LOCUS       NM_011069               2439 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus peroxisomal biogenesis factor 11 beta (Pex11b),
            transcript variant 1, mRNA.
ACCESSION   NM_011069
VERSION     NM_011069.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2439)
  AUTHORS   Garikapati,V., Karnati,S., Bhandari,D.R., Baumgart-Vogt,E. and
            Spengler,B.
  TITLE     High-resolution atmospheric-pressure MALDI mass spectrometry
            imaging workflow for lipidomic analysis of late fetal mouse lungs
  JOURNAL   Sci Rep 9 (1), 3192 (2019)
   PUBMED   30816198
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2439)
  AUTHORS   Ahlemeyer,B., Gottwald,M. and Baumgart-Vogt,E.
  TITLE     Deletion of a single allele of the Pex11beta gene is sufficient to
            cause oxidative stress, delayed differentiation and neuronal death
            in mouse brain
  JOURNAL   Dis Model Mech 5 (1), 125-140 (2012)
   PUBMED   21954064
  REMARK    GeneRIF: The alterations in the brain caused by the deletion of a
            single allele of the Pex11beta gene, are reported.
REFERENCE   3  (bases 1 to 2439)
  AUTHORS   Karnati,S. and Baumgart-Vogt,E.
  TITLE     Peroxisomes in airway epithelia and future prospects of these
            organelles for pulmonary cell biology
  JOURNAL   Histochem Cell Biol 131 (4), 447-454 (2009)
   PUBMED   19229552
REFERENCE   4  (bases 1 to 2439)
  AUTHORS   Koch,A., Schneider,G., Luers,G.H. and Schrader,M.
  TITLE     Peroxisome elongation and constriction but not fission can occur
            independently of dynamin-like protein 1
  JOURNAL   J Cell Sci 117 (Pt 17), 3995-4006 (2004)
   PUBMED   15286177
REFERENCE   5  (bases 1 to 2439)
  AUTHORS   Carninci,P., Waki,K., Shiraki,T., Konno,H., Shibata,K., Itoh,M.,
            Aizawa,K., Arakawa,T., Ishii,Y., Sasaki,D., Bono,H., Kondo,S.,
            Sugahara,Y., Saito,R., Osato,N., Fukuda,S., Sato,K., Watahiki,A.,
            Hirozane-Kishikawa,T., Nakamura,M., Shibata,Y., Yasunishi,A.,
            Kikuchi,N., Yoshiki,A., Kusakabe,M., Gustincich,S., Beisel,K.,
            Pavan,W., Aidinis,V., Nakagawara,A., Held,W.A., Iwata,H., Kono,T.,
            Nakauchi,H., Lyons,P., Wells,C., Hume,D.A., Fagiolini,M.,
            Hensch,T.K., Brinkmeier,M., Camper,S., Hirota,J., Mombaerts,P.,
            Muramatsu,M., Okazaki,Y., Kawai,J. and Hayashizaki,Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
REFERENCE   6  (bases 1 to 2439)
  AUTHORS   Li,X., Baumgart,E., Dong,G.X., Morrell,J.C., Jimenez-Sanchez,G.,
            Valle,D., Smith,K.D. and Gould,S.J.
  TITLE     PEX11alpha is required for peroxisome proliferation in response to
            4-phenylbutyrate but is dispensable for peroxisome
            proliferator-activated receptor alpha-mediated peroxisome
            proliferation
  JOURNAL   Mol Cell Biol 22 (23), 8226-8240 (2002)
   PUBMED   12417726
REFERENCE   7  (bases 1 to 2439)
  AUTHORS   Li,X., Baumgart,E., Morrell,J.C., Jimenez-Sanchez,G., Valle,D. and
            Gould,S.J.
  TITLE     PEX11 beta deficiency is lethal and impairs neuronal migration but
            does not abrogate peroxisome function
  JOURNAL   Mol Cell Biol 22 (12), 4358-4365 (2002)
   PUBMED   12024045
REFERENCE   8  (bases 1 to 2439)
  AUTHORS   Li,X. and Gould,S.J.
  TITLE     PEX11 promotes peroxisome division independently of peroxisome
            metabolism
  JOURNAL   J Cell Biol 156 (4), 643-651 (2002)
   PUBMED   11839773
REFERENCE   9  (bases 1 to 2439)
  AUTHORS   Bodnar,J.S., Chatterjee,A., Castellani,L.W., Ross,D.A., Ohmen,J.,
            Cavalcoli,J., Wu,C., Dains,K.M., Catanese,J., Chu,M., Sheth,S.S.,
            Charugundla,K., Demant,P., West,D.B., de Jong,P. and Lusis,A.J.
