LOCUS       NM_028730               4093 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus peroxisomal biogenesis factor 26 (Pex26), transcript
            variant 1, mRNA.
ACCESSION   NM_028730
VERSION     NM_028730.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4093)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4093)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   3  (bases 1 to 4093)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 4093)
  AUTHORS   Matsumoto,N., Tamura,S. and Fujiki,Y.
  TITLE     The pathogenic peroxin Pex26p recruits the Pex1p-Pex6p AAA ATPase
            complexes to peroxisomes
  JOURNAL   Nat Cell Biol 5 (5), 454-460 (2003)
   PUBMED   12717447
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK087637.1, BC058694.1,
            AK014598.1 and AC153584.5.
            
            On Feb 10, 2015 this sequence version replaced NM_028730.5.
            
            Summary: This gene is a member of the peroxin-26 family. The
            encoded protein is probably required for protein import into
            peroxisomes. It may anchor Pex1 and Pex6 to peroxisome membranes.
            Defects in a similar gene in human are the cause of peroxisome
            biogenesis disorder complementation group 8 (PBD-CG8). PBD refers
            to a group of four disorders: Zellweger syndrome (ZWS), neonatal
            adrenoleukodystrophy (NALD), infantile Refsum disease (IRD), and
            classical rhizomelic chondrodysplasia punctata (RCDP).
            Alternatively spliced transcript variants have been identified for
            this gene. [provided by RefSeq, Feb 2015].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK087637.1, AK014598.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-248               AK087637.1         2-249
            249-2789            BC058694.1         1-2541
            2790-4022           BC058694.1         2543-3775
            4023-4086           AK014598.1         3801-3864
            4087-4093           AC153584.5         87892-87898         c
FEATURES             Location/Qualifiers
     source          1..4093
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 57.13 cM"
     gene            1..4093
                     /gene="Pex26"
                     /gene_synonym="4632428M11Rik"
                     /note="peroxisomal biogenesis factor 26"
                     /db_xref="GeneID:74043"
                     /db_xref="MGI:MGI:1921293"
     exon            1..816
                     /gene="Pex26"
                     /gene_synonym="4632428M11Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             599..1516
                     /gene="Pex26"
                     /gene_synonym="4632428M11Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     peroxisome biogenesis factor 26; peroxisome assembly
                     protein 26; peroxin-26"
                     /codon_start=1
                     /product="peroxisome assembly protein 26 isoform 1"
                     /protein_id="NP_083006.1"
                     /db_xref="CCDS:CCDS20488.1"
                     /db_xref="GeneID:74043"
                     /db_xref="MGI:MGI:1921293"
                     /translation="MKSDASTSAAPLKGLVGPLRSSEPALALPAVSPAVHLLEEASDL
