LOCUS       NM_011068               2291 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Mus musculus peroxisomal biogenesis factor 11 alpha (Pex11a),
            transcript variant 1, mRNA.
ACCESSION   NM_011068
VERSION     NM_011068.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2291)
  AUTHORS   Weng,H., Ji,X., Endo,K. and Iwai,N.
  TITLE     Pex11a deficiency is associated with a reduced abundance of
            functional peroxisomes and aggravated renal interstitial lesions
  JOURNAL   Hypertension 64 (5), 1054-1060 (2014)
   PUBMED   25113963
  REMARK    GeneRIF: Pex11a deficiency is associated with a reduced abundance
            of functional peroxisomes and aggravated renal interstitial
            lesions.
REFERENCE   2  (bases 1 to 2291)
  AUTHORS   Weng,H., Ji,X., Naito,Y., Endo,K., Ma,X., Takahashi,R., Shen,C.,
            Hirokawa,G., Fukushima,Y. and Iwai,N.
  TITLE     Pex11alpha deficiency impairs peroxisome elongation and division
            and contributes to nonalcoholic fatty liver in mice
  JOURNAL   Am J Physiol Endocrinol Metab 304 (2), E187-E196 (2013)
   PUBMED   23169785
  REMARK    GeneRIF: Pex11alpha deficiency impairs peroxisome elongation and
            abundance and peroxisomal fatty acid oxidation, which contributes
            to increased lipid accumulation in the liver.
REFERENCE   3  (bases 1 to 2291)
  AUTHORS   Wu,Y. and Smas,C.M.
  TITLE     Wdnm1-like, a new adipokine with a role in MMP-2 activation
  JOURNAL   Am J Physiol Endocrinol Metab 295 (1), E205-E215 (2008)
   PUBMED   18492766
REFERENCE   4  (bases 1 to 2291)
  AUTHORS   Li,X., Baumgart,E., Dong,G.X., Morrell,J.C., Jimenez-Sanchez,G.,
            Valle,D., Smith,K.D. and Gould,S.J.
  TITLE     PEX11alpha is required for peroxisome proliferation in response to
            4-phenylbutyrate but is dispensable for peroxisome
            proliferator-activated receptor alpha-mediated peroxisome
            proliferation
  JOURNAL   Mol Cell Biol 22 (23), 8226-8240 (2002)
   PUBMED   12417726
  REMARK    GeneRIF: required for peroxisome proliferation in response to
            4-phenylbutyrate but dispensable for peroxisome
            proliferator-activated receptor alpha-mediated peroxisome
            proliferation
REFERENCE   5  (bases 1 to 2291)
  AUTHORS   Schrader,M., Reuber,B.E., Morrell,J.C., Jimenez-Sanchez,G.,
            Obie,C., Stroh,T.A., Valle,D., Schroer,T.A. and Gould,S.J.
  TITLE     Expression of PEX11beta mediates peroxisome proliferation in the
            absence of extracellular stimuli
  JOURNAL   J Biol Chem 273 (45), 29607-29614 (1998)
   PUBMED   9792670
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK076776.1 and AK149387.1.
            
            On Jan 26, 2018 this sequence version replaced NM_011068.1.
            
            Transcript Variant: This variant (1) represents the protein-coding
            transcript.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK149387.1, AF093669.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-109               AK076776.1         1-109
            110-892             AK149387.1         2-784
            893-2291            AK149387.1         786-2184
FEATURES             Location/Qualifiers
     source          1..2291
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 45.12 cM"
     gene            1..2291
                     /gene="Pex11a"
                     /gene_synonym="PEX11alpha"
                     /note="peroxisomal biogenesis factor 11 alpha"
                     /db_xref="GeneID:18631"
                     /db_xref="MGI:MGI:1338788"
     exon            1..222
                     /gene="Pex11a"
                     /gene_synonym="PEX11alpha"
                     /inference="alignment:Splign:2.1.0"
     CDS             167..907
                     /gene="Pex11a"
                     /gene_synonym="PEX11alpha"
                     /note="PEX11-alpha; peroxin-11A; protein PEX11 homolog
