LOCUS       NM_023651               3266 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus peroxisomal biogenesis factor 13 (Pex13), transcript
            variant 1, mRNA.
ACCESSION   NM_023651
VERSION     NM_023651.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3266)
  AUTHORS   Park,W.Y., Park,J., Lee,S., Song,G., Nam,I.K., Ahn,K.S., Choe,S.K.
            and Um,J.Y.
  TITLE     PEX13 is required for thermogenesis of white adipose tissue in
            cold-exposed mice
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1867 (1), 159046 (2022)
   PUBMED   34517131
  REMARK    GeneRIF: PEX13 is required for thermogenesis of white adipose
            tissue in cold-exposed mice.
REFERENCE   2  (bases 1 to 3266)
  AUTHORS   Rishi,G., Bhatia,M., Secondes,E.S., Melino,M., Crane,D.I. and
            Subramaniam,V.N.
  TITLE     Hepatocyte-specific deletion of peroxisomal protein PEX13 results
            in disrupted iron homeostasis
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1866 (10), 165882 (2020)
   PUBMED   32565019
  REMARK    GeneRIF: Hepatocyte-specific deletion of peroxisomal protein PEX13
            results in disrupted iron homeostasis.
REFERENCE   3  (bases 1 to 3266)
  AUTHORS   Brauns,A.K., Heine,M., Todter,K., Baumgart-Vogt,E., Luers,G.H. and
            Schumacher,U.
  TITLE     A defect in the peroxisomal biogenesis in germ cells induces a
            spermatogenic arrest at the round spermatid stage in mice
  JOURNAL   Sci Rep 9 (1), 9553 (2019)
   PUBMED   31267012
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3266)
  AUTHORS   Rahim,R.S., St John,J.A., Crane,D.I. and Meedeniya,A.C.B.
  TITLE     Impaired neurogenesis and associated gliosis in mouse brain with
            PEX13 deficiency
  JOURNAL   Mol Cell Neurosci 88, 16-32 (2018)
   PUBMED   29187321
  REMARK    GeneRIF: An increasing reactive gliosis in the PEX13 mutant brain
            started at E14.5 in association with the pathology
REFERENCE   5  (bases 1 to 3266)
  AUTHORS   Lee,M.Y., Sumpter,R. Jr., Zou,Z., Sirasanagandla,S., Wei,Y.,
            Mishra,P., Rosewich,H., Crane,D.I. and Levine,B.
  TITLE     Peroxisomal protein PEX13 functions in selective autophagy
  JOURNAL   EMBO Rep 18 (1), 48-60 (2017)
   PUBMED   27827795
REFERENCE   6  (bases 1 to 3266)
  AUTHORS   Kikuchi,M., Hatano,N., Yokota,S., Shimozawa,N., Imanaka,T. and
            Taniguchi,H.
  TITLE     Proteomic analysis of rat liver peroxisome: presence of
            peroxisome-specific isozyme of Lon protease
  JOURNAL   J Biol Chem 279 (1), 421-428 (2004)
   PUBMED   14561759
REFERENCE   7  (bases 1 to 3266)
  AUTHORS   Maxwell,M., Bjorkman,J., Nguyen,T., Sharp,P., Finnie,J.,
            Paterson,C., Tonks,I., Paton,B.C., Kay,G.F. and Crane,D.I.
  TITLE     Pex13 inactivation in the mouse disrupts peroxisome biogenesis and
            leads to a Zellweger syndrome phenotype
  JOURNAL   Mol Cell Biol 23 (16), 5947-5957 (2003)
   PUBMED   12897163
  REMARK    GeneRIF: pex13 has a role in peroxisome biogenesis and its
            disruption in mice causes a Zellweger syndrome phenotype
REFERENCE   8  (bases 1 to 3266)
  AUTHORS   Fuchs,S., Resch,K., Thiel,C., Ulbrich,M., Platzer,M., Jockusch,H.
            and Schmitt-John,T.
  TITLE     Comparative transcription map of the wobbler critical region on
            mouse chromosome 11 and the homologous region on human chromosome
            2p13-14
  JOURNAL   BMC Genet 3, 14 (2002)
   PUBMED   12174196
REFERENCE   9  (bases 1 to 3266)
  AUTHORS   Bjorkman,J., Tonks,I., Maxwell,M.A., Paterson,C., Kay,G.F. and
            Crane,D.I.
  TITLE     Conditional inactivation of the peroxisome biogenesis Pex13 gene by
            Cre-loxP excision
  JOURNAL   Genesis 32 (2), 179-180 (2002)
   PUBMED   11857814
REFERENCE   10 (bases 1 to 3266)
  AUTHORS   Bjorkman,J., Gould,S.J. and Crane,D.I.