                     LVVHLDFHAALETCERAWQSLAEEPVSGTIVEVKCSLCVVGIQALAEMDRWREALSWV
                     LRYYQVPEKLPPKVLELCILLYSKMKEPGAVLDVASAWLQDPDNQGLPDYGSLARLHV
                     FRLLLPSGRLSEAEELAVRSAAFSEEQRVEALQAIHLARQQHTQEHTQEHSDSQEPQK
                     LRQEGSFSQKLLSLLMLLRRLWGSVVSHLLSQPFRKGLLAALILCLLILRFDPAAPSS
                     LPFLYQLTQLFRRIQKATLSRLYPLALRD"
     exon            817..957
                     /gene="Pex26"
                     /gene_synonym="4632428M11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1265
                     /gene="Pex26"
                     /gene_synonym="4632428M11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1412
                     /gene="Pex26"
                     /gene_synonym="4632428M11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..4093
                     /gene="Pex26"
                     /gene_synonym="4632428M11Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4074..4079
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pex26"
                     /gene_synonym="4632428M11Rik"
                     /note="hexamer: AATAAA"
     polyA_site      4093
                     /gene="Pex26"
                     /gene_synonym="4632428M11Rik"
                     /note="major polyA site"
ORIGIN      
        1 agcgaaggaa ggatcacatt tctcaggaca aaggcatttc actaatggtt tagcttcctc
       61 atcttttcca ccccaaagct ggcgacccag tgcgttctct ctggaagatg gcagtctctg
      121 ggcgcgagag gttccccgaa gcttcacaga cccaagagcc caggactaca actcccagaa
      181 tccttcgctc cagcgtgcgc gtgcgtcgta gtggctaaga ggggtggaga ggaggtgtcc
      241 accgtcgtgg gttccccgtg caggtcttct gttgtcgcgc tctctactct gggagtttcg
      301 gtgcttttag caccggtcca gggacaggag gaactagtgc tgggccttcg gcagcactag
      361 tcttgaacag acagtcttga acaggccagt gccccaaggg ttaggctgtc agtgagcgca
      421 ggctgtgccc gggtccagct ccttcctggt ccttccttag gaacagacct ggagaggcgc
      481 ggaggggaag agtgcgaggc ttgcgggaca tctaccaggc ccagtccgaa tttccaggaa
      541 gctcccgaga agctgtcctc ctgacgtgtg aggagacctg gtcgaaccca ggctggctat
      601 gaagagcgac gcctcgacgt ctgcagcccc tttgaaaggg ctcgtgggcc ctctgcggag
      661 cagcgagccc gcgctcgccc tccccgctgt gtcccccgcg gtgcacctgc tggaagaggc
      721 gtccgacctg ttggtggtgc acctggactt ccatgccgca ctagagactt gcgaacgagc
      781 ctggcagagc ctggcggagg agcccgtgag tggcaccatt gtggaggtga aatgctccct
      841 gtgtgtggtg gggatccagg ctctggcaga aatggatcga tggagagaag ccctgtcctg
      901 ggtcctccgg tactaccagg ttcctgaaaa gctgcctccc aaagtcctgg agctgtgcat
      961 ccttttatac agcaaaatga aagagcccgg agctgtgctg gatgtggcca gtgcctggct
     1021 ccaagatcca gataaccagg gccttcctga ttatggatcg ctggccagac tccacgtgtt
     1081 ccggctgctg ctaccctcgg gtcgcttgtc agaggccgag gaactggcag tgcgctctgc
     1141 ggccttcagc gaggagcagc gggtagaagc gctccaggcc atccacttag cacggcagca
     1201 gcacacgcaa gagcacacgc aggagcactc ggactcccag gagccccaga agctgaggca
     1261 ggaaggttcg ttctcccaga agttgctgtc gctgctgatg ctgcttcgcc ggctctgggg
     1321 ctccgtggtg agccacctcc tctcgcagcc cttcagaaag ggcctcctgg ctgccttgat
     1381 cctctgcctc ttgattctac ggtttgaccc agcagctcct tcttcgctgc ccttcctcta
     1441 ccagctgacc cagctcttcc gccggatcca gaaggccaca ctttctcggc tctaccccct
     1501 cgccctccgg gactgagtgg tcctacctgg ctgtctctac ctcttacact ccacatctat