                     alpha; peroxisomal biogenesis factor 11a"
                     /codon_start=1
                     /product="peroxisomal membrane protein 11A"
                     /protein_id="NP_035198.1"
                     /db_xref="CCDS:CCDS21386.1"
                     /db_xref="GeneID:18631"
                     /db_xref="MGI:MGI:1338788"
                     /translation="MDAFIRVANQSQGRDRLFRATQHACMLLRYLLESKADKEAVVLK
                     LKRLETSVSTGRKWFRLGNVFHAIQATEQSIQAADLAPRLCLTLANLNRVVYYICDTV
                     LWAKSVGLTSGVNREKWQRWAARHYYYFLLLSLVRDLYEILLQMGQVARDRAKREKSS
                     RDPPKYSVANEETEWLQSFLLLLFQSLKRHPPLLLDTVKNFCDILIPLNQLGIYKSNL
                     GVVGLGGLISSLAGLLTVVYPQLKLKAR"
     exon            223..338
                     /gene="Pex11a"
                     /gene_synonym="PEX11alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            339..2291
                     /gene="Pex11a"
                     /gene_synonym="PEX11alpha"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaactccaaa agccgcgttt ccgaaggtgt gcccaccccc gtgtgggcgg agagacgaag
       61 tcccacccac ctggcaacta atctgttccc gctgtccccc gggaccggcg acgtcccagg
      121 ggacccacga gggagcgggc gcaacgcgtg gctgtgggtg ggagccatgg acgccttcat
      181 ccgagtcgcc aaccaaagcc agggccggga ccgacttttc agagccactc agcacgcatg
      241 catgttgctt agatatttgt tagagtctaa agctgacaaa gaggccgtgg tactgaagct
      301 caagaggctg gagaccagtg tgagcactgg ccgtaaatgg ttcagactgg gcaacgtgtt
      361 ccatgccatc caggcaactg agcagagcat ccaagccgct gacctcgcgc cccgcttatg
      421 cctgacatta gccaacctca accgcgtggt ttattacatc tgtgacactg tcctctgggc
      481 gaagagtgtg ggtcttacct ctggagtcaa cagagagaaa tggcaaaggt gggcggctcg
      541 ccattactac tacttcctct tgctgagcct ggtccgggat ctgtatgaga tcttgctgca
      601 gatgggacaa gttgcacgtg acagagcaaa gagagagaaa tcctctcggg accctcctaa
      661 gtacagcgtg gctaatgaag agactgaatg gctccagtcc ttcctcctcc tcctattcca
      721 gtctctaaag cgacatcctc ccttgctcct ggacaccgtg aagaacttct gtgacatcct
      781 gatccctctg aaccagcttg ggatctacaa gtccaatctc ggcgtggtag gacttggagg
      841 tctcatatcc tctttggctg gtctcctcac ggtagtgtat cctcagctga aactgaaggc
      901 ccgctagggt gtttggaggc tttaaggcta gcagttcagt ggaacaaaca tttggttttg
      961 tcccaatgtt tactgtgctt aatttaaaaa aaaaaaaaaa atcatgtgag caccttacca
     1021 tcctatgagc agaggtagga ccagcagtgg cgcatgctac agtaacttca tttctgttca
     1081 ggtaacatta ctgagcatct tttatgtaca tagtaagagc ctagtgttgc tggacaaata
     1141 aagatgaaaa ggagagaaac catgaaagac ccaaagaaac tagaattaca gatcaggttg
     1201 cacaggtccc tgattccaca caagcacacc agggctgaag cacagcactc ccagctctgc
     1261 ttaagttttc ccttttctcc catctgttat tatcccccac tcccacgggt gtcaggagtg
     1321 agatggaggg gagctgggct cagcgcctgt taacctgctg gtcccggtca ttgctgcagt
     1381 cgtgtcctga ccatgtccag tagcctcaga agaacatcag tgcctctggg gcggaggctg
     1441 tgtccacagg tagaaggctc tcggtaatgc taggagcaag caagagccac agaagggacc
     1501 agaggtgaaa gcaggtggga ggtcaccgcg gcctgttatg tcatccgtca cagataagga
     1561 ctatgacagt acaaaacaaa gctgatagca cagattcatt gggagacttt ccaggatgat
     1621 ccgcgtgatc tcgttacctt cagcggtctt cccgggctca gagcccttag ccccttaaca
     1681 tgcccccgag tcctggagct tcagttgatg gtttctgtcc cagtctatga aatgcaaagc
     1741 aatctagact cacccaggtt ggtttgattt agctacataa cagtttatgc aattccacag
     1801 taatttttat caaaataaga gaattaaatt ttttctgtct atagatgtag gaacgtcagt
     1861 tttctgtgac aaatctggtt ttctcaggac aactgagagg gacaggaaag agcaataggg
     1921 ccagtggagg ggtcgtgggg acaccgggtc agtgcatttg cccgtgttca cacttcacgg
     1981 ttcagtcttc ctgtcttgag tttggttggt ttaggtgtgt ggtgtgggag acactggcca
     2041 gcaggcgggt catgtctact aagtggaaat gagaactatg cactaagcaa ttgtttccca
     2101 taaatgtgaa ggtgattctt gaaaagtgga ctcaggccct tggcattctc tacttttaaa
     2161 atgataatgt gctttgagaa gactttgggg gcgggggttg agattaaagt ggctaaaaca
     2221 agacaaatac cagcaaatgc ctatttgcac tgtaacttta attatgtcta ataaatttct
     2281 agataaaatt g
//