  TITLE     Pex13, the mouse ortholog of the human peroxisome biogenesis
            disorder PEX13 gene: gene structure, tissue expression, and
            localization of the protein to peroxisomes
  JOURNAL   Genomics 79 (2), 162-168 (2002)
   PUBMED   11829486
  REMARK    GeneRIF: gene structure, tissue expression, and localization of the
            protein to peroxisomes
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL672049.13.
            
            On Jul 6, 2018 this sequence version replaced NM_023651.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK031975.1, AK031710.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-137               AL672049.13        209777-209913       c
            138-832             AL672049.13        199466-200160       c
            833-958             AL672049.13        194960-195085       c
            959-2356            AL672049.13        192223-193620       c
            2357-3266           AL672049.13        191313-192222       c
FEATURES             Location/Qualifiers
     source          1..3266
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 14.34 cM"
     gene            1..3266
                     /gene="Pex13"
                     /gene_synonym="2610008O20Rik"
                     /note="peroxisomal biogenesis factor 13"
                     /db_xref="GeneID:72129"
                     /db_xref="MGI:MGI:1919379"
     exon            1..137
                     /gene="Pex13"
                     /gene_synonym="2610008O20Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..1257
                     /gene="Pex13"
                     /gene_synonym="2610008O20Rik"
                     /note="peroxin-13"
                     /codon_start=1
                     /product="peroxisomal membrane protein PEX13"
                     /protein_id="NP_076140.2"
                     /db_xref="CCDS:CCDS24478.1"
                     /db_xref="GeneID:72129"
                     /db_xref="MGI:MGI:1919379"
                     /translation="MASQPPPPPKPWESRRIPGAGPGPGSGPGPTYQSADLGPTLLTR
                     PGQPTLTRVPPPILPRPSQQTGSNNVNTFRPAYSSFSSGYGAYGNSFYGSYSPYSYGY
                     NGLGFNRLRVDDLPPSRFVQQAEESSRGAFQSIESIVHAFASVSMMMDATFSAVYNSF
                     RAVLDVANHFSRLKIHFTKVFSAFALVRTIRYLYRRLQWMMGLRRGSENEDLWAESEG
                     TVACLSAEDQATNSAKSWPIFLFFAVILGGPYLIWKLLSTHNDEVTDNTNWASGEDDH
                     VVARAEYDFVAVSDEEISFRAGDMLNLALKEQQPKVRGWLLASLDGQTTGLIPANYVK
                     ILGKRRGRKTIESSTMLKQQQSFTNPTLIKGVTTTNPLDEQEAAFESVFVETNKVSSA
                     PDSTGKNGDKQDL"
     exon            138..832
                     /gene="Pex13"
                     /gene_synonym="2610008O20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            833..958
                     /gene="Pex13"
                     /gene_synonym="2610008O20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            959..3266
                     /gene="Pex13"
                     /gene_synonym="2610008O20Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1706..1711
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pex13"
                     /gene_synonym="2610008O20Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1727
                     /gene="Pex13"
                     /gene_synonym="2610008O20Rik"
                     /note="major polyA site"
     regulatory      2444..2449
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pex13"
                     /gene_synonym="2610008O20Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2474
                     /gene="Pex13"
                     /gene_synonym="2610008O20Rik"
     regulatory      3019..3024
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pex13"
                     /gene_synonym="2610008O20Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3036
                     /gene="Pex13"
                     /gene_synonym="2610008O20Rik"
     regulatory      3073..3078
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pex13"
                     /gene_synonym="2610008O20Rik"
                     /note="hexamer: ATTATA"
     polyA_site      3092
                     /gene="Pex13"
