LOCUS       NM_023041               3131 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus peroxisomal biogenesis factor 19 (Pex19), transcript
            variant 1, mRNA.
ACCESSION   NM_023041
VERSION     NM_023041.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3131)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3131)
  AUTHORS   Wu,C.C., Chen,W.C., Hsiao,W.P., Huang,K.F., Liao,Y.S., Lin,H.B.,
            Wu,Y.J., Kao,C.H. and Chen,S.L.
  TITLE     Reciprocal Regulation of Peroxisome Biogenesis and Myogenic Factors
            Is Critical for Myogenesis
  JOURNAL   Int J Mol Sci 24 (15), 12262 (2023)
   PUBMED   37569637
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3131)
  AUTHORS   Kashiwayama,Y., Seki,M., Yasui,A., Murasaki,Y., Morita,M.,
            Yamashita,Y., Sakaguchi,M., Tanaka,Y. and Imanaka,T.
  TITLE     70-kDa peroxisomal membrane protein related protein (P70R/ABCD4)
            localizes to endoplasmic reticulum not peroxisomes, and
            NH2-terminal hydrophobic property determines the subcellular
            localization of ABC subfamily D proteins
  JOURNAL   Exp Cell Res 315 (2), 190-205 (2009)
   PUBMED   19010322
REFERENCE   4  (bases 1 to 3131)
  AUTHORS   Tompkins,V., Hagen,J., Zediak,V.P. and Quelle,D.E.
  TITLE     Identification of novel ARF binding proteins by two-hybrid
            screening
  JOURNAL   Cell Cycle 5 (6), 641-646 (2006)
   PUBMED   16582619
REFERENCE   5  (bases 1 to 3131)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3131)
  AUTHORS   Murdoch,J.N., Doudney,K., Paternotte,C., Copp,A.J. and Stanier,P.
  TITLE     Severe neural tube defects in the loop-tail mouse result from
            mutation of Lpp1, a novel gene involved in floor plate
            specification
  JOURNAL   Hum Mol Genet 10 (22), 2593-2601 (2001)
   PUBMED   11709546
REFERENCE   7  (bases 1 to 3131)
  AUTHORS   Kibar,Z., Vogan,K.J., Groulx,N., Justice,M.J., Underhill,D.A. and
            Gros,P.
  TITLE     Ltap, a mammalian homolog of Drosophila Strabismus/Van Gogh, is
            altered in the mouse neural tube mutant Loop-tail
  JOURNAL   Nat Genet 28 (3), 251-255 (2001)
   PUBMED   11431695
REFERENCE   8  (bases 1 to 3131)
  AUTHORS   Sugihara,T., Kaul,S.C., Kato,J., Reddel,R.R., Nomura,H. and
            Wadhwa,R.
  TITLE     Pex19p dampens the p19ARF-p53-p21WAF1 tumor suppressor pathway
  JOURNAL   J Biol Chem 276 (22), 18649-18652 (2001)
   PUBMED   11259404
REFERENCE   9  (bases 1 to 3131)
  AUTHORS   Doudney,K., Murdoch,J.N., Paternotte,C., Bentley,L., Gregory,S.,
            Copp,A.J. and Stanier,P.
  TITLE     Comparative physical and transcript maps of approximately 1 Mb
            around loop-tail, a gene for severe neural tube defects on distal
            mouse chromosome 1 and human chromosome 1q22-q23
  JOURNAL   Genomics 72 (2), 180-192 (2001)
   PUBMED   11401431
REFERENCE   10 (bases 1 to 3131)
  AUTHORS   Eddleston,J., Murdoch,J.N., Copp,A.J. and Stanier,P.
  TITLE     Physical and transcriptional map of a 3-Mb region of mouse
            chromosome 1 containing the gene for the neural tube defect mutant
            loop-tail (Lp)
  JOURNAL   Genomics 56 (2), 149-159 (1999)
   PUBMED   10051400
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK029368.1, AK075576.1 and AK028449.1.
