     The Effect of a Pex3 Mutation on Hearing and Lipid Content of the
            Inner Ear
  JOURNAL   Cells 11 (20), 3206 (2022)
   PUBMED   36291074
  REMARK    GeneRIF: The Effect of a Pex3 Mutation on Hearing and Lipid Content
            of the Inner Ear.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2303)
  AUTHORS   Tanaka,H., Okazaki,T., Aoyama,S., Yokota,M., Koike,M., Okada,Y.,
            Fujiki,Y. and Gotoh,Y.
  TITLE     Peroxisomes control mitochondrial dynamics and the
            mitochondrion-dependent apoptosis pathway
  JOURNAL   J Cell Sci 132 (11) (2019)
   PUBMED   31076512
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2303)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2303)
  AUTHORS   Liakath-Ali,K., Vancollie,V.E., Heath,E., Smedley,D.P., Estabel,J.,
            Sunter,D., Ditommaso,T., White,J.K., Ramirez-Solis,R., Smyth,I.,
            Steel,K.P. and Watt,F.M.
  TITLE     Novel skin phenotypes revealed by a genome-wide mouse reverse
            genetic screen
  JOURNAL   Nat Commun 5, 3540 (2014)
   PUBMED   24721909
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2303)
  AUTHORS   Sansom,S.N., Griffiths,D.S., Faedo,A., Kleinjan,D.J., Ruan,Y.,
            Smith,J., van Heyningen,V., Rubenstein,J.L. and Livesey,F.J.
  TITLE     The level of the transcription factor Pax6 is essential for
            controlling the balance between neural stem cell self-renewal and
            neurogenesis
  JOURNAL   PLoS Genet 5 (6), e1000511 (2009)
   PUBMED   19521500
REFERENCE   10 (bases 1 to 2303)
  AUTHORS   Muntau,A.C., Mayerhofer,P.U., Albet,S., Schmid,T.E., Bugaut,M.,
            Roscher,A.A. and Kammerer,S.
  TITLE     Genomic organization, expression analysis, and chromosomal
            localization of the mouse PEX3 gene encoding a peroxisomal assembly
            protein
  JOURNAL   Biol Chem 381 (4), 337-342 (2000)
   PUBMED   10839463
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153979.3, AK146934.1 and CJ299039.1.
            
            On Aug 14, 2009 this sequence version replaced NM_019961.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF152996.1, AK146934.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                AC153979.3         81950-81971         c
            23-2109             AK146934.1         2-2088
            2110-2303           CJ299039.1         299-492
FEATURES             Location/Qualifiers
     source          1..2303
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 4.89 cM"
     gene            1..2303
                     /gene="Pex3"
                     /gene_synonym="1700014F15Rik; 2810027F19Rik;
                     2900010N04Rik"
                     /note="peroxisomal biogenesis factor 3"
                     /db_xref="GeneID:56535"
                     /db_xref="MGI:MGI:1929646"
     exon            1..317
                     /gene="Pex3"
                     /gene_synonym="1700014F15Rik; 2810027F19Rik;
                     2900010N04Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             245..1363
                     /gene="Pex3"
                     /gene_synonym="1700014F15Rik; 2810027F19Rik;
                     2900010N04Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     peroxisomal assembly protein 3; peroxin-3; peroxisomal
                     assembly protein PEX3"
                     /codon_start=1
                     /product="peroxisomal biogenesis factor 3 isoform 1"
                     /protein_id="NP_064345.1"
                     /db_xref="CCDS:CCDS23702.1"
                     /db_xref="GeneID:56535"
                     /db_xref="MGI:MGI:1929646"