     1561 agaagcggag aagttgagcc cagtgcctgg gtccaagatg gcaccttggg aatgggccca
     1621 ttggttctag aaggagtgac caaggcaggt gagccatgga tggctgactt tgaaccctcc
     1681 ctttggtatc ccactgtggc tggcctcaga gggagtttgg gaacagtggt gcccgaggcc
     1741 cagtgcacag aacacaagtc tggctgccca gaacactgca acagctcatc aaaaaggagg
     1801 gttaggagca gggagtgggg cttgagacag tctcatttct tgacaaaggc agagggtgac
     1861 tttccagatc tggtgctgag ggatctggga tttacagatt tacctctgaa aactgctcta
     1921 cagctcagaa tttgaatttg agtaagacca gaggtccctc ggtcccccac tcccctcctc
     1981 catacccttc ccccacgccc ctcccacaga tcagttcacc atcccctccc attggtctgg
     2041 cagtagggca agaggctttc tgctagaggc cttttgctgt tcagaccgga tatggcttct
     2101 gactcaccca ggtggccacc tggagcaaag tgagcctgcc tgaccttatc tctggggaat
     2161 gtgatctttc ttggtgccgc tgagtcttag ctcagttttc cagctcgcca ggggccaagc
     2221 tctgccctct gggacccagt gtcttcccac cacaccccac cccaccacct tttgatctgt
     2281 ctagccaact gtgtcacacc actgtctctc cttgatcctt tctctgggtc ctagttgtgg
     2341 tccattgttt gaataatgcc ctagtctctc tgctcgtgtg gtgtgaaaag taggccaggc
     2401 tcagggctga cagctgaaaa tggaactggg taatcaggtg agctgtgaga accgtggggg
     2461 ctgggcagag gggctggggg gtggggcaaa gggacaaccc cagggaggag gcactgcgtg
     2521 cgtgcgcttc agcctcagca tttctgtgta aaaaaataca ggctcctctg gtgccgccag
     2581 gaaggaggtc ctcagccgcc cacccacact ggatccctga cacgggatgg caagagtgca
     2641 gaggctttgc tagtcttttg ttggctgata tttaggaact gtgagtcaac agcttttctc
     2701 tagaagagga aacgtcacag aaacttactt agaattccat ctaaaccctg aagacttggc
     2761 aactaggttc atcatttttt tttttttttg tatgcctttt aagtagaccc tagatcacac
     2821 tggggaggga aaaggattca ggaagggttg aaatcccttg acagtgattc cttcagtgtt
     2881 gtcgcccaac ttggcccaga acacctgggc tccagtgctg agctccgccc tccagcttcg
     2941 agcgtctgtg actcacacac cttatgacag tggttttgaa gtgaggacct acccattcac
     3001 tgccctagaa gaaactcctt aacggctttc atggcccaca ggatacaaat ccagattctt
     3061 tttaatagaa acttaggcca gtgttcgcac gtctggctga cagctccttt actgtgttgc
     3121 cctgttcgct gagcaggctg tactctagct gccaggtcct cctcaggcct ccctgtgatg
     3181 gcttagctgt atctgctgga gggtcttgga gcagctctgc tctagaccct tggctttcca
     3241 ggctctcaag ggttacccag cattctttgc tgcccagccc atctcctgcc cctcctgtag
     3301 tgggggcctg gtggtgggtg gtgggactgt ttgcctcttc cagtgccgta agctccatga
     3361 ggctgcagag tgtttgagtc gggctggcat tcctgtgtgg gtgactgttg gccagggttc
     3421 tgctttctca tctgtaagtc ggttctcttc tcacagggcc tcttctacga gtaatgggca
     3481 cttaggactc ttggcacttt tgacagccac taggaagagt tctcgtgagc agtggtattc
     3541 ccaggctcag ctgagcatgg gtgggtcctc agggctgagt ggactggtgg aagagggcat
     3601 gcgcttctgg tgctgtgaaa ccctgaacag atcggcttgt ctttctgctc tctcctgatg
     3661 ctcctcacag ttgttctgct ggtggcccat ggggctctgt ttatttttac ctgactgctg
     3721 cagggctgtc tgtaccttaa ccacctgcct atccagccag gaactcgaat cccaaactgt
     3781 tgctgttact ttgtcctttc caaggatgta ggctggtcct cggctctggg cttaaagagg
     3841 tcagagtgaa gggagggcct tcttggtggg tccagcacag cagccatcag ccaaaggtag
     3901 cttttgagca tttgaattgt gtgcggctca tccacgtgga cacatgctgt aattgttaaa
     3961 catgcacact ggatttcaaa gaccaagtac taaaaaataa aataaaagaa tggaaacaca
     4021 aagattttta tattgactgt atgttgaaat aatattttag atatattggg ttaaataaaa
     4081 tcaattaaaa taa
//