            
            On Apr 18, 2009 this sequence version replaced NM_023041.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.68045.1,
                                           SRR1660821.173643.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-66                AK029368.1         2-67
            67-1914             AK075576.1         54-1901
            1915-3131           AK028449.1         1633-2849
FEATURES             Location/Qualifiers
     source          1..3131
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 79.54 cM"
     gene            1..3131
                     /gene="Pex19"
                     /gene_synonym="Pxf"
                     /note="peroxisomal biogenesis factor 19"
                     /db_xref="GeneID:19298"
                     /db_xref="MGI:MGI:1334458"
     exon            1..94
                     /gene="Pex19"
                     /gene_synonym="Pxf"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..924
                     /gene="Pex19"
                     /gene_synonym="Pxf"
                     /note="isoform a is encoded by transcript variant 1;
                     peroxisomal farnesylated protein; peroxisome biogenesis
                     factor 19; peroxin-19"
                     /codon_start=1
                     /product="peroxisomal biogenesis factor 19 isoform a"
                     /protein_id="NP_075528.3"
                     /db_xref="CCDS:CCDS15508.1"
                     /db_xref="GeneID:19298"
                     /db_xref="MGI:MGI:1334458"
                     /translation="MAAAEEGCGVGVEDDRELEELLESALDDFDKAKPSPEHAPTISA
                     PDASGPQKRAPGDTAKDALFASQEKFFQELFDSELASQATAEFEKAMKELAEEEPHLV
                     EQFQKLSEAAGRVGSDASSQQEFTSCLKETLSGLAKNATELQNSGMSEEELMKAMEGL
                     GMDEGDGEASILPIMQSIMQNLLSKDVLYPSLKEITEKYPEWLQSHQDSTPPEQFEKY
                     QQQHSVMVKICEQFEAETPTDSEATQRARFEAMLDLMQQLQALGHPPKELAGEMPPGL
                     NFDLDALNLSGPPGANGEQCLIM"
     exon            95..204
                     /gene="Pex19"
                     /gene_synonym="Pxf"
                     /inference="alignment:Splign:2.1.0"
     exon            205..370
                     /gene="Pex19"
                     /gene_synonym="Pxf"
                     /inference="alignment:Splign:2.1.0"
     exon            371..456
                     /gene="Pex19"
                     /gene_synonym="Pxf"
                     /inference="alignment:Splign:2.1.0"
     exon            457..618
                     /gene="Pex19"
                     /gene_synonym="Pxf"
                     /inference="alignment:Splign:2.1.0"
     exon            619..795
                     /gene="Pex19"
                     /gene_synonym="Pxf"
                     /inference="alignment:Splign:2.1.0"
     exon            796..840
                     /gene="Pex19"
                     /gene_synonym="Pxf"
                     /inference="alignment:Splign:2.1.0"
     exon            841..3131
                     /gene="Pex19"
                     /gene_synonym="Pxf"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1899..1904
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pex19"
                     /gene_synonym="Pxf"
                     /note="hexamer: AATAAA"
     polyA_site      1917
                     /gene="Pex19"
                     /gene_synonym="Pxf"
                     /note="major polyA site"
     regulatory      2388..2393
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pex19"
                     /gene_synonym="Pxf"
                     /note="hexamer: AAGAAA"
     polyA_site      2411
                     /gene="Pex19"
                     /gene_synonym="Pxf"
     regulatory      2908..2913
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pex19"
                     /gene_synonym="Pxf"
                     /note="hexamer: AATAAA"
     polyA_site      2926
                     /gene="Pex19"
                     /gene_synonym="Pxf"
     regulatory      3104..3109
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pex19"
                     /gene_synonym="Pxf"