  TITLE     Positional cloning of the combined hyperlipidemia gene Hyplip1
  JOURNAL   Nat Genet 30 (1), 110-116 (2002)
   PUBMED   11753387
REFERENCE   10 (bases 1 to 2439)
  AUTHORS   Schrader,M., Reuber,B.E., Morrell,J.C., Jimenez-Sanchez,G.,
            Obie,C., Stroh,T.A., Valle,D., Schroer,T.A. and Gould,S.J.
  TITLE     Expression of PEX11beta mediates peroxisome proliferation in the
            absence of extracellular stimuli
  JOURNAL   J Biol Chem 273 (45), 29607-29614 (1998)
   PUBMED   9792670
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY789006.1, AK011709.1, AK082778.1 and BB010355.2.
            
            On Jun 23, 2009 this sequence version replaced NM_011069.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1). Both variants 1 and
            2 encode the same isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.118625.1, AK011709.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-220               BY789006.1         4-223
            221-902             AK011709.1         19-700
            903-1359            AK082778.1         624-1080
            1360-1782           AK011709.1         1158-1580
            1783-2424           AK082778.1         1503-2144
            2425-2439           BB010355.2         698-712
FEATURES             Location/Qualifiers
     source          1..2439
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 41.93 cM"
     gene            1..2439
                     /gene="Pex11b"
                     /gene_synonym="PEX11beta; Pex11pbeta"
                     /note="peroxisomal biogenesis factor 11 beta"
                     /db_xref="GeneID:18632"
                     /db_xref="MGI:MGI:1338882"
     exon            1..314
                     /gene="Pex11b"
                     /gene_synonym="PEX11beta; Pex11pbeta"
                     /inference="alignment:Splign:2.1.0"
     CDS             259..1038
                     /gene="Pex11b"
                     /gene_synonym="PEX11beta; Pex11pbeta"
                     /note="isoform 1 is encoded by transcript variant 1;
                     peroxin-11B; peroxisomal membrane protein 11B; PEX11-beta;
                     protein PEX11 homolog beta; peroxisomal biogenesis factor
                     11b"
                     /codon_start=1
                     /product="peroxisomal membrane protein 11B isoform 1"
                     /protein_id="NP_035199.3"
                     /db_xref="CCDS:CCDS17643.1"
                     /db_xref="GeneID:18632"
                     /db_xref="MGI:MGI:1338882"
                     /translation="MDAWVRFSAQSQARERLCRAAQYACSLLGHALQRHGASPELQKQ
                     IRQLEGHLSLGRKLLRLGNSTDALESAKRAVHLSDVVLRFCITVSHLNRALYFACDNV
                     LWAGKSGLAPRVDQEKWAQRSFRYYLFSLIMNLSRDAYEIRLLMEQETSAYSRRMKVS
                     GVGVSGGVETVGPGGPGTPGGSLPQLALKFRLRILLLARVLRGHPPLLLDVLRNACDL
                     FIPLDKLGLWRCGPGIVGLCGLISSILSILTLICPWLRLKP"
     exon            315..430
                     /gene="Pex11b"
                     /gene_synonym="PEX11beta; Pex11pbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            431..632
                     /gene="Pex11b"
                     /gene_synonym="PEX11beta; Pex11pbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            633..2439
                     /gene="Pex11b"
                     /gene_synonym="PEX11beta; Pex11pbeta"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1764..1769
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pex11b"
                     /gene_synonym="PEX11beta; Pex11pbeta"
                     /note="hexamer: ATTAAA"