                     /translation="MLRSMWNFLKRHKKKCIFLGTVLGGVYILGKYGQKKIREIQERE
                     AAEYIAQARRQYHFESNQRTCNMTVLSMLPTLREALMQQLNSESLTALLKSRPSNKLE
                     IWEDLKIISFTRSIVAVYSTCMLVVLLRVQLNIIGGYIYLDNATVGKNGTTVLAPPDV
                     QQQYLSSIQHLLGDGLTELVTVIKQAVQRILGSVSLKHSLSLLDLEQKLKEIRILVEQ
                     HQSSWNDKDVSRSSLCQYMMPDEETPLAAQAYGLSHRDITTIKLLNETRDMLESPDFS
                     TVLNTCLNRGFSRLLDNMAEFFRPTEQDLQHGNSINSLSSVSLPLAKIIPIVNGQIHS
                     VCSETPSHFVQDLLMMEQVKDFAANVYEAFSTPQQLEK"
     exon            318..449
                     /gene="Pex3"
                     /gene_synonym="1700014F15Rik; 2810027F19Rik;
                     2900010N04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            450..531
                     /gene="Pex3"
                     /gene_synonym="1700014F15Rik; 2810027F19Rik;
                     2900010N04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            532..575
                     /gene="Pex3"
                     /gene_synonym="1700014F15Rik; 2810027F19Rik;
                     2900010N04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            576..700
                     /gene="Pex3"
                     /gene_synonym="1700014F15Rik; 2810027F19Rik;
                     2900010N04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            701..767
                     /gene="Pex3"
                     /gene_synonym="1700014F15Rik; 2810027F19Rik;
                     2900010N04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            768..822
                     /gene="Pex3"
                     /gene_synonym="1700014F15Rik; 2810027F19Rik;
                     2900010N04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            823..988
                     /gene="Pex3"
                     /gene_synonym="1700014F15Rik; 2810027F19Rik;
                     2900010N04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1059
                     /gene="Pex3"
                     /gene_synonym="1700014F15Rik; 2810027F19Rik;
                     2900010N04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1182
                     /gene="Pex3"
                     /gene_synonym="1700014F15Rik; 2810027F19Rik;
                     2900010N04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1279
                     /gene="Pex3"
                     /gene_synonym="1700014F15Rik; 2810027F19Rik;
                     2900010N04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..2303
                     /gene="Pex3"
                     /gene_synonym="1700014F15Rik; 2810027F19Rik;
                     2900010N04Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1453..1458
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pex3"
                     /gene_synonym="1700014F15Rik; 2810027F19Rik;
                     2900010N04Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1475
                     /gene="Pex3"
                     /gene_synonym="1700014F15Rik; 2810027F19Rik;
                     2900010N04Rik"
                     /note="major polyA site"
     regulatory      2094..2099
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pex3"
                     /gene_synonym="1700014F15Rik; 2810027F19Rik;
                     2900010N04Rik"
                     /note="hexamer: AATAAA"
     regulatory      2112..2117
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pex3"
                     /gene_synonym="1700014F15Rik; 2810027F19Rik;
                     2900010N04Rik"
                     /note="hexamer: AATATA"