                     /note="hexamer: ATTAAA"
     polyA_site      3127
                     /gene="Pex19"
                     /gene_synonym="Pxf"
ORIGIN      
        1 ctacggcaag tcggaggcag taagatggcg gctgctgagg aaggttgcgg tgttggggtc
       61 gaagacgacc gggaactgga ggagcttctg gaaagtgctc ttgatgattt cgacaaagcc
      121 aaaccctccc cagaacatgc tccgaccatc tcggctcccg acgcttcagg accccagaag
      181 agagcgccag gagatactgc caaagatgct ctcttcgcct cccaagagaa atttttccag
      241 gaactgtttg acagtgagct ggcttcccaa gctactgcgg agtttgagaa ggcaatgaag
      301 gagctggctg aggaagagcc ccatctggtg gagcagttcc agaagctctc agaggcagct
      361 gggagagtgg gcagcgatgc aagttctcag caagagttta cttcttgcct aaaggagacg
      421 ttaagtggcc tggccaaaaa cgccactgag ctgcagaact cgggcatgtc tgaagaggag
      481 ctgatgaaag ccatggaagg gctgggcatg gatgaggggg atggggaagc gagcattctc
      541 cccatcatgc agagcatcat gcagaacctc ctgtctaagg atgtgctgta cccatccctg
      601 aaggagatca cagaaaagta tccagaatgg ctccagagtc accaggactc cactcctccc
      661 gagcagtttg agaagtacca gcagcagcac agcgtcatgg tcaaaatctg tgagcagttt
      721 gaggccgaga cgcccacaga cagcgaggct actcagaggg ctcgctttga ggccatgcta
      781 gatctcatgc agcagttaca ggccttgggc catcctccaa aagagctggc tggggagatg
      841 cctcctggcc tcaactttga cctggatgct ctcaatctgt cgggcccccc aggtgctaat
      901 ggcgaacagt gtctgatcat gtgaaacaca gcacagtttc ctccctgagc cccagccgtg
      961 gggaacatct ggagtcaaca gagtcactgg gaactgaggc aggagtatca tctgtgggag
     1021 ctggctgccc cacccacact ctccatccca ttcaagactg tgccatacca gctgatctgt
     1081 aggccttttc tatgagtcct actccatcag ggtttctgct gttagaaaca ggccaattat
     1141 ctgccaggtg aaggaaggca tcccttgtgg ggcatttcac ttcttcccac tccccaaata
     1201 atgttacaca tggcagtact catgttcccc ttgattccca gggacgtcgc gccttgtttc
     1261 tcctccctct ctgtgtctgg ggaggaggag ctgagtcctg actctgtgct cctgttaggc
     1321 agggcctctg ggaagaggag aaatgtagcc tgagctgggg ctggaggctg gtcaccgcat
     1381 atccttgcct tcctttggaa ttctcttaag ggaaaggaat tttgcactta gccatggtcg
     1441 ggttggaagc aaagccttgg gcttttcctg tccctaggtg ctgagcccca atcccccttt
     1501 cctcctgaga actcatgttg ctgccctggt tctttctaca gctctgggat ttagggggag
     1561 ccaactcttg gccttccttt gctccctgac tgtccttacg tcctctctgt ttagagtctt
     1621 atttattctg cccttttaac cagtgctgtg atggatgaag gccaatcttg tttcctttca
     1681 tctagtacct ggaccattct ccctagaccc ttgccttcct ccctggccaa cacatacttg
     1741 cagtgtcaga tctggtacat gaatggccat tctacccaga taggttttag cttatatata
     1801 ggacatcaga ttccctggaa tccttggttc aggaaggtgc ttgggaaagg ggtgtagcca
     1861 gaatattttt tccctgcaag ccctatgggg tagtatctaa taaatattct gagcaagtgt
     1921 gtgggttatt tttcatccag gtctatttct aatcttccct agtttctata aactgcagag
     1981 tgagatgtgt taggagatgg atagttctgt atagtgttgt taggctctac catggcccag
     2041 ccctccagct cagcaaaaga atactgtctt cgtctccttg gcacttattt cagtcttaac
     2101 gttttacgat atagctgatg ttagtgattg atatattatc aacatgtttt ctaaattatc
     2161 taactttgaa tcaacctgct ttttcacagt ggttctaagc accatggttg ccatatattt
     2221 tatggatatt cttttaggcc acctagctag ttcacttgga aaataacgtt ttaaaaatat
     2281 attttttatt tattctttgg aattttatac atgtatacaa tgtatcctga tcatatccac
     2341 cctcccaccc caccccaccc cacctgctgg aaaataactt tggcaagaag aaattcacat
     2401 ttatcatttg agtcacttcg agttcgtaac atcatttccc ctgggctaaa accacattta
     2461 aggatgcaac atattctatg gaaatgtgct tgcggcctcg gtctgggaac ttcccagcca
     2521 gcacagctta tcaaacggaa gactcggggt ctgaatttga gactcctcca tgcgctgagg
     2581 aagggaaaat gaatgtacca gctgatctgt ggtgatgagt ggggtctgaa ttgccaatat
     2641 tttattgatg ctcctgacaa aagcttgaca aggacaggtg aggagacagg aacaggaatg
     2701 atcggccctt ggaactgttc tcattgccat gctggccaaa ctttattctc atttctgctg
     2761 gtgatgctgt ggtccaccat ggttttattt tcaagacttt tttttttttt ttttttttca
     2821 ttttaatttg gttgaacatg agcaagttga ccttgggttg gacttttttc ctaaatacca
     2881 tttgaattac tctgggactt agagctgaat aaaacctggt accctagggc agtcctcctc
     2941 aaggtatgtg tggtaaagga ccagagttta gtccctctgc atcagtatgt ggatctgttg
     3001 cccgtgacag atatgtaatt gagactatat acaacttgta tacaaatttg aaaacaccta
     3061 aactgtctag actctgttac aggttaagcc cactgatcac ataattaaat ttcacagcta
     3121 tatcaaatac t
//
