LOCUS       NM_019781               1973 bp    mRNA    linear   ROD 26-JUN-2024
DEFINITION  Mus musculus peroxisomal biogenesis factor 14 (Pex14), mRNA.
ACCESSION   NM_019781 XM_207022
VERSION     NM_019781.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1973)
  AUTHORS   Zhang,D., Deng,W., Jiang,T., Zhao,Y., Bai,D., Tian,Y., Kong,S.,
            Zhang,L., Wang,H., Gao,S. and Lu,Z.
  TITLE     Maternal Ezh1/2 deficiency impairs the function of mitochondria in
            mouse oocytes and early embryos
  JOURNAL   J Cell Physiol 239 (6), e31244 (2024)
   PUBMED   38529784
REFERENCE   2  (bases 1 to 1973)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1973)
  AUTHORS   Bhosle,V.K., Tan,J.M., Li,T., Hua,R., Kwon,H., Li,Z., Patel,S.,
            Tessier-Lavigne,M., Robinson,L.A., Kim,P.K. and Brumell,J.H.
  TITLE     SLIT2/ROBO1 signaling suppresses mTORC1 for organelle control and
            bacterial killing
  JOURNAL   Life Sci Alliance 6 (8), e202301964 (2023)
   PUBMED   37311584
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1973)
  AUTHORS   Catela,C., Chen,Y., Weng,Y., Wen,K. and Kratsios,P.
  TITLE     Control of spinal motor neuron terminal differentiation through
            sustained Hoxc8 gene activity
  JOURNAL   Elife 11, e70766 (2022)
   PUBMED   35315772
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1973)
  AUTHORS   Okumoto,K., El Shermely,M., Natsui,M., Kosako,H., Natsuyama,R.,
            Marutani,T. and Fujiki,Y.
  TITLE     The peroxisome counteracts oxidative stresses by suppressing
            catalase import via Pex14 phosphorylation
  JOURNAL   Elife 9, e55896 (2020)
   PUBMED   32831175
  REMARK    GeneRIF: The peroxisome counteracts oxidative stresses by
            suppressing catalase import via Pex14 phosphorylation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1973)
  AUTHORS   Nguyen,T., Bjorkman,J., Paton,B.C. and Crane,D.I.
  TITLE     Failure of microtubule-mediated peroxisome division and trafficking
            in disorders with reduced peroxisome abundance
  JOURNAL   J Cell Sci 119 (Pt 4), 636-645 (2006)
   PUBMED   16449325
REFERENCE   7  (bases 1 to 1973)
  AUTHORS   Nagase,T., Shimozawa,N., Takemoto,Y., Suzuki,Y., Komori,M. and
            Kondo,N.
  TITLE     Peroxisomal localization in the developing mouse cerebellum:
            implications for neuronal abnormalities related to deficiencies in
            peroxisomes
  JOURNAL   Biochim Biophys Acta 1671 (1-3), 26-33 (2004)
   PUBMED   15026142
REFERENCE   8  (bases 1 to 1973)
  AUTHORS   Bliskovsky,V., Ramsay,E.S., Scott,J., DuBois,W., Shi,W., Zhang,S.,
            Qian,X., Lowy,D.R. and Mock,B.A.
  TITLE     Frap, FKBP12 rapamycin-associated protein, is a candidate gene for
            the plasmacytoma resistance locus Pctr2 and can act as a tumor
            suppressor gene
  JOURNAL   Proc Natl Acad Sci U S A 100 (25), 14982-14987 (2003)
   PUBMED   14634209
REFERENCE   9  (bases 1 to 1973)
  AUTHORS   Oliveira,M.E., Reguenga,C., Gouveia,A.M., Guimaraes,C.P.,
            Schliebs,W., Kunau,W.H., Silva,M.T., Sa-Miranda,C. and Azevedo,J.E.