     polyA_site      2115
                     /gene="Pex3"
                     /gene_synonym="1700014F15Rik; 2810027F19Rik;
                     2900010N04Rik"
     polyA_site      2132
                     /gene="Pex3"
                     /gene_synonym="1700014F15Rik; 2810027F19Rik;
                     2900010N04Rik"
     regulatory      2282..2287
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pex3"
                     /gene_synonym="1700014F15Rik; 2810027F19Rik;
                     2900010N04Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2303
                     /gene="Pex3"
                     /gene_synonym="1700014F15Rik; 2810027F19Rik;
                     2900010N04Rik"
ORIGIN      
        1 acggacccag gcgtcccgga tcagtaagcg gcggctgggg gaccgaaagc gtcgctgctc
       61 cgctctagtc cacgccccct tcctccgctt aagccacaac ctctgctcag agaaacgtct
      121 gtggtttctg gagagcacct agcgccgcca ccgcgctgct gccggaggtc caggccaggt
      181 ggacggaaga cacggtgagc cagcccctct cccctaggca acccacacaa cacggggtct
      241 ggagatgctg agatcaatgt ggaattttct gaaacgtcac aaaaagaaat gcatcttcct
      301 gggcacagtc ctcggaggag tatatatcct gggaaaatat ggacagaaaa aaattagaga
      361 aatacaagaa agagaagctg cagaatacat tgcccaagct cggcgacagt accattttga
      421 aagcaaccag aggacttgca atatgacagt gctgtccatg ctgccgacac tgagagaggc
      481 cttaatgcag cagctcaact cggagagtct cacagctctg ttgaaaagca ggccttcaaa
      541 caagctggaa atatgggagg acctaaagat aataagtttc acaagaagta ttgtagctgt
      601 atatagcacg tgtatgctgg tggttctttt gcgagtccag ttaaacataa ttggtggata
      661 tatttacctg gataatgcaa cagttggcaa aaatggcact accgttcttg ctcctccgga
      721 tgtacagcag cagtatttat caagtattca acacctcctt ggagacggcc tcacagagtt
      781 ggtcactgtc attaaacaag ctgtacaaag gatcttagga agtgtctctc ttaaacattc
      841 cttgtccctt ttggacttgg agcaaaaact aaaagaaatc agaattcttg ttgagcaaca
      901 tcagtcttct tggaatgata aagatgtgtc caggtcttca ctgtgccagt acatgatgcc
      961 agatgaggag acaccattgg cagctcaggc ctatgggctt tctcacagag atatcaccac
     1021 tattaaactt ctcaatgaga caagagacat gctggaaagt ccagatttta gtacagtttt
     1081 gaatacctgt ctaaacagag gcttcagtcg gcttctagac aacatggccg aattctttcg
     1141 acccactgag caggacctac agcatggtaa ctccataaac agtctgtcca gtgtcagcct
     1201 gcctttagct aagataattc ccatagtgaa cgggcagatc cattcagttt gcagtgagac
     1261 acctagtcat tttgtgcagg atctgctgat gatggaacag gtgaaagact ttgctgctaa
     1321 cgtgtacgaa gcgtttagta ccccccaaca actggagaaa tgattgtttt ctttccagaa
     1381 aactacagcg gactcatcta catcaaaaag tactctgaat aaatcaccta tacaatttgc
     1441 aaccaaatgc ctaataaaat ctgttcttga gcaaagtctt catttcataa tgaagtagat
     1501 tcatttagca ccttactgta tttttaattc atcagcagtc tacttcatca ggtgtatcta
     1561 actggtgcac aaattacatc aggatcaatc atgatttctt aaagtctgga tagctgatcc
     1621 aaaccaacta ggtacttcca tacgtatatg gaatggaatg tggtgtcctt tcacacatag
     1681 aatgagggaa gatatgtctt caaaagtaga tctaggagtg gtggactctg aaattaggat
     1741 gtttaactaa ctatgaagtt tcctggactc tgaagtaagc aagagcaagc cagattctct
     1801 ccggccaccc tgataaggca catgtgattt gcttgaacac acgtgccaga gggcttatca
     1861 ccaaggaatc agtgcatttg aacccctatg gtcaactttt ctttactgtt gtttcttcaa
     1921 tatttatttg cagcattttc taaagctttg ttagcaaccc tcagaaggtt gtatatagat
     1981 tttcaggcta atgttatgtc gcttactcac aattattaat aattacagaa gtttattcat
     2041 ttgtgtataa atttaataac tttgtattga ttttgagtat gataacttgt tgcaataaac
     2101 tattttaata aaatatagct ttgtttagtt aatgcttttt agccattaat ttatttgtcc
     2161 tttagtaata tttttgctgt tttttttttt tttgtgagag gttgctagtt taaagtttta
     2221 actggtatat agttggtgct ttcttataac ttgtttcttt ttttcagaaa aactaattaa
     2281 aaataaatta tctcttgtct cta
//