                     /gene_synonym="2610008O20Rik"
ORIGIN      
        1 gcagtcgctt ccctgagccg gagcggagct ggcggagaga tggcctccca gccgccgccg
       61 ccccccaaac cctgggagtc tcgcagaatt cccggggccg gccccgggcc gggctccggc
      121 cccggcccca cttaccaatc tgctgatttg ggccctactt tattgacaag acctggacaa
      181 ccaacactta caagagtgcc cccgcctatt cttcccaggc catcccagca gacagggagc
      241 aacaatgtaa acactttcag acctgcttac agttcatttt cttctggata tggagcctac
      301 ggaaattcat tttatggaag ctatagccct tatagttatg gatacaatgg tttgggcttt
      361 aaccgcctcc gtgtagatga tcttcctccc agtaggtttg ttcagcaagc tgaagaaagc
      421 agcagaggtg catttcagtc cattgaaagt attgtgcatg catttgcctc tgtcagcatg
      481 atgatggatg ctaccttttc agccgtctat aacagtttca gggctgtatt ggatgtagca
      541 aatcactttt cccggctaaa aatacacttt acaaaggttt tttcagcctt tgcattagtt
      601 aggactataa gatatcttta tagacggtta cagtggatga tgggtttaag aagaggctct
      661 gagaatgagg acctgtgggc agaaagtgaa ggaactgtgg cctgccttag tgctgaggac
      721 caggcaacta actcagcaaa atcttggcca atattcctgt tctttgctgt tatccttggc
      781 ggtccttatc tcatctggaa acttctatct acacacaatg atgaagtaac agacaacacc
      841 aactgggcaa gtggtgagga tgaccacgta gttgcaagag cagagtacga ttttgttgcc
      901 gtgtctgatg aagaaatttc tttccgtgct ggtgatatgc taaatttagc cctcaaagaa
      961 caacaaccca aagtgcgtgg ttggcttctg gctagtcttg acggtcaaac aacaggactt
     1021 atacctgcaa attatgtcaa aattcttggt aaaagaagag gcagaaaaac aatagaatcg
     1081 agtacaatgc tcaagcaaca acagtctttt accaacccaa cattaattaa aggagtcact
     1141 accaccaatc ctttggatga acaggaagct gcctttgaat ctgtttttgt tgaaactaat
     1201 aaggtttcca gtgcacctga ttctacaggg aaaaatggag acaaacaaga tctttgatgt
     1261 gtttcatgtt tgtgggcagg tgaacaatat tttagagtat tttaaaaaat catttcttac
     1321 agagaaatta atttgcagtt gaatgaaagc atttgctcgt ggctgtgccg agtgttctgc
     1381 tgctagaagt tatgtagtca cacgctagct gctagtcaag tgatctgtct acacttgact
     1441 gtcttgtgga ccacgaggac atttgtttca cctagttttt aagattatgg agatagttgt
     1501 cagctccatc ttatctcagt ccctaggctt attggaacag taaatttgat gaacagtaga
     1561 acacacaagc tgcctcagaa gggatcatta acgcttctta aagttctgag ttagttgact
     1621 tgaagtcttc aaaaattgag tgataacatc tacttataag aacagacaaa aggctaattt
     1681 ttttaacctt ataaataaac taaataataa aaattttctc atctgtatta tgtccagtgt
     1741 tgaatttact ttaggtgatg tgtttttacc agcaaataat tgatagtatt atcttttatt
     1801 gtatttataa aagtgtgttc ttaagaggtc actggagcac tgtgaagaag atggttctga
     1861 ctgacagctt cttaacctcc ttacagtgtc acagatctca tcctgagcga gtcacaatat
     1921 atagctagat ctcatcctga gcgagtcaca atatatggat ttttgttctt ttcctccaac
     1981 taaggcagga gtcctttaag attatactta atgatataat caattctggc agtaatgatt
     2041 tttaatcctg aattttctgc ttctatataa gataattact tttgtaaatt ccaaaatcag
     2101 gttatacatt aaatatttga aatatgtctg tcggggttgg ggatttagct cagtggtaga
     2161 gcgcttgctt gcaaggccct gggttcggtc ctcagctctg gaaagaaaaa cacaaaataa
     2221 caaaaggacc aaaaaaaccc aaggtaactg aaatatgtct gtcacattgg atagatttct
     2281 tgtggttttc actactgaga ctataatttg cttgctattt caaatacgat gactttttgt
     2341 ttggttgttt ttttttgctt aatagtgaat tttatgtgtt tccccataga attggaagct
     2401 ttatacgctt gctgtgaata tactacagat tagaactgtc agaaataaat cacagaattc
     2461 atttatagac actactaaca gctgtgggtt ttgataaaaa gtgatttggg ttttgcttct
     2521 ttcatataga taggtttatc aaataaataa ttctggagga gttcatatta aaccatgtct
     2581 aacccaatat ctgctcagaa cagaagcact aaagacttcc taggaagccc ttttttgaaa
     2641 tgacaatata ataagtaatg tatcttttca tcttaagata gagagaagca tttacggtac
     2701 tcatttatct tttaggctga tttttctgac attcagtagt aacttttcag ttgagaaagg
     2761 gggttgaata atctaccact gaggcatggc cctgactctc aaaggtttta acaaatattt
     2821 acttctgact tgagatgcct gaacttttct catgtctaaa tgttactcca gacatctaga
     2881 ctaagcacta ggagtaaagt agaaataaaa tgttgagtca gcactattta ggtttggggt
     2941 gttgttttgt tttagaagat gagctttaaa ataggatttg tgactaatat ttcagttgta
     3001 taggaaagag cttagacaaa taaatgataa aactttcttt tagggtcttt attgtttggc
     3061 tgtctatgct agattatata gtattaacct aataactacc tgtgtccatt cttttttatt
     3121 tgtttgtttg tttgtttgtt tgtttgtttc aagacagggt ttctctgtat aggcctggct
     3181 gtcctggaac tcactttgta gaccagactg gcttcgaact cagaaatctg cctcccaagt
     3241 gctgggatta aaggcatgcg ccacca
//