     polyA_site      1787
                     /gene="Pex11b"
                     /gene_synonym="PEX11beta; Pex11pbeta"
                     /note="major polyA site"
     regulatory      2405..2410
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pex11b"
                     /gene_synonym="PEX11beta; Pex11pbeta"
                     /note="hexamer: AATAAA"
     polyA_site      2425
                     /gene="Pex11b"
                     /gene_synonym="PEX11beta; Pex11pbeta"
                     /note="major polyA site"
ORIGIN      
        1 gctgctgaga atttaaagca gaatgtgctc ctaggggcgt gcttaaaagc cggagaccat
       61 cccagagaag ggtgagctgc cggaaatgca cccacgatct cgcttcgcgt cctgaaattc
      121 cacttcaagg ccggctccgg ctgcttggct ttcctgccgc cgtttgtccc tcgcgaagcc
      181 ccgttgctcg cccaggaggc gtgacttggg gctggaagca ggcgggccgc tgcgccgtgg
      241 gcccgggctg ccgctgtcat ggacgcctgg gtccgcttca gtgctcagag ccaagcccgg
      301 gagcggctgt gtagggccgc ccagtatgcc tgttcccttc tcggccatgc tttgcagaga
      361 catggggcta gtcccgagtt acagaaacag attcgacaac tggagggtca tctgagcctc
      421 ggacgaaagt tgctacgcct ggggaactca acagatgccc tggagtcagc caaaagggct
      481 gtgcacctgt cagatgtcgt tctgagattc tgcatcactg tcagtcacct caaccgagcc
      541 ttgtactttg cctgtgacaa tgtcctatgg gctggaaagt ctgggctagc tccccgagtg
      601 gaccaggaaa agtgggcaca gcgttcattc agatactatc tgttttccct catcatgaat
      661 ctgagccgtg atgcttatga gattcgccta ttgatggaac aagagacttc agcttacagc
      721 aggcgaatga aggtttctgg agtaggagtc tcaggaggag tagaaactgt gggacctgga
      781 ggaccaggga ctccaggagg aagtctgcca caactggctt tgaagtttcg gctccgaatc
      841 ctgctactgg ctcgtgtcct tcgaggtcat ccccctctct tgctggatgt gctcagaaat
      901 gcctgtgacc ttttcatccc actggacaaa ctaggcctct ggcgttgtgg ccctgggatt
      961 gtggggctgt gtggcctcat atcctccatt ctgtctattc tcaccctaat ctgtccctgg
     1021 ctacgactca agccctgact gacactgtgg tacaagataa ggagggagcc caggtgggtg
     1081 agatggaagc tgagatggtc actgtgtgcc aacctcattg taattcaact ccttgactga
     1141 agttaaaatc cagatcctta gggatgaggg gaagaacctg ccaaagacgg gtcaggaagg
     1201 cagtgctaag ggaaggctcc tgcaggcctc tgcagttggg cttcattcag tcccattgcc
     1261 agaatctcat agctcttccc tttatctctc tgtcttgagt ctagttaaga atttgttacc
     1321 gtgagacaga attctctttc ttagcctcct ggccagatat ttaaaaggag gggggtgggt
     1381 tactttttgg taggggaagc ttaagttatg gatagcaaag tgctaattgt attctttttt
     1441 tctgaaacct catgtagcat ttttcttccc ttccaccctc catactttcc caggcttcat
     1501 ttcatgcccg gcgtctcttc gctcacaccg ctgcaggctg tttgaggctt ctcccctggg
     1561 tctgcctcag cagactgcct ccacactttc cagtttctgc gtacacgttg atattagagt
     1621 ttccttccgc acttggctct tgctctttct ctgactaccc aggctgatgc catgtctggc
     1681 ctcttcctgt aaatactgta caatgattct atgtaaataa ctggtccttg cccacagagc
     1741 aagcaagcct tctaggctaa caaattaaag atcagtttgc tcactgactt ttttattcaa
     1801 ttcaagatgg cgggggtggg gtggggggac ggattgcctg ttttcactgt ggtacctagg
     1861 cagggctgaa gctctgagct cccctgcttt aggcttctga gtagcctaca gtgagtgtta
     1921 ctgtgtccag ctgctcgttg acatctggtc tctcatggtc tggtcattgt aagccttagc
     1981 tctctgactg tggatggctt tccttggcgt tagcagctaa catggttaca ggatttcact
     2041 gaaaatttaa atgttggggg aaaggtgcgg acacaccata atggtcccaa ttcaaaacaa
     2101 tccgtgaaca gcctcaagtt aggggtgaga tgttttcaac caaagtaatt atcttgacac
     2161 cacaaagcac acctgtctac aggcagtgac tccccaaaag ctattagaca cacacaagca
     2221 tgaccataac tcagtggatt ggcaaggtca cacagtagga ctgcccttca cacagtaggt
     2281 aggaaaatgc tgctgtcact gctgtcagct gttattttgc atatcccatg ttaagattaa
     2341 taaggcaaaa aatattgtct ctaagtccta ctttctgttc caaactggag gaaattattg
     2401 aataaataaa ccgtgcataa aagtagcctc agaaagggt
//