  TITLE     Mammalian Pex14p: membrane topology and characterisation of the
            Pex14p-Pex14p interaction
  JOURNAL   Biochim Biophys Acta 1567 (1-2), 13-22 (2002)
   PUBMED   12488033
REFERENCE   10 (bases 1 to 1973)
  AUTHORS   Hayashi,M., Nito,K., Toriyama-Kato,K., Kondo,M., Yamaya,T. and
            Nishimura,M.
  TITLE     AtPex14p maintains peroxisomal functions by determining protein
            targeting to three kinds of plant peroxisomes
  JOURNAL   EMBO J 19 (21), 5701-5710 (2000)
   PUBMED   11060021
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL611967.21.
            
            On Apr 27, 2018 this sequence version replaced NM_019781.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC028952.1, AF097512.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-72                AL611967.21        151514-151585       c
            73-120              AL611967.21        127762-127809       c
            121-205             AL611967.21        93463-93547         c
            206-334             AL611967.21        35779-35907         c
            335-420             AL611967.21        22292-22377         c
            421-523             AL611967.21        19266-19368         c
            524-621             AL611967.21        17964-18061         c
            622-713             AL611967.21        15184-15275         c
            714-1973            AL611967.21        12277-13536         c
FEATURES             Location/Qualifiers
     source          1..1973
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 78.87 cM"
     gene            1..1973
                     /gene="Pex14"
                     /gene_synonym="Pex14p"
                     /note="peroxisomal biogenesis factor 14"
                     /db_xref="GeneID:56273"
                     /db_xref="MGI:MGI:1927868"
     exon            1..72
                     /gene="Pex14"
                     /gene_synonym="Pex14p"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..1167
                     /gene="Pex14"
                     /gene_synonym="Pex14p"
                     /note="peroxin-14; PTS1 receptor-docking protein;
                     peroxisomal membrane anchor protein PEX14"
                     /codon_start=1
                     /product="peroxisomal membrane protein PEX14"
                     /protein_id="NP_062755.1"
                     /db_xref="CCDS:CCDS18950.1"
                     /db_xref="GeneID:56273"
                     /db_xref="MGI:MGI:1927868"
                     /translation="MASSEQAEQPNQPSSPPGSENVVPREPLIATAVKFLQNSRVRQS
                     PLATRRAFLKKKGLTDEEIDLAFQQSGTAADEPSPLGPATPVVPVQPPHLTPQPYSPR
                     GSRWRDYGALAIIMAGIAFGFHQLYKRYLLPLILGGREDRKQLERMAASLSELSGTVA
                     QTVTQVQTTLASVQELLRQQQQKVQELAHELATAKATTSTNWILESQNINELKSEINS
                     LKGLLLNRRQFPPSPSAPKIPSWQIPVKSSSPSSPAAVNHHSSSDISPVSNESTSSSP
                     GKDSHSPEGSTATYHLLGPQEEGEGVLDVKGQVRMEVQGEEEKREDKEDEDDEDDDVS
                     HVDEEDVLGVQREDRRGGDGQINEQVEKLRRPEGASNETERD"
     exon            73..120
                     /gene="Pex14"
                     /gene_synonym="Pex14p"
                     /inference="alignment:Splign:2.1.0"
     exon            121..205
                     /gene="Pex14"
                     /gene_synonym="Pex14p"
                     /inference="alignment:Splign:2.1.0"
     exon            206..334
                     /gene="Pex14"
                     /gene_synonym="Pex14p"
                     /inference="alignment:Splign:2.1.0"
     exon            335..420
                     /gene="Pex14"
                     /gene_synonym="Pex14p"
                     /inference="alignment:Splign:2.1.0"
     exon            421..523
                     /gene="Pex14"
                     /gene_synonym="Pex14p"
                     /inference="alignment:Splign:2.1.0"
     exon            524..621
                     /gene="Pex14"
                     /gene_synonym="Pex14p"
                     /inference="alignment:Splign:2.1.0"
     exon            622..713
                     /gene="Pex14"
                     /gene_synonym="Pex14p"
                     /inference="alignment:Splign:2.1.0"
     exon            714..1973
                     /gene="Pex14"
                     /gene_synonym="Pex14p"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1949..1954
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pex14"
                     /gene_synonym="Pex14p"
                     /note="hexamer: AATAAA"
     polyA_site      1973
                     /gene="Pex14"
                     /gene_synonym="Pex14p"
                     /note="major polyA site"
ORIGIN      
        1 gggccagcgg cggtcgacta gtcaggcctg aggaagatgg cgtcgtcgga gcaggcagag
       61 cagccgaacc agccaagctc tcctccagga agtgaaaatg tggtgccccg agagccactg
      121 attgccacag cagtgaagtt cctacagaat tctcgggtcc ggcagagccc acttgcgacc
      181 aggagagcat ttcttaagaa gaaaggactg acagacgaag agattgacct ggctttccag
      241 cagtcgggca cagctgccga cgagccttca cccctgggcc cagctacccc agtggttcct
      301 gtccagcccc ctcacctcac tccgcagcca tacagcccca gaggctcccg atggcgagat
      361 tatggtgcct tggctatcat catggcagga attgcatttg gctttcacca actctacaag
      421 aggtacctgc tgcccctcat cctgggaggc cgagaggaca gaaagcagct ggagaggatg
      481 gcagcgagtc tctcggaact gagtggcacc gtggcccaga cagtgactca ggtgcagaca
      541 acactggcct ctgtccaaga gctactgaga cagcagcagc agaaggtcca ggagctagct
      601 cacgagctgg ccactgccaa ggccaccaca tcaaccaact ggatcctgga gtcccagaat
      661 attaatgagc tcaagtcgga aatcaactcc ttgaaaggac ttcttttgaa tcggagacag
      721 ttccctcctt ccccgtcggc cccgaagatc ccctcctggc agatcccagt gaagtcttca
      781 tcaccctcca gccctgcggc tgtcaaccac cacagcagca gtgacatctc ccctgtcagc
      841 aacgagtcta cgtcatcctc tcctgggaag gacagccaca gcccggaggg ctccacggcc
      901 acataccacc tgctgggtcc ccaggaagag ggtgaagggg tgctagatgt caagggccag
      961 gtgaggatgg aggtgcaggg tgaggaggag aagagggagg acaaggagga tgaggacgat
     1021 gaggatgatg acgtcagcca tgtggatgag gaggacgtcc ttggggtgca gagggaggac
     1081 cgacggggcg gcgatgggca gatcaatgag caggtagaga agctgcggcg gccggaaggt
     1141 gccagcaatg agactgagcg agactagggc tggcacttgg ctgcccgcct tcccagtgcc
     1201 ccgggacatc agaggcaggt gggcaagggc tgcggctctg cctccacgac tgggcggaag
     1261 cccaggtagg ggtggggctg cccttcagcg cagcagtgtg ggctgcattt ctgttcacca
     1321 gcctcccaaa cacggcccag ccccagccag ccccagccag ccccagcggc tctggctgtc
     1381 cacaagccag gcagagaact caggagctct gcactcaacg cccctgctgc ctcgccccct
     1441 ccctgacagg tgtcttgtca aggtgtatcc tccgagtatc ttgaccacct ggcaccatgc
     1501 atggccagag ctcatgtcat ctcctgcctc tgtcacctca gtgcagggaa actatggccc
     1561 ctgtggtctt gctgtctctc ccactgtgcc ctggcctggc ttgtggcttc ttctttgcct
     1621 gttccaaaag ccagggccct gggcctgctc ttcatcttgc gggcctccta ggacccagcc
     1681 ttccaaagtc ctggctgaca gatgctgctc ttgggcacct gtccccaccc cacctgccct
     1741 gctgtcctct gtatcacaca agacgtctcg cttgctgtgt cgtggtttag ctcctcggtg
     1801 gtgaggcgtg cttctccctc ctggtggagc caggcagcag ggccttcctg accaacagcc
     1861 atgtctgacc ttcccactga gaaacacatg ttcatttatg tgatcatgta tagatttcag
     1921 aatataagat atgactgtac ataattgtaa taaatacgag ttgccatatt taa
//
